ES2090701T3 - Agentes antihelminticos de bencimidazol. - Google Patents

Agentes antihelminticos de bencimidazol.

Info

Publication number
ES2090701T3
ES2090701T3 ES92923126T ES92923126T ES2090701T3 ES 2090701 T3 ES2090701 T3 ES 2090701T3 ES 92923126 T ES92923126 T ES 92923126T ES 92923126 T ES92923126 T ES 92923126T ES 2090701 T3 ES2090701 T3 ES 2090701T3
Authority
ES
Spain
Prior art keywords
c4alkoxy
pct
heteroaryl
aryl
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92923126T
Other languages
English (en)
Inventor
Bernard Joseph Banks
Christopher James Dutton
Alexander Crossan Goudie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2090701T3 publication Critical patent/ES2090701T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

AGENTES ANTIHELMINTICOS DE BENZIMIDAZOL DE LA FORMULA (I) Y SUS SALES NO TOXICAS, DONDE R1, QUE ESTA EN LA POSICION 5(6) ES O BIEN H O BIEN CIERTO SUSTITUYENTE INDICADO, "ALK" ES UN GRUPO METILENO O ETILENO; R2 ES CIANO, ALQUENILO C2.C4, ALQUINILO C2-C4, ALCANOILO C2-C4, ALCOXI C2-C4. ALQUENOXI C2-C4, ARILO, HETEROARILO, ALCOXIARILO C1-C4, O ALCOXIHETEROARILO C1-C4, DONDE "ARIL" SIGNIFICA FENILO OPCIONALMENTE SUSTITUIDO POR 1 A 3 SUSTITUYENTES CADA UNO ELEGIDO INDEPENDIENTEMENTE ENTRE HALO, ALQUILO C1-C4, ALCOXI C1-C4, ALQUILTIO C1.C4, ALQUILSULFINILO C1-C4, Y ALQUILSULFONILO C1-C4 EN DONDE "HETEROARIL" SIGNIFICA TIENILO, FURILOO PIRIDINILIO TODOS OPCIONALMENTE SUSTITUIDOS POR 1 A 3 SUSTITUYENTES CADA UNO INDEPENDIENTES ELEGIDO ENTRE HALO, ALQUILO C1-C4, ALCOXI C1-C4, ALQUILTIO C1-C4, ALQUILSUFINILO C1-C4 Y ALQUILSULFONILO C1-C4; Y R3 ES UN GRUPO ALQUILO C1-C4 Y PARENTERALMENTE ACTIVOS, Y SON ASI APROPIADOS PARA LA ADMINISTRACION PARENTERAL (ESPECIALMENTE INTRAMUSCULAR) POR GOTEO O VERTIDO.
ES92923126T 1991-11-12 1992-11-04 Agentes antihelminticos de bencimidazol. Expired - Lifetime ES2090701T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919124002A GB9124002D0 (en) 1991-11-12 1991-11-12 Benzimidazole anthelmintic agents

Publications (1)

Publication Number Publication Date
ES2090701T3 true ES2090701T3 (es) 1996-10-16

Family

ID=10704487

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92923126T Expired - Lifetime ES2090701T3 (es) 1991-11-12 1992-11-04 Agentes antihelminticos de bencimidazol.

Country Status (16)

Country Link
US (1) US5475005A (es)
EP (1) EP0613469B1 (es)
JP (1) JP2818030B2 (es)
AT (1) ATE141594T1 (es)
AU (1) AU681047B2 (es)
BR (1) BR9206731A (es)
CA (1) CA2120616C (es)
DE (1) DE69213021T2 (es)
DK (1) DK0613469T3 (es)
ES (1) ES2090701T3 (es)
GB (1) GB9124002D0 (es)
GR (1) GR3021344T3 (es)
NZ (1) NZ245089A (es)
PT (1) PT101047B (es)
WO (1) WO1993010101A1 (es)
ZA (1) ZA928684B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU662580B2 (en) * 1991-12-26 1995-09-07 Microsules Argentina S.A. De Servicios C.I.I.A. Subcutaneous or intramuscular injectable compositions containing benzimidazole as active agent for the treatment of gastrointestinal helminthiasis and method for their preparation
WO2006050148A2 (en) * 2004-10-29 2006-05-11 Teva Pharmaceutical Industries, Ltd. Propargyl trifluoromethoxy aminobenzimidazole derivatives
BR112014009391A2 (pt) * 2011-10-26 2017-04-18 Dow Agrosciences Llc dosagem faseada de clopidogrel

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2933502A (en) * 1958-02-12 1960-04-19 Du Pont Benzimidazolone derivatives
US3010698A (en) * 1960-04-14 1961-11-28 Stanray Corp Lift jack
BE666795A (es) * 1964-08-04 1966-01-13
US3427388A (en) * 1966-05-06 1969-02-11 Du Pont Esters of benzimidazolecarbamic acid as mite ovicides
FR2046114A5 (en) * 1970-01-30 1971-03-05 Dynachim Sarl Benzimidazole derivs anthelmintic, antifung - al bactericidal, aericidal, insecticidal, nema
US4002640A (en) * 1972-12-29 1977-01-11 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
HU169503B (es) * 1974-02-05 1976-12-28
DE2425704A1 (de) * 1974-05-28 1975-12-18 Hoechst Ag Substituierte phenylmercapto-benzimidazole
US3915986A (en) * 1974-06-19 1975-10-28 Smithkline Corp Methyl 5-propylthio-2-benzimidazolecarbamate
US4032536A (en) * 1976-07-22 1977-06-28 Janssen Pharmaceutica N.V. (1h-benzimidazol-2-yl)carbamates
IN149762B (es) * 1978-06-16 1982-04-10 Ciba Geigy India Ltd
DE2840927A1 (de) * 1978-09-20 1980-04-10 Bayer Ag 3,4-dihydroisochinoline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4512998A (en) * 1980-10-20 1985-04-23 Schering Corporation Anthelmintic benzimidazole carbamates
US4435418A (en) * 1982-12-13 1984-03-06 Smithkline Beckman Corporation 5-Phenylethenylbenzimidazoles
DE3247615A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4826841A (en) * 1985-04-05 1989-05-02 Eli Lilly And Company Alkanoyl anilides as pesticides
NZ232785A (en) * 1989-03-15 1991-03-26 Janssen Pharmaceutica Nv 5-(1,2 benzisoxazol-, benzimidazol and benzisothiazol-3- yl)-1h-benzimadazol-2-yl carbamic acid ester derivatives preparatory processes, intermediates and anthelmintic compositions

Also Published As

Publication number Publication date
CA2120616C (en) 1998-09-22
NZ245089A (en) 1995-04-27
AU681047B2 (en) 1997-08-14
WO1993010101A1 (en) 1993-05-27
GB9124002D0 (en) 1992-01-02
DE69213021D1 (de) 1996-09-26
DE69213021T2 (de) 1996-12-19
AU3283195A (en) 1996-04-04
PT101047B (pt) 1999-08-31
ZA928684B (en) 1994-05-11
JPH07501326A (ja) 1995-02-09
EP0613469A1 (en) 1994-09-07
DK0613469T3 (da) 1996-09-09
GR3021344T3 (en) 1997-01-31
EP0613469B1 (en) 1996-08-21
JP2818030B2 (ja) 1998-10-30
BR9206731A (pt) 1995-10-31
US5475005A (en) 1995-12-12
AU2912592A (en) 1993-06-15
PT101047A (pt) 1994-02-28
ATE141594T1 (de) 1996-09-15
CA2120616A1 (en) 1993-05-27
AU660338B2 (en) 1995-06-22

Similar Documents

Publication Publication Date Title
YU56492A (sh) Derivati hinuklidina
MY129408A (en) Disubstituted bicyclic, heterocycles, the preparation and the use thereof as pharmaceutical compositions
ES2175079T3 (es) Derivados de indol utiles como inhibidores de cgmp-pde.
ATE228115T1 (de) Bizyklische fibrinogenantagonisten
DK0597088T3 (da) Nye imidazolderivater, deres fremstilling og terapeutiske anvendelser
TR200000611T2 (tr) IL-8 Reseptörü antagonistleri
CA2337825A1 (en) Disubstituted bicyclic heterocycles, the preparation thereof and their use as pharmaceutical compositions
NO20064089L (no) Kondensert ring 4-oksopyrimidinderivat
NZ325449A (en) Naphthyl-substituted benzimidazole derivatives as anticoagulants
EA199901014A1 (ru) C-4"-замещенные макролидные производные
PT880508E (pt) Derivados de quinazolina como inibidores de vegf
ATE59644T1 (de) 5,6-dihydro-2-(substituiertes phenyl)-1,2,4triazin-3,5(2h,4h)-dione.
BG105111A (bg) Бензимидазоли, тяхното получаване и употребата имкато лекарствени средства
EA200000614A1 (ru) 2,3-замещенные соединения индола в качестве ингибиторов сох-2
BR0015195A (pt) Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma condição associada com a transmissão reduzida de nicotina para o tratamento ou profilaxia de distúrbios psicóticos ou distúrbios de deterioração intelectual e para o tratamento ou profilaxia de doenças ou condições humanas
ES2071325T3 (es) Derivados de 4-alquilimidazol.
DE60111774D1 (de) Antibakterielle verbindungen
TR199801218T2 (xx) Takikinin antagonistleri olarak N-asil-2-ikameli-4-(Benzimidazolil-ya da imidazopiridinil-ikameli art�klar)-piperidinler.
ES2090701T3 (es) Agentes antihelminticos de bencimidazol.
ATE161837T1 (de) Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält
KR930006024A (ko) 이미다조 인돌리진 유도체 및 그의 제조방법
ES2094545T3 (es) Derivados n-substituidos del 3-azabiciclo(3.2.0)heptano, como neurolepticos etc..
RU94022663A (ru) Производные 2-меркаптобензимидазола, обладающие селективной анксиолитической активностью
TR200200485T2 (tr) Yeni A-500359 türevleri.
DE69828390D1 (de) Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 613469

Country of ref document: ES

FG2A Definitive protection

Ref document number: 613469

Country of ref document: ES