ES2091244T3 - Uso terapeutico de un compuesto anti-invasion. - Google Patents

Uso terapeutico de un compuesto anti-invasion.

Info

Publication number
ES2091244T3
ES2091244T3 ES90909266T ES90909266T ES2091244T3 ES 2091244 T3 ES2091244 T3 ES 2091244T3 ES 90909266 T ES90909266 T ES 90909266T ES 90909266 T ES90909266 T ES 90909266T ES 2091244 T3 ES2091244 T3 ES 2091244T3
Authority
ES
Spain
Prior art keywords
invasion
metastasis
compound
cancer
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909266T
Other languages
English (en)
Inventor
Elsie C Kohn
Lance A Liotta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Commerce
US Department of Health and Human Services
Original Assignee
United States Department of Commerce
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Commerce, US Department of Health and Human Services filed Critical United States Department of Commerce
Application granted granted Critical
Publication of ES2091244T3 publication Critical patent/ES2091244T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVASION DE TUMOR Y METASTASIS ES EL ASPECTO DEL CANCER MAS AMENAZADOR PARA LA VIDA. LA INVASION Y LA METASTASIS ES UN PROCESO DE PASOS MULTIPLES. LAS FUNCIONES CELULARES REQUERIDAS PARA LA INVASION SON ADHERENCIA, LOCOMOCION Y MIGRACION DIRIGIDA. LA REGULACION DE ESTOS PROCESOS PUEDE SER INDEPENDIENTE DEL CRECIMIENTO DE LA CELULA. SE DESCUBRIO QUE UN COMPUESTO CARBOXIL-AMINO-IMIDAZOLE ERA UN POTENTE INHIBIDOR DE ADHERENCIA, MOTILIDAD, INVASION, PROLIFERACION Y METASTASIS DE LA CELULA TUMORAL. ESTE COMPUESTO Y LOS DERIVADOS DEL MISMO CONSTITUYEN UN AGENTE DE TRATAMIENTO DEL CANCER DE PARTICULAR UTILIZACION EN EL TRATAMIENTO DE LA CARCINOMATOSIS PERITONEAL DEL CANCER OVARICO.
ES90909266T 1989-05-19 1990-05-18 Uso terapeutico de un compuesto anti-invasion. Expired - Lifetime ES2091244T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/355,744 US5132315A (en) 1989-05-19 1989-05-19 Therapeutic application of an anti-invasive compound

Publications (1)

Publication Number Publication Date
ES2091244T3 true ES2091244T3 (es) 1996-11-01

Family

ID=23398663

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909266T Expired - Lifetime ES2091244T3 (es) 1989-05-19 1990-05-18 Uso terapeutico de un compuesto anti-invasion.

Country Status (10)

Country Link
US (1) US5132315A (es)
EP (1) EP0472661B1 (es)
JP (1) JP2559641B2 (es)
AT (1) ATE140850T1 (es)
AU (1) AU649400B2 (es)
CA (1) CA2057021C (es)
DE (1) DE69027991T2 (es)
DK (1) DK0472661T3 (es)
ES (1) ES2091244T3 (es)
WO (1) WO1990014009A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688519A (en) * 1987-04-06 1997-11-18 Leonard; Robert J. Flash-flow fused medicinal implants
US5359078A (en) * 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds
US5880129A (en) * 1989-05-19 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting invasion and metastasis of malignant solid tumors
US5498620A (en) * 1989-05-19 1996-03-12 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor 1,2,3-triazolo compounds
US5633274A (en) * 1993-02-18 1997-05-27 President And Fellows Of Harvard College Cancer treatments
US5358959A (en) * 1993-02-18 1994-10-25 President And Fellows Of Harvard University Methods for treating arteriosclerosis
US5512591A (en) * 1993-02-18 1996-04-30 President And Fellows Of Harvard College Treatments for diseases characterized by neovascularization
US5405782A (en) * 1993-03-31 1995-04-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection and quantitation method for therapeutic agents in blood
CA2472404A1 (en) 1993-07-19 1995-02-02 Angiotech Pharmaceuticals, Inc. Combination of stent and anti-angiogenic factor
US20030203976A1 (en) * 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5602156A (en) * 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
US5744492A (en) * 1993-09-17 1998-04-28 United States Of America Method for inhibiting angiogenesis
US6057346A (en) * 1994-12-12 2000-05-02 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of retroviral LTR promoters by calcium response modifiers
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
US5935860A (en) * 1995-03-07 1999-08-10 The George Washington University Use of uteroglobin expression as a molecular marker for prostatic intraepithelial neoplasia
US5556871A (en) * 1995-04-24 1996-09-17 President & Fellows Of Harvard College Method for treating epithelial precancerous lesions with topical inidazoles
DE69633566T2 (de) 1995-07-21 2005-12-08 Savvipharm Inc. Orotatsalze von 5-amino- oder substituierten amino-1,2,3-triazolen zur behandlung von neoplasmen
US5728707A (en) * 1995-07-21 1998-03-17 Constantia Gruppe Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide
US5741777A (en) * 1995-10-31 1998-04-21 Board Of Regents, The University Of Texas System Modulation of wound contraction by blocking protein tyrosine phosphatase
US7276050B2 (en) 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CN101164538B (zh) * 2006-10-16 2011-12-14 中国医学科学院基础医学研究所 羧胺三唑类化合物及其盐在制备治疗疼痛性疾病和/或炎症性疾病的药物中的应用
NZ598482A (en) * 2009-09-04 2014-05-30 Tactical Therapeutics Inc Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazole orotate formulations
US8912223B2 (en) 2009-09-04 2014-12-16 Tactical Therapeutics Inc Compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazoles orotate formulations
CN120817906A (zh) * 2024-04-12 2025-10-21 广东银珠医药科技有限公司 一种三氮唑类化合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590201A (en) * 1984-02-02 1986-05-20 Merck & Co., Inc. 5-amino or substituted amino 1,2,3-triazoles
EP0151528B1 (en) * 1984-02-02 1990-07-04 Merck & Co. Inc. 5-(amino or substituted amino)-1,2,3-triazoles
US4847257A (en) * 1987-08-20 1989-07-11 Merck & Co., Inc. 5-Amino or substituted amino 1,2,3,-triazoles useful as antiproliferative agents
US4923885A (en) * 1988-08-19 1990-05-08 Merck & Co., Inc. 5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs as antiproliferative agents
US5359078A (en) 1989-05-19 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Signal transduction inhibitor compounds

Also Published As

Publication number Publication date
DK0472661T3 (da) 1996-10-07
JPH04506516A (ja) 1992-11-12
AU5825190A (en) 1990-12-18
AU649400B2 (en) 1994-05-26
CA2057021C (en) 1993-09-07
ATE140850T1 (de) 1996-08-15
CA2057021A1 (en) 1990-11-20
EP0472661A1 (en) 1992-03-04
WO1990014009A1 (en) 1990-11-29
DE69027991T2 (de) 1997-02-06
JP2559641B2 (ja) 1996-12-04
DE69027991D1 (de) 1996-09-05
EP0472661B1 (en) 1996-07-31
EP0472661A4 (en) 1992-04-22
US5132315A (en) 1992-07-21

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