ES2091948T3 - 1,3-oxatiolanos sustituidos con propiedades antiviricas. - Google Patents

1,3-oxatiolanos sustituidos con propiedades antiviricas.

Info

Publication number
ES2091948T3
ES2091948T3 ES91919496T ES91919496T ES2091948T3 ES 2091948 T3 ES2091948 T3 ES 2091948T3 ES 91919496 T ES91919496 T ES 91919496T ES 91919496 T ES91919496 T ES 91919496T ES 2091948 T3 ES2091948 T3 ES 2091948T3
Authority
ES
Spain
Prior art keywords
substituted
oxatiolanes
antiviric
properties
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91919496T
Other languages
English (en)
Inventor
Bernard Belleau
Livio Brasili
Nghe Nguyen-Ba
Chan Chun Kong Laval
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
IAF BioChem International Inc
Biochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IAF BioChem International Inc, Biochem Pharma Inc filed Critical IAF BioChem International Inc
Application granted granted Critical
Publication of ES2091948T3 publication Critical patent/ES2091948T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS 1,3-OXATIOLANOS SUSTITUIDOS Y A 1,3-DITIOLANOS SUSTITUIDOS DE LA FORMULA I EN LA QUE X ES S, S=O, O SO2; Y ES O, S, S=O, O SO2; R1 ES HIDROGENO, SILIL TRISUSTITUIDO, ALQUIL C1-C6 SUSTITUIDO O INSUSTITUIDO, ARALQUIL SUSTITUIDO O INSUSTITUIDO, O ACIL C1-C16 SUSTITUIDO O INSUSTITUIDO; Y R2 ES UNA PURINA O UNA BASE DE PIRIMIDINA O UN ANALOGO O UN DERIVADO DE LAS MISMAS; ASIMISMO SE PRESENTAN LOS DERIVADOS FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS. ESTA INVENCION TAMBIEN SE REFIERE A UN PROCESO PARA PREPARAR ESTOS COMPUESTOS, A LOS PRODUCTOS INTERMEDIOS UTILES EN SU PREPARACION, A SUS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y AL USO DE ESTOS COMPUESTOS COMO AGENTES ANTIVIRALES.
ES91919496T 1990-11-13 1991-11-12 1,3-oxatiolanos sustituidos con propiedades antiviricas. Expired - Lifetime ES2091948T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61284090A 1990-11-13 1990-11-13

Publications (1)

Publication Number Publication Date
ES2091948T3 true ES2091948T3 (es) 1996-11-16

Family

ID=24454850

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91919496T Expired - Lifetime ES2091948T3 (es) 1990-11-13 1991-11-12 1,3-oxatiolanos sustituidos con propiedades antiviricas.

Country Status (11)

Country Link
EP (1) EP0560794B1 (es)
JP (1) JP2960164B2 (es)
AT (1) ATE143016T1 (es)
AU (1) AU8864191A (es)
CA (1) CA2095613C (es)
DE (1) DE69122264T2 (es)
DK (1) DK0560794T3 (es)
ES (1) ES2091948T3 (es)
GR (1) GR3021074T3 (es)
HK (1) HK12597A (es)
WO (1) WO1992008717A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175008B1 (en) * 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
ES2196004T3 (es) * 1989-02-08 2003-12-16 Iaf Biochem Int Procedimiento para preparar 1,3-oxatiolanos sustituidos con propiedades antivirales.
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US6228860B1 (en) * 1990-11-13 2001-05-08 Biochem Pharma Inc. Substituted 1,3-oxathiolanes with antiviral properties
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
US6369066B1 (en) 1990-11-13 2002-04-09 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes with antiviral properties
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
IL100965A (en) * 1991-02-22 1999-12-31 Univ Emory 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it
US6812233B1 (en) 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
GB9226879D0 (en) * 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
US6005107A (en) * 1992-12-23 1999-12-21 Biochem Pharma, Inc. Antiviral compounds
US6444656B1 (en) 1992-12-23 2002-09-03 Biochem Pharma, Inc. Antiviral phosphonate nucleotides
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
FR2720397B1 (fr) * 1994-05-24 1996-08-23 Laphal Laboratoires Sa Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.
ATE346651T1 (de) 1995-06-07 2006-12-15 Univ Emory Nucleoside mit anti-hepatitis b virus wirksamkeit
US6046228A (en) * 1996-07-05 2000-04-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof
IT1290447B1 (it) * 1997-03-28 1998-12-03 Zambon Spa Derivati 1,3-ossatiolanici ad attivita' antivirale
DK1140937T3 (da) 1998-12-23 2004-03-22 Shire Biochem Inc Antivirale nucleosid-analoger
ATE397001T1 (de) * 2000-02-10 2008-06-15 Mitsui Chemicals Inc Verfahren zur selektiven herstellung eines 1- phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
PL218777B1 (pl) * 2001-06-15 2015-01-30 Shire Canada Inc Stereoselektywny sposób wytwarzania nukleozydów
RU2215002C1 (ru) * 2002-04-29 2003-10-27 Катаев Валерий Алексеевич Смесь изомеров 2-моноэтаноламино-5(6)-нитро-1-(тиетанил-3)бензимидазола
US7501514B1 (en) 2003-10-15 2009-03-10 Shire Biochem, Inc. Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides
RU2430919C2 (ru) * 2005-03-14 2011-10-10 Шайр Канада Инк. Способы получения оптически активного цис-2-гидроксиметил-4-(цитозин-1'-ил)-1,3-оксатиолана или его фармацевтически приемлемых солей
KR100993031B1 (ko) * 2005-03-14 2010-11-08 샤이어 캐나다 인코포레이티드 광학적으로 활성인시스-2-하이드록시메틸-4-(사이토신-1'-일)-1,3-옥사티올란또는 그의 약제학적으로 허용가능한 염의 제조공정과 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties

Also Published As

Publication number Publication date
ATE143016T1 (de) 1996-10-15
EP0560794B1 (en) 1996-09-18
DK0560794T3 (da) 1996-12-23
GR3021074T3 (en) 1996-12-31
CA2095613C (en) 2001-01-02
CA2095613A1 (en) 1992-05-14
DE69122264T2 (de) 1997-02-06
DE69122264D1 (de) 1996-10-24
JP2960164B2 (ja) 1999-10-06
WO1992008717A1 (en) 1992-05-29
AU8864191A (en) 1992-06-11
HK12597A (en) 1997-02-14
EP0560794A1 (en) 1993-09-22
JPH06504266A (ja) 1994-05-19

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