ATE310738T1 - Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen - Google Patents

Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen

Info

Publication number
ATE310738T1
ATE310738T1 AT97942372T AT97942372T ATE310738T1 AT E310738 T1 ATE310738 T1 AT E310738T1 AT 97942372 T AT97942372 T AT 97942372T AT 97942372 T AT97942372 T AT 97942372T AT E310738 T1 ATE310738 T1 AT E310738T1
Authority
AT
Austria
Prior art keywords
pct
dithiaheterocyclic
compounds
pharmaceutical preparations
preparations containing
Prior art date
Application number
AT97942372T
Other languages
English (en)
Inventor
William G Rice
Robert R Schultz
David C Baker
Louis E Henderson
Original Assignee
Us Gov Health & Human Serv
Univ Tennessee Res Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Univ Tennessee Res Corp filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE310738T1 publication Critical patent/ATE310738T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT97942372T 1996-07-05 1997-07-03 Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen ATE310738T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2166596P 1996-07-05 1996-07-05
PCT/US1997/010870 WO1998001440A2 (en) 1996-07-05 1997-07-03 Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof

Publications (1)

Publication Number Publication Date
ATE310738T1 true ATE310738T1 (de) 2005-12-15

Family

ID=21805475

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97942372T ATE310738T1 (de) 1996-07-05 1997-07-03 Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen

Country Status (7)

Country Link
US (1) US6046228A (de)
EP (1) EP1023284B1 (de)
AT (1) ATE310738T1 (de)
AU (1) AU737038B2 (de)
CA (1) CA2260128A1 (de)
DE (1) DE69734734D1 (de)
WO (1) WO1998001440A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417180B1 (en) * 1998-10-07 2002-07-09 University Of Massachusetts Zinc finger-reactive antimicrobial compounds
DE69920497T2 (de) 1998-10-26 2006-02-09 The Research Foundation Of State University Of New York Liponsaürederivate und deren verwendung bei der behandlung von krankheiten
US6204288B1 (en) 1999-03-08 2001-03-20 The University Of Mississippi 1,2-dithiolane derivatives
US6288106B1 (en) * 1999-05-25 2001-09-11 Chronorx, Llc Processes for the synthesis and use of various α-lipoic acid complexes
WO2001025226A1 (en) * 1999-10-05 2001-04-12 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
US6638915B1 (en) * 2000-06-30 2003-10-28 Harold Killam Anti-viral composition
EP1172110A3 (de) * 2000-07-07 2003-09-17 Basf Aktiengesellschaft Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen
AU2002322721B2 (en) 2001-08-03 2009-01-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents
TWI281916B (en) * 2001-10-25 2007-06-01 Lilly Co Eli Antitumor compounds and methods
DE10163836A1 (de) 2001-12-22 2003-07-10 Friz Biochem Gmbh Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren
US7101676B2 (en) * 2002-01-11 2006-09-05 Douglas Buechter Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA
AU2003279916A1 (en) * 2002-10-08 2004-05-04 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid
EP2125775A4 (de) 2007-03-01 2011-07-13 Cedars Sinai Medical Center Antioxidationspolymere mit [1,2]-dithiolanteilen und ihre verwendung
WO2009086547A1 (en) 2008-01-03 2009-07-09 Cedars-Sinai Medical Center Antioxidant nanosphere comprising [1,2]-dithiolane moieties
US8603531B2 (en) 2008-06-02 2013-12-10 Cedars-Sinai Medical Center Nanometer-sized prodrugs of NSAIDs
ES2529060T3 (es) 2008-11-24 2015-02-16 Cedars-Sinai Medical Center Derivados antioxidantes de la camptotecina y nanoesferas antineoplásicas antioxidantes de los mismos
WO2011156674A2 (en) 2010-06-10 2011-12-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thioether prodrug compositions as anti-hiv and anti-retroviral agents
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
JP6480340B2 (ja) * 2012-11-15 2019-03-06 ブランデイズ ユニバーシティー 環状ジスルフィドを用いるシステイン残基のテザリング
CN104955818B (zh) 2012-12-06 2017-08-04 默沙东公司 核苷激酶旁路组合物和方法
WO2015035003A1 (en) 2013-09-05 2015-03-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thioether prodrug compositions as anti-hiv and anti-retroviral agents
WO2017017669A1 (en) * 2015-07-24 2017-02-02 Aposense Ltd. Pro-drugs and related methods
CA2994298A1 (en) 2015-08-18 2017-02-23 Brandeis University Tethering cysteine residues using cyclic disulfides
WO2019130319A1 (en) 2018-01-01 2019-07-04 Aposense Ltd. Compounds and methods for trans-membrane delivery of molecules
WO2022049219A1 (en) 2020-09-02 2022-03-10 Université De Genève Methods for treating viral infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3158621A (en) * 1962-06-20 1964-11-24 American Cyanamid Co Dithiolium compounds and their preparation
CH656382A5 (de) * 1983-10-24 1986-06-30 Sandoz Ag Sulfoxide, verfahren zu ihrer herstellung und ihre verwendung.
EP0318891B1 (de) * 1987-12-04 1992-01-02 ASTA Medica Aktiengesellschaft Injizierbare Lösung des Thioctsäuresalzes mit Trometamol und/oder basischen Aminosäuren
AT500684B8 (de) * 1989-11-09 2006-11-15 Meda Pharma Gmbh & Co Kg Verwendung von schwefelhältigen carbonsäuren zur herstellung eines arzneimittels zur bekämpfung von erkrankungen durch retroviren
DK0560794T3 (da) * 1990-11-13 1996-12-23 Iaf Biochem Int Substituerede 1,3-oxathiolaner med antivirale egenskaber
FR2676057B1 (fr) * 1991-05-02 1995-03-03 Therapeutique Moder Lab Derives de 1,2-dithiole-3-thione, procede de preparation de ces derives, ainsi que l'utilisation de ces derives comme intermediaires de synthese ou comme medicaments.
US6001555A (en) * 1994-09-23 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein
US5693460A (en) * 1996-06-24 1997-12-02 Eastman Kodak Company Silver halide photographic elements containing dioxide compunds a stabilizers
EP0855396A1 (de) * 1997-01-22 1998-07-29 ASTA Medica Aktiengesellschaft Metabolite von Thioctsäure und deren Verwendung

Also Published As

Publication number Publication date
AU4408597A (en) 1998-02-02
AU737038B2 (en) 2001-08-09
DE69734734D1 (de) 2005-12-29
EP1023284B1 (de) 2005-11-23
WO1998001440A3 (en) 1998-05-14
US6046228A (en) 2000-04-04
WO1998001440A2 (en) 1998-01-15
CA2260128A1 (en) 1998-01-15
EP1023284A2 (de) 2000-08-02

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