ES2092699T3 - Composicion para tratamiento cosmetico y/o farmaceutico, de larga duracion, de las capas superiores de la epidermis, por una aplicacion topica sobre la piel. - Google Patents
Composicion para tratamiento cosmetico y/o farmaceutico, de larga duracion, de las capas superiores de la epidermis, por una aplicacion topica sobre la piel.Info
- Publication number
- ES2092699T3 ES2092699T3 ES92919214T ES92919214T ES2092699T3 ES 2092699 T3 ES2092699 T3 ES 2092699T3 ES 92919214 T ES92919214 T ES 92919214T ES 92919214 T ES92919214 T ES 92919214T ES 2092699 T3 ES2092699 T3 ES 2092699T3
- Authority
- ES
- Spain
- Prior art keywords
- cosmetic
- epidermis
- skin
- topical application
- upper layers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Emergency Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA COMPOSICION CONTIENE, EN UN VEHICULO APROPIADO, NANOPARTICULAS CONSTITUIDAS DE POLIMERO(S) NO BIODEGRADABLES(S) QUE ENCAPSULAN UNA FASE ACEITOSA. ESTA FASE ACEITOSA CONTIENE AL MENOS UN ACEITE ACTIVO Y/O AL MENOS UN ACEITE DE SOPORTE Y/O AL MENOS UN ACTIVO EN UN ACEITE ACTIVO Y/O EN UN ACEITE SOPORTE. AL MENOS UN ACTIVO ES ELEGIDO ENTRE LOS QUE DEBEN TENER UNA ACCION COSMETICA Y/O FARMACEUTICA DE LARGA DURACION. LAS NANOCAPSULAS TIENEN DIMENSIONES COMPRENDIDAS ENTRE 100 Y 1000 NM.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9111344A FR2681248B1 (fr) | 1991-09-13 | 1991-09-13 | Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2092699T3 true ES2092699T3 (es) | 1996-12-01 |
Family
ID=9416942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92919214T Expired - Lifetime ES2092699T3 (es) | 1991-09-13 | 1992-08-27 | Composicion para tratamiento cosmetico y/o farmaceutico, de larga duracion, de las capas superiores de la epidermis, por una aplicacion topica sobre la piel. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5993831A (es) |
| EP (1) | EP0557489B1 (es) |
| JP (2) | JPH06502874A (es) |
| AT (1) | ATE143793T1 (es) |
| CA (1) | CA2095617A1 (es) |
| DE (1) | DE69214425T2 (es) |
| ES (1) | ES2092699T3 (es) |
| FR (1) | FR2681248B1 (es) |
| WO (1) | WO1993005753A1 (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2681248B1 (fr) * | 1991-09-13 | 1995-04-28 | Oreal | Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau. |
| GB9211708D0 (en) * | 1992-06-03 | 1992-07-15 | Unilever Plc | Cosmetic composition |
| EP0669124A1 (en) * | 1994-02-28 | 1995-08-30 | Rohm And Haas Company | Ultraviolet radiation absorbing composition |
| US5663213A (en) * | 1994-02-28 | 1997-09-02 | Rohm And Haas Company | Method of improving ultraviolet radiation absorption of a composition |
| FR2723848B1 (fr) * | 1994-08-31 | 1997-06-20 | Oreal | Composition cosmetique ou dermatologique contenant des extraits vegetaux encapsules |
| FR2734480B1 (fr) * | 1995-05-22 | 1997-08-08 | Gueyne Edith | Composition cosmetique pour la peau comprenant une nanodispersion de corps gras dans l'eau |
| FR2742677B1 (fr) | 1995-12-21 | 1998-01-16 | Oreal | Nanoparticules enrobees d'une phase lamellaire a base de tensioactif silicone et compositions les contenant |
| JP4494539B2 (ja) * | 1997-02-28 | 2010-06-30 | ディーエスエム アイピー アセッツ ビー.ブイ. | 流動自由な乾燥粒子 |
| FR2760641B1 (fr) * | 1997-03-13 | 2000-08-18 | Oreal | Emulsion huile-dans-eau stable, son procede de fabrication et son utilisation dans les domaines cosmetique et dermatologique |
| DE19852196A1 (de) * | 1998-11-04 | 2000-05-11 | Coty Bv | Vitaminhaltiger Lippen- oder Pflegestift |
| GB9812181D0 (en) * | 1998-06-05 | 1998-08-05 | Unilever Plc | Personal washing compositions |
| JP4472035B2 (ja) * | 1998-06-17 | 2010-06-02 | 森下仁丹株式会社 | 長期保存安定性に優れたカプセル製剤 |
| US6632457B1 (en) * | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| FR2787729B1 (fr) * | 1998-12-29 | 2001-01-26 | Oreal | Nanocapsules a base de polymeres anioniques hydrodispersibles, leur procede de preparation et compositions cosmetiques ou dermatologiques les contenant |
| FR2787730B1 (fr) * | 1998-12-29 | 2001-02-09 | Oreal | Nanocapsules a base de poly(alkylene adipate), leur procede de preparation et compositions cosmetiques ou dermatologiques les contenant |
| FR2790405B1 (fr) * | 1999-03-02 | 2001-04-20 | Oreal | Nanocapsules a base de polymeres dendritiques |
| DE19911058B4 (de) * | 1999-03-12 | 2004-09-30 | Biotec Asa | Verwendung von nanoskaligen wasserlöslichen β-(1,3)-Glucanen |
| NO20002309L (no) * | 1999-05-12 | 2000-11-13 | Hoffmann La Roche | Fotostabile kosmetiske lysavskjermende sammensetninger |
| ATE353210T1 (de) * | 1999-05-25 | 2007-02-15 | Sol Gel Technologies Ltd | Ein verfahren zur herstellung von einem lichtstabilen sonnenschutzmittel |
| FR2805761B1 (fr) * | 2000-03-02 | 2002-08-30 | Mainelab | Nanocapsules lipidiques, procede de preparation et utilisation comme medicament |
| US7758888B2 (en) * | 2000-04-21 | 2010-07-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
| CN1189159C (zh) * | 2000-05-05 | 2005-02-16 | 欧莱雅 | 含水溶性美容活性组分水性核的微胶囊及含其的组合物 |
| US20020153508A1 (en) * | 2000-06-29 | 2002-10-24 | Lynch Matthew Lawrence | Cubic liquid crystalline compositions and methods for their preparation |
| US6977171B1 (en) | 2001-04-03 | 2005-12-20 | University Of Florida | Detoxification and decontamination using nanotechnology therapy |
| WO2002080885A1 (en) * | 2001-04-03 | 2002-10-17 | University Of Florida | Detoxification and decontamination using nanotechnology therapy |
| KR100463167B1 (ko) * | 2001-04-13 | 2004-12-23 | 주식회사 태평양 | 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물 |
| FR2836381B1 (fr) * | 2002-02-22 | 2004-09-10 | Oreal | Nanocapsules a base de polyester polyol, et compositions cosmetiques ou dermatologiques les contenant |
| US7923030B2 (en) | 2003-03-14 | 2011-04-12 | Sol-Gel Technologies, Inc. | Agent-encapsulating micro- and nanoparticles, methods for preparation of same and products containing same |
| DE10312763A1 (de) * | 2003-03-21 | 2004-09-30 | IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG | Verfahren zur Herstellung einer SLN-Dispersion |
| US7837742B2 (en) * | 2003-05-19 | 2010-11-23 | The Procter & Gamble Company | Cosmetic compositions comprising a polymer and a colorant |
| EA008771B1 (ru) * | 2003-07-31 | 2007-08-31 | Сол-Джел Текнолоджиз Лтд. | Микрокапсулы, заполненные активными ингредиентами, и способ их приготовления |
| AU2006274541B2 (en) | 2005-08-02 | 2012-12-13 | Sol-Gel Technologies Ltd. | Metal oxide coating of water insoluble ingredients |
| DE102005037844A1 (de) * | 2005-08-04 | 2007-04-05 | Intendis Gmbh | Wasserfreies Mehr-Phasen-Gel-System |
| FR2895257A1 (fr) * | 2005-12-22 | 2007-06-29 | Oreal | Actif pour le traitement du contour des yeux. |
| FR2910345A1 (fr) * | 2006-12-20 | 2008-06-27 | Oreal | Particules coeur/ecorce a base de composes silicones |
| FR2910284B1 (fr) * | 2006-12-20 | 2009-04-17 | Oreal | Produit cosmetique comprenant des composes silicones et un polymere amphiphile |
| KR20090121291A (ko) * | 2007-02-01 | 2009-11-25 | 솔-겔 테크놀로지스 리미티드 | 산화금속 코팅을 포함한 입자의 제조방법 및 산화금속 코팅을 포함한 입자 |
| BRPI0808163A2 (pt) | 2007-02-01 | 2014-11-04 | Sol Gel Technologies Ltd | Composição para aplicação tópica, métodos para tratar uma condição de superfície em um indivíduo, para preparar uma composição, e para usar o kit, e, kit |
| FR2914189A1 (fr) | 2007-03-26 | 2008-10-03 | Oreal | Utilisation d'une fraction lipopolysaccharidique de vitreoscilla filiformis comme agent stimulant la synthese de peptides antimicrobiens de la peau. |
| FR2918885B1 (fr) | 2007-07-17 | 2009-08-28 | Oreal | Utilisation d'extrait de bacterie cultivee sur eau thermale pour diminuer les poches et/ou les cernes perioculaires |
| FR2920309B1 (fr) | 2007-08-28 | 2010-05-28 | Galderma Res & Dev | Utilisation de travoprost pour traiter la chute des cheveux |
| BRPI0805854A2 (pt) | 2008-10-10 | 2010-08-24 | Biolab Sanus Farmaceutica Ltda | sistema nanoparticulado, processo de preparaÇço do mesmo, uso do mesmo, composiÇço fotoproterora, processo de preparaÇço da mesma, mÉtodo de prevenÇço de doenÇas e distérbios da pele |
| FR2967573B1 (fr) | 2010-11-23 | 2012-11-09 | Rhodia Poliamida E Especialidades Ltda | Kit cosmetique et utilisation pour ameliorer l'aspect de la peau |
| US9271921B2 (en) | 2011-12-14 | 2016-03-01 | Avon Products, Inc. | Cosmetic compositions having persistent tightening effects |
| US8771656B2 (en) | 2011-12-14 | 2014-07-08 | Avon Products, Inc | Long-lasting easy wash-off cosmetic compositions |
| WO2014074555A1 (en) * | 2012-11-06 | 2014-05-15 | CoLabs International Corporation | Composition containing a cellulose derived capsule with a sunscreen |
| US9687465B2 (en) | 2012-11-27 | 2017-06-27 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
| FR3066121B1 (fr) | 2017-05-12 | 2021-10-01 | Ab7 Innovation | Combinaison d'un applicateur et d'une suspension comportant un actif |
| WO2019012537A1 (en) | 2017-07-12 | 2019-01-17 | Sol-Gel Technologies Ltd | COMPOSITIONS COMPRISING ENCAPSULATED TRETTINOIN |
| DE202019005710U1 (de) | 2018-12-14 | 2021-07-20 | Mary Kay Inc. | Kosmetikzusammensetzungen |
| IL286995B2 (en) | 2019-04-07 | 2025-05-01 | Ahava Dead Sea Laboratories Ltd | Nanoparticles containing Dead Sea extract and their uses |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3965033A (en) * | 1970-07-27 | 1976-06-22 | Fuji Photo Film Co., Ltd. | Process for the production of oil-containing microcapsules |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| AU594789B2 (en) * | 1986-07-18 | 1990-03-15 | Minnesota Mining And Manufacturing Company | Cosmetic compositions containing polymer-thickened oil microcapsules |
| FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
| FR2649888B1 (fr) * | 1989-07-18 | 1994-08-26 | Exsymol Sa | Produits pour applications cutanees, a effets cosmetiques ou/et therapeutiques |
| FR2681248B1 (fr) * | 1991-09-13 | 1995-04-28 | Oreal | Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau. |
-
1991
- 1991-09-13 FR FR9111344A patent/FR2681248B1/fr not_active Expired - Fee Related
-
1992
- 1992-08-27 US US08/050,315 patent/US5993831A/en not_active Expired - Fee Related
- 1992-08-27 WO PCT/FR1992/000824 patent/WO1993005753A1/fr not_active Ceased
- 1992-08-27 CA CA002095617A patent/CA2095617A1/fr not_active Abandoned
- 1992-08-27 JP JP5505824A patent/JPH06502874A/ja not_active Ceased
- 1992-08-27 EP EP92919214A patent/EP0557489B1/fr not_active Expired - Lifetime
- 1992-08-27 AT AT92919214T patent/ATE143793T1/de active
- 1992-08-27 ES ES92919214T patent/ES2092699T3/es not_active Expired - Lifetime
- 1992-08-27 DE DE69214425T patent/DE69214425T2/de not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/473,359 patent/US5556617A/en not_active Expired - Lifetime
-
2005
- 2005-09-28 JP JP2005282730A patent/JP2006052229A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2095617A1 (fr) | 1993-03-14 |
| US5556617A (en) | 1996-09-17 |
| JP2006052229A (ja) | 2006-02-23 |
| US5993831A (en) | 1999-11-30 |
| EP0557489A1 (fr) | 1993-09-01 |
| FR2681248B1 (fr) | 1995-04-28 |
| WO1993005753A1 (fr) | 1993-04-01 |
| DE69214425T2 (de) | 1997-02-20 |
| EP0557489B1 (fr) | 1996-10-09 |
| JPH06502874A (ja) | 1994-03-31 |
| FR2681248A1 (fr) | 1993-03-19 |
| DE69214425D1 (de) | 1996-11-14 |
| ATE143793T1 (de) | 1996-10-15 |
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