ES2093211T3 - Derivados de nucleosidos de pirimidina que tienen una actividad antitumoral su preparacion y uso. - Google Patents

Derivados de nucleosidos de pirimidina que tienen una actividad antitumoral su preparacion y uso.

Info

Publication number
ES2093211T3
ES2093211T3 ES92308904T ES92308904T ES2093211T3 ES 2093211 T3 ES2093211 T3 ES 2093211T3 ES 92308904 T ES92308904 T ES 92308904T ES 92308904 T ES92308904 T ES 92308904T ES 2093211 T3 ES2093211 T3 ES 2093211T3
Authority
ES
Spain
Prior art keywords
group
pirimidine
nucleosides
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92308904T
Other languages
English (en)
Inventor
Masakatsu Kaneko
Hitoshi Hotoda
Tomoyuki Shibata
Tomowo Kobayashi
Yoshihiro Mitsuhashi
Akira Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2093211T3 publication Critical patent/ES2093211T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I): EN LA QUE R1, R2 Y R3 SON IGUALES O DIFERENTES Y REPRESENTAN CADA UNA UN ATOMO DE HIDROGENO, UN GRUPO DE ALCANOIOL OPCIONALMENTE SUBSTITUIDO O UN GRUPO DE ALQUENILCARBONIL, CON LA CONDICION DE QUE AL MENOS UNA DE R1, R2 Y R3 REPRESENTA UN GRUPO DE ALCANOIL SUBSTITUIDO QUE TENGA ENTRE 5 Y 24 ATOMOS DE CARBONO, UN GRUPO ALCANOIL O UN GRUPO ALQUENILCARBONIL; Y UNA DE ENTRE R4 Y R5 REPRESENTA UN ATOMO DE HIDROGENO Y LA OTRA REPRESENTA UN GRUPO DE CIANO; LOS COMPUESTOS PRESENTAN UNA ACTIVIDAD ANTITUMORAL EVALUABLE.
ES92308904T 1991-09-30 1992-09-30 Derivados de nucleosidos de pirimidina que tienen una actividad antitumoral su preparacion y uso. Expired - Lifetime ES2093211T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25201591 1991-09-30

Publications (1)

Publication Number Publication Date
ES2093211T3 true ES2093211T3 (es) 1996-12-16

Family

ID=17231394

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92308904T Expired - Lifetime ES2093211T3 (es) 1991-09-30 1992-09-30 Derivados de nucleosidos de pirimidina que tienen una actividad antitumoral su preparacion y uso.

Country Status (24)

Country Link
US (1) US5691319A (es)
EP (1) EP0536936B1 (es)
JP (1) JP2569251B2 (es)
KR (1) KR100255491B1 (es)
CN (1) CN1033227C (es)
AT (1) ATE141281T1 (es)
AU (1) AU654212B2 (es)
BR (1) BR1100621A (es)
CA (1) CA2079413C (es)
CZ (1) CZ289477B6 (es)
DE (1) DE69212759T2 (es)
DK (1) DK0536936T3 (es)
ES (1) ES2093211T3 (es)
FI (1) FI105556B (es)
GR (1) GR3020893T3 (es)
HK (1) HK204296A (es)
HU (2) HU221812B1 (es)
IL (1) IL103301A (es)
MX (1) MXPA92005623A (es)
NO (1) NO179675C (es)
NZ (1) NZ244574A (es)
RU (1) RU2085557C1 (es)
TW (1) TW205042B (es)
ZA (1) ZA927474B (es)

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US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
GB9515279D0 (en) 1995-07-25 1995-09-20 Norsk Hydro As Improved therapeutic agents
CN1050846C (zh) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 一种抗肿瘤抗生素云南霉素及其制备方法
ATE236188T1 (de) * 1997-01-24 2003-04-15 Conpharma As Gemcitabin-derivate
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
WO2000067760A1 (fr) * 1999-05-11 2000-11-16 Sankyo Company, Limited Preparation de liposomes a base de medicaments antitumoraux liposolubles
US6908906B2 (en) 2001-02-09 2005-06-21 Sankyo Company, Limited Crystalline forms of pyrimidine nucleoside derivative
JP3748536B2 (ja) * 2001-02-09 2006-02-22 三共株式会社 ピリミジンヌクレオシド誘導体の結晶
WO2003087119A1 (en) * 2002-04-12 2003-10-23 Achillion Pharmaceuticals, Inc. METHOD FOR SYNTHESIZING β-L-FLUORO-2´,3´DIDEHYDROCYTIDINE (β-L-FD4C)
US20050014716A1 (en) * 2003-05-21 2005-01-20 Wang Jin Wei Pancreatic cancer treatment
GB0328180D0 (en) * 2003-12-04 2004-01-07 Cyclacel Ltd Combination
TW200637870A (en) * 2005-01-31 2006-11-01 Taiho Pharmaceutical Co Ltd Novel pyrimidine nucleoside compound and salt thereof
GB0523041D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
US20100216736A2 (en) * 2006-07-21 2010-08-26 Taiho Pharmaceutical Co., Ltd. 2'-cyanopyrimidine nucleoside compound
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US8124593B2 (en) 2007-11-05 2012-02-28 Cyclacel Limited Methods of treatment using sapacitabine
GB0808357D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
GB2459779A (en) * 2008-05-08 2009-11-11 Cyclacel Ltd Process for the preparation of 2'-cyano-2'-deoxy-N4-palmitoyl-1-beta-D-arabinofuranosylcytosine
GB0808359D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
NZ589719A (en) 2008-06-09 2012-08-31 Cyclacel Ltd Combinations of sapacitabine or cndac with dna methyltransferase inhibitors such as decitabine and procaine
EP2431376B2 (en) * 2009-05-15 2024-02-07 Delta-Fly Pharma, Inc. Novel stable crystal of 1-(2'-cyano-2'-deoxy-beta -d-arabinofuranosyl)cytosine monohydrochloride
HUE046177T2 (hu) 2011-04-14 2020-02-28 Cyclacel Ltd Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
UA117095C2 (uk) 2011-12-22 2018-06-25 Аліос Біофарма, Інк. Нуклеозидна сполука або її фармацевтично прийнятна сіль
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2013241341B2 (en) * 2012-03-28 2016-09-08 Fujifilm Corporation Salt of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine
WO2013171473A1 (en) 2012-05-15 2013-11-21 Cyclacel Limited Dosage regimen for sapacitabine and seliciclib
DK3236972T3 (en) * 2014-12-26 2021-10-04 Univ Emory Antivirale N4-hydroxycytidin-derivativer
US11104698B2 (en) 2015-12-03 2021-08-31 Biosight Ltd. Salts of conjugates for cancer therapy
US12064445B2 (en) 2015-12-03 2024-08-20 Biosight Ltd. Cytarabine conjugates for cancer therapy
BR112018011177A2 (pt) 2015-12-03 2018-11-21 Biosight Ltd conjugados de citarabina para terapia de câncer
US12071450B2 (en) 2015-12-03 2024-08-27 Biosight Ltd. Salts of conjugates for cancer therapy
WO2019081951A1 (en) 2017-10-27 2019-05-02 Cyclacel Limited DOSAGE REGIME
JP6804790B1 (ja) 2017-12-07 2020-12-23 エモリー ユニバーシティー Ｎ４−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途
CN108610384B (zh) * 2018-05-31 2022-02-22 沈阳药科大学 基于肠道mct1载体蛋白设计的前药及其制备方法
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
WO1985000608A1 (fr) * 1983-07-20 1985-02-14 Teijin Limited Agent antineoplastique
US4818750A (en) * 1985-09-17 1989-04-04 Burroughs Wellcome Co. Treatment of human viral infections
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
FR2640267B2 (fr) * 1988-01-19 1992-02-14 Univ Paris Curie Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
FR2632442B1 (fr) * 1988-06-06 1990-09-14 Framatome Sa Dispositif de mesure de parametres dans le coeur d'un reacteur nucleaire en service
EP0348170A3 (en) * 1988-06-21 1990-12-05 Moses Nam Fong Lee Antiviral pyrimidine derivatives
FR2635778A1 (fr) * 1988-08-26 1990-03-02 Ire Celltarg Sa Nouveaux derives de la 3(prime) azido-3(prime) deoxythymidine (azt) actifs contre le virus hiv du sida
JPH0678338B2 (ja) * 1988-09-09 1994-10-05 帝人株式会社 ２′，３′−ジデオキシシチジン−２′−エン誘導体、その製造方法及びそれを有効成分とする抗レトロウイルス剤
JP2559917B2 (ja) * 1990-06-15 1996-12-04 三共株式会社 ピリミジンヌクレオシド誘導体

Also Published As

Publication number Publication date
HK204296A (en) 1996-11-15
HU9203115D0 (en) 1992-12-28
FI924381A0 (fi) 1992-09-29
NO179675C (no) 1996-11-27
CA2079413C (en) 2003-09-09
TW205042B (es) 1993-05-01
HUT62310A (en) 1993-04-28
DK0536936T3 (da) 1997-01-13
EP0536936A1 (en) 1993-04-14
EP0536936B1 (en) 1996-08-14
ATE141281T1 (de) 1996-08-15
IL103301A (en) 1997-07-13
GR3020893T3 (en) 1996-11-30
CZ289477B6 (cs) 2002-01-16
JP2569251B2 (ja) 1997-01-08
MXPA92005623A (es) 2002-06-19
AU654212B2 (en) 1994-10-27
JPH05194497A (ja) 1993-08-03
NZ244574A (en) 1994-01-26
BR1100621A (pt) 1999-12-07
CN1033227C (zh) 1996-11-06
RU2085557C1 (ru) 1997-07-27
FI105556B (fi) 2000-09-15
KR100255491B1 (ko) 2000-05-01
KR930006045A (ko) 1993-04-20
NO923794D0 (no) 1992-09-30
DE69212759D1 (de) 1996-09-19
AU2602692A (en) 1993-04-01
DE69212759T2 (de) 1997-04-03
IL103301A0 (en) 1993-02-21
ZA927474B (en) 1993-07-14
NO179675B (no) 1996-08-19
NO923794L (no) 1993-03-31
HU221812B1 (hu) 2003-01-28
FI924381A7 (fi) 1993-03-31
CN1072686A (zh) 1993-06-02
CZ298592A3 (en) 1993-12-15
CA2079413A1 (en) 1993-03-31
HU211851A9 (en) 1995-12-28
US5691319A (en) 1997-11-25

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