ES2093523T3 - Catalizadores quirales y reacciones de epoxidacion catalizadas por los mismos. - Google Patents

Catalizadores quirales y reacciones de epoxidacion catalizadas por los mismos.

Info

Publication number
ES2093523T3
ES2093523T3 ES94906734T ES94906734T ES2093523T3 ES 2093523 T3 ES2093523 T3 ES 2093523T3 ES 94906734 T ES94906734 T ES 94906734T ES 94906734 T ES94906734 T ES 94906734T ES 2093523 T3 ES2093523 T3 ES 2093523T3
Authority
ES
Spain
Prior art keywords
pct
same
hydrogen
nrd
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906734T
Other languages
English (en)
Inventor
David Bell
David Miller
Robin Patrick Attrill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929216662A external-priority patent/GB9216662D0/en
Priority claimed from GB939308968A external-priority patent/GB9308968D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2093523T3 publication Critical patent/ES2093523T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/2243—At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/04—Seven-membered rings not condensed with other rings
    • C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/70—Oxidation reactions, e.g. epoxidation, (di)hydroxylation, dehydrogenation and analogues
    • B01J2231/72—Epoxidation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
    • B01J2531/0241—Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
    • B01J2531/0252—Salen ligands or analogues, e.g. derived from ethylenediamine and salicylaldehyde
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/70—Complexes comprising metals of Group VII (VIIB) as the central metal
    • B01J2531/72—Manganese

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN COMPUESTO DE FORMULA (I),EN LA QUE M ES UN ION DE METAL DE TRANSICION; A ES UN CONTRAION SI SE QUIERE; R S Y T SON INDEPENDIENTEMENTE 0 A 3 DE MODO QUE R+S+T+ ESTA EN LA GAMA QUE VA DE 1 A 3; RA, RB, RC SON CADA UNO INDEPENDIENTEMENTE HIDROGENO O CH2OR DONDE R ES HIDROGENO O UN GRUPO ORGANICO; B Y E SON INDEPENDIENTEMENTE OXIGENO, CH2, NRD ES ALQUILO, HIDROGENO, ALQUILCARBONILO O ARILCARBONILO O SON DONDE N ES 0 O UN NUMERO ENTERO 1 O 2, SIEMPRE QUE B Y E NO SEAN SIMULTANEAMENTE CH2 Y QUE CUANDO B SEA OXIGENO, NRD O SON, ENTONCES R NO PUEDE SER 0, Y CUANDO E SEA OXIGENO, NRD OSON, ENTONCES T NO PUEDE SER O; R1, R2, R3, R4, R5, R6, R7, R8, R9 Y R10 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO O ALCOXI.
ES94906734T 1992-08-06 1993-08-05 Catalizadores quirales y reacciones de epoxidacion catalizadas por los mismos. Expired - Lifetime ES2093523T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216662A GB9216662D0 (en) 1992-08-06 1992-08-06 Novel compounds and process
GB939308968A GB9308968D0 (en) 1993-04-30 1993-04-30 Novel compounds and process

Publications (1)

Publication Number Publication Date
ES2093523T3 true ES2093523T3 (es) 1996-12-16

Family

ID=26301377

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906734T Expired - Lifetime ES2093523T3 (es) 1992-08-06 1993-08-05 Catalizadores quirales y reacciones de epoxidacion catalizadas por los mismos.

Country Status (16)

Country Link
US (1) US5616750A (es)
EP (1) EP0655950B1 (es)
JP (1) JP3322877B2 (es)
KR (1) KR100292137B1 (es)
CN (1) CN1043425C (es)
AT (1) ATE144441T1 (es)
AU (1) AU672995B2 (es)
CA (1) CA2141790A1 (es)
DE (1) DE69305645T2 (es)
DK (1) DK0655950T3 (es)
ES (1) ES2093523T3 (es)
GR (1) GR3021743T3 (es)
MX (1) MX9304761A (es)
NZ (1) NZ254917A (es)
TW (1) TW418210B (es)
WO (1) WO1994003271A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP615A (en) * 1994-02-04 1997-09-10 Smithkline Beecham Plc Process for epoxidising prochiral olefins and a catalyst therefor and intermediates for making the catalyst.
KR19980702645A (ko) * 1995-03-08 1998-08-05 알베르투스 빌헬무스 요아네스 쩨스트라텐 촉매 조성물내 브리지된 비스-아미도 4족 금속 화합물
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US20030017941A1 (en) 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
AU732147B2 (en) 1997-03-07 2001-04-12 Procter & Gamble Company, The Bleach compositions
ZA981883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
TWI246520B (en) * 1997-04-25 2006-01-01 Mitsui Chemicals Inc Processes for olefin polymerization
US5981424A (en) * 1997-07-31 1999-11-09 Sunoco, Inc. (R&M) Catalysts for hydroxylation and ammination of aromatics using molecular oxygen as the terminal oxidant without coreductant
NL1007776C2 (nl) * 1997-12-12 1999-06-15 Dsm Nv Katalysator voor de bereiding van chirale producten in optisch actieve vorm.
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
US6656450B2 (en) 2000-07-17 2003-12-02 California Institute Of Technology, Inc. Macrocyclic magnetic resonance imaging contrast agents
CN1186125C (zh) * 2002-06-18 2005-01-26 中国科学院成都有机化学研究所 用于氧化偶联萘酚的手性催化剂
FR2875500A1 (fr) * 2004-09-21 2006-03-24 Centre Nat Rech Scient Complexe chiraux macrocycliques utilisables comme catalyseurs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023075A1 (en) * 1979-07-13 1981-01-28 Imperial Chemical Industries Plc Process for the preparation of cyclopropane carboxylic acid esters
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
FR2588265B3 (fr) * 1985-10-04 1988-01-15 Inst Francais Du Petrole Procede d'adoucissement d'une charge d'hydrocarbures contenant des produits soufres
JPS6490150A (en) * 1987-09-30 1989-04-06 Soda Aromatic Production of 3,5,5-trimethylcyclohex-2-ene-1,4-dione
DE69128528T2 (de) * 1990-03-21 1998-07-30 Res Corp Technologies Inc Chirale katalysatoren und dadurch katalysierte epoxydierungsreaktionen
ES2156880T3 (es) * 1994-02-23 2001-08-01 Nissan Chemical Ind Ltd Procedimiento de epoxidacion asimetrica utilizando complejos de manganeso opticamente activos.

Also Published As

Publication number Publication date
NZ254917A (en) 1996-11-26
DE69305645D1 (de) 1996-11-28
TW418210B (en) 2001-01-11
ATE144441T1 (de) 1996-11-15
CN1043425C (zh) 1999-05-19
AU672995B2 (en) 1996-10-24
JPH08500099A (ja) 1996-01-09
AU4722393A (en) 1994-03-03
EP0655950A1 (en) 1995-06-07
JP3322877B2 (ja) 2002-09-09
HK1006289A1 (en) 1999-02-19
EP0655950B1 (en) 1996-10-23
KR100292137B1 (ko) 2001-10-24
DK0655950T3 (da) 1996-11-18
MX9304761A (es) 1994-05-31
CN1098415A (zh) 1995-02-08
WO1994003271A1 (en) 1994-02-17
US5616750A (en) 1997-04-01
KR950702872A (ko) 1995-08-23
GR3021743T3 (en) 1997-02-28
DE69305645T2 (de) 1997-06-05
CA2141790A1 (en) 1994-02-17

Similar Documents

Publication Publication Date Title
ES2093523T3 (es) Catalizadores quirales y reacciones de epoxidacion catalizadas por los mismos.
TW370450B (en) Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
DK0663907T3 (da) Fremgangsmåde til fremstilling af taxanderivater
PE20011348A1 (es) Agentes antivirales de imidazopiridina e imidazopimiridina
ES2188280T3 (es) Acetales heteroaril-ciclicos.
BG96630A (bg) Нови хербициди
DK0530285T3 (da) Fremgangsmåde til enantioselektiv fremstilling af phenylisoserinderivater
TW356415B (en) 2-Amino-1,3,5-triazines, processes for their preparation, and their use as herbicides
DK0667866T3 (da) 1,4-benzothiazepiner anvendelige som neurologiske midler
ES8600293A1 (es) Un procedimiento para preparar profarmacos de alopurinol
AU637695B2 (en) Therapeutic agents
MY102239A (en) Chemical compounds
DK0632805T3 (da) Melaminderivater til anvendelse i behandlingen af cancer
GB9319377D0 (en) Fungicides
TW281673B (es)
PE20000734A1 (es) Compuestos heterociclicos derivados de furopiridina y su uso terapeutico
MY100206A (en) Certain substituted 3-amino-2-benzoylcyclohex-2- enones
ATE246010T1 (de) Materialien zur behandlung des glaukoms
ATE151597T1 (de) Fungizide verbindungen
CA2206168A1 (en) Organic peroxide stabilization with .alpha.-hydroxyalkyl peroxides
MY106839A (en) Carboxylate compounds, liquid crystal compositions containing said compounds and liquid crystal elements.
ZA946627B (en) Thienyl-and furylpyrrole insecticidal and acaricidal agents
IL107389A (en) N-substituted carbonyloxyalkyl- pyrroles and insecticidal, acaricidal and molluscicidal compositions containing them
AR247750A1 (es) Sistema inhibidor de polimerizacion y composicion estabilizada que lo comprende.
ES445543A1 (es) Un procedimiento para la preparacion de amino-esteres de acidos benzoil-alcanoicos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 655950

Country of ref document: ES