ES2093625T3 - Administracion extendida de farmaco de moleculas pequeñas solubles en agua. - Google Patents

Administracion extendida de farmaco de moleculas pequeñas solubles en agua.

Info

Publication number
ES2093625T3
ES2093625T3 ES90116768T ES90116768T ES2093625T3 ES 2093625 T3 ES2093625 T3 ES 2093625T3 ES 90116768 T ES90116768 T ES 90116768T ES 90116768 T ES90116768 T ES 90116768T ES 2093625 T3 ES2093625 T3 ES 2093625T3
Authority
ES
Spain
Prior art keywords
fluid
biologically active
water
polymeric matrix
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90116768T
Other languages
English (en)
Inventor
Bernhard A Dr Sabel
Andrew Freese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of ES2093625T3 publication Critical patent/ES2093625T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DISPOSITIVO POLIMERICO QUE LIBERA MATERIALES HIDROSOLUBLES BIOLOGICAMENTE ACTIVOS CON UN PESO MOLECULAR INFERIOR A 1000 DE UNA FORMA CONTROLADA, CONTINUA Y LINEAL DURANTE UN PERIODO EXTENDIDO DE TIEMPO. LAS MATRICES DE POLIMEROS INSOLUBLES PUEDEN DEFINIRSE DE CUALQUIER FORMA, TAMAÑO Y CONTENIDO FARMACOLOGICO. CUANDO SE APLICA AL USO MEDICO, SE USAN LOS POLIMEROS BIOCOMPATIBLES PARA QUE EL DISPOSITIVO SEA IMPLANTABLE. EL DISPOSITIVO SE LLEVA A CABO AL MODIFICAR DISPOSITIVOS ANTERIORES BASADOS EN LA DIFUSION DEL FLUIDO EN UNA MATRIZ POLIMERICA QUE CONTENGA MOLECULAS ACTIVAS BIOLOGICAMENTE DISPERSAS, PARA PRODUCIR UN DISPOSITIVO POLIMERICO QUE PUEDA SITUARSE EN UN ENTORNO DE FLUIDOS, A FIN DE QUE EL FLUIDO SEA ABSORBIDO POR EL DISPOSITIVO Y LAS MOLECULAS DE AGUA SOLUBLE SE DIFUNDAN EN EL ENTORNO DEL FLUIDO, DEJANDO DETRAS DE SI POROS Y CANALES, EN DONDE LA VELOCIDAD DE DIFUSION QUEDA LIMITADA POR UN REVESTIMIENTO IMPERMEABLE SOBRE UNA PORCION DE LA MATRIZ POLIMERICA Y/O AL AJUSTAR LA CARGA DELFARMACO PARA PRODUCIR EL NUMERO Y TAMAÑO DE POROS Y CANALES EN LA SUPERFICIE DE LA MATRIZ POLIMERICA QUE PRODUCE LA VELOCIDAD DESEADA DE LIBERACION DE LAS MOLECULAS BIOLOGICAMENTE ACTIVAS. EL DISPOSITIVO SE CARACTERIZA POR VARIAS CARACTERISTICAS DISTINTIVAS: UN MECANISMO NORMALMENTE ASOCIADO A LA LIBERACION MACROMOLECULAR QUE ES APLICABLE A PEQUEÑAS MOLECULAS HIDROSOLUBLES Y LA LIBERACION LINEAL, CONTROLADA Y DURADERA DE GRANDES CANTIDADES DEL FARMACO.
ES90116768T 1989-09-14 1990-08-31 Administracion extendida de farmaco de moleculas pequeñas solubles en agua. Expired - Lifetime ES2093625T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/407,418 US5114719A (en) 1987-04-29 1989-09-14 Extended drug delivery of small, water-soluble molecules

Publications (1)

Publication Number Publication Date
ES2093625T3 true ES2093625T3 (es) 1997-01-01

Family

ID=23612002

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90116768T Expired - Lifetime ES2093625T3 (es) 1989-09-14 1990-08-31 Administracion extendida de farmaco de moleculas pequeñas solubles en agua.

Country Status (6)

Country Link
US (1) US5114719A (es)
EP (1) EP0417572B1 (es)
AT (1) ATE141047T1 (es)
DE (1) DE69028011T2 (es)
DK (1) DK0417572T3 (es)
ES (1) ES2093625T3 (es)

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Also Published As

Publication number Publication date
DE69028011D1 (de) 1996-09-12
DK0417572T3 (da) 1996-09-02
US5114719A (en) 1992-05-19
EP0417572A2 (en) 1991-03-20
ATE141047T1 (de) 1996-08-15
EP0417572A3 (en) 1991-06-12
EP0417572B1 (en) 1996-08-07
DE69028011T2 (de) 1997-01-23

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