ES2093731T3 - Utilizacion de esteroides aminados para la preparacion de composiciones farmaceuticas. - Google Patents

Utilizacion de esteroides aminados para la preparacion de composiciones farmaceuticas.

Info

Publication number
ES2093731T3
ES2093731T3 ES92104675T ES92104675T ES2093731T3 ES 2093731 T3 ES2093731 T3 ES 2093731T3 ES 92104675 T ES92104675 T ES 92104675T ES 92104675 T ES92104675 T ES 92104675T ES 2093731 T3 ES2093731 T3 ES 2093731T3
Authority
ES
Spain
Prior art keywords
alkyl
preparation
aminated
steroids
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92104675T
Other languages
English (en)
Inventor
Philip M Weintraub
Thomas R Blohm
Cynthia A Gates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2093731T3 publication Critical patent/ES2093731T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE EL USO DE COMPUESTOS CON LA FORMULA GENERAL (I) EN DONDE LAS LINEAS DE PUNTOS INDICAN LA PRESENCIA OPCIONAL DE UN ENLACE DOBLE, R ES -(C1-6 ALQUILO) YFENILO SUSTITUIDO) O Y-BENZOILO SUSTITUIDO EN DONDE Y ES METILO, HALOGENO O METOXI, PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA PARA LA INHIBICION DEL ENZIMA C17-20 LIASA Y PARA EL TRATAMIENTO DE DESORDENES ANDROGENO DEPENDIENTES.
ES92104675T 1991-03-19 1992-03-18 Utilizacion de esteroides aminados para la preparacion de composiciones farmaceuticas. Expired - Lifetime ES2093731T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/671,555 US5143909A (en) 1991-03-19 1991-03-19 Aminosteroids in a method for inhibiting c17-20 lyase

Publications (1)

Publication Number Publication Date
ES2093731T3 true ES2093731T3 (es) 1997-01-01

Family

ID=24694981

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92104675T Expired - Lifetime ES2093731T3 (es) 1991-03-19 1992-03-18 Utilizacion de esteroides aminados para la preparacion de composiciones farmaceuticas.

Country Status (13)

Country Link
US (1) US5143909A (es)
EP (1) EP0509259B1 (es)
JP (1) JP3031585B2 (es)
KR (1) KR100227717B1 (es)
AT (1) ATE141507T1 (es)
AU (1) AU651670B2 (es)
DE (1) DE69212878T2 (es)
DK (1) DK0509259T3 (es)
ES (1) ES2093731T3 (es)
GR (1) GR3021298T3 (es)
IE (1) IE73639B1 (es)
TW (1) TW239076B (es)
ZA (1) ZA921891B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5318961A (en) * 1990-08-01 1994-06-07 Merrell Dow Pharmaceuticals Inc. 4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
WO1993014762A1 (en) * 1992-01-27 1993-08-05 Merck & Co., Inc. 17β-HYDROXYBENZOYL-4-AZA-5α-ANDROST-1-EN-3-ONES USEFUL TO TREAT BALDNESS
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
ATE175419T1 (de) * 1994-05-02 1999-01-15 Merrell Pharma Inc Verfahren zur herstellung von 4-amino-delta 4-3- ketosteroiden via 4-nitro-delta-4-3-ketosteroiden
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
CN116874547A (zh) * 2023-06-12 2023-10-13 陕西汉江药业集团股份有限公司 一种黄体酮杂质羧酸物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1154008A (en) * 1979-05-02 1983-09-20 Thomas R. Blohm STEROID 5.alpha.-REDUCTASE INHIBITORS
EP0155934B1 (en) * 1983-07-29 1989-12-06 Duke University Pharmaceutical compositions for treating androgen-related disorders in humans
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8711579D0 (en) * 1987-05-15 1987-06-17 Erba Farmitalia 4-amino-androstenedione derivatives
ATE230994T1 (de) * 1989-07-07 2003-02-15 Endorech Inc Methode zur behandlung androgenbedingter krankheiten
AU637247B2 (en) * 1990-08-01 1993-05-20 Merrell Dow Pharmaceuticals Inc. 4-amino-delta4-steroids and their use as 5alpha-reductase inhibitors

Also Published As

Publication number Publication date
DE69212878D1 (de) 1996-09-26
IE73639B1 (en) 1997-06-18
ZA921891B (en) 1992-11-25
GR3021298T3 (en) 1997-01-31
EP0509259B1 (en) 1996-08-21
JP3031585B2 (ja) 2000-04-10
EP0509259A1 (en) 1992-10-21
KR100227717B1 (ko) 1999-11-01
DE69212878T2 (de) 1997-01-23
DK0509259T3 (da) 1996-09-09
IE920864A1 (en) 1992-09-23
AU651670B2 (en) 1994-07-28
US5143909A (en) 1992-09-01
TW239076B (es) 1995-01-21
ATE141507T1 (de) 1996-09-15
AU1289792A (en) 1992-09-24
JPH05125093A (ja) 1993-05-21

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