ATE141507T1 - Verwendung von aminosteroiden zur herstellung von pharmazeutischen zubereitungen - Google Patents

Verwendung von aminosteroiden zur herstellung von pharmazeutischen zubereitungen

Info

Publication number: ATE141507T1
Authority: AT; Austria
Prior art keywords: alkyl; aminosteroids; production; pharmaceutical preparations; benzoyl
Prior art date: 1991-03-19

Application number

AT92104675T

Other languages

English (en)

Inventor

Philip M Weintraub

Thomas R Blohm

Cynthia A Gates

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-19

Filing date

1992-03-18

Publication date

1996-09-15

1992-03-18 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141507T1 publication Critical patent/ATE141507T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
102000004317 Lyases Human genes 0.000 abstract 1
108090000856 Lyases Proteins 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92104675T 1991-03-19 1992-03-18 Verwendung von aminosteroiden zur herstellung von pharmazeutischen zubereitungen ATE141507T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/671,555 US5143909A (en)	1991-03-19	1991-03-19	Aminosteroids in a method for inhibiting c17-20 lyase

Publications (1)

Publication Number	Publication Date
ATE141507T1 true ATE141507T1 (de)	1996-09-15

Family

ID=24694981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92104675T ATE141507T1 (de)	1991-03-19	1992-03-18	Verwendung von aminosteroiden zur herstellung von pharmazeutischen zubereitungen

Country Status (13)

Country	Link
US (1)	US5143909A (de)
EP (1)	EP0509259B1 (de)
JP (1)	JP3031585B2 (de)
KR (1)	KR100227717B1 (de)
AT (1)	ATE141507T1 (de)
AU (1)	AU651670B2 (de)
DE (1)	DE69212878T2 (de)
DK (1)	DK0509259T3 (de)
ES (1)	ES2093731T3 (de)
GR (1)	GR3021298T3 (de)
IE (1)	IE73639B1 (de)
TW (1)	TW239076B (de)
ZA (1)	ZA921891B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5318961A (en) *	1990-08-01	1994-06-07	Merrell Dow Pharmaceuticals Inc.	4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
WO1993014762A1 (en) *	1992-01-27	1993-08-05	Merck & Co., Inc.	17β-HYDROXYBENZOYL-4-AZA-5α-ANDROST-1-EN-3-ONES USEFUL TO TREAT BALDNESS
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
ATE175419T1 (de) *	1994-05-02	1999-01-15	Merrell Pharma Inc	Verfahren zur herstellung von 4-amino-delta 4-3- ketosteroiden via 4-nitro-delta-4-3-ketosteroiden
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US6365597B1 (en)	1996-02-14	2002-04-02	Aventis Pharmaceuticals Inc.	4-aza steroids
CN116874547A (zh) *	2023-06-12	2023-10-13	陕西汉江药业集团股份有限公司	一种黄体酮杂质羧酸物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1154008A (en) *	1979-05-02	1983-09-20	Thomas R. Blohm	STEROID 5.alpha.-REDUCTASE INHIBITORS
EP0155934B1 (de) *	1983-07-29	1989-12-06	Duke University	Pharmazeutische Zusammensetzungen zur Behandlung von Störungen, bedingt durch Humanendrogen
GB8503940D0 (en) *	1985-02-15	1985-03-20	Erba Farmitalia	4-substituted androstendione derivatives
GB8622330D0 (en) *	1986-09-17	1986-10-22	Erba Farmitalia	4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8711579D0 (en) *	1987-05-15	1987-06-17	Erba Farmitalia	4-amino-androstenedione derivatives
ATE230994T1 (de) *	1989-07-07	2003-02-15	Endorech Inc	Methode zur behandlung androgenbedingter krankheiten
AU637247B2 (en) *	1990-08-01	1993-05-20	Merrell Dow Pharmaceuticals Inc.	4-amino-delta4-steroids and their use as 5alpha-reductase inhibitors

1991
- 1991-03-19 US US07/671,555 patent/US5143909A/en not_active Expired - Fee Related
1992
- 1992-03-13 AU AU12897/92A patent/AU651670B2/en not_active Ceased
- 1992-03-13 ZA ZA921891A patent/ZA921891B/xx unknown
- 1992-03-14 TW TW081101939A patent/TW239076B/zh active
- 1992-03-18 DK DK92104675.1T patent/DK0509259T3/da active
- 1992-03-18 KR KR1019920004407A patent/KR100227717B1/ko not_active Expired - Fee Related
- 1992-03-18 DE DE69212878T patent/DE69212878T2/de not_active Expired - Fee Related
- 1992-03-18 IE IE920864A patent/IE73639B1/en not_active IP Right Cessation
- 1992-03-18 AT AT92104675T patent/ATE141507T1/de not_active IP Right Cessation
- 1992-03-18 ES ES92104675T patent/ES2093731T3/es not_active Expired - Lifetime
- 1992-03-18 EP EP92104675A patent/EP0509259B1/de not_active Expired - Lifetime
- 1992-03-19 JP JP4092468A patent/JP3031585B2/ja not_active Expired - Fee Related
1996
- 1996-10-09 GR GR960402669T patent/GR3021298T3/el unknown

Also Published As

Publication number	Publication date
DE69212878D1 (de)	1996-09-26
IE73639B1 (en)	1997-06-18
ZA921891B (en)	1992-11-25
GR3021298T3 (en)	1997-01-31
EP0509259B1 (de)	1996-08-21
JP3031585B2 (ja)	2000-04-10
EP0509259A1 (de)	1992-10-21
KR100227717B1 (ko)	1999-11-01
DE69212878T2 (de)	1997-01-23
DK0509259T3 (da)	1996-09-09
IE920864A1 (en)	1992-09-23
ES2093731T3 (es)	1997-01-01
AU651670B2 (en)	1994-07-28
US5143909A (en)	1992-09-01
TW239076B (de)	1995-01-21
AU1289792A (en)	1992-09-24
JPH05125093A (ja)	1993-05-21

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
2004-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
NO900831L (no)	1990-08-23	Fremgangsmaate for fremstilling av piperidinforbindelser.
NO308736B1 (no)	2000-10-23	1,2-difenylpyrrolderivater, farmasøytiske preparater inneholdende disse, og deres anvendelse
DE69413274D1 (de)	1998-10-22	Chinoloncarbonsäurederivate, ihre Herstellung und ihre Verwendung als Zelladhäsion Inhibitoren
NZ330216A (en)	2000-09-29	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and use in treatment of atherosclerosis
IL148014A0 (en)	2002-09-12	Cell adhesion inhibitors
ES2057126T3 (es)	1994-10-16	Metodo de tratamiento de la caquexia y algunos nuevos compuestos para utilizar en este metodo.
AU2868689A (en)	1989-07-27	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
AP9701010A0 (en)	1997-07-31	Piperidineacetic acid derivatives useful as fibrinogen.
ATE141507T1 (de)	1996-09-15	Verwendung von aminosteroiden zur herstellung von pharmazeutischen zubereitungen
FI895046A0 (fi)	1989-10-24	4-amino-3-acylkinolinderivat samt deras anvaendning saosom inhibitorer av sekretion av matsmaeltningsvaetskor.
ATE64925T1 (de)	1991-07-15	Benzothiazepin-vasodilatoren mit aralkylsubstitution.
ATE121395T1 (de)	1995-05-15	Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen.
TW221429B (de)	1994-03-01
AU2717100A (en)	2000-07-31	Prenyl transferase inhibitors
NO955075L (no)	1996-06-17	Tienopyridoner
CA2049655A1 (en)	1992-03-18	Pharmaceutical composition for inhibiting platelet aggregation
GR3022761T3 (en)	1997-06-30	Novel benzopyran derivatives and processes for the preparation thereof
NO872874D0 (no)	1987-07-10	Amid-derivater.
ATE18993T1 (de)	1986-04-15	Dibenzocycloheptenyliden-verbindungen zur verwendung bei der modulation der immunreaktion.
ES556048A0 (es)	1988-02-16	Un procedimiento para la preparacion de un derivado de tiazolidina.