ES2094346T3 - Procedimiento para la separacion de enantiomeros sobre fases de separacion quirales con ayuda de un procedimiento cromatografico a contra-corriente en continuo. - Google Patents

Procedimiento para la separacion de enantiomeros sobre fases de separacion quirales con ayuda de un procedimiento cromatografico a contra-corriente en continuo.

Info

Publication number
ES2094346T3
ES2094346T3 ES92905421T ES92905421T ES2094346T3 ES 2094346 T3 ES2094346 T3 ES 2094346T3 ES 92905421 T ES92905421 T ES 92905421T ES 92905421 T ES92905421 T ES 92905421T ES 2094346 T3 ES2094346 T3 ES 2094346T3
Authority
ES
Spain
Prior art keywords
separation
procedure
aid
continuous
chasal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92905421T
Other languages
English (en)
Other versions
ES2094346T5 (es
Inventor
Dieter Arlt
Walter Lange
Bruno Bomer
Rolf Grosser
Hanns-Ingolf Paul
Gunter Schnabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6427227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2094346(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2094346T3 publication Critical patent/ES2094346T3/es
Publication of ES2094346T5 publication Critical patent/ES2094346T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1828—Simulated moving beds characterised by process features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3833—Chiral chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

EN UN PROCEDIMIENTO DE CROMATOGRAFIA EN CONTRACORRIENTE FUNCIONAMIENTO EN CONTINUO SE PRODUCE UN MOVIMIENTO RELATIVO ENTRE EL ABSORBENTE CONSISTENTE EN UNA FASE SOLIDA Y UNA FASE LIQUIDA MOVIL EN COLUMNAS DE CROMATOGRAFIA CONECTADAS UNA TRAS OTRA A TRAVES DE APERTURAS SECUENCIALES DE POSICIONES DE TOMA Y DE ADICION DE LIQUIDOS A LO LARGO DE LAS COLUMNAS DE CROMATOGRAFIA. COMO ABSORBENTE SE EMPLEA UN POLIMERO O MATERIAL QUIRAL SOBRE UN SOPORTE INORGANICO. DE ESTE MODO TIENE EXITO LA SEPARACION DE UNA MEZCLA DE ENANTIOMEROS CON AYUDA DE LA CROMATOGRAFIA EN CONTRACORRIENTE CONTINUA. PARTICULARMENTE DAN BUEN RESULTADO LOS ABSORBENTES DE POLIMERIZADOS RETICULADOS QUE SE OBTIENEN DE ACRILAMIDAS, METACRILAMIDAS Y FLUROACRILAMIDAS OPTICAMENTE ACTIVAS.
ES92905421T 1991-03-14 1992-02-28 Procedimiento para la separacion de enantiomeros sobre fases de separacion quirales con ayuda de un procedimiento cromatografico a contra-corriente en continuo. Expired - Lifetime ES2094346T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4108188 1991-03-14
DE4108188 1991-03-14

Publications (2)

Publication Number Publication Date
ES2094346T3 true ES2094346T3 (es) 1997-01-16
ES2094346T5 ES2094346T5 (es) 2005-09-16

Family

ID=6427227

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92905421T Expired - Lifetime ES2094346T5 (es) 1991-03-14 1992-02-28 Procedimiento para la separacion de enantiomeros sobre fases de separacion quirales con ayuda de un procedimiento cromatografico a contra-corriente en continuo.

Country Status (7)

Country Link
EP (1) EP0586385B2 (es)
AT (1) ATE144909T1 (es)
DE (1) DE59207503D1 (es)
DK (1) DK0586385T4 (es)
ES (1) ES2094346T5 (es)
GR (1) GR3021891T3 (es)
WO (1) WO1992016274A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577079B1 (en) * 1992-06-30 1999-12-01 Daicel Chemical Industries, Ltd. Simulated moving bed separation system
FR2699917B1 (fr) * 1992-12-30 1995-01-27 Inst Francais Du Petrole Méthode et dispositif de régulation d'un procédé de séparation d'isomères d'hydrocarbures aromatiques à 8 à 10 atomes de carbone.
US5470464A (en) * 1994-04-06 1995-11-28 Uop Small scale simulated moving bed separation apparatus and process
JPH07285889A (ja) * 1994-04-20 1995-10-31 Daicel Chem Ind Ltd 光学異性体の分離方法
JPH09206502A (ja) * 1995-12-01 1997-08-12 Daicel Chem Ind Ltd 擬似移動床式分離装置
US5635072A (en) * 1995-01-31 1997-06-03 Uop Simulated moving bed adsorptive separation process
FR2743002B1 (fr) * 1995-12-27 1998-01-30 Inst Francais Du Petrole Procede de regulation d'au moins un debit de fluide circulant dans une boucle de separation chromatographique en lit mobile simule
EP0880984A1 (en) * 1997-05-28 1998-12-02 Uop Apparatus and process for simulated moving bed adsorptive separation
FR2766385B1 (fr) * 1997-07-24 1999-09-03 Novasep Procede pour le controle de la pression dans un systeme de separation a lit mobile simule
DE10226923A1 (de) 2002-06-17 2003-12-24 Bayer Ag Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonan
DE102004025000A1 (de) 2004-05-21 2005-12-08 Bayer Technology Services Gmbh Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3268605A (en) * 1961-11-06 1966-08-23 Universal Oil Prod Co Supervisory control system for a simulated moving bed separation process
DE2500523C2 (de) * 1975-01-08 1985-03-14 Merck Patent Gmbh, 6100 Darmstadt Vernetzte Polymerisate, Verfahren zu ihrer Herstellung und ihre Verwendung
GB1581727A (en) * 1976-12-21 1980-12-17 Shell Int Research Coated marine structure
JPS6041507A (ja) * 1983-08-12 1985-03-05 Mitsubishi Kasei Techno Engineers Kk クロマト分離装置の制御方法
DE3619303A1 (de) * 1986-06-07 1987-12-10 Merck Patent Gmbh Optisch aktive adsorbentien

Also Published As

Publication number Publication date
EP0586385B1 (de) 1996-11-06
DK0586385T4 (da) 2005-04-18
EP0586385B2 (de) 2005-03-30
ATE144909T1 (de) 1996-11-15
DE59207503D1 (de) 1996-12-12
GR3021891T3 (en) 1997-03-31
ES2094346T5 (es) 2005-09-16
DK0586385T3 (da) 1997-04-01
WO1992016274A1 (de) 1992-10-01
EP0586385A1 (de) 1994-03-16

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