ES2095672T3 - Procedimiento para la obtencion de la desacetil-10 bacatina iii. - Google Patents

Procedimiento para la obtencion de la desacetil-10 bacatina iii.

Info

Publication number
ES2095672T3
ES2095672T3 ES93921986T ES93921986T ES2095672T3 ES 2095672 T3 ES2095672 T3 ES 2095672T3 ES 93921986 T ES93921986 T ES 93921986T ES 93921986 T ES93921986 T ES 93921986T ES 2095672 T3 ES2095672 T3 ES 2095672T3
Authority
ES
Spain
Prior art keywords
desacetil
iii
bacatina
obtaining
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921986T
Other languages
English (en)
Inventor
Rodolphe Margraff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2095672T3 publication Critical patent/ES2095672T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCESO DE OBTENCION DE LA DESACETIL-10 BACATINA III A PARTIR DE LA DIFERENTES PARTES DEL TAJO (TAXUS SP.) POR EXTRACCION POR UN SOLVENTE ORGANICO APROPIADO DE LA SOLUCION ACUOSA OBTENIDA TRAS EL TRATAMIENTO CON AGUA DE LA PARTE APROPIADA DEL IF O POR ADSORCION DE LA SOLUCION ACUOSA SOBRE UN SOPORTE APROPIADO Y DESORCION DE LA DESACETIL-10 BACTAINA III POR UN SOLVENTE APROPIADO Y ACONTINUACION CRISTALIZACION SELECTIVA DE LA DESACETIL-10 BACATINA III.
ES93921986T 1992-10-05 1993-10-04 Procedimiento para la obtencion de la desacetil-10 bacatina iii. Expired - Lifetime ES2095672T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211745A FR2696462B1 (fr) 1992-10-05 1992-10-05 Procédé d'obtention de la désacétyl-10 baccatine III.

Publications (1)

Publication Number Publication Date
ES2095672T3 true ES2095672T3 (es) 1997-02-16

Family

ID=9434123

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921986T Expired - Lifetime ES2095672T3 (es) 1992-10-05 1993-10-04 Procedimiento para la obtencion de la desacetil-10 bacatina iii.

Country Status (30)

Country Link
US (2) US5393896A (es)
EP (1) EP0663909B1 (es)
JP (1) JP3299753B2 (es)
KR (1) KR100301238B1 (es)
CN (1) CN1041310C (es)
AT (1) ATE147381T1 (es)
AU (1) AU680440B2 (es)
CA (2) CA2146248C (es)
CZ (2) CZ286452B6 (es)
DE (1) DE69307333T2 (es)
DK (1) DK0663909T3 (es)
EE (1) EE03124B1 (es)
ES (1) ES2095672T3 (es)
FI (1) FI109797B (es)
FR (1) FR2696462B1 (es)
GE (1) GEP19981433B (es)
GR (1) GR3022229T3 (es)
HU (1) HU225969B1 (es)
LT (1) LT3465B (es)
LV (1) LV10620B (es)
MX (1) MX9305770A (es)
NO (1) NO310414B1 (es)
NZ (1) NZ256449A (es)
PL (1) PL173993B1 (es)
RU (1) RU2108330C1 (es)
SK (1) SK280335B6 (es)
TW (1) TW404944B (es)
UA (1) UA40601C2 (es)
WO (1) WO1994007881A1 (es)
ZA (1) ZA937312B (es)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1502331A (zh) 1993-07-19 2004-06-09 Ѫ�ܼ���ҩ�﹫˾ 抗血管生长组合物及使用方法
FR2714053B1 (fr) * 1993-12-22 1996-03-08 Pf Medicament Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III.
CN1112433A (zh) * 1994-05-24 1995-11-29 郭明 红豆杉属植物提取物及其应用
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
FR2736355B1 (fr) * 1995-07-07 1997-11-07 Pf Medicament Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
US5965752A (en) * 1996-08-23 1999-10-12 Institut National De La Recherche Scientifique Preparative scale isolation and purification of taxanes
US6111144A (en) 1997-08-21 2000-08-29 Florida State University Method for the synthesis of a taxane intermediate
US6066748A (en) * 1997-12-17 2000-05-23 Han; Man Woo Process of extracting TAXOL® from taxus cuspidata
EP1068192B1 (en) 1998-01-14 2002-06-12 Bristol-Myers Squibb Company Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol
WO2002085337A1 (en) * 2001-04-20 2002-10-31 The University Of British Columbia Micellar drug delivery systems for hydrophobic drugs
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US5969165A (en) * 1999-01-07 1999-10-19 508037 (Nb) Inc. Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
CA2307393A1 (en) 2000-05-01 2001-11-01 The University Of British Columbia Ginsenoside chemotherapy
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
EP1418945A2 (en) * 2001-03-13 2004-05-19 Angiotech Pharmaceuticals, Inc. Micellar drug delivery vehicles and uses thereof
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CA2512170A1 (en) * 2002-12-31 2004-07-22 Natural Pharmaceuticals Inc. Pelletizing yew biomass for extraction of taxanes and other natural products
JP2007525188A (ja) 2003-05-16 2007-09-06 インターミューン インコーポレイテッド 合成ケモカイン受容体リガンドおよびその使用方法
US8770459B2 (en) * 2003-10-17 2014-07-08 Covidien Lp Surgical stapling device with independent tip rotation
US7407973B2 (en) 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US20060127510A1 (en) * 2003-12-30 2006-06-15 Natural Pharmaceuticals, Inc. Harvesting and pelletizing yew biomass for extraction of taxanes and other natural products
US7846940B2 (en) 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US20050240036A1 (en) * 2004-04-23 2005-10-27 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates from a mixture of taxanes
US20050250954A1 (en) * 2004-05-04 2005-11-10 Phytogen Life Sciences Inc. Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US20050272807A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20080214847A1 (en) * 2004-07-02 2008-09-04 Ivax Pharmaceuticals S.R.O. Process for the Separation of Paclitaxel and Cephalomannin
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
WO2006089218A2 (en) 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating angiogenesis
WO2007045093A1 (en) * 2005-10-21 2007-04-26 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Natural Resources Canada, Canadian Forest Service Preparation of taxanes
AU2007228984B2 (en) 2006-03-22 2012-05-03 Syncore Biotechnology Co., Ltd Treatment of triple receptor negative breast cancer
WO2008005284A2 (en) 2006-06-30 2008-01-10 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
CN100404520C (zh) * 2006-08-15 2008-07-23 北京诺瑞医药技术有限公司 从欧洲红豆杉枝叶中提取分离10－去乙酰基巴卡汀ⅲ的方法
CN101230053B (zh) * 2007-12-04 2010-06-02 北京诺瑞医药技术有限公司 从红豆杉枝叶中超声提取分离10-去乙酰基巴卡汀ⅲ的方法
US8420110B2 (en) 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
US8409601B2 (en) 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
US8273404B2 (en) 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
EP2296645B1 (en) 2008-05-22 2014-11-19 Galera Therapeutics, LLC Combination antitumor therapy
WO2010005850A1 (en) 2008-07-08 2010-01-14 The J. David Gladstone Institutes Methods and compositions for modulating angiogenesis
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US20120302954A1 (en) 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
US20120303115A1 (en) 2011-05-25 2012-11-29 Dadino Ronald C Expandable devices coated with a rapamycin composition
ES2712804T3 (es) 2011-09-26 2019-05-14 Fresenius Kabi Oncology Ltd Procedimientos para la preparación de carbazitaxel que implican la sililación en C(7)-OH y C(13)-OH o solo la sililación en C(7)-OH
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
JP6578206B2 (ja) 2012-07-19 2019-09-18 レッドウッド バイオサイエンス， インコーポレイテッド Ｃｄ２２に特異的な抗体およびその使用方法
WO2014074218A1 (en) 2012-11-12 2014-05-15 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
SI3300745T1 (sl) 2013-02-15 2020-01-31 The Regents Of The University Of California Himerni antigenski receptor in postopki njihove uporabe
WO2014160185A2 (en) 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
CN103508984B (zh) * 2013-10-22 2017-03-08 北京诺瑞医药技术有限公司 连续浸漉吸附富集法从红豆杉中提取10-dab的方法
CN105744935B (zh) 2013-11-27 2022-09-30 雷德伍德生物科技股份有限公司 肼基-吡咯并化合物及用于生成缀合物的方法
WO2015127137A1 (en) 2014-02-19 2015-08-27 Aldea Pharmaceuticals, Inc. Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer
CA2995029C (en) 2015-09-25 2022-10-25 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
WO2017083637A1 (en) 2015-11-12 2017-05-18 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
HUP1500603A2 (en) * 2015-12-11 2017-06-28 Rotachrom Tech Kft Process for the separation of 10-deacetyl baccatin iii
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
CN109071634A (zh) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 抗体偶联物及其制备和使用方法
EP3463308B2 (en) 2016-06-01 2026-01-07 Servier IP UK Limited Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
CN106397371A (zh) * 2016-08-31 2017-02-15 重庆市碚圣医药科技股份有限公司 一种用曼地亚红豆杉高产10‑dabⅲ的方法
TWI852903B (zh) 2017-01-05 2024-08-21 杏國新藥股份有限公司 胰臟癌治療
KR102905343B1 (ko) 2017-01-18 2025-12-29 바이오아트라, 인코퍼레이티드 Axl 또는 ror2에 대한 키메라 항원 수용체 및 이의 사용 방법
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
CN118652192A (zh) 2017-05-24 2024-09-17 德克萨斯州大学系统董事会 用于抗体药物缀合物的接头
IL276407B2 (en) 2018-01-31 2025-01-01 Galera Labs Llc Combination cancer therapy with a pentase macrocyclic ring complex and a platinum-based anticancer agent
CA3095757A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas
EP3773632A4 (en) 2018-04-06 2022-05-18 The Regents of The University of California METHODS OF TREATMENT OF EGFRVIII-EXPRESSING GLIOBLASTOMA
CN112368011A (zh) 2018-04-11 2021-02-12 俄亥俄州创新基金会 缓释微粒用于眼用药物递送的方法和组合物
MX2021000644A (es) 2018-07-18 2021-08-19 Manzanita Pharmaceuticals Inc Conjugados para suministrar un agente contra el cancer a las celulas nerviosas, metodos de uso y metodos para la elaboracion de los mismos.
WO2020148612A1 (en) 2019-01-14 2020-07-23 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
CA3129883A1 (en) 2019-02-14 2020-08-20 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
BR112021019701A2 (pt) 2019-04-02 2021-12-14 Kenjockety Biotechnology Inc Anticorpos multiespecíficos para antígeno de câncer de bomba de efluxo e composições, reagentes, kits e métodos relacionados aos mesmos
CA3163805A1 (en) 2019-12-12 2021-06-17 Ignite Immunotherapy, Inc. Variant oncolytic vaccinia virus and methods of use thereof
BR112022013870A2 (pt) 2020-01-29 2022-09-13 Kenjockety Biotechnology Inc Anticorpos anti-mdr1 e usos dos mesmos
WO2021247426A1 (en) 2020-06-04 2021-12-09 Kenjockety Biotechnology, Inc. Anti-abcg2 antibodies and uses thereof
EP4161564A1 (en) 2020-06-04 2023-04-12 Kenjockety Biotechnology, Inc. Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
US20220033784A1 (en) 2020-07-14 2022-02-03 Pfizer Inc. Recombinant vaccinia virus
JP7747741B2 (ja) 2020-09-02 2025-10-01 ウィリアム ロバート アラスーン リビング トラスト デイテッド オーガスト 29, 2016 抗ａｂｃｃ１抗体及びその使用
EP4244257A1 (en) 2020-11-13 2023-09-20 Kenjockety Biotechnology, Inc. Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
MX2023005979A (es) 2020-11-20 2023-08-11 Scherer Technologies Llc R P Enlazadores de escisión doble de glicósido para conjugados de anticuerpo y fármaco.
CN112694458A (zh) * 2020-12-29 2021-04-23 重庆臻源红豆杉发展有限公司 一种10-去乙酰基巴卡亭ⅲ提取纯化方法
KR20240116829A (ko) 2021-12-13 2024-07-30 윌리엄 로버트 아라툰 리빙 트러스트 데이티드 어거스트 29, 2016 항-abcb1 항체
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5279953A (en) * 1992-06-24 1994-01-18 Esca Genetics Corporation In vivo production of taxanes
FR2696463B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.

Also Published As

Publication number Publication date
EP0663909A1 (fr) 1995-07-26
CA2470124A1 (fr) 1994-04-14
KR950703549A (ko) 1995-09-20
PL173993B1 (pl) 1998-05-29
DK0663909T3 (es) 1997-01-27
SK43195A3 (en) 1995-08-09
AU5115493A (en) 1994-04-26
HUT72678A (en) 1996-05-28
CZ84495A3 (en) 1995-09-13
KR100301238B1 (ko) 2001-11-22
WO1994007881A1 (fr) 1994-04-14
JPH08501791A (ja) 1996-02-27
CA2146248A1 (fr) 1994-04-14
CZ286593B6 (cs) 2000-05-17
TW404944B (en) 2000-09-11
FR2696462A1 (fr) 1994-04-08
DE69307333D1 (de) 1997-02-20
DE69307333T2 (de) 1997-04-30
CA2470124C (fr) 2007-08-07
GR3022229T3 (en) 1997-04-30
ZA937312B (en) 1994-04-25
LT3465B (en) 1995-10-25
EE03124B1 (et) 1998-10-15
US5393896A (en) 1995-02-28
UA40601C2 (uk) 2001-08-15
FR2696462B1 (fr) 1994-11-25
HU225969B1 (en) 2008-01-28
RU95110662A (ru) 1996-12-27
LTIP1398A (en) 1994-11-25
LV10620A (lv) 1995-04-20
NO951281D0 (no) 1995-04-03
LV10620B (en) 1995-10-20
CZ286452B6 (en) 2000-04-12
MX9305770A (es) 1994-05-31
RU2108330C1 (ru) 1998-04-10
CA2146248C (fr) 2006-12-12
SK280335B6 (sk) 1999-12-10
NZ256449A (en) 1996-09-25
HU9500969D0 (en) 1995-06-28
PL308243A1 (en) 1995-07-24
FI951590A0 (fi) 1995-04-04
EP0663909B1 (fr) 1997-01-08
FI951590L (fi) 1995-04-04
JP3299753B2 (ja) 2002-07-08
GEP19981433B (en) 1998-10-30
CN1041310C (zh) 1998-12-23
CN1085552A (zh) 1994-04-20
NO951281L (no) 1995-04-03
FI109797B (fi) 2002-10-15
US5736366A (en) 1998-04-07
AU680440B2 (en) 1997-07-31
ATE147381T1 (de) 1997-01-15
NO310414B1 (no) 2001-07-02

Similar Documents

Publication Publication Date Title
MX9305770A (es) Procedimiento para la obtencion de la 10-desacetil-baccatina iii.
AR026302A1 (es) Un metodo para estabilizar solventes siliconados para la limpieza en seco, un adsorbente y un proceso de limpieza en seco.
FR2629818B1 (fr) Procede de preparation du taxol
MX9301569A (es) Procedimiento de extraccion de compuestos organicos a partir de soluciones acuosas.
CO4820399A1 (es) Material absorbente y metodo de obtencion . .
ES2180194T3 (es) Procedimiento para la obtencion de una solucion acuosa de hidroxilamina libre.
MX167139B (es) Procedimiento para la extraccion de disolventes
IT7828071A0 (it) Processo per la separazione di contaminanti polimerici da soluzioni acquose assorbenti usate per trattare correnti gassose contenenti gas organici.
ES2030379T3 (es) Procedimiento de recuperacion del anhidrido maleico de mezclas gaseosas de reaccion.
MX9306653A (es) Proceso para recuperar azufre e hidrogeno a partir de sulfuro de hidrogeno.
ES2174042T3 (es) Metodo para el tratamiento de piezas carnicas por martilleo y maquina para su realizacion.
ES2136142T3 (es) Cristales de un compuesto antimicrobiano.
ES2077996T3 (es) Procedimiento para la purificacion y la recuperacion de acido ortofosforico por extraccion liquido-liquido.
BR8802018A (pt) Processo de eliminacao de radioatividade de uma solucao aquosa que inclui um nitrato de radio
ES2024461B3 (es) Procedimiento para el trasvase automatico de precintos de alambre de botellas de champaña desde un puesto de tratamiento a una descarga, o desde una descarga a un puesto de tratamiento ulterior, asi como una disposicion para el desarrollo del procedimiento.
ES2033830T3 (es) Procedimiento para producir compuestos macrolidos.
ITMI20022409A1 (it) Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
JPS524650A (en) Purifying method for polluted water
PT1207165E (pt) Isomerizacao de 6-beta-fluoroesterouides nos derivados 6-alfa-fluoro correspondentes
PT82935A (fr) Procede de preparation des derives n-methyles du lysergol et du methoxy-10 alpha lumilysergol
ES2130705T3 (es) Metodo para separar una sulfona de una corriente de hidrocarburos que tiene una pequeña concentracion de sulfona.
ES2120426T3 (es) Procedimiento para la deshalogenacion de derivados de naftaleno.
IT1238003B (it) Processo per la rigenerazione di carbone attivo
AR213388A1 (es) Procedimiento para la recuperacion de glucagon,de las aguas madres de cristalizacion alcalina de la insulina
ES1009822Y (es) Dispositivo para el tratamiento de la impotencia sexual de hombres.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 663909

Country of ref document: ES