ES2096484T3 - Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos. - Google Patents

Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos.

Info

Publication number
ES2096484T3
ES2096484T3 ES94925713T ES94925713T ES2096484T3 ES 2096484 T3 ES2096484 T3 ES 2096484T3 ES 94925713 T ES94925713 T ES 94925713T ES 94925713 T ES94925713 T ES 94925713T ES 2096484 T3 ES2096484 T3 ES 2096484T3
Authority
ES
Spain
Prior art keywords
nucleosides
oligonucleotides derived
new oligonucleotides
links
carbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925713T
Other languages
English (en)
Inventor
Ivan Habus
Sudhir Agrawal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Application granted granted Critical
Publication of ES2096484T3 publication Critical patent/ES2096484T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION PROPORCIONA SINTONOS QUE CONTIENEN UN ENLACE INTERNUCLEOSIDO DE CARBAMATO NOVEDOSO, METODOS PARA UTILIZARLOS EN LA PRODUCCION DE OLIGONUCLEOTIDOS QUE CONTIENEN TALES ENLACES , Y OLIGONUCLEOTIDOS QUE CONTIENEN LOS MISMOS.
ES94925713T 1993-07-28 1994-07-27 Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos. Expired - Lifetime ES2096484T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/098,945 US6605708B1 (en) 1993-07-28 1993-07-28 Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom

Publications (1)

Publication Number Publication Date
ES2096484T3 true ES2096484T3 (es) 1997-03-01

Family

ID=22271676

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925713T Expired - Lifetime ES2096484T3 (es) 1993-07-28 1994-07-27 Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos.

Country Status (15)

Country Link
US (1) US6605708B1 (es)
EP (1) EP0711302B1 (es)
JP (1) JPH09503494A (es)
KR (1) KR960703938A (es)
CN (1) CN1131951A (es)
AT (1) ATE144525T1 (es)
AU (1) AU682533B2 (es)
CA (1) CA2167679A1 (es)
DE (1) DE69400807T2 (es)
DK (1) DK0711302T3 (es)
ES (1) ES2096484T3 (es)
FI (1) FI960375L (es)
GR (1) GR3021955T3 (es)
NO (1) NO960304L (es)
WO (1) WO1995004066A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
JP2006512927A (ja) 2002-12-11 2006-04-20 コーリー ファーマシューティカル グループ，インコーポレイテッド ５’ｃｐｇ核酸およびその使用方法
AU2004275876B2 (en) 2003-09-25 2011-03-31 Coley Pharmaceutical Gmbh Nucleic acid-lipophilic conjugates
CA2567789A1 (en) * 2004-06-08 2006-08-03 Coley Pharmaceutical Gmbh Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
WO2006025154A1 (ja) * 2004-08-30 2006-03-09 Gifu University 修飾オリゴヌクレオチド
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
US7232923B2 (en) * 2005-02-15 2007-06-19 Imperial Innovations Limited Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines
CN101517082B (zh) 2006-09-27 2014-01-22 科勒制药有限责任公司 具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物
WO2011005861A1 (en) * 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. Oligonucleotide end caps
JP5544833B2 (ja) * 2009-11-17 2014-07-09 富士通株式会社 インドール基用保護基

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920702409A (ko) * 1989-10-24 1992-09-04 원본미기재 새로운 결합을 갖는 올리고뉴클레오티드 유사체
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
ES2099718T3 (es) 1990-07-02 1997-06-01 Hoechst Ag Analogos de oligonucleotidos con uniones internucleotidicas de 3'-3' o 5'-5' terminales.
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs

Also Published As

Publication number Publication date
US6605708B1 (en) 2003-08-12
FI960375A7 (fi) 1996-03-25
FI960375A0 (fi) 1996-01-26
CA2167679A1 (en) 1995-02-09
JPH09503494A (ja) 1997-04-08
WO1995004066A1 (en) 1995-02-09
GR3021955T3 (en) 1997-03-31
NO960304L (no) 1996-03-04
EP0711302B1 (en) 1996-10-23
KR960703938A (ko) 1996-08-31
AU682533B2 (en) 1997-10-09
DK0711302T3 (da) 1997-03-17
CN1131951A (zh) 1996-09-25
DE69400807T2 (de) 1997-04-03
FI960375L (fi) 1996-03-25
ATE144525T1 (de) 1996-11-15
NO960304D0 (no) 1996-01-25
DE69400807D1 (de) 1996-11-28
EP0711302A1 (en) 1996-05-15
AU7552894A (en) 1995-02-28

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