ES2096484T3 - Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos. - Google Patents

Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos.

Info

Publication number
ES2096484T3
ES2096484T3 ES94925713T ES94925713T ES2096484T3 ES 2096484 T3 ES2096484 T3 ES 2096484T3 ES 94925713 T ES94925713 T ES 94925713T ES 94925713 T ES94925713 T ES 94925713T ES 2096484 T3 ES2096484 T3 ES 2096484T3
Authority
ES
Spain
Prior art keywords
nucleosides
oligonucleotides derived
new oligonucleotides
links
carbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925713T
Other languages
English (en)
Inventor
Ivan Habus
Sudhir Agrawal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Application granted granted Critical
Publication of ES2096484T3 publication Critical patent/ES2096484T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION PROPORCIONA SINTONOS QUE CONTIENEN UN ENLACE INTERNUCLEOSIDO DE CARBAMATO NOVEDOSO, METODOS PARA UTILIZARLOS EN LA PRODUCCION DE OLIGONUCLEOTIDOS QUE CONTIENEN TALES ENLACES , Y OLIGONUCLEOTIDOS QUE CONTIENEN LOS MISMOS.
ES94925713T 1993-07-28 1994-07-27 Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos. Expired - Lifetime ES2096484T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/098,945 US6605708B1 (en) 1993-07-28 1993-07-28 Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom

Publications (1)

Publication Number Publication Date
ES2096484T3 true ES2096484T3 (es) 1997-03-01

Family

ID=22271676

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925713T Expired - Lifetime ES2096484T3 (es) 1993-07-28 1994-07-27 Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos.

Country Status (15)

Country Link
US (1) US6605708B1 (es)
EP (1) EP0711302B1 (es)
JP (1) JPH09503494A (es)
KR (1) KR960703938A (es)
CN (1) CN1131951A (es)
AT (1) ATE144525T1 (es)
AU (1) AU682533B2 (es)
CA (1) CA2167679A1 (es)
DE (1) DE69400807T2 (es)
DK (1) DK0711302T3 (es)
ES (1) ES2096484T3 (es)
FI (1) FI960375A7 (es)
GR (1) GR3021955T3 (es)
NO (1) NO960304L (es)
WO (1) WO1995004066A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
EP1578954A4 (en) 2002-12-11 2010-08-11 Coley Pharm Group Inc 5'-CPG NUCLEIC ACIDS AND USE METHOD
CA2536139A1 (en) 2003-09-25 2005-04-07 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
AU2005326144A1 (en) * 2004-06-08 2006-08-03 Coley Pharmaceutical Gmbh Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
WO2006025154A1 (ja) * 2004-08-30 2006-03-09 Gifu University 修飾オリゴヌクレオチド
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
US7232923B2 (en) * 2005-02-15 2007-06-19 Imperial Innovations Limited Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines
NZ575437A (en) 2006-09-27 2012-02-24 Coley Pharm Gmbh Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity
WO2011005861A1 (en) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. Oligonucleotide end caps
JP5544833B2 (ja) 2009-11-17 2014-07-09 富士通株式会社 インドール基用保護基

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006629A1 (en) * 1989-10-24 1991-05-16 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
EP0464638B1 (de) 1990-07-02 1997-04-02 Hoechst Aktiengesellschaft Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs

Also Published As

Publication number Publication date
AU7552894A (en) 1995-02-28
DK0711302T3 (da) 1997-03-17
GR3021955T3 (en) 1997-03-31
ATE144525T1 (de) 1996-11-15
JPH09503494A (ja) 1997-04-08
FI960375L (fi) 1996-03-25
FI960375A0 (fi) 1996-01-26
WO1995004066A1 (en) 1995-02-09
CA2167679A1 (en) 1995-02-09
KR960703938A (ko) 1996-08-31
NO960304D0 (no) 1996-01-25
US6605708B1 (en) 2003-08-12
AU682533B2 (en) 1997-10-09
CN1131951A (zh) 1996-09-25
EP0711302A1 (en) 1996-05-15
EP0711302B1 (en) 1996-10-23
NO960304L (no) 1996-03-04
FI960375A7 (fi) 1996-03-25
DE69400807D1 (de) 1996-11-28
DE69400807T2 (de) 1997-04-03

Similar Documents

Publication Publication Date Title
ES2096484T3 (es) Bloques constitutivos con enlaces de carbamato entre nucleosidos y nuevos oligonucleotidos derivados de los mismos.
IL135068A0 (en) Stimulation of hematopoietic cells in vitro
DK0853627T3 (da) Substituerede liposaccharider, som er egnede til behandling og forebyggelse af endotoksæmi
MX9302036A (es) Aluminosilicatos.
PT910448E (pt) Metodo para o fraccionamento de uma solucao por um processo cromatografico em leito movel simulado
GR3032605T3 (en) Sugar-modified cytostatics
DK155351C (da) Fremgangsmaade og apparat til identificering af genstande, som f.eks. flasker
ES2055218T3 (es) Muelle de goma para manguitos amortiguado hidraulicamente.
ATE307206T1 (de) Herstellung von akariogenen zuckerersatzstoffen
FI882125A0 (fi) Som nmri kontrastmedel anvaendbara dipyridoxalfosfat.
IL113004A0 (en) Branched polyoxaalkyl macromolecules, process for making them and their uses
ES2180907T3 (es) Sistema celular de transmision radioelectrica de informacion entre una infraestructura y moviles.
HUT67611A (en) Process for producing optical active 1-(4-nitrophenyl)-4-methyl-7,8-methylen dioxi-3,4-dihydro-2h-2,2-benzodiazepine
DK35483D0 (da) Expressionsvectorer for catechol-2,3-oxygenase, de vundne enzymer og deres anvendelse
DK0719328T3 (da) Genet GRB 3-3, varianter deraf og anvendelse deraf
ATE268996T1 (de) Verbessertes formverfahren für konfektprodukte
NO983802L (no) Benzothiofener, formuleringer inneholdende samme og fremgangsmåter
IT8361973V0 (it) Cintura di protezione della colonna vertebrale, particolarmente per motociclisti.
FI891364A0 (fi) Fast, vattenfri raney-katalysatordispersion.
IT8323879A0 (it) Processo per la idrogenazione selettiva di dieni in gasolina da pirolisi.
IL115007A (en) Process for making sulfonyl isocyanates
ES289145U (es) Cabeza de combate
ES2003083A6 (es) Instalacion de rociado para torres de refrigeracion
NO971553L (no) Cytoplasmisk tyrosinkinase
IT1269457B (it) Forno periodico

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 711302

Country of ref document: ES