ES2096653T3 - Composiciones de aerosol presurizado. - Google Patents

Composiciones de aerosol presurizado.

Info

Publication number
ES2096653T3
ES2096653T3 ES91912173T ES91912173T ES2096653T3 ES 2096653 T3 ES2096653 T3 ES 2096653T3 ES 91912173 T ES91912173 T ES 91912173T ES 91912173 T ES91912173 T ES 91912173T ES 2096653 T3 ES2096653 T3 ES 2096653T3
Authority
ES
Spain
Prior art keywords
compositions
pressurized aerosol
surfactant
medicinal product
polyetoxylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91912173T
Other languages
English (en)
Inventor
Asit Somani
Clive Booles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909014526A external-priority patent/GB9014526D0/en
Priority claimed from GB909014527A external-priority patent/GB9014527D0/en
Priority claimed from GB909023953A external-priority patent/GB9023953D0/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Application granted granted Critical
Publication of ES2096653T3 publication Critical patent/ES2096653T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Fertilizers (AREA)

Abstract

SE PRESENTAN COMPOSICIONES PARA AEROSOLES A PRESION QUE COMPRENDEN UN MEDICAMENTO, UN PROPELENTE DE HIDROFLUOROCARBONO Y UN SURFACTANTE POLIETOXILADO, LAS COMPOSICIONES NO CONTIENEN SUBSTANCIALMENTE OTRO DISOLVENTE QUE EL PROPELENTE, INCREMENTANDOSE LA SOLUBILIDAD DEL SURFACTANTE EN EL PROPELENTE. LAS COMPOSICIONES DE ACUERDO CON LA INVENCION TIENEN LA VENTAJA DE QUE LA SOLUBILIDAD DEL SURFACTANTE ES TAL QUE ASEGURA UNA BUENA DISPERSION DEL MEDICAMENTO Y UN FUNCIONAMIENTO SUAVE DE LA VALVULA DEL AEROSOL.
ES91912173T 1990-06-29 1991-06-25 Composiciones de aerosol presurizado. Expired - Lifetime ES2096653T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909014526A GB9014526D0 (en) 1990-06-29 1990-06-29 Aerosol formulation
GB909014527A GB9014527D0 (en) 1990-06-29 1990-06-29 Aerosol formulation
GB909023953A GB9023953D0 (en) 1990-11-03 1990-11-03 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
ES2096653T3 true ES2096653T3 (es) 1997-03-16

Family

ID=27265168

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91912173T Expired - Lifetime ES2096653T3 (es) 1990-06-29 1991-06-25 Composiciones de aerosol presurizado.

Country Status (21)

Country Link
US (1) US5846521A (es)
EP (1) EP0536235B1 (es)
JP (1) JP2854974B2 (es)
AT (1) ATE147973T1 (es)
AU (1) AU8055691A (es)
BR (1) BR9106595A (es)
CA (1) CA2085884C (es)
CZ (1) CZ392592A3 (es)
DE (1) DE69124374T2 (es)
DK (1) DK0536235T3 (es)
ES (1) ES2096653T3 (es)
FI (1) FI925852A0 (es)
GR (1) GR3023065T3 (es)
HU (1) HUT63554A (es)
IE (1) IE912220A1 (es)
MX (1) MX9100008A (es)
NO (1) NO924954L (es)
NZ (1) NZ238746A (es)
PT (1) PT98133A (es)
SK (1) SK392592A3 (es)
WO (1) WO1992000061A1 (es)

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US5776434A (en) 1988-12-06 1998-07-07 Riker Laboratories, Inc. Medicinal aerosol formulations
US5785952A (en) * 1990-11-09 1998-07-28 Glaxo Group Limited Aerosol medicament formulation having a surface coating of surfactant
CA2111002C (en) * 1991-06-10 2000-08-22 Julianne Fassberg Non-chlorofluorocarbon aerosol formulations
ATE339952T1 (de) 1991-06-10 2006-10-15 Schering Corp Fluorchlorkohlenwasserstofffreie aerosolformulierungen
US5916540A (en) 1994-10-24 1999-06-29 Glaxo Group Limited Aerosol formulations containing P134A and/or P227 and particulate medicament
CA2455115C (en) 1991-12-12 2008-05-27 Glaxo Group Limited Pharmaceutical aerosol formulation
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US5376359A (en) * 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
MX9304585A (es) * 1992-07-31 1994-03-31 Glaxo Group Ltd Formulacion farmaceutica en aerosol, lata adecuada para liberar la formulacion e inhalador de dosis dosificada que comprende la lata.
ES2122261T3 (es) * 1993-03-17 1998-12-16 Minnesota Mining & Mfg Formulacion de aerosol que contiene un adyuvante de dispersion derivado de un ester, una amida o un mercaptoester.
ES2107203T3 (es) * 1993-03-17 1997-11-16 Minnesota Mining & Mfg Una formulacion de aerosol que contiene un adyuvante de dispersion derivado de un diol-diacido.
US5593661A (en) * 1993-03-29 1997-01-14 Henry; Richard A. Lidocaine aerosol anaesthetic
JPH09506097A (ja) * 1993-12-02 1997-06-17 アボツト・ラボラトリーズ 非ｃｆｃ噴射剤と共に用いるエアロゾル薬物調剤
US5502076A (en) * 1994-03-08 1996-03-26 Hoffmann-La Roche Inc. Dispersing agents for use with hydrofluoroalkane propellants
US5635159A (en) * 1994-08-26 1997-06-03 Abbott Laboratories Aerosol drug formulations containing polyglycolyzed glycerides
US5635161A (en) * 1995-06-07 1997-06-03 Abbott Laboratories Aerosol drug formulations containing vegetable oils
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
JP2001511160A (ja) 1997-02-05 2001-08-07 ヤゴ リサーチ アクチェンゲゼルシャフト 医学用エアゾール配合物
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
GB9805938D0 (en) 1998-03-19 1998-05-13 Glaxo Group Ltd Valve for aerosol container
GB9807232D0 (en) 1998-04-03 1998-06-03 Univ Cardiff Aerosol composition
US6451285B2 (en) 1998-06-19 2002-09-17 Baker Norton Pharmaceuticals, Inc. Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
ES2234266T3 (es) 1998-07-24 2005-06-16 Jago Research Ag Formulaciones medicas para aerosoles.
JP4672143B2 (ja) * 1998-08-04 2011-04-20 ヤゴテック アーゲー 医薬用エーロゾル製剤
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US6451287B1 (en) 2000-05-26 2002-09-17 Smithkline Beecham Corporation Fluorinated copolymer surfactants and use thereof in aerosol compositions
US7217409B2 (en) 2000-09-22 2007-05-15 Smithkline Beecham Corporation Alkanoic acid derivatives
JP2005504715A (ja) 2000-12-29 2005-02-17 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続放出特性を有する吸入用粒子
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB0125127D0 (en) 2001-10-19 2001-12-12 Glaxo Group Ltd Compounds
AU2002352836B2 (en) 2001-11-20 2005-09-29 Alkermes, Inc. Improved particulate compositions for pulmonary delivery
PT1458360E (pt) 2001-12-19 2011-07-13 Novartis Ag Derivados de indole como agonistas do recetor s1p1
CA2470520A1 (en) * 2001-12-21 2003-07-24 3M Innovative Properties Company Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient
CA2474626A1 (en) 2002-02-13 2003-08-21 Glaxo Group Limited Carboxylic acid compounds for use as surfactants
GB0205327D0 (en) * 2002-03-06 2002-04-17 Glaxo Group Ltd compounds
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
AU2004264941B2 (en) 2003-08-11 2008-11-27 Glaxo Group Limited Pharmaceutical metered dose inhaler and methods relating thereto
EP1658105B1 (en) 2003-08-29 2018-03-14 Glaxo Group Limited Pharmaceutical metered dose inhaler and methods relating thereto
WO2008097664A1 (en) 2007-02-11 2008-08-14 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
GB0712454D0 (en) 2007-06-27 2007-08-08 Generics Uk Ltd Pharmaceutical compositions
US20170189329A1 (en) 2014-07-29 2017-07-06 3M Innovative Properties Company Method of preparing a pharmaceutical composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7708731A (nl) * 1976-08-13 1978-02-15 Montedison Spa Werkwijze voor de bereiding van nieuwe drijf- middelsamenstellingen voor aerosolen.
CA1136547A (en) * 1979-03-08 1982-11-30 Song-Ling Lin Aerosol anesthetic compositions
GB8432063D0 (en) * 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
DE3872635T2 (de) * 1987-04-09 1992-12-17 Fisons Plc Pentamidin enthaltende pharmazeutische zusammensetzungen.
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
GB8828477D0 (en) * 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
GB8828544D0 (en) * 1988-12-07 1989-01-11 Ici Plc Chemical process
DE3905726A1 (de) * 1989-02-24 1990-08-30 Hoechst Ag Druckgaspackung und treibmittel fuer aerosole
GB8908250D0 (en) * 1989-04-12 1989-05-24 Fisons Plc Formulations
US5658549A (en) * 1991-12-12 1997-08-19 Glaxo Group Limited Aerosol formulations containing propellant 134a and fluticasone propionate
US5653962A (en) * 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments

Also Published As

Publication number Publication date
IE912220A1 (en) 1992-01-01
NZ238746A (en) 1992-10-28
WO1992000061A1 (en) 1992-01-09
FI925852L (fi) 1992-12-23
NO924954D0 (no) 1992-12-21
EP0536235A1 (en) 1993-04-14
JPH05507712A (ja) 1993-11-04
CA2085884A1 (en) 1991-12-30
FI925852A7 (fi) 1992-12-23
JP2854974B2 (ja) 1999-02-10
NO924954L (no) 1992-12-21
DK0536235T3 (da) 1997-04-14
DE69124374T2 (de) 1997-06-19
PT98133A (pt) 1992-04-30
BR9106595A (pt) 1993-04-20
CZ392592A3 (en) 1993-05-12
HUT63554A (en) 1993-09-28
EP0536235B1 (en) 1997-01-22
FI925852A0 (fi) 1992-12-23
HU9204098D0 (en) 1993-03-29
ATE147973T1 (de) 1997-02-15
AU8055691A (en) 1992-01-23
CA2085884C (en) 2001-12-04
DE69124374D1 (de) 1997-03-06
GR3023065T3 (en) 1997-07-30
US5846521A (en) 1998-12-08
SK392592A3 (en) 1994-07-06
MX9100008A (es) 1992-02-03

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