ES2096708T3 - Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina. - Google Patents

Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina.

Info

Publication number
ES2096708T3
ES2096708T3 ES92202213T ES92202213T ES2096708T3 ES 2096708 T3 ES2096708 T3 ES 2096708T3 ES 92202213 T ES92202213 T ES 92202213T ES 92202213 T ES92202213 T ES 92202213T ES 2096708 T3 ES2096708 T3 ES 2096708T3
Authority
ES
Spain
Prior art keywords
methyl ester
phenylalanine methyl
aspartil
apm
crystallizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92202213T
Other languages
English (en)
Inventor
Kengo Okajima
Winfried Johannes Wout Vermijs
Tsuguo Murakami
Hidetaka Egashira
Yukio Takeshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Holland Sweetener Co VOF
Original Assignee
Holland Sweetener Co VOF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holland Sweetener Co VOF filed Critical Holland Sweetener Co VOF
Application granted granted Critical
Publication of ES2096708T3 publication Critical patent/ES2096708T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN METODO PARA CRISTALIZAR UN ESTER DE METILO DE ALFA ASPARTIL ENFRIAMIENTO. EN ESTE METODO, SE PRECIPITAN LOS CRISTALES DE APM POR ENFRIAMIENTO DE UNA SOLUCION DE APM A TRAVES DEL CONTACTO DIRECTO CON HIELO. LOS CRISTALES DE APM PRECIPITADOS SEGUN ESTE METODO SON GRANDES, FUERTES Y TIENEN EXCELENTES PROPIEDADES DE FILTRADO.
ES92202213T 1991-07-19 1992-07-17 Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina. Expired - Lifetime ES2096708T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20370391 1991-07-19

Publications (1)

Publication Number Publication Date
ES2096708T3 true ES2096708T3 (es) 1997-03-16

Family

ID=16478456

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92202213T Expired - Lifetime ES2096708T3 (es) 1991-07-19 1992-07-17 Metodo para cristalizar ester metilico de alfa-l-aspartil-l-fenilalanina.

Country Status (8)

Country Link
EP (1) EP0523813B1 (es)
KR (1) KR930702384A (es)
AT (1) ATE145650T1 (es)
CA (1) CA2089359A1 (es)
DE (1) DE69215444T2 (es)
ES (1) ES2096708T3 (es)
MX (1) MX9204243A (es)
WO (1) WO1993002100A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE201694T1 (de) * 1994-12-22 2001-06-15 Holland Sweetener Co Crystallisierung vom alpha-l-aspartyl-l- phenylalanylmethylester aus wässrigen lösungen
DE69525839T2 (de) * 1995-06-30 2002-10-31 Holland Sweetener Co. V.O.F., Geleen Kristallisierung von alpha-L-aspartyl-L-phenylalaninmethylester aus wässerigen Lösungen
KR20000009984A (ko) * 1998-07-29 2000-02-15 고두모 알파-엘-아스파틸-엘-페닐알라닌 메틸 에스테르의 결정화 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2017137A1 (en) * 1989-05-22 1990-11-22 Shigeaki Irino Method for crystallizing &-l-aspartyl-l-phenylalanine methyl ester
JPH0327398A (ja) * 1989-06-26 1991-02-05 Mitsui Toatsu Chem Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析方法

Also Published As

Publication number Publication date
WO1993002100A1 (en) 1993-02-04
EP0523813B1 (en) 1996-11-27
EP0523813A1 (en) 1993-01-20
ATE145650T1 (de) 1996-12-15
KR930702384A (ko) 1993-09-08
CA2089359A1 (en) 1993-01-20
DE69215444T2 (de) 1997-06-12
MX9204243A (es) 1994-02-28
DE69215444D1 (de) 1997-01-09

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