ES2097083A1 - Procedimiento para la preparcion de particulas tratadas en seco, las particulas tratadas en seco asi obtenidas, y composiciones farmaceuticas que contienen tales particulas. - Google Patents

Procedimiento para la preparcion de particulas tratadas en seco, las particulas tratadas en seco asi obtenidas, y composiciones farmaceuticas que contienen tales particulas.

Info

Publication number
ES2097083A1
ES2097083A1 ES09400996A ES9400996A ES2097083A1 ES 2097083 A1 ES2097083 A1 ES 2097083A1 ES 09400996 A ES09400996 A ES 09400996A ES 9400996 A ES9400996 A ES 9400996A ES 2097083 A1 ES2097083 A1 ES 2097083A1
Authority
ES
Spain
Prior art keywords
dry
particles
particles treated
procedure
treated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400996A
Other languages
English (en)
Other versions
ES2097083B1 (es
Inventor
Jean Marc Ruiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES2097083A1 publication Critical patent/ES2097083A1/es
Application granted granted Critical
Publication of ES2097083B1 publication Critical patent/ES2097083B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PARTICULAS TRATADAS EN SECO, LAS PARTICULAS TRATADAS EN SECO ASI OBTENIDAS, Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES PARTICULAS, QUE TIENEN FORMA SUSTANCIALMENTE ESFEROIDAL Y CONSTAN DE UN INGREDIENTE ACTIVO INCORPORADO EN UN POLIMERO BIOCOMPATIBLE DE ALTO PUNTO DE FUSION, CUYO PROCEDIMIENTO COMPRENDE MEZCLAR, CON AGITACION, DICHO POLIMERO BIOCOMPATIBLE Y DICHO INGREDIENTE ACTIVO, DENTRO DE UNA FASE VISCOSA HOMOGENEA SUSTENTADORA, NO MISCIBLE, SIENDO DICHO INGREDIENTE ACTIVO Y DICHO POLIMERO BIOCOMPATIBLE INSOLUBLES EN DICHA FASE LIQUIDA HOMOGENEA SUSTENTADORA, LUEGO MANTENER LA AGITACION, HASTA LA FORMACION DE MICROBOLAS DEL POLIMERO BIOCOMPATIBLE Y LA INCORPORACION COMPLETA DEL INGREDIENTE ACTIVO EN LAS MISMAS, ESTANDO LA TEMPERATURA DE TRATAMIENTO POR ENCIMA DE LA TEMPERATURA DE TRANSICION VITREA DEL POLIMERO BIOCOMPATIBLE; Y FINALMENTE RECUPERAR LAS MICROBOLAS ASI OBTENIDAS.
ES09400996A 1993-05-15 1994-05-11 Procedimiento para la preparcion de particulas tratadas en seco, las particulas tratadas en seco asi obtenidas, y composiciones farmaceuticas que contienen tales particulas. Expired - Fee Related ES2097083B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939310030A GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same

Publications (2)

Publication Number Publication Date
ES2097083A1 true ES2097083A1 (es) 1997-03-16
ES2097083B1 ES2097083B1 (es) 1997-12-01

Family

ID=10735537

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400996A Expired - Fee Related ES2097083B1 (es) 1993-05-15 1994-05-11 Procedimiento para la preparcion de particulas tratadas en seco, las particulas tratadas en seco asi obtenidas, y composiciones farmaceuticas que contienen tales particulas.

Country Status (35)

Country Link
JP (1) JP3139913B2 (es)
KR (1) KR100341261B1 (es)
CN (1) CN1050534C (es)
AT (1) AT406017B (es)
AU (1) AU685094B2 (es)
BE (1) BE1008323A3 (es)
BR (1) BR9401968A (es)
CA (1) CA2123481C (es)
CH (1) CH688572A5 (es)
DE (1) DE4416812C2 (es)
DK (1) DK171454B1 (es)
DZ (1) DZ1779A1 (es)
ES (1) ES2097083B1 (es)
FI (1) FI112915B (es)
FR (1) FR2705232B1 (es)
GB (2) GB9310030D0 (es)
GR (1) GR1002034B (es)
HK (1) HK1002831A1 (es)
HU (1) HU220617B1 (es)
IE (1) IE940392A1 (es)
IN (1) IN182330B (es)
IT (1) IT1269508B (es)
LU (1) LU88482A1 (es)
MA (1) MA23194A1 (es)
NL (1) NL9400795A (es)
NO (1) NO307403B1 (es)
NZ (1) NZ260520A (es)
OA (1) OA09939A (es)
PL (1) PL175780B1 (es)
PT (1) PT101518B (es)
RU (1) RU2125869C1 (es)
SE (1) SE519004C2 (es)
SG (1) SG46631A1 (es)
TN (1) TNSN94046A1 (es)
ZA (1) ZA943316B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE381349T1 (de) * 1993-01-06 2008-01-15 Ipsen Mfg Ireland Ltd Bioabbaubare polyester zur herstellung ionischer molekularer konjugate mit bioaktiven polypeptiden
JPH08505395A (ja) * 1993-01-06 1996-06-11 キナートン リミティド 生物分解性ポリエステルと生物活性ポリペプチドのイオン分子結合体
DE19604744A1 (de) 1996-02-09 1997-08-14 Henkel Kgaa Technische Di-/Triglyceridgemische
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
DE19617137C1 (de) * 1996-04-29 1997-02-27 Henkel Kgaa Verwendung von Copolymerestern für die Herstellung von Mikrosphären
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US6867181B1 (en) 1997-06-02 2005-03-15 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
DE60005819T2 (de) * 1999-06-14 2004-05-06 Cosmo S.P.A. Geschmacksmaskierte orale pharmazeutische zusammensetzungen mit kontrollierter abgabe
EP1229940B1 (en) 1999-11-15 2014-05-14 Piramal Healthcare (Canada) Limited Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
MY133977A (en) 2000-06-16 2007-11-30 Nippon Catalytic Chem Ind Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070153A1 (es) * 1969-10-23 1971-09-10 Du Pont
GB2246514A (en) * 1990-08-01 1992-02-05 Scras Sustained release particles preparation
WO1992021326A1 (en) * 1991-05-27 1992-12-10 Medinvent Method of producing reproducible particles

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH468192A (de) * 1964-06-19 1969-02-15 Ciba Geigy Verfahren zur Herstellung von Arzneimitteln in Perlenform
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH672887A5 (es) * 1987-10-14 1990-01-15 Debiopharm Sa
WO1989003678A1 (en) * 1987-10-30 1989-05-05 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
DE3916020C2 (de) * 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
ES2096624T3 (es) * 1990-04-12 1997-03-16 Shionogi & Co Composicion revestida y su procedimiento de preparacion.
JP3116311B2 (ja) * 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
GB9016885D0 (en) * 1990-08-01 1990-09-12 Scras Sustained release pharmaceutical compositions
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
CA2055522A1 (en) * 1990-12-12 1992-06-13 Masako Andoh Microspheres for ophthalmic use
GB9203689D0 (en) * 1992-02-20 1992-04-08 Euro Celtique Sa Pharmaceutical composition
EP0630234B1 (en) * 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
SE9200858L (sv) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
ES2181691T5 (es) * 1992-06-11 2007-10-01 Alkermes Controlled Therapeutics, Inc. Sistema de distribucion de proteina eritropoyetina.
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070153A1 (es) * 1969-10-23 1971-09-10 Du Pont
GB2246514A (en) * 1990-08-01 1992-02-05 Scras Sustained release particles preparation
WO1992021326A1 (en) * 1991-05-27 1992-12-10 Medinvent Method of producing reproducible particles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MATHIOWITZ E., Polyanhydride Microspheres as drug carners I. Hot-melt microencapsulation. Journal of Controlled Release 5 (1987) 13-22 *

Also Published As

Publication number Publication date
SE519004C2 (sv) 2002-12-17
HUT67599A (en) 1995-04-28
JPH072652A (ja) 1995-01-06
GR1002034B (en) 1995-10-31
CH688572A5 (fr) 1997-11-28
KR100341261B1 (ko) 2002-09-27
NO307403B1 (no) 2000-04-03
PL175780B1 (pl) 1999-02-26
SE9401557L (sv) 1994-11-16
GB2277915A (en) 1994-11-16
FI942222A0 (fi) 1994-05-13
NL9400795A (nl) 1994-12-01
DE4416812C2 (de) 2003-02-06
JP3139913B2 (ja) 2001-03-05
HU220617B1 (hu) 2002-03-28
HK1002831A1 (en) 1998-09-18
AT406017B (de) 2000-01-25
TNSN94046A1 (fr) 1995-04-25
ITMI940931A0 (it) 1994-05-11
HU9401412D0 (en) 1994-08-29
FI112915B (fi) 2004-02-13
RU2125869C1 (ru) 1999-02-10
ITMI940931A1 (it) 1995-11-11
CN1104557A (zh) 1995-07-05
PT101518A (pt) 1995-03-01
NZ260520A (en) 1994-12-22
AU6308494A (en) 1994-11-17
AU685094B2 (en) 1998-01-15
PT101518B (pt) 2000-12-29
SG46631A1 (en) 1998-02-20
IN182330B (es) 1999-03-20
IT1269508B (it) 1997-04-01
FI942222L (fi) 1994-11-16
IE940392A1 (en) 1994-11-16
CN1050534C (zh) 2000-03-22
BR9401968A (pt) 1994-12-13
BE1008323A3 (fr) 1996-04-02
DE4416812A1 (de) 1994-11-17
FR2705232A1 (fr) 1994-11-25
NO941810L (no) 1994-11-16
FR2705232B1 (fr) 1995-08-25
NO941810D0 (no) 1994-05-13
ES2097083B1 (es) 1997-12-01
DK171454B1 (da) 1996-11-04
GB9409565D0 (en) 1994-07-06
CA2123481C (en) 2005-01-11
GB9310030D0 (en) 1993-06-30
LU88482A1 (fr) 1994-12-01
DK54994A (da) 1994-11-16
ZA943316B (en) 1995-01-16
DZ1779A1 (fr) 2002-02-17
OA09939A (fr) 1994-11-15
SE9401557D0 (sv) 1994-05-05
CA2123481A1 (en) 1994-11-16
ATA98794A (de) 1999-06-15
GB2277915B (en) 1997-10-29
MA23194A1 (fr) 1994-12-31

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