|
US6140466A
(en)
|
1994-01-18 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
|
USRE39229E1
(en)
|
1994-08-20 |
2006-08-08 |
Gendaq Limited |
Binding proteins for recognition of DNA
|
|
US7262055B2
(en)
|
1998-08-25 |
2007-08-28 |
Gendaq Limited |
Regulated gene expression in plants
|
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
|
GB9710809D0
(en)
*
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
US6410248B1
(en)
|
1998-01-30 |
2002-06-25 |
Massachusetts Institute Of Technology |
General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
|
|
ES2341926T3
(es)
|
1998-03-02 |
2010-06-29 |
Massachusetts Institute Of Technology |
Poliproteinas con dedos de cinc que tienen enlazadores mejorados.
|
|
CA2323064C
(en)
|
1998-03-17 |
2011-05-31 |
Gendaq Limited |
Nucleic acid binding proteins
|
|
US7897843B2
(en)
|
1999-03-23 |
2011-03-01 |
Mendel Biotechnology, Inc. |
Transcriptional regulation of plant biomass and abiotic stress tolerance
|
|
US20050086718A1
(en)
|
1999-03-23 |
2005-04-21 |
Mendel Biotechnology, Inc. |
Plant transcriptional regulators of abiotic stress
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US7070934B2
(en)
|
1999-01-12 |
2006-07-04 |
Sangamo Biosciences, Inc. |
Ligand-controlled regulation of endogenous gene expression
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US20030104526A1
(en)
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US6794136B1
(en)
*
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
US7030215B2
(en)
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
AU4940700A
(en)
|
1999-05-28 |
2000-12-18 |
Sangamo Biosciences, Inc. |
Gene switches
|
|
WO2001000815A1
(en)
*
|
1999-05-28 |
2001-01-04 |
Sangamo Biosciences, Inc. |
Molecular switches
|
|
GB9915126D0
(en)
|
1999-06-30 |
1999-09-01 |
Imp College Innovations Ltd |
Control of gene expression
|
|
US7943731B1
(en)
|
1999-08-11 |
2011-05-17 |
Massachusetts Institute Of Technology |
Dimerizing peptides
|
|
EP1950306A1
(de)
|
1999-11-17 |
2008-07-30 |
Mendel Biotechnology, Inc. |
Umweltstress-Toleranzgene
|
|
AU1919901A
(en)
|
1999-11-17 |
2001-05-30 |
Luc Adam |
Pathogen tolerance genes
|
|
AU776576B2
(en)
|
1999-12-06 |
2004-09-16 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
ATE355368T1
(de)
|
2000-01-24 |
2006-03-15 |
Gendaq Ltd |
Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne
|
|
US20020061512A1
(en)
*
|
2000-02-18 |
2002-05-23 |
Kim Jin-Soo |
Zinc finger domains and methods of identifying same
|
|
US7923542B2
(en)
|
2000-04-28 |
2011-04-12 |
Sangamo Biosciences, Inc. |
Libraries of regulatory sequences, methods of making and using same
|
|
AU2001257331A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Methods for designing exogenous regulatory molecules
|
|
CA2407695C
(en)
*
|
2000-04-28 |
2015-03-31 |
Sangamo Biosciences, Inc. |
Methods for binding an exogenous molecule to cellular chromatin
|
|
AU2001255870B2
(en)
|
2000-04-28 |
2006-07-13 |
Sangamo Biosciences, Inc. |
Databases of regulatory sequences; methods of making and using same
|
|
AU2001257421A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
|
|
US6492117B1
(en)
*
|
2000-07-12 |
2002-12-10 |
Gendaq Limited |
Zinc finger polypeptides capable of binding DNA quadruplexes
|
|
WO2002008286A2
(en)
*
|
2000-07-21 |
2002-01-31 |
Syngenta Participations Ag |
Zinc finger domain recognition code and uses thereof
|
|
WO2002015675A1
(en)
|
2000-08-22 |
2002-02-28 |
Mendel Biotechnology, Inc. |
Genes for modifying plant traits iv
|
|
AU2002228841C1
(en)
|
2000-12-07 |
2006-11-23 |
Sangamo Biosciences, Inc |
Regulation of angiogenesis with zinc finger proteins
|
|
US7067317B2
(en)
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
|
WO2002057293A2
(en)
|
2001-01-22 |
2002-07-25 |
Sangamo Biosciences, Inc. |
Modified zinc finger binding proteins
|
|
AU2002225187A1
(en)
*
|
2001-01-22 |
2002-07-30 |
Sangamo Biosciences, Inc. |
Zinc finger polypeptides and their use
|
|
CA2457095A1
(en)
*
|
2001-08-17 |
2003-02-27 |
Toolgen, Inc. |
Zinc finger domain libraries
|
|
WO2003027247A2
(en)
|
2001-09-24 |
2003-04-03 |
Sangamo Biosciences, Inc. |
Modulation of stem cells using zinc finger proteins
|
|
CN100463962C
(zh)
*
|
2001-12-07 |
2009-02-25 |
图尔金株式会社 |
嵌合蛋白质的表型筛选
|
|
US7262054B2
(en)
|
2002-01-22 |
2007-08-28 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
|
WO2003087341A2
(en)
|
2002-01-23 |
2003-10-23 |
The University Of Utah Research Foundation |
Targeted chromosomal mutagenesis using zinc finger nucleases
|
|
SI1504108T1
(sl)
|
2002-02-01 |
2013-07-31 |
Oxford Biomedica (Uk) Limited |
Lentiviralni vektor
|
|
US20060078880A1
(en)
*
|
2002-02-07 |
2006-04-13 |
The Scripps Research Institute |
Zinc finger libraries
|
|
WO2004013333A2
(de)
|
2002-07-26 |
2004-02-12 |
Basf Plant Science Gmbh |
Revertierung der negativ-selektiven wirkung von negativen markerproteinen als selektionsverfahren
|
|
US7361635B2
(en)
|
2002-08-29 |
2008-04-22 |
Sangamo Biosciences, Inc. |
Simultaneous modulation of multiple genes
|
|
AU2003260973A1
(en)
*
|
2002-09-05 |
2004-03-29 |
Toolgen, Inc. |
Bioinformatics analysis of cellular effects of artificial transcription factors
|
|
EP2806025B1
(de)
|
2002-09-05 |
2019-04-03 |
California Institute of Technology |
Verwendung von Zinkfingernukleasen zur Stimulierung von Gentargeting
|
|
EP3249046B1
(de)
|
2002-09-18 |
2020-07-08 |
Mendel Biotechnology, Inc. |
Polynukleotide und polypeptide in pflanzen
|
|
GB0228289D0
(en)
|
2002-12-04 |
2003-01-08 |
Genome Inst Of Singapore Nat U |
Method
|
|
US20070134796A1
(en)
|
2005-07-26 |
2007-06-14 |
Sangamo Biosciences, Inc. |
Targeted integration and expression of exogenous nucleic acid sequences
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
AU2004263865B2
(en)
|
2003-08-08 |
2007-05-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US11311574B2
(en)
|
2003-08-08 |
2022-04-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US20120196370A1
(en)
|
2010-12-03 |
2012-08-02 |
Fyodor Urnov |
Methods and compositions for targeted genomic deletion
|
|
EP1678315B1
(de)
|
2003-09-19 |
2011-08-03 |
Sangamo BioSciences, Inc. |
Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression
|
|
US7329725B1
(en)
*
|
2003-10-29 |
2008-02-12 |
Nastech Pharmaceutical Company Inc. |
Phage displayed Trp cage ligands
|
|
US7972854B2
(en)
|
2004-02-05 |
2011-07-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
EP1732945B1
(de)
*
|
2004-04-08 |
2014-12-24 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur modulation der kardialen kontraktivität
|
|
AU2005232665B2
(en)
*
|
2004-04-08 |
2010-05-13 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating neuropathic and neurodegenerative conditions
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
US7501121B2
(en)
|
2004-06-17 |
2009-03-10 |
Wyeth |
IL-13 binding agents
|
|
AU2005287278B2
(en)
*
|
2004-09-16 |
2011-08-04 |
Sangamo Biosciences, Inc. |
Compositions and methods for protein production
|
|
EP2163632A1
(de)
|
2004-10-05 |
2010-03-17 |
SunGene GmbH |
Konstitutive Expressionskassetten zur Regulation der Pflanzenexpression
|
|
EP1655364A3
(de)
|
2004-11-05 |
2006-08-02 |
BASF Plant Science GmbH |
Expressionskassetten zur bevorzugten Expression in Pflanzensamen
|
|
EP2163631B1
(de)
|
2004-11-25 |
2013-05-22 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in pflanzlichen Schliesszellen
|
|
EP1666599A3
(de)
|
2004-12-04 |
2006-07-12 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in Mesophyll- und/oder Epidermiszellen in Pflanzen
|
|
EP1669455B1
(de)
|
2004-12-08 |
2009-10-28 |
SunGene GmbH |
Expressionskassetten für preferentiell vaskuläre Expression in Pflanzen
|
|
EP1669456A3
(de)
|
2004-12-11 |
2006-07-12 |
SunGene GmbH |
Expressionskasseten für meristembevorzugte Expression in Pflanzen
|
|
US7470777B2
(en)
|
2004-12-22 |
2008-12-30 |
Iowa State University Research Foundation, Inc. |
Compositions and methods related to modified retroviral vectors for restricted, site specific integration
|
|
CN101155922A
(zh)
|
2005-02-09 |
2008-04-02 |
巴斯福植物科学有限公司 |
在单子叶植物中调控表达的表达盒
|
|
DE102005008765B4
(de)
*
|
2005-02-25 |
2016-06-16 |
Siemens Healthcare Gmbh |
Kontrastmittel auf der Basis von Bakteriophagen, diese enthaltende Zusammensetzung, deren Verwendung und Verfahren zu deren Herstellung
|
|
BRPI0607378A2
(pt)
|
2005-02-26 |
2010-03-23 |
Basf Plant Science Gmbh |
cassetes de expressço, seqÜÊncia nucleotÍdica isolada, vetor, cÉlula hospedeira transgÊnica ou organismo nço humano, cÉlula de planta ou planta transgÊnica, mÉtodos para identificar e/ou isolar uma seqÜÊncia nucleotÍdica reguladora da transcriÇço, para prover ou produzir um cassete de expressço transgÊnica, e para prover uma seqÜÊncia nucleotÍdica reguladora de transcriÇço sintÉtica, e, seqÜÊncia reguladora de transcriÇço sintÉtica
|
|
ATE553122T1
(de)
|
2005-02-28 |
2012-04-15 |
Sangamo Biosciences Inc |
Antiangiogene methoden und zusammensetzungen
|
|
EP1882037A2
(de)
|
2005-05-10 |
2008-01-30 |
BASF Plant Science GmbH |
Expressionskassetten zur bevorzugten expression in pflanzensamen
|
|
US7919583B2
(en)
*
|
2005-08-08 |
2011-04-05 |
Discovery Genomics, Inc. |
Integration-site directed vector systems
|
|
US7704953B2
(en)
*
|
2006-02-17 |
2010-04-27 |
Mdrna, Inc. |
Phage displayed cell binding peptides
|
|
ES2465996T3
(es)
*
|
2006-05-25 |
2014-06-09 |
Sangamo Biosciences, Inc. |
Métodos y composiciones para la inactivación genética
|
|
EP2027262B1
(de)
|
2006-05-25 |
2010-03-31 |
Sangamo Biosciences Inc. |
Variante foki-spaltungshälften-domänen
|
|
BRPI0716427A2
(pt)
|
2006-08-11 |
2014-03-11 |
Dow Agrosciences Llc |
Recombinação homóloga mediada por nuclease de apêndice de zinco
|
|
WO2008060510A2
(en)
|
2006-11-13 |
2008-05-22 |
Sangamo Biosciences, Inc. |
Zinc finger nuclease for targeting the human glucocorticoid receptor locus
|
|
WO2008067840A1
(en)
|
2006-12-08 |
2008-06-12 |
Swetree Technologies Ab |
Plants having improved growth characteristics and method for making the same
|
|
ES2586210T3
(es)
|
2006-12-14 |
2016-10-13 |
Sangamo Biosciences, Inc. |
Proteínas de dedo de zinc no canónicas optimizadas
|
|
EP2074219B1
(de)
|
2007-02-16 |
2013-11-20 |
BASF Plant Science GmbH |
Nukleinsäuresequenzen zur regulierung embryospezifischer expression in einkeimblättrigen pflanzen
|
|
DE602008003684D1
(de)
|
2007-04-26 |
2011-01-05 |
Sangamo Biosciences Inc |
Gezielte integration in die ppp1r12c-position
|
|
EP2171052B1
(de)
|
2007-07-12 |
2014-08-27 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzung zur deaktivierung der alpha-1,6-fucosyltransferase-genexpression
|
|
EP2188384B1
(de)
|
2007-09-27 |
2015-07-15 |
Sangamo BioSciences, Inc. |
Schnelle in-vivo-identifizierung von biologisch aktiven nukleasen
|
|
HRP20161004T1
(hr)
|
2007-09-27 |
2016-10-21 |
Dow Agrosciences Llc |
Tehnološki konstruirani proteini cinkovi prsti koji imaju kao cilj gene za sintazu 5-enolpiruvilshikimat-3-fosfata
|
|
US11235026B2
(en)
|
2007-09-27 |
2022-02-01 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating PD1
|
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
|
EP2205752B1
(de)
|
2007-10-25 |
2016-08-10 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen für gezielte integration
|
|
ES2647767T3
(es)
|
2007-12-03 |
2017-12-26 |
Syngenta Participations Ag |
Generación por ingeniería genética de proteínas enzimáticamente susceptibles
|
|
US8937219B2
(en)
|
2007-12-28 |
2015-01-20 |
Sweetree Technologies Ab |
Woody plants having improved growth characteristics and method for making the same using transcription factors
|
|
DE102008013623A1
(de)
*
|
2008-03-10 |
2009-09-24 |
Freie Universität Berlin |
Pharmazeutische Zusammensetzung zur Diagnose oder Behandlung von Zinkfinger Protein assoziierten Erkrankungen
|
|
CA2720903C
(en)
|
2008-04-14 |
2019-01-15 |
Sangamo Biosciences, Inc. |
Linear donor constructs for targeted integration
|
|
AU2009239333A1
(en)
|
2008-04-21 |
2009-10-29 |
Danziger Innovations Ltd. |
Plant viral expression vectors and use of same for generating genotypic variations in plant genomes
|
|
JP5746016B2
(ja)
|
2008-04-30 |
2015-07-08 |
サンバイオ,インコーポレイティド |
Dnaメチル化における改変を伴う神経再生細胞連邦政府の援助に関する申告適用なし
|
|
US9394531B2
(en)
|
2008-05-28 |
2016-07-19 |
Sangamo Biosciences, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
|
EP2130836B1
(de)
*
|
2008-06-03 |
2013-02-13 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Mittel und Verfahren zur Herstellung von Zinkfingern und Konkatemere daraus
|
|
WO2009151591A2
(en)
|
2008-06-10 |
2009-12-17 |
Sangamo Biosciences, Inc. |
Methods and compositions for generation of bax- and bak-deficient cell lines
|
|
SG191561A1
(en)
|
2008-08-22 |
2013-07-31 |
Sangamo Biosciences Inc |
Methods and compositions for targeted single-stranded cleavage and targeted integration
|
|
JP5756016B2
(ja)
|
2008-10-29 |
2015-07-29 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
グルタミンシンセターゼ遺伝子の発現を不活性化する方法及び組成物
|
|
UY32220A
(es)
|
2008-11-03 |
2010-06-30 |
Swetree Technologies Ab |
Material vegetal, plantas y metodo para producir la planta que contiene propiedades alteradas de lignina
|
|
EP2352369B1
(de)
|
2008-12-04 |
2017-04-26 |
Sangamo BioSciences, Inc. |
Genomänderung bei ratten mithilfe von zink-finger-nukleasen
|
|
CN102333868B
(zh)
|
2008-12-17 |
2015-01-07 |
陶氏益农公司 |
靶向整合入Zp15 基因座
|
|
AU2010211057B2
(en)
|
2009-02-04 |
2014-12-18 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating neuropathies
|
|
EP2408921B1
(de)
|
2009-03-20 |
2017-04-19 |
Sangamo BioSciences, Inc. |
Modifikation von cxcr4 mit manipulierten zink-fingerproteinen
|
|
EP2419511B1
(de)
|
2009-04-09 |
2018-01-17 |
Sangamo Therapeutics, Inc. |
Gezielte integration in stammzellen
|
|
US8772008B2
(en)
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
|
EP2449135B1
(de)
|
2009-06-30 |
2016-01-06 |
Sangamo BioSciences, Inc. |
Schnelles screening biologisch aktiver nukleasen und isolation nukleasemodifizierter zellen
|
|
EP2451837B1
(de)
|
2009-07-08 |
2015-03-25 |
Cellular Dynamics International, Inc. |
Modifizierte ips-zellen mit einer mutanten form des hiv-zelleintrittsgens
|
|
CA2769262C
(en)
|
2009-07-28 |
2019-04-30 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating trinucleotide repeat disorders
|
|
WO2011017315A2
(en)
*
|
2009-08-03 |
2011-02-10 |
Recombinetics, Inc. |
Methods and compositions for targeted gene modification
|
|
WO2011017293A2
(en)
*
|
2009-08-03 |
2011-02-10 |
The General Hospital Corporation |
Engineering of zinc finger arrays by context-dependent assembly
|
|
JP5940977B2
(ja)
|
2009-08-11 |
2016-06-29 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
標的改変によるホモ接合生物
|
|
US8586526B2
(en)
|
2010-05-17 |
2013-11-19 |
Sangamo Biosciences, Inc. |
DNA-binding proteins and uses thereof
|
|
WO2011048600A1
(en)
|
2009-10-21 |
2011-04-28 |
Danziger Innovations Ltd. |
Generating genotypic variations in plant genomes by gamete infection
|
|
WO2011049627A1
(en)
|
2009-10-22 |
2011-04-28 |
Dow Agrosciences Llc |
Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
EP2504439B1
(de)
|
2009-11-27 |
2016-03-02 |
BASF Plant Science Company GmbH |
Optimierte endonukleasen und ihre verwendung
|
|
US9420770B2
(en)
|
2009-12-01 |
2016-08-23 |
Indiana University Research & Technology Corporation |
Methods of modulating thrombocytopenia and modified transgenic pigs
|
|
MX336846B
(es)
|
2010-01-22 |
2016-02-03 |
Sangamo Biosciences Inc |
Alteracion genomica dirigida.
|
|
ES2751916T3
(es)
|
2010-02-08 |
2020-04-02 |
Sangamo Therapeutics Inc |
Semidominios de escisión genomanipulados
|
|
EP2660318A1
(de)
|
2010-02-09 |
2013-11-06 |
Sangamo BioSciences, Inc. |
Gezielte Genommodifikation mit partiell einzelsträngigen Donatormolekülen
|
|
US9567573B2
(en)
|
2010-04-26 |
2017-02-14 |
Sangamo Biosciences, Inc. |
Genome editing of a Rosa locus using nucleases
|
|
HRP20200254T1
(hr)
|
2010-05-03 |
2020-05-29 |
Sangamo Therapeutics, Inc. |
Pripravci za povezivanje modula cink fingera
|
|
AU2011281062B2
(en)
|
2010-07-21 |
2015-01-22 |
Board Of Regents, The University Of Texas System |
Methods and compositions for modification of a HLA locus
|
|
US9512444B2
(en)
|
2010-07-23 |
2016-12-06 |
Sigma-Aldrich Co. Llc |
Genome editing using targeting endonucleases and single-stranded nucleic acids
|
|
AU2011312562B2
(en)
|
2010-09-27 |
2014-10-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for inhibiting viral entry into cells
|
|
US9175280B2
(en)
|
2010-10-12 |
2015-11-03 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating hemophilia B
|
|
US20130316391A1
(en)
|
2010-12-29 |
2013-11-28 |
Sigmaaldrich Co., LLC |
Cells having disrupted expression of proteins involved in adme and toxicology processes
|
|
WO2012094132A1
(en)
|
2011-01-05 |
2012-07-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene correction
|
|
CA2828196A1
(en)
|
2011-03-18 |
2012-09-27 |
Basf Plant Science Company Gmbh |
Promoters for regulating expression in plants
|
|
WO2012139045A1
(en)
|
2011-04-08 |
2012-10-11 |
Gilead Biologics, Inc. |
Methods and compositions for normalization of tumor vasculature by inhibition of loxl2
|
|
US8980583B2
(en)
|
2011-06-30 |
2015-03-17 |
Sigma-Aldrich Co. Llc |
Cells deficient in CMP-N-acetylneuraminic acid hydroxylase and/or glycoprotein alpha-1,3-galactosyltransferase
|
|
WO2013006619A1
(en)
|
2011-07-05 |
2013-01-10 |
The General Hospital Corporation |
Rna-yy1 interactions
|
|
US9161995B2
(en)
|
2011-07-25 |
2015-10-20 |
Sangamo Biosciences, Inc. |
Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
|
|
CA2848417C
(en)
|
2011-09-21 |
2023-05-02 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of transgene expression
|
|
US8951752B2
(en)
|
2011-10-20 |
2015-02-10 |
University Of Iowa Research Foundation |
N-demethyase genes and uses thereof
|
|
CA3099582A1
(en)
|
2011-10-27 |
2013-05-02 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of the hprt locus
|
|
HK1200871A1
(en)
|
2011-11-16 |
2015-08-14 |
Sangamo Therapeutics, Inc. |
Modified dna-binding proteins and uses thereof
|
|
US9376484B2
(en)
|
2012-01-11 |
2016-06-28 |
Sigma-Aldrich Co. Llc |
Production of recombinant proteins with simple glycoforms
|
|
EP2806881A1
(de)
|
2012-01-27 |
2014-12-03 |
SanBio, Inc. |
Verfahren und zusammensetzungen zur modulation der angiogenese und vaskulogenese
|
|
CN105658792B
(zh)
|
2012-02-28 |
2020-11-10 |
西格马-奥尔德里奇有限责任公司 |
靶向组蛋白乙酰化
|
|
WO2013130824A1
(en)
|
2012-02-29 |
2013-09-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
EP2839013B1
(de)
|
2012-04-18 |
2020-08-26 |
The Board of Trustees of the Leland Stanford Junior University |
Disruptionsfreies gen-targeting
|
|
AU2013204327B2
(en)
|
2012-04-20 |
2016-09-01 |
Aviagen |
Cell transfection method
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
MX369788B
(es)
|
2012-05-02 |
2019-11-21 |
Dow Agrosciences Llc |
Modificacion dirigida de deshidrogenasa de malato.
|
|
AU2013259647B2
(en)
|
2012-05-07 |
2018-11-08 |
Corteva Agriscience Llc |
Methods and compositions for nuclease-mediated targeted integration of transgenes
|
|
US11120889B2
(en)
|
2012-05-09 |
2021-09-14 |
Georgia Tech Research Corporation |
Method for synthesizing a nuclease with reduced off-site cleavage
|
|
EP2861740A1
(de)
|
2012-06-15 |
2015-04-22 |
University of Iowa Research Foundation |
Koffeinreaktive promotoren und regulatorische gene
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
JP6329537B2
(ja)
|
2012-07-11 |
2018-05-23 |
サンガモ セラピューティクス, インコーポレイテッド |
生物学的薬剤の送達のための方法および組成物
|
|
EP3196301B1
(de)
|
2012-07-11 |
2018-10-17 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung von monogener krankheiten
|
|
SG10201701601WA
(en)
|
2012-08-29 |
2017-04-27 |
Sangamo Biosciences Inc |
Methods and compositions for treatment of a genetic condition
|
|
WO2014039513A2
(en)
|
2012-09-04 |
2014-03-13 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
|
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
|
US9914930B2
(en)
|
2012-09-07 |
2018-03-13 |
Dow Agrosciences Llc |
FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
|
|
AU2013329186B2
(en)
|
2012-10-10 |
2019-02-14 |
Sangamo Therapeutics, Inc. |
T cell modifying compounds and uses thereof
|
|
US9255250B2
(en)
|
2012-12-05 |
2016-02-09 |
Sangamo Bioscience, Inc. |
Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene
|
|
MX2015007574A
(es)
|
2012-12-13 |
2015-10-22 |
Dow Agrosciences Llc |
Gen de precision dirigido a un locus particular en el maiz.
|
|
PT2963113T
(pt)
|
2013-02-14 |
2020-02-14 |
Univ Osaka |
Método para isolar região genómica específica utilizando molécula que se liga especificamente a sequência de adn endógena
|
|
US10227610B2
(en)
|
2013-02-25 |
2019-03-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
US9937207B2
(en)
|
2013-03-21 |
2018-04-10 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell receptor genes using talens
|
|
CN105263312A
(zh)
|
2013-04-05 |
2016-01-20 |
美国陶氏益农公司 |
用于在植物基因组内整合外源序列的方法和组合物
|
|
EP2994531B1
(de)
|
2013-05-10 |
2018-03-28 |
Sangamo Therapeutics, Inc. |
Freisetzungsverfahren und zusammensetzungen für nukleasevermitteltes genomengineering
|
|
WO2014186435A2
(en)
|
2013-05-14 |
2014-11-20 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for reducing neointima formation
|
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
CA3131284C
(en)
|
2013-08-28 |
2023-09-19 |
David Paschon |
Compositions for linking dna-binding domains and cleavage domains
|
|
US10117899B2
(en)
|
2013-10-17 |
2018-11-06 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
|
EP3441468B1
(de)
|
2013-10-17 |
2021-05-19 |
Sangamo Therapeutics, Inc. |
Freisetzungsverfahren und zusammensetzungen für nukleasevermitteltes genomengineering
|
|
NZ746567A
(en)
|
2013-11-04 |
2019-09-27 |
Dow Agrosciences Llc |
Optimal soybean loci
|
|
NZ719494A
(en)
|
2013-11-04 |
2017-09-29 |
Dow Agrosciences Llc |
Optimal maize loci
|
|
UY35812A
(es)
|
2013-11-04 |
2015-05-29 |
Dow Agrosciences Llc |
?loci de maíz óptimos?.
|
|
CN105980395A
(zh)
|
2013-11-04 |
2016-09-28 |
美国陶氏益农公司 |
最优大豆座位
|
|
WO2015070212A1
(en)
|
2013-11-11 |
2015-05-14 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
DK3492593T3
(da)
|
2013-11-13 |
2021-11-08 |
Childrens Medical Center |
Nukleasemedieret regulering af genekspression
|
|
US9932607B2
(en)
|
2013-11-15 |
2018-04-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Site-specific integration of transgenes into human cells
|
|
CN105940013B
(zh)
|
2013-12-09 |
2020-03-27 |
桑格摩生物科学股份有限公司 |
用于治疗血友病的方法和组合物
|
|
US10774338B2
(en)
|
2014-01-16 |
2020-09-15 |
The Regents Of The University Of California |
Generation of heritable chimeric plant traits
|
|
US10072066B2
(en)
|
2014-02-03 |
2018-09-11 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a beta thalessemia
|
|
WO2015127439A1
(en)
|
2014-02-24 |
2015-08-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease-mediated targeted integration
|
|
TW201538518A
(zh)
|
2014-02-28 |
2015-10-16 |
Dow Agrosciences Llc |
藉由嵌合基因調控元件所賦予之根部特異性表現
|
|
KR20220013460A
(ko)
|
2014-03-04 |
2022-02-04 |
시그마-알드리치 컴퍼니., 엘엘씨 |
바이러스 내성 세포 및 이의 용도
|
|
CN106459894B
(zh)
|
2014-03-18 |
2020-02-18 |
桑格摩生物科学股份有限公司 |
用于调控锌指蛋白表达的方法和组合物
|
|
BR112016019940A2
(pt)
|
2014-03-21 |
2017-10-24 |
Univ Leland Stanford Junior |
edição de genoma sem nucleases
|
|
WO2015153889A2
(en)
|
2014-04-02 |
2015-10-08 |
University Of Florida Research Foundation, Incorporated |
Materials and methods for the treatment of latent viral infection
|
|
WO2015164748A1
(en)
|
2014-04-24 |
2015-10-29 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (tale) proteins
|
|
WO2015171932A1
(en)
|
2014-05-08 |
2015-11-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
ES2966886T3
(es)
|
2014-05-09 |
2024-04-24 |
Univ Yale |
Partículas recubiertas con poliglicerol hiperramificado y métodos de elaboración y uso de las mismas
|
|
US11918695B2
(en)
|
2014-05-09 |
2024-03-05 |
Yale University |
Topical formulation of hyperbranched polymer-coated particles
|
|
WO2015175642A2
(en)
|
2014-05-13 |
2015-11-19 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a disease
|
|
WO2015188056A1
(en)
|
2014-06-05 |
2015-12-10 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease design
|
|
AR100874A1
(es)
|
2014-06-16 |
2016-11-09 |
Consejo Nac De Investig Científicas Y Técnicas (Conicet) |
Genes quiméricos y proteínas de resistencia oxidativa, y plantas transgénicas que incluyen los mismos
|
|
US20170159065A1
(en)
|
2014-07-08 |
2017-06-08 |
Vib Vzw |
Means and methods to increase plant yield
|
|
DK3169778T5
(da)
|
2014-07-14 |
2024-10-14 |
Univ Washington State |
Nanos-knockout, der eliminerer kimbaneceller
|
|
KR20170032406A
(ko)
|
2014-07-15 |
2017-03-22 |
주노 쎄러퓨티크스 인코퍼레이티드 |
입양 세포 치료를 위한 조작된 세포
|
|
WO2016011381A1
(en)
|
2014-07-18 |
2016-01-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Reducing cxcr4 expression and/or function to enhance engraftment of hematopoietic stem cells
|
|
WO2016014837A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Gene editing for hiv gene therapy
|
|
WO2016014794A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
WO2016019144A2
(en)
|
2014-07-30 |
2016-02-04 |
Sangamo Biosciences, Inc. |
Gene correction of scid-related genes in hematopoietic stem and progenitor cells
|
|
DK3194570T3
(da)
|
2014-09-16 |
2021-09-13 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til nukleasemedieret genommodificering og -korrektion i hæmatopoietiske stamceller
|
|
US10889834B2
(en)
|
2014-12-15 |
2021-01-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing targeted transgene integration
|
|
HK1246690A1
(zh)
|
2015-01-21 |
2018-09-14 |
Sangamo Therapeutics, Inc. |
用於鉴定高度特异性核酸酶的方法和组合物
|
|
WO2016123100A1
(en)
|
2015-01-26 |
2016-08-04 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
WO2016130600A2
(en)
|
2015-02-09 |
2016-08-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
CA2981077A1
(en)
|
2015-04-03 |
2016-10-06 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
|
BR112017021703B1
(pt)
|
2015-04-15 |
2023-11-28 |
Corteva Agriscience Llc |
Promotor de planta para expressão de transgene
|
|
US9914934B2
(en)
|
2015-04-15 |
2018-03-13 |
Dow Agrosciences Llc |
Root-preferred promoter from a Panicum virgatum metallothionein-like gene
|
|
WO2016178207A1
(en)
|
2015-05-04 |
2016-11-10 |
Ramot At Tel-Aviv University Ltd. |
Methods and kits for fragmenting dna
|
|
US10179918B2
(en)
|
2015-05-07 |
2019-01-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for increasing transgene activity
|
|
AU2016261927B2
(en)
|
2015-05-12 |
2022-04-07 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
WO2016196388A1
(en)
|
2015-05-29 |
2016-12-08 |
Juno Therapeutics, Inc. |
Composition and methods for regulating inhibitory interactions in genetically engineered cells
|
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
AU2016291778B2
(en)
|
2015-07-13 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
HK1255161A1
(zh)
|
2015-07-15 |
2019-08-09 |
Juno Therapeutics, Inc. |
用於过继性细胞治疗的工程细胞
|
|
RS65691B1
(sr)
|
2015-08-06 |
2024-07-31 |
Univ Missouri |
Svinja i ćelije rezistentne na virus reproduktivnog i respiratornog sindroma svinja (prrsv) koje imaju modifikovane cd163 gene
|
|
WO2017031370A1
(en)
|
2015-08-18 |
2017-02-23 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
WO2017049136A1
(en)
*
|
2015-09-18 |
2017-03-23 |
President And Fellows Of Harvard College |
Nucleic acid frameworks for structural determination
|
|
TW201718862A
(zh)
|
2015-09-22 |
2017-06-01 |
Dow Agrosciences Llc |
用於轉殖基因表現之植物啟動子及3’utr
|
|
TW201718861A
(zh)
|
2015-09-22 |
2017-06-01 |
道禮責任有限公司 |
用於轉殖基因表現之植物啟動子及3’utr
|
|
JP6853257B2
(ja)
|
2015-09-23 |
2021-03-31 |
サンガモ セラピューティクス, インコーポレイテッド |
Httリプレッサー及びその使用
|
|
EP4089175A1
(de)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genom-engineering mit typ-i-crispr-systemen in eukaryotischen zellen
|
|
EP3365451B1
(de)
|
2015-10-22 |
2020-06-24 |
Dow Agrosciences LLC |
Pflanzenpromoter zur transgenen expression
|
|
KR20250141836A
(ko)
|
2015-11-04 |
2025-09-29 |
페이트 세러퓨틱스, 인코포레이티드 |
만능 세포의 유전자 조작
|
|
WO2017078935A1
(en)
|
2015-11-04 |
2017-05-11 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
SG11201803145RA
(en)
|
2015-11-04 |
2018-05-30 |
Fate Therapeutics Inc |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
|
US10639383B2
(en)
|
2015-11-23 |
2020-05-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for engineering immunity
|
|
KR102787119B1
(ko)
|
2015-11-30 |
2025-03-27 |
듀크 유니버시티 |
유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
|
|
BR112018012235A2
(pt)
|
2015-12-18 |
2018-12-04 |
Sangamo Therapeutics Inc |
rompimento alvejado do receptor de células de mhc
|
|
EP3389677B1
(de)
|
2015-12-18 |
2024-06-26 |
Sangamo Therapeutics, Inc. |
Gezielte zerstörung des t-zell-rezeptors
|
|
IL260532B2
(en)
|
2016-01-11 |
2023-12-01 |
Univ Leland Stanford Junior |
Chimeric proteins- containing systems and uses thereof in regulating gene expression
|
|
MX2018008345A
(es)
|
2016-01-11 |
2018-12-06 |
Univ Leland Stanford Junior |
Proteínas quiméricas y métodos de inmunoterapia.
|
|
WO2017123757A1
(en)
|
2016-01-15 |
2017-07-20 |
Sangamo Therapeutics, Inc. |
Methods and compositions for the treatment of neurologic disease
|
|
KR20180101442A
(ko)
|
2016-02-02 |
2018-09-12 |
상가모 테라퓨틱스, 인코포레이티드 |
Dna-결합 도메인 및 절단 도메인을 연결시키기 위한 조성물
|
|
JP2019508037A
(ja)
|
2016-02-16 |
2019-03-28 |
イェール ユニバーシティーYale Universit |
標的化遺伝子編集を増強するための組成物およびその使用方法
|
|
US20200308590A1
(en)
|
2016-02-16 |
2020-10-01 |
Yale University |
Compositions and methods for treatment of cystic fibrosis
|
|
WO2023150553A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Gpr17 promoter-based targeting and transduction of glial progenitor cells
|
|
EP3433362B1
(de)
|
2016-03-23 |
2021-05-05 |
Dana-Farber Cancer Institute, Inc. |
Verfahren zur erhöhung der effizienz der geneditierung
|
|
US20190117799A1
(en)
|
2016-04-01 |
2019-04-25 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
WO2017189914A1
(en)
|
2016-04-27 |
2017-11-02 |
Massachusetts Institute Of Technology |
Sequence-controlled polymer random access memory storage
|
|
WO2017189870A1
(en)
|
2016-04-27 |
2017-11-02 |
Massachusetts Institute Of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
|
WO2018005445A1
(en)
|
2016-06-27 |
2018-01-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting and treating diabetes
|
|
EP3475706B1
(de)
|
2016-06-27 |
2021-08-11 |
Juno Therapeutics, Inc. |
Mhc-e-beschränkte epitopen, bindungsmoleküle, und zugehörige verfahren und verwendungen
|
|
US20200182884A1
(en)
|
2016-06-27 |
2020-06-11 |
Juno Therapeutics, Inc. |
Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
|
|
MA45670A
(fr)
|
2016-07-13 |
2019-05-22 |
Vertex Pharma |
Procédés, compositions et kits pour augmenter l'efficacité d'édition du génome
|
|
EP4321623A3
(de)
|
2016-07-15 |
2024-05-15 |
Salk Institute for Biological Studies |
Verfahren und zusammensetzungen zum genom-editieren von sich nichtteilenden zellen
|
|
JP7490211B2
(ja)
|
2016-07-19 |
2024-05-27 |
デューク ユニバーシティ |
Cpf1に基づくゲノム編集の治療適用
|
|
KR20190031306A
(ko)
|
2016-07-21 |
2019-03-25 |
맥스시티 인코포레이티드 |
게놈 dna를 변경하기 위한 방법 및 조성물
|
|
CN114652735A
(zh)
|
2016-07-27 |
2022-06-24 |
凯斯西储大学 |
促进髓鞘形成的化合物和方法
|
|
WO2018029034A1
(en)
|
2016-08-09 |
2018-02-15 |
Vib Vzw |
Cellulose synthase inhibitors and mutant plants
|
|
CA2941315C
(en)
|
2016-08-12 |
2018-03-06 |
Api Labs Inc. |
High thebaine poppy and methods of producing the same
|
|
EP3995574A1
(de)
|
2016-08-24 |
2022-05-11 |
Sangamo Therapeutics, Inc. |
Regulierung der genexpression mit manipulierten nukleasen
|
|
KR102455249B1
(ko)
|
2016-08-24 |
2022-10-17 |
상가모 테라퓨틱스, 인코포레이티드 |
가공된 표적 특이적 뉴클레아제
|
|
CA3035534A1
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
|
US12499971B2
(en)
|
2016-09-28 |
2025-12-16 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
CA3038520A1
(en)
|
2016-10-03 |
2018-04-12 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
US10400246B2
(en)
|
2016-10-03 |
2019-09-03 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
MX2019003768A
(es)
|
2016-10-03 |
2019-06-24 |
Juno Therapeutics Inc |
Moleculas de enlace especificas de hpv.
|
|
DK3523326T3
(da)
|
2016-10-04 |
2020-08-03 |
Prec Biosciences Inc |
Samstimulerende domæner til anvendelse i genetisk modificerede celler
|
|
JP7248571B2
(ja)
|
2016-10-05 |
2023-03-29 |
フジフィルム セルラー ダイナミクス,インコーポレイテッド |
MeCP2が破壊された誘導多能性幹細胞からの成熟系列の生成
|
|
JP7623784B2
(ja)
|
2016-10-13 |
2025-01-29 |
ジュノー セラピューティクス インコーポレイテッド |
トリプトファン代謝経路調節剤を含む免疫療法の方法および組成物
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
KR102712926B1
(ko)
|
2016-10-20 |
2024-10-07 |
상가모 테라퓨틱스, 인코포레이티드 |
파브리병의 치료를 위한 방법 및 조성물
|
|
WO2018081138A1
(en)
|
2016-10-24 |
2018-05-03 |
Yale University |
Biodegradable contraceptive implants
|
|
WO2018081775A1
(en)
|
2016-10-31 |
2018-05-03 |
Sangamo Therapeutics, Inc. |
Gene correction of scid-related genes in hematopoietic stem and progenitor cells
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
IL266862B2
(en)
|
2016-12-01 |
2024-01-01 |
Sangamo Therapeutics Inc |
Tau modulators and methods and preparations for their administration
|
|
US11793833B2
(en)
|
2016-12-02 |
2023-10-24 |
Juno Therapeutics, Inc. |
Engineered B cells and related compositions and methods
|
|
KR20190098747A
(ko)
|
2016-12-05 |
2019-08-22 |
주노 쎄러퓨티크스 인코퍼레이티드 |
입양 세포 치료법을 위한 조작된 세포의 제조방법
|
|
EP3551754B1
(de)
|
2016-12-08 |
2023-08-30 |
Case Western Reserve University |
Verfahren und zusammensetzungen zur erhöhung der herstellung von funktionalem myelin
|
|
WO2018112470A1
(en)
|
2016-12-16 |
2018-06-21 |
The Brigham And Women's Hospital, Inc. |
Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
|
|
WO2018140478A1
(en)
|
2017-01-24 |
2018-08-02 |
Sigma-Aldrich Co. Llc |
Viral resistant cells and culture systems
|
|
AU2018213044B2
(en)
*
|
2017-01-26 |
2024-08-01 |
The Regents Of The University Of California |
Targeted gene demethylation in plants
|
|
EP3585895A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Zusammensetzungen und verfahren zur geneditierung
|
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
WO2018187493A1
(en)
|
2017-04-04 |
2018-10-11 |
Yale University |
Compositions and methods for in utero delivery
|
|
US12590288B2
(en)
|
2017-04-12 |
2026-03-31 |
The Broad Institute, Inc. |
Method of treating an inflammatory disease by administering an agent which binds a surface receptor on a tuft cell that induces an ILC class 2 inflammatory response
|
|
US12331319B2
(en)
|
2017-04-12 |
2025-06-17 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
EP3610266A4
(de)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
Tumorsignatur für metastasen, zusammensetzungen von substanzen und verwendung davon
|
|
MX2019010286A
(es)
|
2017-04-20 |
2019-10-21 |
Univ Oregon Health & Science |
Correccion de genes humanos.
|
|
US12208140B2
(en)
|
2017-04-21 |
2025-01-28 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
US11655275B2
(en)
|
2017-05-03 |
2023-05-23 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
EP4029943A1
(de)
|
2017-05-08 |
2022-07-20 |
Precision Biosciences, Inc. |
Nukleinsäuremoleküle, die einen manipulierten antigenrezeptor und ein hemmendes nukleinsäuremolekül codieren, und verfahren zur verwendung davon
|
|
EP3622092A4
(de)
|
2017-05-11 |
2021-06-23 |
The Broad Institute, Inc. |
Verfahren und zusammensetzungen zur verwendung von cd8+-tumor-infiltrierenden lymphozyten-subtypen und gensignaturen davon
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
US11512287B2
(en)
|
2017-06-16 |
2022-11-29 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell and/or HLA receptors
|
|
KR102761791B1
(ko)
|
2017-06-26 |
2025-02-05 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법
|
|
US10457955B2
(en)
|
2017-06-28 |
2019-10-29 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
EP3645038B1
(de)
|
2017-06-30 |
2026-02-18 |
Precision Biosciences, Inc. |
Genetisch modifizierte t-zellen mit einem modifizierten intron im t-zell-rezeptor-alpha-gen
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
US12105089B2
(en)
|
2017-07-17 |
2024-10-01 |
The Broad Institute, Inc. |
Cell atlas of the healthy and ulcerative colitis human colon
|
|
AU2018313167A1
(en)
|
2017-08-08 |
2020-02-27 |
Sangamo Therapeutics, Inc. |
Chimeric antigen receptor mediated cell targeting
|
|
EP4269560A3
(de)
|
2017-10-03 |
2024-01-17 |
Precision Biosciences, Inc. |
Modifizierte epidermale wachstumsfaktorrezeptorpeptide zur verwendung in genetisch modifizierten zellen
|
|
JP2020537515A
(ja)
|
2017-10-03 |
2020-12-24 |
ジュノー セラピューティクス インコーポレイテッド |
Hpv特異的結合分子
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
CN111295093B
(zh)
|
2017-10-30 |
2024-06-11 |
美国陶氏益农公司 |
用于转基因表达的植物启动子
|
|
WO2019089913A1
(en)
|
2017-11-01 |
2019-05-09 |
Precision Biosciences, Inc. |
Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
|
|
US11851679B2
(en)
|
2017-11-01 |
2023-12-26 |
Juno Therapeutics, Inc. |
Method of assessing activity of recombinant antigen receptors
|
|
BR112020008568A2
(pt)
|
2017-11-09 |
2020-10-06 |
Sangamo Therapeutics, Inc. |
modificação genética de gene de proteína contendo sh2 indutível por citoquina (cish)
|
|
US10940171B2
(en)
|
2017-11-10 |
2021-03-09 |
Massachusetts Institute Of Technology |
Microbial production of pure single stranded nucleic acids
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
EP3710039A4
(de)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
Verfahren und zusammensetzungen zur behandlung von krebs durch targeting des clec2d-klrb1-wegs
|
|
US12221720B2
(en)
|
2017-11-13 |
2025-02-11 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
CR20200251A
(es)
|
2017-11-17 |
2020-07-17 |
Iovance Biotherapeutics Inc |
Expansión de til de aspirados con aguja fina y biopsias por punción
|
|
EP3713644B1
(de)
|
2017-11-20 |
2024-08-07 |
University of Georgia Research Foundation, Inc. |
Zusammensetzungen und verfahren zur modulation von hif-2a zur verbesserung der muskelbildung und -reparatur
|
|
EP3714041A1
(de)
|
2017-11-22 |
2020-09-30 |
Iovance Biotherapeutics, Inc. |
Expansion von peripheren blutlymphozyten (pbls) aus peripherem blut
|
|
EP3717505A4
(de)
|
2017-12-01 |
2021-12-01 |
Encoded Therapeutics, Inc. |
Gentechnisch veränderte dna-bindende proteine
|
|
US11459577B2
(en)
|
2017-12-18 |
2022-10-04 |
Syngenta Participations Ag |
Targeted insertion sites in the maize genome
|
|
IL316257A
(en)
|
2017-12-22 |
2024-12-01 |
Fate Therapeutics Inc |
Enhanced immune effector cells and use thereof
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
JP7466448B2
(ja)
|
2018-01-17 |
2024-04-12 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Dna-pk阻害剤
|
|
BR112020013626A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
compostos de quinoxalinona, composições, métodos e kits para aumentar a eficiência de edição de genoma
|
|
MA51619A
(fr)
|
2018-01-17 |
2021-04-14 |
Vertex Pharma |
Inhibiteurs de la protéine kinase dépendante de l'adn
|
|
EP3740580A4
(de)
|
2018-01-19 |
2021-10-20 |
Duke University |
Genom-engineering mit crispr-cas-systemen bei eukaryonten
|
|
CA3089587A1
(en)
|
2018-02-08 |
2019-08-15 |
Sangamo Therapeutics, Inc. |
Engineered target specific nucleases
|
|
KR102817092B1
(ko)
|
2018-03-29 |
2025-06-09 |
페이트 세러퓨틱스, 인코포레이티드 |
조작된 면역 효과기 세포 및 이의 용도
|
|
MA52207A
(fr)
|
2018-04-05 |
2021-02-17 |
Editas Medicine Inc |
Lymphocytes t exprimant un récepteur recombinant, polynucléotides et procédés associés
|
|
EP3773908A1
(de)
|
2018-04-05 |
2021-02-17 |
Juno Therapeutics, Inc. |
T-zell-rezeptoren und gentechnisch veränderte zellen zur expression davon
|
|
CA3094468A1
(en)
|
2018-04-05 |
2019-10-10 |
Juno Therapeutics, Inc. |
Methods of producing cells expressing a recombinant receptor and related compositions
|
|
JP7522038B2
(ja)
|
2018-04-06 |
2024-07-24 |
ザ チルドレンズ メディカル センター コーポレーション |
体細胞リプログラミングおよびインプリンティングのモジュレートのための組成物および方法
|
|
US11421007B2
(en)
|
2018-04-18 |
2022-08-23 |
Sangamo Therapeutics, Inc. |
Zinc finger protein compositions for modulation of huntingtin (Htt)
|
|
HUE059223T2
(hu)
|
2018-04-24 |
2022-10-28 |
Kws Saat Se & Co Kgaa |
Jobb emészthetõségû növények és marker haplotípusok
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
WO2019210131A1
(en)
|
2018-04-27 |
2019-10-31 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
WO2019213660A2
(en)
|
2018-05-04 |
2019-11-07 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
MX2020012028A
(es)
|
2018-05-11 |
2021-03-29 |
Crispr Therapeutics Ag |
Metodos y composiciones para tratar el cancer.
|
|
US11690921B2
(en)
|
2018-05-18 |
2023-07-04 |
Sangamo Therapeutics, Inc. |
Delivery of target specific nucleases
|
|
EP3784776A4
(de)
|
2018-05-23 |
2022-01-26 |
National University of Singapore |
Blockade der cd2-oebrflächenexpression und expression chimärer antigenrezeptoren für die immuntherapie von t-zell-malignomen
|
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
GB201809273D0
(en)
|
2018-06-06 |
2018-07-25 |
Vib Vzw |
Novel mutant plant cinnamoyl-coa reductase proteins
|
|
EP3800998A1
(de)
|
2018-06-07 |
2021-04-14 |
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) |
Verfahren zur regenerierung und transformation von cannabis
|
|
EP3802839A1
(de)
|
2018-06-07 |
2021-04-14 |
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) |
Nukleinsäurekonstrukte und verfahren zu deren verwendung
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
US11939593B2
(en)
|
2018-08-01 |
2024-03-26 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for improving embryo development
|
|
US12421507B2
(en)
|
2018-08-20 |
2025-09-23 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of CRISPR-CAS9
|
|
AU2019326408A1
(en)
|
2018-08-23 |
2021-03-11 |
Sangamo Therapeutics, Inc. |
Engineered target specific base editors
|
|
CA3111186A1
(en)
|
2018-08-31 |
2020-03-05 |
Yale University |
Compositions and methods for enhancing triplex and nuclease-based gene editing
|
|
EP3844287B1
(de)
|
2018-08-31 |
2024-05-22 |
Yale University |
Zusammensetzungen und verfahren zur verbesserung der oligonukleotidbasierten geneditierung
|
|
WO2020056170A1
(en)
|
2018-09-12 |
2020-03-19 |
Fred Hutchinson Cancer Research Center |
Reducing cd33 expression to selectively protect therapeutic cells
|
|
KR20210060533A
(ko)
|
2018-09-18 |
2021-05-26 |
상가모 테라퓨틱스, 인코포레이티드 |
프로그램화된 세포 사멸 1 (pd1) 특이적 뉴클레아제
|
|
AU2019343045A1
(en)
|
2018-09-18 |
2021-05-13 |
Vnv Newco Inc. |
ARC-based capsids and uses thereof
|
|
IL281615B2
(en)
|
2018-09-21 |
2026-01-01 |
Acuitas Therapeutics Inc |
Systems and methods for producing lipid nanoparticles and liposomes
|
|
WO2020072677A1
(en)
|
2018-10-02 |
2020-04-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulation of tau proteins
|
|
US20220411783A1
(en)
|
2018-10-12 |
2022-12-29 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
JP2022505139A
(ja)
|
2018-10-15 |
2022-01-14 |
フォンダッツィオーネ・テレソン |
ゲノム編集の方法及び構築物
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
CA3116576A1
(en)
|
2018-10-18 |
2020-04-23 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
|
MY210603A
(en)
|
2018-11-05 |
2025-10-01 |
Iovance Biotherapeutics Inc |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
JP7854297B2
(ja)
|
2018-11-05 |
2026-05-01 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
改良された腫瘍反応性t細胞の選択
|
|
WO2020096927A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathway inhibitors
|
|
US12611427B2
(en)
|
2018-11-05 |
2026-04-28 |
Iovance Biotherapeutics, Inc. |
Treatment of NSCLC patients refractory for anti-PD-1 antibody
|
|
WO2020095249A1
(en)
|
2018-11-07 |
2020-05-14 |
Crispr Therapeutics Ag |
Anti-liv1 immune cell cancer therapy
|
|
CA3118830A1
(en)
|
2018-11-07 |
2020-05-14 |
Crispr Therapeutics Ag |
Anti-ptk7 immune cell cancer therapy
|
|
BR112021008041A2
(pt)
|
2018-11-07 |
2021-08-10 |
Crispr Therapeutics Ag |
terapia contra o câncer com células imunitárias anti-cd33
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
WO2020112195A1
(en)
|
2018-11-30 |
2020-06-04 |
Yale University |
Compositions, technologies and methods of using plerixafor to enhance gene editing
|
|
MX2021006194A
(es)
|
2018-12-02 |
2021-06-30 |
Fate Therapeutics Inc |
Inmunoterapias mediante el uso de celulas efectoras potenciadas derivadas de ipsc.
|
|
WO2020118073A1
(en)
|
2018-12-05 |
2020-06-11 |
Vertex Pharmaceuticals Incorporated |
Gene-editing systems for editing a cystic fibrosis transmembrane regulator (cftr) gene
|
|
GB201820109D0
(en)
|
2018-12-11 |
2019-01-23 |
Vib Vzw |
Plants with a lignin trait and udp-glycosyltransferase mutation
|
|
CN109627290B
(zh)
*
|
2018-12-12 |
2022-03-29 |
华南理工大学 |
α螺旋自组装短肽及其在蛋白质纯化中的应用
|
|
CN113544266A
(zh)
|
2018-12-17 |
2021-10-22 |
博德研究所 |
Crispr相关转座酶系统和其使用方法
|
|
CA3123392A1
(en)
|
2018-12-19 |
2020-06-25 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
|
WO2020132659A1
(en)
|
2018-12-21 |
2020-06-25 |
Precision Biosciences, Inc. |
Genetic modification of the hydroxyacid oxidase 1 gene for treatment of primary hyperoxaluria
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
PT3908568T
(pt)
|
2019-01-11 |
2024-09-30 |
Acuitas Therapeutics Inc |
Lípidos para a administração de agentes ativos por nanopartículas lipídicas
|
|
US12156877B1
(en)
|
2019-01-15 |
2024-12-03 |
The Regents Of The University Of California |
Methods of treating conditions related to a thiamine deficiency, a thiamine-dependent enzyme, or an associated cofactor
|
|
WO2020154595A1
(en)
|
2019-01-24 |
2020-07-30 |
Massachusetts Institute Of Technology |
Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom
|
|
SG11202107720UA
(en)
|
2019-01-31 |
2021-08-30 |
Agency Science Tech & Res |
Cnx/erp57 inhibitor for use in the treatment or prevention of cancer
|
|
AU2019428629A1
(en)
|
2019-02-06 |
2021-01-28 |
Sangamo Therapeutics, Inc. |
Method for the treatment of mucopolysaccharidosis type I
|
|
US20230053540A1
(en)
|
2019-02-19 |
2023-02-23 |
Massachusetts Institute Of Technology |
Treatment of liver injury
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
WO2020180733A1
(en)
|
2019-03-01 |
2020-09-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
US20220175781A1
(en)
|
2019-03-08 |
2022-06-09 |
Obsidian Therapeutics, Inc. |
Cd40l compositions and methods for tunable regulation
|
|
US20220154282A1
(en)
|
2019-03-12 |
2022-05-19 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
US12419915B2
(en)
|
2019-03-13 |
2025-09-23 |
The Broad Institute, Inc. |
Microglial progenitors for regeneration of functional microglia in the central nervous system and therapeutics uses thereof
|
|
EP3937969A1
(de)
|
2019-03-14 |
2022-01-19 |
The Broad Institute, Inc. |
Zusammensetzungen und verfahren zur modulation der cgrp-signalisierung zur regulierung der angeborenen lymphoiden darmzellen
|
|
EP3942023A1
(de)
|
2019-03-18 |
2022-01-26 |
The Broad Institute, Inc. |
Zusammensetzungen und verfahren zur modulation metabolischer regulatoren der t-zell-pathogenität
|
|
US20220152148A1
(en)
|
2019-03-18 |
2022-05-19 |
The Broad Institute, Inc. |
Modulation of type 2 immunity by targeting clec-2 signaling
|
|
CA3132167A1
(en)
|
2019-04-02 |
2020-10-08 |
Weston P. MILLER IV |
Methods for the treatment of beta-thalassemia
|
|
KR102691932B1
(ko)
|
2019-04-03 |
2024-08-06 |
프리시젼 바이오사이언시스 인코포레이티드 |
마이크로RNA-적응 shRNA(shRNAmiR)를 포함하는 유전자-변형 면역 세포
|
|
EP3947646A1
(de)
|
2019-04-05 |
2022-02-09 |
Precision BioSciences, Inc. |
Verfahren zur herstellung von populationen genetisch modifizierter immunzellen
|
|
TW202521561A
(zh)
|
2019-04-23 |
2025-06-01 |
美商聖加莫治療股份有限公司 |
染色體9開放讀框72基因表現之調節子及其用途
|
|
WO2020223535A1
(en)
|
2019-05-01 |
2020-11-05 |
Juno Therapeutics, Inc. |
Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
|
|
CA3136742A1
(en)
|
2019-05-01 |
2020-11-05 |
Juno Therapeutics, Inc. |
Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods
|
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
WO2020229533A1
(en)
|
2019-05-13 |
2020-11-19 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
|
WO2020232271A1
(en)
|
2019-05-14 |
2020-11-19 |
The Broad Institute, Inc. |
Compositions and methods for targeting multinucleated cells
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
US20220226464A1
(en)
|
2019-05-28 |
2022-07-21 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
PL3976798T3
(pl)
|
2019-05-29 |
2026-04-07 |
Encoded Therapeutics, Inc. |
Kompozycje i sposoby selektywnej regulacji genów
|
|
WO2020243661A1
(en)
|
2019-05-31 |
2020-12-03 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
AU2020291939A1
(en)
|
2019-06-13 |
2021-12-02 |
Allogene Therapeutics, Inc. |
Anti-TALEN antibodies and uses thereof
|
|
WO2020252455A1
(en)
|
2019-06-13 |
2020-12-17 |
The General Hospital Corporation |
Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
|
|
US11905532B2
(en)
|
2019-06-25 |
2024-02-20 |
Massachusetts Institute Of Technology |
Compositions and methods for molecular memory storage and retrieval
|
|
WO2020261219A1
(en)
|
2019-06-27 |
2020-12-30 |
Crispr Therapeutics Ag |
Use of chimeric antigen receptor t cells and nk cell inhibitors for treating cancer
|
|
CN114258429A
(zh)
|
2019-07-17 |
2022-03-29 |
菲特治疗公司 |
免疫效应细胞工程化和其用途
|
|
US20220273715A1
(en)
|
2019-07-25 |
2022-09-01 |
Precision Biosciences, Inc. |
Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
|
|
US20220267732A1
(en)
|
2019-08-01 |
2022-08-25 |
Sana Biotechnology, Inc. |
Dux4 expressing cells and uses thereof
|
|
EP3772542A1
(de)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifzierung der genetischen variation bei nutzpflanzen durch modulation des pachytän-checkpointproteins 2
|
|
WO2021030627A1
(en)
|
2019-08-13 |
2021-02-18 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
CA3148179A1
(en)
|
2019-08-20 |
2021-02-25 |
Bruce J. Mccreedy Jr. |
Lymphodepletion dosing regimens for cellular immunotherapies
|
|
WO2021035170A1
(en)
|
2019-08-21 |
2021-02-25 |
Precision Biosciences, Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
JP7728747B2
(ja)
|
2019-08-23 |
2025-08-25 |
サナ バイオテクノロジー,インコーポレイテッド |
Cd24発現細胞およびそれらの用途
|
|
WO2021042060A1
(en)
|
2019-08-30 |
2021-03-04 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
KR20220051401A
(ko)
|
2019-09-06 |
2022-04-26 |
크리스퍼 테라퓨틱스 아게 |
배양 중 개선된 지속성을 갖는 유전적으로 조작된 t 세포
|
|
AU2020356962A1
(en)
|
2019-10-02 |
2022-04-14 |
Sangamo Therapeutics, Inc. |
Zinc finger protein transcription factors for repressing alpha-synuclein expression
|
|
JP7824873B2
(ja)
|
2019-10-02 |
2026-03-05 |
サンガモ セラピューティクス, インコーポレイテッド |
プリオン病の治療のためのジンクフィンガータンパク質転写因子
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
EP4045522A1
(de)
|
2019-10-17 |
2022-08-24 |
KWS SAAT SE & Co. KGaA |
Verbesserte krankheitsresistenz von nutzpflanzen durch herunterregulieren von repressor-genen
|
|
EP4048295A1
(de)
|
2019-10-25 |
2022-08-31 |
Iovance Biotherapeutics, Inc. |
Genbearbeitung von tumorinfiltrierenden lymphozyten und deren verwendungen in der immuntherapie
|
|
US20220411479A1
(en)
|
2019-10-30 |
2022-12-29 |
Precision Biosciences, Inc. |
Cd20 chimeric antigen receptors and methods of use for immunotherapy
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
WO2021087361A1
(en)
|
2019-11-01 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Zinc finger nuclease variants for treating or preventing lysosomal storage diseases
|
|
US20210130828A1
(en)
|
2019-11-01 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Gin recombinase variants
|
|
US12241830B2
(en)
|
2019-12-06 |
2025-03-04 |
Broad Institute, Inc. |
Living biosensors
|
|
WO2021113543A1
(en)
|
2019-12-06 |
2021-06-10 |
Precision Biosciences, Inc. |
Methods for cancer immunotherapy, using lymphodepletion regimens and cd19, cd20 or bcma allogeneic car t cells
|
|
US12516291B2
(en)
|
2019-12-11 |
2026-01-06 |
Iovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (TILs) and methods of using the same
|
|
CN120683228A
(zh)
|
2019-12-13 |
2025-09-23 |
中外制药株式会社 |
检测细胞外嘌呤受体配体的系统和导入该系统的非人动物
|
|
WO2021142376A1
(en)
|
2020-01-08 |
2021-07-15 |
Obsidian Therapeutics, Inc. |
Compositions and methods for tunable regulation of transcription
|
|
TW202134288A
(zh)
|
2020-01-22 |
2021-09-16 |
美商聖加莫治療股份有限公司 |
用於抑制tau蛋白表現之鋅指蛋白轉錄因子
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
US20250011748A1
(en)
|
2020-01-28 |
2025-01-09 |
The Broad Institute, Inc. |
Base editors, compositions, and methods for modifying the mitochondrial genome
|
|
WO2021158915A1
(en)
|
2020-02-06 |
2021-08-12 |
Precision Biosciences, Inc. |
Recombinant adeno-associated virus compositions and methods for producing and using the same
|
|
CN116209756A
(zh)
|
2020-03-04 |
2023-06-02 |
旗舰先锋创新Vi有限责任公司 |
调控基因组的方法和组合物
|
|
KR20220158046A
(ko)
|
2020-03-25 |
2022-11-29 |
사나 바이오테크놀로지, 인크. |
신경계 장애 및 병태의 치료를 위한 면역저하성 신경 세포
|
|
US20230263121A1
(en)
|
2020-03-31 |
2023-08-24 |
Elo Life Systems |
Modulation of endogenous mogroside pathway genes in watermelon and other cucurbits
|
|
US20230203469A1
(en)
|
2020-04-02 |
2023-06-29 |
Takeda Pharmaceutical Company Limited |
Adamts13 variant, compositions, and uses thereof
|
|
US20230167436A1
(en)
*
|
2020-04-30 |
2023-06-01 |
New York University |
Compositions and methods for identification of zinc fingers
|
|
CA3176826A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
EP4146797A1
(de)
|
2020-05-06 |
2023-03-15 |
Orchard Therapeutics (Europe) Limited |
Behandlung von neurodegenerativen erkrankungen
|
|
EP4146284A1
(de)
|
2020-05-06 |
2023-03-15 |
Cellectis S.A. |
Verfahren zur genetischen modifizierung von zellen zur freisetzung therapeutischer proteine
|
|
CN115803435A
(zh)
|
2020-05-06 |
2023-03-14 |
塞勒克提斯公司 |
用于在细胞基因组中靶向插入外源序列的方法
|
|
US20230183664A1
(en)
|
2020-05-11 |
2023-06-15 |
Precision Biosciences, Inc. |
Self-limiting viral vectors encoding nucleases
|
|
CN115835873A
(zh)
|
2020-05-13 |
2023-03-21 |
朱诺治疗学股份有限公司 |
用于产生表达重组受体的供体分批细胞的方法
|
|
US20230190871A1
(en)
|
2020-05-20 |
2023-06-22 |
Sana Biotechnology, Inc. |
Methods and compositions for treatment of viral infections
|
|
AR122206A1
(es)
|
2020-05-29 |
2022-08-24 |
Kws Saat Se & Co Kgaa |
Inducción de haploides en plantas
|
|
WO2021247836A1
(en)
|
2020-06-03 |
2021-12-09 |
Board Of Regents, The University Of Texas System |
Methods for targeting shp-2 to overcome resistance
|
|
JP2023530234A
(ja)
|
2020-06-05 |
2023-07-14 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新生物を治療するための組成物および方法
|
|
BR112022025806A2
(pt)
|
2020-06-19 |
2023-03-07 |
Fate Therapeutics Inc |
Combinação de tipos de células efetoras derivadas de ipsc para uso em imunoterapia
|
|
JP2023531531A
(ja)
|
2020-06-26 |
2023-07-24 |
ジュノ セラピューティクス ゲーエムベーハー |
組換え受容体を条件付きで発現する操作されたt細胞、関連ポリヌクレオチド、および方法
|
|
ES3054438T3
(en)
|
2020-07-16 |
2026-02-03 |
Acuitas Therapeutics Inc |
Cationic lipids for use in lipid nanoparticles
|
|
CA3189601A1
(en)
|
2020-07-24 |
2022-01-27 |
The General Hospital Corporation |
Enhanced virus-like particles and methods of use thereof for delivery to cells
|
|
EP4192486A4
(de)
|
2020-08-07 |
2024-05-01 |
The Broad Institute, Inc. |
Therapeutisches targeting der phosphatdysregulation bei krebs über den xpr1:kids220-proteinkomplex
|
|
EP4192875A1
(de)
|
2020-08-10 |
2023-06-14 |
Precision BioSciences, Inc. |
Antikörper und fragmente spezifisch für b-zellreifungsantigen und verwendungen davon
|
|
WO2022036150A1
(en)
|
2020-08-13 |
2022-02-17 |
Sana Biotechnology, Inc. |
Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
|
|
US12152251B2
(en)
|
2020-08-25 |
2024-11-26 |
Kite Pharma, Inc. |
T cells with improved functionality
|
|
CN116529266A
(zh)
|
2020-08-31 |
2023-08-01 |
耶鲁大学 |
用于将核酸递送到细胞的组合物和方法
|
|
CN116322716A
(zh)
|
2020-09-23 |
2023-06-23 |
克里斯珀医疗股份公司 |
Regnase-1和/或TGFBRII被破坏的基因工程化T细胞具有改善的功能性和持久性
|
|
CN116261594A
(zh)
|
2020-09-25 |
2023-06-13 |
桑格摩生物治疗股份有限公司 |
用于核碱基编辑的锌指融合蛋白
|
|
CN116917335A
(zh)
|
2020-10-02 |
2023-10-20 |
桑格摩生物治疗股份有限公司 |
用于阻遏α-突触核蛋白(SYNUCLEIN)表达的新颖锌指蛋白转录因子
|
|
JP2023546359A
(ja)
|
2020-10-06 |
2023-11-02 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球療法によるnsclc患者の治療
|
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
WO2022076547A1
(en)
|
2020-10-07 |
2022-04-14 |
Precision Biosciences, Inc. |
Lipid nanoparticle compositions
|
|
US20240060079A1
(en)
|
2020-10-23 |
2024-02-22 |
Elo Life Systems |
Methods for producing vanilla plants with improved flavor and agronomic production
|
|
EP4240756A1
(de)
|
2020-11-04 |
2023-09-13 |
Juno Therapeutics, Inc. |
Zellen zur expression eines chimären rezeptors aus einem modifizierten invarianten kettenlocus der cd3-immunglobulin-superfamilie und zugehörige polynukleotide und verfahren
|
|
US20240000051A1
(en)
|
2020-11-16 |
2024-01-04 |
Pig Improvement Company Uk Limited |
Influenza a-resistant animals having edited anp32 genes
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
KR20230118887A
(ko)
|
2020-12-03 |
2023-08-14 |
센츄리 쎄라퓨틱스 인코포레이티드 |
유전자 조작 세포 및 이의 용도
|
|
AU2021401302A1
(en)
|
2020-12-17 |
2023-07-06 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
|
EP4262827A1
(de)
|
2020-12-17 |
2023-10-25 |
Iovance Biotherapeutics, Inc. |
Behandlung von krebs mit tumorinfiltrierenden lymphozyten
|
|
WO2022137181A1
(en)
|
2020-12-23 |
2022-06-30 |
Crispr Therapeutics Ag |
Co-use of lenalidomide with car-t cells
|
|
JP2024501971A
(ja)
|
2020-12-31 |
2024-01-17 |
サナ バイオテクノロジー,インコーポレイテッド |
Car-t活性を調節するための方法及び組成物
|
|
JP2024502630A
(ja)
|
2021-01-12 |
2024-01-22 |
マーチ セラピューティクス, インコーポレイテッド |
コンテキスト依存性二本鎖dna特異的デアミナーゼ及びその使用
|
|
US20250127811A1
(en)
|
2021-01-28 |
2025-04-24 |
Precision Biosciences, Inc. |
Modulation of tgf beta signaling in genetically-modified eukaryotic cells
|
|
WO2022165260A1
(en)
|
2021-01-29 |
2022-08-04 |
Iovance Biotherapeutics, Inc. |
Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
|
|
EP4305153A1
(de)
|
2021-03-09 |
2024-01-17 |
CRISPR Therapeutics AG |
Genetisch veränderte t-zellen mit ptpn2-knockout mit verbesserter funktionalität und antitumoraktivität
|
|
US20240191191A1
(en)
|
2021-03-19 |
2024-06-13 |
Iovance Biotherapeutics, Inc. |
Methods for infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
|
CN117321200A
(zh)
|
2021-03-22 |
2023-12-29 |
朱诺治疗学股份有限公司 |
评估病毒载体颗粒效力的方法
|
|
JP2024512029A
(ja)
|
2021-03-25 |
2024-03-18 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
T細胞共培養効力アッセイのための方法及び組成物、ならびに細胞療法製品との使用
|
|
BR112023018844A2
(pt)
|
2021-04-07 |
2023-10-10 |
Century Therapeutics Inc |
Composições e métodos para geração de células t gama-delta de células-tronco pluripotentes induzidas
|
|
WO2022216624A1
(en)
|
2021-04-07 |
2022-10-13 |
Century Therapeutics, Inc. |
Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells
|
|
CN117479952A
(zh)
|
2021-04-07 |
2024-01-30 |
世纪治疗股份有限公司 |
用于嵌合抗原受体细胞的组合的人工细胞死亡/报告系统多肽及其用途
|
|
CA3215830A1
(en)
|
2021-04-19 |
2022-10-27 |
Rafael CUBAS |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
|
US20240141311A1
(en)
|
2021-04-22 |
2024-05-02 |
North Carolina State University |
Compositions and methods for generating male sterile plants
|
|
US20240191186A1
(en)
|
2021-05-05 |
2024-06-13 |
FUJIFILM Cellular Dynamics, Inc. |
Methods and compositions for ipsc-derived microglia
|
|
JP2024519029A
(ja)
|
2021-05-17 |
2024-05-08 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Pd-1遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用
|
|
KR20240011831A
(ko)
|
2021-05-26 |
2024-01-26 |
후지필름 셀룰러 다이내믹스, 인코포레이티드 |
만능 줄기 세포에서 유전자의 신속한 사일런싱을 방지하기 위한 방법
|
|
US20240226164A1
(en)
|
2021-05-27 |
2024-07-11 |
Sana Biotechnology, Inc. |
Hypoimmunogenic cells comprising engineered hla-e or hla-g
|
|
KR20240046319A
(ko)
|
2021-07-14 |
2024-04-08 |
사나 바이오테크놀로지, 인크. |
저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현
|
|
JP2024527961A
(ja)
|
2021-07-28 |
2024-07-26 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Kras阻害剤と併用した腫瘍浸潤リンパ球療法によるがん患者の治療
|
|
CA3227103A1
(en)
|
2021-07-30 |
2023-02-02 |
Matthew P. GEMBERLING |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
US20240252684A1
(en)
|
2021-07-30 |
2024-08-01 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
WO2023006933A1
(en)
|
2021-07-30 |
2023-02-02 |
KWS SAAT SE & Co. KGaA |
Plants with improved digestibility and marker haplotypes
|
|
AU2022325232A1
(en)
|
2021-08-11 |
2024-02-08 |
Sana Biotechnology, Inc. |
Genetically modified primary cells for allogeneic cell therapy
|
|
EP4384598A1
(de)
|
2021-08-11 |
2024-06-19 |
Sana Biotechnology, Inc. |
Genetisch modifizierte zellen für allogene zelltherapie zur reduzierung komplementvermittelter entzündungsreaktionen
|
|
US20240358761A1
(en)
|
2021-08-11 |
2024-10-31 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy
|
|
JP2024535677A
(ja)
|
2021-08-11 |
2024-10-02 |
サナ バイオテクノロジー,インコーポレイテッド |
即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞
|
|
AU2022327174A1
(en)
|
2021-08-11 |
2024-02-15 |
Sana Biotechnology, Inc. |
Inducible systems for altering gene expression in hypoimmunogenic cells
|
|
AU2022343268A1
(en)
|
2021-09-08 |
2024-03-28 |
Flagship Pioneering Innovations Vi, Llc |
Methods and compositions for modulating a genome
|
|
US20230183644A1
(en)
|
2021-09-10 |
2023-06-15 |
FUJIFILM Cellular Dynamics, Inc. |
Compositions of induced pluripotent stem cell-derived cells and methods of use thereof
|
|
US20230128917A1
(en)
|
2021-09-14 |
2023-04-27 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having a disrupted cd83 gene
|
|
WO2023064872A1
(en)
|
2021-10-14 |
2023-04-20 |
Precision Biosciences, Inc. |
Combinations of anti-bcma car t cells and gamma secretase inhibitors
|
|
IL312244A
(en)
|
2021-10-19 |
2024-06-01 |
Prec Biosciences Inc |
Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency
|
|
WO2023070043A1
(en)
|
2021-10-20 |
2023-04-27 |
Yale University |
Compositions and methods for targeted editing and evolution of repetitive genetic elements
|
|
CA3234404A1
(en)
|
2021-10-20 |
2023-04-27 |
Steven A. Goldman |
Treatment with genetically modified cells, and genetically modified cells per se, with increased competitive advantage and/or decreased competitive disadvantage
|
|
WO2023069478A1
(en)
|
2021-10-20 |
2023-04-27 |
University Of Rochester |
Methods and compositions for rejuvenating cns glial populations by suppression of transcription factors
|
|
JP2024540987A
(ja)
|
2021-10-21 |
2024-11-06 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
低免疫細胞
|
|
US20250313861A1
(en)
|
2021-10-22 |
2025-10-09 |
Sana Biotechnology, Inc. |
Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
|
|
WO2023076880A1
(en)
|
2021-10-25 |
2023-05-04 |
Board Of Regents, The University Of Texas System |
Foxo1-targeted therapy for the treatment of cancer
|
|
WO2023077015A2
(en)
|
2021-10-27 |
2023-05-04 |
Iovance Biotherapeutics, Inc. |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
|
CA3235390A1
(en)
|
2021-10-29 |
2023-05-04 |
Deepika Rajesh |
Dopaminergic neurons comprising mutations and methods of use thereof
|
|
WO2023081900A1
(en)
|
2021-11-08 |
2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
|
AU2022386314A1
(en)
|
2021-11-09 |
2024-06-06 |
Amgen Inc. |
Method for producing an antibody peptide conjugate
|
|
EP4430206A1
(de)
|
2021-11-10 |
2024-09-18 |
Encodia, Inc. |
Verfahren zur barcodierung von makromolekülen in einzelnen zellen
|
|
WO2023091910A1
(en)
|
2021-11-16 |
2023-05-25 |
Precision Biosciences, Inc. |
Methods for cancer immunotherapy
|
|
WO2023093862A1
(en)
|
2021-11-26 |
2023-06-01 |
Epigenic Therapeutics Inc. |
Method of modulating pcsk9 and uses thereof
|
|
EP4441074A2
(de)
|
2021-12-03 |
2024-10-09 |
The Broad Institute, Inc. |
Zusammensetzungen und verfahren zur effizienten in-vivo-abgabe
|
|
US20250064032A1
(en)
|
2021-12-10 |
2025-02-27 |
Pig Improvement Company Uk Limited |
Editing tmprss2/4 for disease resistance in livestock
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
WO2023111913A1
(en)
|
2021-12-15 |
2023-06-22 |
Crispr Therapeutics Ag |
Engineered anti-liv1 cell with regnase-1 and/or tgfbrii disruption
|
|
CA3242402A1
(en)
|
2021-12-16 |
2023-06-22 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
|
JP2025504606A
(ja)
|
2021-12-22 |
2025-02-13 |
サンガモ セラピューティクス, インコーポレイテッド |
核酸塩基編集のための新規ジンクフィンガー融合タンパク質
|
|
US20230346836A1
(en)
|
2021-12-22 |
2023-11-02 |
Crispr Therapeutics Ag |
Genetically engineered t cells with disrupted casitas b-lineage lymphoma proto-oncogene-b (cblb) and uses thereof
|
|
CN119072319A
(zh)
|
2021-12-23 |
2024-12-03 |
萨那生物技术股份有限公司 |
用于治疗自身免疫性疾病的嵌合抗原受体(car)t细胞及相关方法
|
|
AU2022423987A1
(en)
|
2021-12-29 |
2024-07-11 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof
|
|
EP4460571A1
(de)
|
2022-01-05 |
2024-11-13 |
Vib Vzw |
Mittel und verfahren zur erhöhung der abiotischen stresstoleranz bei pflanzen
|
|
WO2023131637A1
(en)
|
2022-01-06 |
2023-07-13 |
Vib Vzw |
Improved silage grasses
|
|
US20250154503A1
(en)
|
2022-01-14 |
2025-05-15 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
|
|
US20250134999A1
(en)
|
2022-01-14 |
2025-05-01 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
WO2023144199A1
(en)
|
2022-01-26 |
2023-08-03 |
Vib Vzw |
Plants having reduced levels of bitter taste metabolites
|
|
WO2023150557A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Methods of generating a population of neurons from human glial progenitor cells and genetic constructs for carrying out such methods
|
|
US20250302953A1
(en)
|
2022-02-14 |
2025-10-02 |
Sana Biotechnology, Inc. |
Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
|
|
EP4479416A1
(de)
|
2022-02-17 |
2024-12-25 |
Sana Biotechnology, Inc. |
Manipulierte cd47-proteine und verwendungen davon
|
|
TW202340457A
(zh)
|
2022-02-28 |
2023-10-16 |
美商凱特製藥公司 |
同種異體治療細胞
|
|
WO2023166425A1
(en)
|
2022-03-01 |
2023-09-07 |
Crispr Therapeutics Ag |
Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
|
|
CA3244807A1
(en)
|
2022-03-04 |
2023-09-07 |
Sigma-Aldrich Co. Llc |
METABOLIC SELECTION VIA THE ASPARAGIN BIOSYNTHESIS PATHWAY
|
|
WO2023173123A1
(en)
|
2022-03-11 |
2023-09-14 |
Sana Biotechnology, Inc. |
Genetically modified cells and compositions and uses thereof
|
|
US20230293646A1
(en)
|
2022-03-21 |
2023-09-21 |
Crispr Therapeutics Ag |
Methods and compositions for treating lipoprotein-related diseases
|
|
US20230303713A1
(en)
|
2022-03-23 |
2023-09-28 |
Crispr Therapeutics Ag |
Anti-cd19 car-t cells with multiple gene edits and therapeutic uses thereof
|
|
US20230331841A1
(en)
|
2022-03-23 |
2023-10-19 |
Crispr Therapeutics Ag |
Anti-cd83 car-t cells with regnase-1 and/or tgfbrii disruption
|
|
US20230302423A1
(en)
|
2022-03-28 |
2023-09-28 |
Massachusetts Institute Of Technology |
Rna scaffolded wireframe origami and methods thereof
|
|
IL316038A
(en)
|
2022-04-04 |
2024-11-01 |
Univ California |
Preparations and methods for genetic complementation
|
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
US20250228943A1
(en)
|
2022-04-08 |
2025-07-17 |
Fate Therapeutics, Inc. |
Cells having solid tumor targeting backbone and use thereof
|
|
US20250222029A1
(en)
|
2022-04-08 |
2025-07-10 |
Fate Therapeutics, Inc. |
Chimeric antigen receptor for tumor targeting
|
|
JP2025512401A
(ja)
|
2022-04-15 |
2025-04-17 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
特定のサイトカインの組み合わせ及び/またはAKTi処理を使用したTIL拡張プロセス
|
|
EP4518907A1
(de)
|
2022-05-02 |
2025-03-12 |
Fondazione Telethon ETS |
Homologieunabhängige gezielte integration zur geneditierung
|
|
CA3251533A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
TREATMENT OF CANCER PATIENTS WITH TUMOR-INFILTRATING LYMPHOCYTE THERAPIES IN COMBINATION WITH AN IL-15R AGONIST
|
|
CN120303407A
(zh)
|
2022-05-17 |
2025-07-11 |
恩维洛普治疗有限责任公司 |
用于有效体内递送的组合物和方法
|
|
EP4278891A1
(de)
|
2022-05-20 |
2023-11-22 |
KWS SAAT SE & Co. KGaA |
Kohlhernienresistenz und marker in brassica
|
|
WO2023230613A1
(en)
|
2022-05-27 |
2023-11-30 |
The Broad Institute, Inc. |
Improved mitochondrial base editors and methods for editing mitochondrial dna
|
|
US20250090582A1
(en)
|
2022-06-08 |
2025-03-20 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof
|
|
JP2025522360A
(ja)
|
2022-06-08 |
2025-07-15 |
センチュリー セラピューティクス,インコーポレイテッド |
Cd16変異体およびnkg2dを発現する遺伝子操作した細胞ならびにその使用
|
|
CN119698467A
(zh)
|
2022-06-08 |
2025-03-25 |
世纪治疗股份有限公司 |
衍生自遗传工程化以具有膜结合的il12的诱导多能干细胞的免疫效应细胞及其用途
|
|
JP2025522474A
(ja)
|
2022-06-17 |
2025-07-15 |
クリスパー・セラピューティクス・アクチェンゲゼルシャフト |
脂質ナノ粒子(lnp)ベースの眼内デリバリー
|
|
US20250381304A1
(en)
|
2022-06-21 |
2025-12-18 |
Crispr Therapeutics Ag |
Methods and compositions for in vivo editing of stem cells
|
|
WO2023248145A1
(en)
|
2022-06-21 |
2023-12-28 |
Crispr Therapeutics Ag |
Compositions and methods for treating human immunodeficiency virus
|
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
|
WO2024003786A1
(en)
|
2022-06-29 |
2024-01-04 |
Crispr Therapeutics Ag |
Chimeric antigen receptor targeting gpc-3 and immune cells expressing such for therapeutic uses
|
|
CN119452078A
(zh)
|
2022-06-29 |
2025-02-14 |
富士胶片控股美国公司 |
Ipsc来源的星形胶质细胞及其使用方法
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
CA3261865A1
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
TARGETED TRANSCRIPTIONAL ACTIVATION COMPOSITIONS, SYSTEMS AND METHODS
|
|
WO2024013514A2
(en)
|
2022-07-15 |
2024-01-18 |
Pig Improvement Company Uk Limited |
Gene edited livestock animals having coronavirus resistance
|
|
CA3262625A1
(en)
|
2022-07-22 |
2024-01-25 |
The Johns Hopkins University |
ADMINISTRATION OF TARGETED INTRACELLULAR CRISPR/CAS SYSTEM ACTIVATED BY DENDRIMER AND GENE EDITING
|
|
WO2024023801A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing-1 (tap-1) gene
|
|
WO2024023804A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing binding protein (tapbp) gene
|
|
WO2024023802A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing-2 (tap-2) gene
|
|
KR20250077608A
(ko)
|
2022-08-19 |
2025-05-30 |
튠 쎄라퓨틱스, 인코포레이티드 |
표적 유전자 억제를 통한 b형 간염 바이러스 조절용 조성물, 시스템 및 방법
|
|
CA3265393A1
(en)
|
2022-08-26 |
2024-02-29 |
KWS SAAT SE & Co. KGaA |
USE OF PAIRED GENES FOR HYBRID SELECTION
|
|
WO2024064642A2
(en)
|
2022-09-19 |
2024-03-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for modulating t cell function
|
|
WO2024062388A2
(en)
|
2022-09-20 |
2024-03-28 |
Crispr Therapeutics Ag |
Genetically engineered immune cells expressing chimeric antigen receptor targeting cd20
|
|
CN120283058A
(zh)
|
2022-09-30 |
2025-07-08 |
西格马-奥尔德里奇有限责任公司 |
经由甘氨酸-甲酸盐生物合成途径的代谢选择
|
|
EP4594506A1
(de)
|
2022-09-30 |
2025-08-06 |
Sigma-Aldrich Co., LLC |
Metabolische auswahl über den serinbiosyntheseweg
|
|
WO2024079157A1
(en)
|
2022-10-11 |
2024-04-18 |
KWS SAAT SE & Co. KGaA |
Virus and insect resistance and markers in barley
|
|
EP4602078A2
(de)
|
2022-10-11 |
2025-08-20 |
Yale University |
Zusammensetzungen und verfahren zur verwendung zellpenetrierender antikörper
|
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
EP4612277A1
(de)
|
2022-11-04 |
2025-09-10 |
Iovance Biotherapeutics, Inc. |
Verfahren zur expansion von tumorinfiltrierenden lymphozyten (til) im zusammenhang mit cd39/cd103-auswahl
|
|
WO2024102277A2
(en)
|
2022-11-07 |
2024-05-16 |
Syngenta Crop Protection Ag |
Genes altering soy plant flowering time and/or maturation and uses thereof
|
|
WO2024100604A1
(en)
|
2022-11-09 |
2024-05-16 |
Juno Therapeutics Gmbh |
Methods for manufacturing engineered immune cells
|
|
WO2024102838A1
(en)
|
2022-11-09 |
2024-05-16 |
Century Therapeutics, Inc. |
Engineered interleukin-7 receptors and uses thereof
|
|
AU2023375625A1
(en)
|
2022-11-10 |
2025-05-15 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-nectin4 chimeric antigen receptors, and uses thereof
|
|
JP2025539816A
(ja)
|
2022-11-21 |
2025-12-09 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の増幅のための2次元プロセス及びそれからの治療法
|
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
|
JP2025540052A
(ja)
|
2022-12-01 |
2025-12-11 |
イェール ユニバーシティー |
細胞内ペイロード送達用刺激応答性トレースレス操作プラットフォーム
|
|
WO2024124044A1
(en)
|
2022-12-07 |
2024-06-13 |
The Brigham And Women’S Hospital, Inc. |
Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
|
|
US20240269189A1
(en)
|
2022-12-19 |
2024-08-15 |
FUJIFILM Holdings America Corporation |
Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof
|
|
WO2024131917A1
(zh)
|
2022-12-23 |
2024-06-27 |
益杰立科(上海)生物科技有限公司 |
复合物及其用途
|
|
KR20250128349A
(ko)
|
2022-12-23 |
2025-08-27 |
에피제닉 테라퓨틱스 피티이 리미티드 |
융합체 및 이의 용도
|
|
WO2024151541A1
(en)
|
2023-01-09 |
2024-07-18 |
Sana Biotechnology, Inc. |
Type-1 diabetes autoimmune mouse
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
JP2026504491A
(ja)
|
2023-02-03 |
2026-02-05 |
ツェー3エス2 ゲーエムベーハー |
操作された免疫細胞の非ウイルス的製造のための方法
|
|
KR20250151430A
(ko)
|
2023-02-15 |
2025-10-21 |
아버 바이오테크놀로지스, 인크. |
스타스민 2(stmn2) 전사체에서 비정상적인 스플라이싱을 억제하는 유전자 편집 방법
|
|
WO2024192141A1
(en)
|
2023-03-13 |
2024-09-19 |
Dana-Farber Cancer Institute, Inc. |
Treatment of cancers having a drug-resistant mesenchymal cell state
|
|
WO2024192108A1
(en)
|
2023-03-14 |
2024-09-19 |
Evolveimmune Therapeutics, Inc. |
Genetically modified car t cells and methods of making and using the same
|
|
WO2024216118A1
(en)
|
2023-04-14 |
2024-10-17 |
Precision Biosciences, Inc. |
Muscle-specific expression cassettes
|
|
WO2024216116A1
(en)
|
2023-04-14 |
2024-10-17 |
Precision Biosciences, Inc. |
Muscle-specific expression cassettes
|
|
KR20260005273A
(ko)
|
2023-04-21 |
2026-01-09 |
카이트 파마 인코포레이티드 |
면역 거부반응의 위험을 감소시키는 동종이계 치료용 세포
|
|
IT202300007968A1
(it)
|
2023-04-21 |
2024-10-21 |
Fond Telethon Ets |
Metodi di editing genomico e costrutti
|
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
|
WO2024226838A2
(en)
|
2023-04-25 |
2024-10-31 |
The Brigham And Women's Hospital, Inc. |
Treatment of autoimmune diseases having a pathogenic t cell state
|
|
AU2024264889A1
(en)
|
2023-05-03 |
2025-11-13 |
Sana Biotechnology, Inc. |
Methods of dosing and administration of engineered islet cells
|
|
EP4713027A1
(de)
|
2023-05-16 |
2026-03-25 |
Omega Therapeutics, Inc. |
Verfahren und zusammensetzungen zur modulation der methylierung eines zielgens
|
|
WO2024238723A1
(en)
|
2023-05-16 |
2024-11-21 |
Omega Therapeutics, Inc. |
Methods and compositions for modulating pcsk9 expression
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
EP4716541A2
(de)
|
2023-05-22 |
2026-04-01 |
Sana Biotechnology, Inc. |
Verfahren zur abgabe von inselzellen und zugehörige verfahren
|
|
CN121729237A
(zh)
|
2023-06-30 |
2026-03-24 |
武田药品工业株式会社 |
Htt阻遏物及其用途
|
|
WO2025019742A1
(en)
|
2023-07-19 |
2025-01-23 |
Omega Therapeutics, Inc. |
Methods and compositions for modulating ctnnb1 expression
|
|
AU2024301706A1
(en)
|
2023-07-21 |
2026-02-05 |
Crispr Therapeutics Ag |
Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene
|
|
CN121909284A
(zh)
|
2023-07-31 |
2026-04-21 |
图恩疗法股份有限公司 |
用于调节il-2基因表达的组合物和方法
|
|
WO2025029840A1
(en)
|
2023-07-31 |
2025-02-06 |
Tune Therapeutics, Inc. |
Compositions and methods for multiplexed activation and repression of t cell gene expression
|
|
KR20260046192A
(ko)
|
2023-07-31 |
2026-04-06 |
시그마-알드리치 컴퍼니., 엘엘씨 |
알라닌 생합성 경로를 통한 대사 선택
|
|
WO2025038494A1
(en)
|
2023-08-11 |
2025-02-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
|
|
WO2025049788A1
(en)
|
2023-08-29 |
2025-03-06 |
The Broad Institute, Inc. |
Optical genetic screens of intracellular and intercellular transcriptional circuits with perturb-fish
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025054540A1
(en)
|
2023-09-08 |
2025-03-13 |
Iovance Biotherapeutics, Inc. |
Methods of gene-editing using programmable nucleases
|
|
WO2025059073A1
(en)
|
2023-09-11 |
2025-03-20 |
Tune Therapeutics, Inc. |
Epigenetic editing methods and systems for differentiating stem cells
|
|
WO2025059215A1
(en)
|
2023-09-12 |
2025-03-20 |
Aadigen, Llc |
Methods and compositions for treating or preventing cancer
|
|
WO2025064408A1
(en)
|
2023-09-18 |
2025-03-27 |
The Broad Institute, Inc. |
Compositions and methods for treating cardiovascular disease
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025101484A1
(en)
|
2023-11-06 |
2025-05-15 |
Iovance Biotherapeutics, Inc. |
Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
|
|
WO2025101938A2
(en)
|
2023-11-10 |
2025-05-15 |
Century Therapeutics, Inc. |
Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof
|
|
WO2025106626A1
(en)
|
2023-11-15 |
2025-05-22 |
Century Therapeutics, Inc. |
Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof
|
|
WO2025129158A1
(en)
|
2023-12-15 |
2025-06-19 |
The Broad Institute, Inc. |
Engineered arc delivery vesicles and uses thereof
|
|
WO2025160155A1
(en)
|
2024-01-22 |
2025-07-31 |
The Broad Institute, Inc. |
Epigenetic targeting of prion diseases
|
|
WO2025186726A1
(en)
|
2024-03-05 |
2025-09-12 |
Crispr Therapeutics Ag |
Modulating expression of agt (angiotensinogen) gene
|
|
WO2025194124A1
(en)
|
2024-03-14 |
2025-09-18 |
Tessera Therapeutics, Inc. |
Modified st1cas9 guide nucleic acids
|
|
WO2025207798A1
(en)
|
2024-03-26 |
2025-10-02 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof
|
|
WO2025207795A1
(en)
|
2024-03-26 |
2025-10-02 |
Juno Therapeutics, Inc. |
Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof
|
|
WO2025224715A1
(en)
|
2024-04-26 |
2025-10-30 |
King Abdullah Univeristy Of Science And Technology |
Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing
|
|
WO2025235563A1
(en)
|
2024-05-07 |
2025-11-13 |
Omega Therapeutics, Inc. |
Epigenetic modulation for upregulation of genes
|
|
US20250345431A1
(en)
|
2024-05-10 |
2025-11-13 |
Juno Therapeutics, Inc. |
Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy
|
|
WO2025260068A1
(en)
|
2024-06-14 |
2025-12-18 |
Tune Therapeutics, Inc. |
Lipid nanoparticle formulation for delivery of nucleic acids to cells
|
|
WO2026006832A1
(en)
|
2024-06-28 |
2026-01-02 |
University Of Connecticut |
Gene modulation for treating cancer
|
|
WO2026015647A1
(en)
|
2024-07-09 |
2026-01-15 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for cell differentiation using targeted gene activation of dll4 and/or vcam1
|
|
WO2026030277A1
(en)
|
2024-08-01 |
2026-02-05 |
Amgen Inc. |
Method for reducing protease activities
|
|
WO2026047626A1
(en)
|
2024-08-30 |
2026-03-05 |
Inceptor Bio, Llc |
Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy
|
|
WO2026064753A1
(en)
|
2024-09-23 |
2026-03-26 |
Tune Therapeutics, Inc. |
Dna methyltransferase-like protein (dnmt3l) or dna methyltransferase 3a (dnmt3a) repressor systems for epigenetic editing
|
|
WO2026083328A1
(en)
|
2024-10-18 |
2026-04-23 |
Precision Biosciences, Inc. |
Base editing nucleotide sequences using homology directed repair
|
|
WO2026083329A1
(en)
|
2024-10-18 |
2026-04-23 |
Precision Biosciences, Inc. |
Methods of nuclease-initiated homology directed repair and replacement and compositions and uses thereof
|