ES2097589T3 - Compuestos 2-beta-alquenil-penam-sulfona como inhibidores de beta-lactamasa. - Google Patents

Compuestos 2-beta-alquenil-penam-sulfona como inhibidores de beta-lactamasa.

Info

Publication number
ES2097589T3
ES2097589T3 ES94112622T ES94112622T ES2097589T3 ES 2097589 T3 ES2097589 T3 ES 2097589T3 ES 94112622 T ES94112622 T ES 94112622T ES 94112622 T ES94112622 T ES 94112622T ES 2097589 T3 ES2097589 T3 ES 2097589T3
Authority
ES
Spain
Prior art keywords
beta
compounds
aroen
penam
lower rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94112622T
Other languages
English (en)
Inventor
Christian Hubschwerlen
Hans Richter
Jean-Luc Specklin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2097589T3 publication Critical patent/ES2097589T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A DERIVADOS PENAM, EN ESPECIAL SE REFIERE A DERIVADO 3 BETA -ALQUENIL RMULA GENERAL DONDE UNO DE LOS R1 Y R2 SIGNIFICAN O ALQUIL INFERIOR O AMBOS CONJUNTAMENTE SIGNIFICAN UN GAMMA LACTAMO R3 ES HIDROGENO, ALQUIL INFERIOR, ARIL O UN RESTO DESDOBLABLE IN VIVO, R4 ES HIDROGENO, ALQUIL INFERIOR, ALCOXI INFERIOR, BENCILOXI, AMINO, ALQUILAMINO INFERIOR O ALQUIL INFERIOR R7, CONTENIENDO COMPUESTOS HETEROAROMATICOS, POR MEDIO DE ANILLO ENLAZADO A TRAVES DE UN ATOMO DE NITROGENO, R6 ES R/ ES COCH2CL, Q ES UN ANILLO HETEROAROMATICO QUE CONTIENEN CINCO O SEIS MIEMBROS, N, S Y/O O Y N SIGNIFICA 0, 1 O 2, ASI COMO LAS SALES TOLERABLES FARMACEUTICAMENTE DE ESTOS COMPUESTOS. ESTOS COMPUESTOS SON BUENOS INHIBIDORES DEL BETA PUEDEN, EVENTUALMENTE DE FORMA CONJUNTA CON UN ANTIBIOTICO BETA LACTAMO SER UTILIZADOS PARA LA PREVENCION O PARA EL TRATAMIENTO DE INFECCIONES BACTERIALES.
ES94112622T 1993-08-24 1994-08-12 Compuestos 2-beta-alquenil-penam-sulfona como inhibidores de beta-lactamasa. Expired - Lifetime ES2097589T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH251193 1993-08-24
CH168794 1994-05-31

Publications (1)

Publication Number Publication Date
ES2097589T3 true ES2097589T3 (es) 1997-04-01

Family

ID=25688383

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94112622T Expired - Lifetime ES2097589T3 (es) 1993-08-24 1994-08-12 Compuestos 2-beta-alquenil-penam-sulfona como inhibidores de beta-lactamasa.

Country Status (22)

Country Link
US (2) US5637579A (es)
EP (1) EP0640607B1 (es)
JP (1) JP2642314B2 (es)
KR (1) KR100362294B1 (es)
CN (1) CN1067078C (es)
AT (1) ATE148705T1 (es)
AU (1) AU674768B2 (es)
CA (1) CA2129564C (es)
CZ (1) CZ203994A3 (es)
DE (1) DE59401750D1 (es)
DK (1) DK0640607T3 (es)
ES (1) ES2097589T3 (es)
FI (1) FI113775B (es)
GR (1) GR3023228T3 (es)
HU (1) HUT67880A (es)
IL (1) IL110711A (es)
NO (1) NO307054B1 (es)
NZ (1) NZ264272A (es)
RU (1) RU2139290C1 (es)
SG (1) SG48064A1 (es)
TW (1) TW383308B (es)
UA (1) UA29435C2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686441A (en) * 1995-08-04 1997-11-11 Syphar Laboratories, Inc. Penam sulfones as β-lactamase inhibitors
US6150350A (en) * 1997-09-15 2000-11-21 Hoffman-La Roche Inc. Antimicrobial compositions
ATE219085T1 (de) 1997-12-29 2002-06-15 Res Corp Technologies Inc 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren
EP1115419A2 (en) * 1998-09-01 2001-07-18 Merck & Co., Inc. Carbapenem antibacterial compositions and methods of treatment
HUP0200013A3 (en) * 1999-01-26 2002-10-28 American Cyanamid Co Madison 3,6-disubstituted penam sulfone derivatives, process for their preparation and pharmaceutical compositions containing them
US6395726B1 (en) 1999-01-26 2002-05-28 American Cyanamid Company 3,6-disubstituted penam sulfone derivatives
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6221859B1 (en) 1999-08-27 2001-04-24 Merck & Co., Inc. Carbapenem antibacterial compositions and methods of the treatment
WO2002022137A1 (en) * 2000-09-12 2002-03-21 Shoichet Brian K β-LACTAM ANALOGS AND USES THEREFOR
AR030878A1 (es) * 2000-10-11 2003-09-03 Healthtrio Inc Sistema para normalizar datos como base para comunicacion entre participantes del cuidado de la salud y aseguradores sobre una red de trabajo
CA2454413A1 (en) 2001-07-24 2003-03-13 Alamx, L.L.C. 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors
WO2003087105A1 (en) 2002-04-04 2003-10-23 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ß-LACTAMASES
AU2012233003B2 (en) * 2005-12-07 2014-12-18 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
CA2783572C (en) * 2005-12-07 2016-08-09 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
CN109475526A (zh) 2016-07-21 2019-03-15 荷兰联合利华有限公司 用于治疗呼吸道感染的内酰胺
EP3487496B1 (en) 2016-07-21 2026-04-08 Unilever IP Holdings B.V. 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one for use in the treatment of gram negative bacterial infections
WO2018015278A1 (en) 2016-07-21 2018-01-25 Unilever Plc Lactams for use in the treatment of skin lesions
US12329747B2 (en) 2019-01-22 2025-06-17 Board of Regents of the Nevada System of Higher Education on behalf of Nevada State College Use of lipophilic beta-lactam antibiotics and carboxylate esters for the treatment of bacterial infections within citrus and other plant species

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331677A (en) * 1978-11-24 1982-05-25 Farmitalia Carlo Erba S.P.A. 7-Oxo-4-1-aza-bicyclo-[3,2,0]-heptane derivatives
US4282236A (en) * 1979-11-07 1981-08-04 Beecham Group Limited β-Lactam antibacterial agents, their use in pharmaceutical compositions, and intermediates
US4365174A (en) * 1980-07-31 1982-12-21 Rca Corporation Pulse counter type circuit for power-up indication
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
US4861768A (en) * 1986-02-27 1989-08-29 Taiho Pharmaceutical Company, Limited 2 β-substituted thiomethylpenicillin derivatives and their preparation and use
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
US5132300A (en) * 1989-06-01 1992-07-21 Pfizer Inc. Beta-lactam elastase inhibitors

Also Published As

Publication number Publication date
EP0640607A1 (de) 1995-03-01
CA2129564A1 (en) 1995-02-25
HU9402391D0 (en) 1994-10-28
JP2642314B2 (ja) 1997-08-20
FI943885A0 (fi) 1994-08-24
TW383308B (en) 2000-03-01
IL110711A (en) 1999-08-17
US5637579A (en) 1997-06-10
EP0640607B1 (de) 1997-02-05
GR3023228T3 (en) 1997-07-30
HUT67880A (en) 1995-05-29
CZ203994A3 (en) 1995-03-15
JPH0782273A (ja) 1995-03-28
NO943104D0 (no) 1994-08-23
CN1106408A (zh) 1995-08-09
AU674768B2 (en) 1997-01-09
AU7035694A (en) 1995-03-09
KR100362294B1 (ko) 2005-08-25
RU2139290C1 (ru) 1999-10-10
SG48064A1 (en) 1998-04-17
US5644053A (en) 1997-07-01
CN1067078C (zh) 2001-06-13
FI943885L (fi) 1995-02-25
DK0640607T3 (da) 1997-06-16
IL110711A0 (en) 1994-11-11
UA29435C2 (uk) 2000-11-15
NO943104L (no) 1995-02-27
NZ264272A (en) 1996-10-28
CA2129564C (en) 2006-07-25
NO307054B1 (no) 2000-01-31
RU94030236A (ru) 1996-06-20
ATE148705T1 (de) 1997-02-15
DE59401750D1 (de) 1997-03-20
FI113775B (fi) 2004-06-15
KR950005830A (ko) 1995-03-20

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