ES2097652T3 - Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso. - Google Patents

Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso.

Info

Publication number
ES2097652T3
ES2097652T3 ES94915514T ES94915514T ES2097652T3 ES 2097652 T3 ES2097652 T3 ES 2097652T3 ES 94915514 T ES94915514 T ES 94915514T ES 94915514 T ES94915514 T ES 94915514T ES 2097652 T3 ES2097652 T3 ES 2097652T3
Authority
ES
Spain
Prior art keywords
sub
sup
quinoxaline
alkyl
members
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94915514T
Other languages
English (en)
Inventor
Poul Jacobsen
Flemming Elmelund Nielsen
Lone Jeppesen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK53593A external-priority patent/DK53593D0/da
Priority claimed from DK128793A external-priority patent/DK128793D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2097652T3 publication Critical patent/ES2097652T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

DERIVADOS DE TRIAZOLO[1,2,4] Y QUINOXALINA[4,3- A ] DE FORMULA (I) EN LA QUE UNO DE R{SUP,1} Y R{SUP,2} ES UN ANILLO QUE CONTIENE N, HETEROCICLICO, DE 5 O 6 MIEMBROS, OPCIONALMENTE SUSTITUIDO, O UN SISTEMA DE ANILLOS FUNDIDOS QUE CONTIENE UN ANILLO QUE CONTIENE N, HETEROCICLICO, DE 5 O 6 MEIMBROS, OPCIONALMENTE SUSTITUIDO, Y EL OTRO DE LA PAREJA R{SUP,1} Y R{SUP,2} ES H, ALQUILO, ALCOXILO, HALOGENO, NO{SUB,2}, NH{SUB,2}, CN, CF{SUB,3}, COC{SUB,1-6} ALQUILO O SO{SUB,2}NR''R'''', DONDE R'' Y R'''' SON INDEPENDIENTEMENTE H O ALQUILO, X ES O O S; Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS QUE TIENEN AFINIDAD HACIA LOS RECEPTORES AMPA Y SON ANTAGONISTAS EN CONEXION CON ESTE TIPO DE RECEPTORES, LOS QUE LES HACE UTILES EN EL TRATAMIENTO DE LOS AFECCIONES SISTEMA NERVIOSO CENTRAL, ESPECIALMENTE EN EL TRATAMIENTO DE LAS NUMEROSAS INDICACIONES CAUSADAS POR LA HIPERACTIVIDAD Y LOS AMINOACIDOS EXCITANTES.
ES94915514T 1993-05-06 1994-04-28 Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso. Expired - Lifetime ES2097652T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK53593A DK53593D0 (da) 1993-05-06 1993-05-06 Oe1,2,4aatriazolooe4,3-aaaquinoxalinonforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK128793A DK128793D0 (es) 1993-11-12 1993-11-12

Publications (1)

Publication Number Publication Date
ES2097652T3 true ES2097652T3 (es) 1997-04-01

Family

ID=26064177

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94915514T Expired - Lifetime ES2097652T3 (es) 1993-05-06 1994-04-28 Compuestos de (1,2,4)triazolo(4,3-a)quinoxalina, su preparacion y uso.

Country Status (19)

Country Link
US (1) US5532236A (es)
EP (1) EP0698024B1 (es)
JP (1) JPH08509747A (es)
KR (1) KR100304177B1 (es)
CN (1) CN1041931C (es)
AT (1) ATE148120T1 (es)
AU (1) AU683062B2 (es)
CA (1) CA2162023A1 (es)
DE (1) DE69401583T2 (es)
DK (1) DK0698024T3 (es)
ES (1) ES2097652T3 (es)
FI (1) FI955304L (es)
GR (1) GR3023001T3 (es)
HU (1) HUT73983A (es)
IL (1) IL109530A (es)
NO (1) NO305516B1 (es)
NZ (1) NZ266127A (es)
TW (1) TW377354B (es)
WO (1) WO1994026746A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996008493A1 (en) * 1994-09-16 1996-03-21 Novo Nordisk A/S [1,2,4]TRIAZOLO[4,3-a]QUINOXALINONE DERIVATIVES, THEIR PREPARATION AND USE
EP0783504B1 (en) * 1994-09-16 2000-03-15 Novo Nordisk A/S [1,2,4]TRIAZOLO[4,3-a]QUINOXALINONE DERIVATIVES, THEIR PREPARATION AND USE AS ANTAGONISTS OF AMPA-RECEPTORS
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung
BR9709085A (pt) 1996-05-15 1999-08-03 Pfizer Novas 2,3-dissubstituído-4(3H)-quinazolinonas
WO1998027097A1 (en) * 1996-12-16 1998-06-25 Warner-Lambert Company Tricyclic quinoxaline derivatives as neuroprotective agents
US6015800A (en) * 1997-09-03 2000-01-18 Warner-Lambert Company Substituted quinoxaline-2-ones as glutamate receptor antagonists
IL125950A0 (en) * 1997-09-05 1999-04-11 Pfizer Prod Inc Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
CA2310072A1 (en) 1997-11-11 1999-05-20 Hiroyuki Ohno Fused pyrazine compounds
US20040152694A1 (en) * 2003-02-04 2004-08-05 Istvan Kurucz Methods and compositions for treating inflammatory disorders of the airways
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
WO2016199943A1 (en) * 2015-06-11 2016-12-15 Takeda Pharmaceutical Company Limited Heterocyclic compounds
HRP20221020T1 (hr) * 2018-07-20 2022-11-11 Grünenthal GmbH Supstituirani derivati triazolo kinoksalina

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400382A (en) * 1980-05-09 1983-08-23 Usv Pharmaceutical Corporation Thiazoloquinoxalin-1,4-diones for treating allergy
DK162491D0 (da) * 1991-09-20 1991-09-20 Novo Nordisk As Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne

Also Published As

Publication number Publication date
EP0698024A1 (en) 1996-02-28
US5532236A (en) 1996-07-02
KR960701877A (ko) 1996-03-28
NO305516B1 (no) 1999-06-14
AU683062B2 (en) 1997-10-30
EP0698024B1 (en) 1997-01-22
JPH08509747A (ja) 1996-10-15
WO1994026746A1 (en) 1994-11-24
CN1041931C (zh) 1999-02-03
AU6720094A (en) 1994-12-12
FI955304A0 (fi) 1995-11-06
GR3023001T3 (en) 1997-07-30
NO954402D0 (no) 1995-11-03
DE69401583D1 (de) 1997-03-06
CN1125446A (zh) 1996-06-26
ATE148120T1 (de) 1997-02-15
NO954402L (no) 1996-01-05
IL109530A0 (en) 1994-08-26
NZ266127A (en) 1997-11-24
IL109530A (en) 1997-01-10
TW377354B (en) 1999-12-21
KR100304177B1 (ko) 2001-11-22
FI955304A7 (fi) 1995-11-06
DK0698024T3 (da) 1997-07-28
CA2162023A1 (en) 1994-11-24
DE69401583T2 (de) 1997-06-12
HUT73983A (en) 1996-10-28
FI955304L (fi) 1995-11-06
HU9503157D0 (en) 1996-01-29

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