ES2097918T3 - Agentes antihelminticos de benzoimidazol. - Google Patents

Agentes antihelminticos de benzoimidazol.

Info

Publication number
ES2097918T3
ES2097918T3 ES92915486T ES92915486T ES2097918T3 ES 2097918 T3 ES2097918 T3 ES 2097918T3 ES 92915486 T ES92915486 T ES 92915486T ES 92915486 T ES92915486 T ES 92915486T ES 2097918 T3 ES2097918 T3 ES 2097918T3
Authority
ES
Spain
Prior art keywords
alkyl
group
pct
benzimidazole compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915486T
Other languages
English (en)
Inventor
Bernard Joseph Banks
Christopher James Dutton
Alexander Crossan Goudie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2097918T3 publication Critical patent/ES2097918T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN DERIVADO DE BENCIMIDAZOL DE FORMULA (IA) O (IB) O UNA SAL NO TOXICA DE ESTE, EN LA QUE R, QUE ESTA EN LOS COMPUESTOS (IA) ESTA EN LA POSICION 6 LOXI, FENILTIO, FENILSULFINILO, FENILSULFONILO, FENILSUFONILOXI, ALQUILO C1-C6, ALCOXI C1-C6, ALQUILSULFINLO C1-C6, ALQUISULFONILO C1-C6, O CARBONILO CICLOALQUILO C3-C7, DICHO GRUPO FENILO, Y LA PARTE FENILO DE DICHO GRUPO BENZOILO, QUE TIENE OPCIONALMENTE 1 A 3 SUSTITUYENTES CADA UNO ELEGIDO INDEPENDIENTEMENTE ENTRE HALO, ALQUILO C1-C4, HALOALQUILO C1-C4, ALCOXI C1-C4, ALQUILTIO C1-C4, ALQUILSULFINILO C1-C4, ALQUILSULFONILO C1-C4, ALCANOILO C2-C4, ISOCIANATO, Y CIANO,. O (II) UN GRUPO DE FORMULA (1A) DONDE X ES O, S, SO, SO2 O NR4 EN EL QUE R4 ES HIDROGENO; ALQUILO C1-C4 FENILO, O ALQUILFENILO C1-C4, DICHOS GRUPOS FENILOS ESTANDO OPCIONALMENTE SUSTITUIDOS POR 1 O 2 SUSTITUYENTES CADA UNO ELEGIDO ENTRE ALQUILO C1-C4, HALO, HIDROXI, Y ALCOXI C1-C4; Y R5 ES H, ALQUILO C1-C4, HALO, HIDROXI O ALCOXI C1C4; (1B) (1C) (1D) DONDE R6 ES ALQUILO C1-C4, ALILO, O FENILO, (1E) (1F) O (1G); Y CUALQUIER (A) R1 ES UN GRUPO 1-(ALCANOILOXIC2C6) ALQUILO C1-C4 O (B) R1 ES H Y R2 ES UN GRUPO 1-(ALCANOILOXI C2-C6) ALQUILOC1-C4, Y R3 ES UN GRUPO ALQUILO C1-C4.
ES92915486T 1991-07-15 1992-07-13 Agentes antihelminticos de benzoimidazol. Expired - Lifetime ES2097918T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919115273A GB9115273D0 (en) 1991-07-15 1991-07-15 Benzimidazole anthelmintics

Publications (1)

Publication Number Publication Date
ES2097918T3 true ES2097918T3 (es) 1997-04-16

Family

ID=10698394

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915486T Expired - Lifetime ES2097918T3 (es) 1991-07-15 1992-07-13 Agentes antihelminticos de benzoimidazol.

Country Status (13)

Country Link
US (2) US5459155A (es)
EP (1) EP0594726B1 (es)
JP (1) JP2918690B2 (es)
AT (1) ATE148461T1 (es)
CA (1) CA2113566C (es)
DE (1) DE69217225T2 (es)
DK (1) DK0594726T3 (es)
ES (1) ES2097918T3 (es)
GB (1) GB9115273D0 (es)
GR (1) GR3022839T3 (es)
IE (1) IE922286A1 (es)
PT (1) PT100683B (es)
WO (1) WO1993002059A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ335166A (en) 1999-04-14 2001-11-30 Ashmont Holdings Ltd Anthelmintic composition containing triclabendazole in at least one solvent
GB9205368D0 (en) * 1992-03-12 1992-04-22 Pfizer Ltd Benzimidozole anthelmintic agents
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
MXPA02007252A (es) * 2000-01-28 2003-01-29 Rohm & Haas Compuestos farmaceuticos con propiedades mejoradas.
US20060222692A1 (en) * 2005-03-31 2006-10-05 Fairfield Clinical Trials Llc Method and compositions for transdermal administration of antimicrobial medications
ES2344275T3 (es) * 2005-07-28 2010-08-23 Intervet International Bv Nuevos (tio) carbamatos de benzimidazol con actividad antiparasitaria y sintesis de ellos.
CN101466317B (zh) * 2006-06-12 2011-08-31 史密夫和内修有限公司 用于进行胫骨切除的系统、方法和装置
PL2037914T3 (pl) 2006-06-14 2014-04-30 Intervet Int Bv Zawiesina zawierająca karbaminian benzoimidazolu i polisorbat
WO2019157338A1 (en) * 2018-02-08 2019-08-15 The Johns Hopkins University Mebendazole prodrugs with enhanced solubility and oral bioavailability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2933502A (en) * 1958-02-12 1960-04-19 Du Pont Benzimidazolone derivatives
US3010968A (en) * 1959-11-25 1961-11-28 Du Pont Process for manufacture of certain alkyl esters of benzimidazole carbamic acids
USRE28403E (en) * 1964-08-04 1975-04-29 Butyl and n-propoxy-z-carbo- methoxyaminobenzimidazoles
US4032536A (en) * 1976-07-22 1977-06-28 Janssen Pharmaceutica N.V. (1h-benzimidazol-2-yl)carbamates
DE2840927A1 (de) * 1978-09-20 1980-04-10 Bayer Ag 3,4-dihydroisochinoline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4512998A (en) * 1980-10-20 1985-04-23 Schering Corporation Anthelmintic benzimidazole carbamates
DE3247615A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4826862A (en) * 1988-02-12 1989-05-02 Janssen Pharmaceutica, N.V. Anthelminthic [(5(6) (1H-azole-1-ylmethyl)benzimidazole]carbamates
NZ232785A (en) * 1989-03-15 1991-03-26 Janssen Pharmaceutica Nv 5-(1,2 benzisoxazol-, benzimidazol and benzisothiazol-3- yl)-1h-benzimadazol-2-yl carbamic acid ester derivatives preparatory processes, intermediates and anthelmintic compositions

Also Published As

Publication number Publication date
EP0594726A1 (en) 1994-05-04
DE69217225T2 (de) 1997-05-15
DE69217225D1 (de) 1997-03-13
JP2918690B2 (ja) 1999-07-12
PT100683A (pt) 1993-08-31
DK0594726T3 (da) 1997-04-01
US5521204A (en) 1996-05-28
US5459155A (en) 1995-10-17
CA2113566C (en) 1997-04-08
CA2113566A1 (en) 1993-02-04
GB9115273D0 (en) 1991-08-28
ATE148461T1 (de) 1997-02-15
GR3022839T3 (en) 1997-06-30
IE922286A1 (en) 1993-01-27
JPH06509066A (ja) 1994-10-13
EP0594726B1 (en) 1997-01-29
PT100683B (pt) 1999-06-30
WO1993002059A1 (en) 1993-02-04

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