ES2098778T3 - Procedimiento para la fabricacion de sistemas terapeuticos percutaneos. - Google Patents

Procedimiento para la fabricacion de sistemas terapeuticos percutaneos.

Info

Publication number
ES2098778T3
ES2098778T3 ES93920730T ES93920730T ES2098778T3 ES 2098778 T3 ES2098778 T3 ES 2098778T3 ES 93920730 T ES93920730 T ES 93920730T ES 93920730 T ES93920730 T ES 93920730T ES 2098778 T3 ES2098778 T3 ES 2098778T3
Authority
ES
Spain
Prior art keywords
band
substrate
active agent
layer
therapeutic systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93920730T
Other languages
English (en)
Inventor
Thomas Hille
Lothar Deurer
Peter Steinborn
Ludwig Grader
Dieter Anhauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Application granted granted Critical
Publication of ES2098778T3 publication Critical patent/ES2098778T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B37/00—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
    • B32B37/14—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers
    • B32B37/16—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating
    • B32B37/22—Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating involving the assembly of both discrete and continuous layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B38/00—Ancillary operations in connection with laminating processes
    • B32B38/18—Handling of layers or the laminate
    • B32B38/1825—Handling of layers or the laminate characterised by the control or constructional features of devices for tensioning, stretching or registration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2309/00—Parameters for the laminating or treatment process; Apparatus details
    • B32B2309/14—Velocity, e.g. feed speeds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/1062—Prior to assembly
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1089—Methods of surface bonding and/or assembly therefor of discrete laminae to single face of additional lamina
    • Y10T156/1092—All laminae planar and face to face
    • Y10T156/1093—All laminae planar and face to face with covering of discrete laminae with additional lamina
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/12—Surface bonding means and/or assembly means with cutting, punching, piercing, severing or tearing
    • Y10T156/1317—Means feeding plural workpieces to be joined
    • Y10T156/1322—Severing before bonding or assembling of parts
    • Y10T156/133—Delivering cut part to indefinite or running length web
    • Y10T156/1335—Cutter also delivers cut piece

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Labeling Devices (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA ELABORACION DE SISTEMAS TERAPEUTICO TRANSDERMALES, EN DONDE LA CAPA QUE CONTIENE EL AGENTE ACTIVO TOMA PRIMERO LA FORMA DE UN LAMINADO CON UN SUBSTRATO Y POSIBLEMENTE OTRAS CAPAS AUXILIARES Y/O DE PROTECCION O SIMILARES CON UNA BANDA DE TIRA. SIENDO ENTONCES TRANSFERIDAS DE FORMA AISLADA O EN COMBINACION CON AL MENOS UNA OTRA CAPA EN SECCIONES AL CENTRO DE UNA SEGUNDA BANDA ENSANCHADA, QUE SE CARACTERIZA PORQUE LA BANDA (1) CON PERFIL DE TIRA Y LA SEGUNDA BANDA (2) SE MUEVEN HACIA ADELANTE PASO A PASO EN MOVIMIENTO DIFERENTE Y ETAPAS ESTACIONARIAS Y/O LONGITUDES DE ETAPA DIFERENTE Y/O VELOCIDADES DIFERENTES, DE MODO QUE EN LAS ETAPAS ESTACIONARIAS DE LAS BANDAS (1,2), LA CAPA QUE CONTIENE EL AGENTE ACTIVO Y POSIBLEMENTE UNA O MAS CAPAS ADICIONALES, EXCEPTO LA DEL SUBSTRATO, SON SUBDIVIDIDAS EN EL MISMO DISPOSITIVO DE FORMA TRANSVERSAL CON RESPECTO A LA DIRECCION DE LA BANDA EN SECCIONES (7,8) CONTENIENDO EL AGENTE ACTIVO Y SIENDO DE TAMAÑOS ADECUADOS PARA EL UTILIZADOR SOBRE LA SEGUNDA BANDA, CON LA ELIMINACION DEL SUBSTRATO (9) A DISTANCIAS CON PREFERENCIA IGUALES POR MEDIO DE UN DISPOSITIVO DE TRANSFERENCIA RECIPROCO EN LA DIRECCION DE LA BANDA.
ES93920730T 1992-09-25 1993-09-15 Procedimiento para la fabricacion de sistemas terapeuticos percutaneos. Expired - Lifetime ES2098778T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4232279A DE4232279C1 (de) 1992-09-25 1992-09-25 Transferverfahren zur Herstellung transdermaler therapeutischer Systeme

Publications (1)

Publication Number Publication Date
ES2098778T3 true ES2098778T3 (es) 1997-05-01

Family

ID=6468892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93920730T Expired - Lifetime ES2098778T3 (es) 1992-09-25 1993-09-15 Procedimiento para la fabricacion de sistemas terapeuticos percutaneos.

Country Status (25)

Country Link
US (1) US5681413A (es)
EP (1) EP0661958B1 (es)
JP (1) JP3621094B2 (es)
KR (1) KR100275307B1 (es)
AT (1) ATE146355T1 (es)
AU (1) AU687011B2 (es)
CA (1) CA2145072C (es)
CZ (1) CZ282780B6 (es)
DE (2) DE4232279C1 (es)
DK (1) DK0661958T3 (es)
ES (1) ES2098778T3 (es)
FI (1) FI116825B (es)
GR (1) GR3022864T3 (es)
HR (1) HRP931236B1 (es)
HU (1) HU216872B (es)
IL (1) IL107076A (es)
MY (1) MY109393A (es)
NO (1) NO311489B1 (es)
NZ (1) NZ256014A (es)
PL (1) PL172928B1 (es)
SI (1) SI9300500A (es)
SK (1) SK279795B6 (es)
WO (1) WO1994007449A1 (es)
YU (1) YU48674B (es)
ZA (1) ZA937069B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4406976C1 (de) * 1994-03-03 1995-06-22 Lohmann Therapie Syst Lts Verfahren zur Übertragung von einseitig selbstklebenden Abschnitten von einer bewegbaren ersten Bahn auf eine bewegbare zweite Bahn sowie Verwendung des Verfahrens
CA2146495C (en) * 1994-04-08 2006-06-27 Len C. Decandia Method for making an elastic adhesive bandage
DE19547691C1 (de) * 1995-12-20 1997-04-24 Lohmann Therapie Syst Lts Verfahren zur Herstellung transdermaler therapeutischer Pflaster (TTS)
DE19641094C1 (de) * 1996-10-04 1997-06-26 Beiersdorf Ag Verfahren zum verlustfreien Stanzen von klebenden Stanzlingen
US6464818B1 (en) * 1996-10-04 2002-10-15 Tesa Ag Method of wasteless punching of adhesive punched items
DE19837764C1 (de) 1998-08-20 2000-03-16 Lohmann Therapie Syst Lts Verfahren zum Herstellen von klebenden Stanzlingen aus einer endlosen Bahn und nach dem Verfahren hergestellter Stanzling
DE19925613A1 (de) * 1999-06-04 2000-12-07 Lohmann Therapie Syst Lts Verbundlaminat und Verfahren zu seiner Herstellung
DE19946384A1 (de) * 1999-09-28 2001-04-05 Lohmann Therapie Syst Lts Verfahren und Vorrichtung zum Spenden haftklebender Laminatabschnitte von einer beweglichen primären auf eine bewegliche sekundäre Trägerbahn
DE19957162A1 (de) * 1999-10-19 2001-04-26 Lohmann Therapie Syst Lts Vorrichtung und Verfahren zum Spenden klebender Laminate von einer Spendebahn auf eine Akzeptorbahn
CA2626268A1 (en) * 2000-03-10 2001-09-20 3M Innovative Properties Company Medical dressings with multiple adhesives and methods of manufacturing
DE10029646A1 (de) * 2000-06-15 2002-01-03 Lohmann Therapie Syst Lts Trägerfolie für selbsthaftende Laminate mit reduzierter Auflagefläche
DE10207776A1 (de) * 2002-02-23 2003-09-04 Tesa Ag Verfahren zur Herstellung eines partiell beschichteten Pflasters
US20050013957A1 (en) * 2003-07-15 2005-01-20 Boris Leschinsky Disposable medical article with multiple adhesives for skin attachment
CN101232875B (zh) 2005-06-10 2014-06-25 3M创新有限公司 处理粘合层叠片片段的方法
JP4327841B2 (ja) * 2006-12-20 2009-09-09 日東電工株式会社 経皮吸収製剤の製造装置および製造方法
DE502008001671D1 (de) * 2007-08-21 2010-12-09 Lohmann Therapie Syst Lts Verfahren zum mehrspurigen konfektionieren transdermaler therapeutischer pflaster
DE102020214263A1 (de) 2020-11-12 2022-05-12 OPTIMA life science GmbH Vorrichtung und Verfahren zum Übertragen einer Membran

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1977046A (en) * 1932-10-19 1934-10-16 Harry A Cumfer Method for making a plaster receiving base
US2372617A (en) * 1942-12-31 1945-03-27 James W Trew Method of producing composite panels
US3447992A (en) * 1965-08-11 1969-06-03 Hobart Corp Label dispenser
US3707422A (en) * 1970-10-19 1972-12-26 Smithe Machine Co Inc F L Patch cutting and application system for two independently timed patches on an envelope blank
DE2555910C2 (de) * 1975-12-12 1987-01-22 Hermann O. 2070 Ahrensburg Steinke Etikettiervorrichtung
DE2555900A1 (de) * 1975-12-12 1977-07-14 Jacobi E & Co Kg Reinigungsvorrichtung bei textilmaschinen
DE3204582A1 (de) * 1982-02-10 1983-08-25 Hassia Verpackung Gmbh, 6479 Ranstadt Verfahren zur kontinuierlichen herstellung von pflasterpackungen fuer die transdermale verabreichung von medikamenten
DE3233546A1 (de) * 1982-09-10 1984-03-15 Hermann Gmbh Co Heinrich Etikettiergeraet
US4664736A (en) * 1983-01-24 1987-05-12 Faasse Jr Adrain L Pharmaceutical packaging method
DE8321825U1 (de) * 1983-07-29 1983-11-24 Heinrich Hermann Gmbh + Co, 7000 Stuttgart Etikettiergeraet
JPS62102934A (ja) * 1985-10-26 1987-05-13 Yoshida Kogyo Kk <Ykk> 接合片切断・接合装置
DE3608542A1 (de) * 1986-03-14 1987-09-24 Bosch Gmbh Robert Farbfernsehkamera
DE3618542A1 (de) * 1986-06-03 1987-12-10 Hermann Gmbh Co Heinrich Verfahren und vorrichtung zum spenden von auf einem traegerband haftenden etiketten
US4838982A (en) * 1987-06-26 1989-06-13 H.G. Weber & Co., Inc. Patch applicator vacuum cylinder for web material
IT1213748B (it) * 1987-12-16 1989-12-29 Giorgio Dotta Macchina per fabbricare e confezionare cerotti
US5405486A (en) * 1988-03-04 1995-04-11 Noven Pharmaceuticals, Inc. Apparatus for forming a transdermal drug device
US5268179A (en) * 1992-02-14 1993-12-07 Ciba-Geigy Corporation Ultrasonically sealed transdermal drug delivery systems

Also Published As

Publication number Publication date
IL107076A (en) 1996-11-14
SI9300500A (en) 1994-03-31
US5681413A (en) 1997-10-28
HUT71526A (en) 1995-12-28
GR3022864T3 (en) 1997-06-30
DE4232279C1 (de) 1993-10-21
HRP931236A2 (en) 1995-04-30
FI951419A7 (fi) 1995-03-24
HRP931236B1 (en) 1998-08-31
YU48674B (sh) 1999-06-15
ZA937069B (en) 1994-04-18
IL107076A0 (en) 1993-12-28
CA2145072C (en) 2005-07-26
NZ256014A (en) 1996-08-27
YU61993A (sh) 1996-05-20
KR100275307B1 (ko) 2001-03-02
PL308146A1 (en) 1995-07-24
KR950703310A (ko) 1995-09-20
SK279795B6 (sk) 1999-03-12
JP3621094B2 (ja) 2005-02-16
CA2145072A1 (en) 1994-04-14
FI951419A0 (fi) 1995-03-24
NO951137L (no) 1995-03-24
CZ282780B6 (cs) 1997-10-15
JPH08501479A (ja) 1996-02-20
WO1994007449A1 (de) 1994-04-14
DK0661958T3 (da) 1997-06-09
NO311489B1 (no) 2001-12-03
NO951137D0 (no) 1995-03-24
ATE146355T1 (de) 1997-01-15
SK38595A3 (en) 1996-11-06
PL172928B1 (pl) 1997-12-31
CZ73895A3 (en) 1995-10-18
DE59304837D1 (de) 1997-01-30
EP0661958A1 (de) 1995-07-12
AU687011B2 (en) 1998-02-19
EP0661958B1 (de) 1996-12-18
AU4817293A (en) 1994-04-26
HU9500868D0 (en) 1995-05-29
FI116825B (fi) 2006-03-15
HU216872B (hu) 1999-09-28
MY109393A (en) 1997-01-31

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