ES2100396T3 - Derivados de 17-(3-furil)- y 17-(4-piridazinil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de 17-(3-furil)- y 17-(4-piridazinil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2100396T3
ES2100396T3 ES93110187T ES93110187T ES2100396T3 ES 2100396 T3 ES2100396 T3 ES 2100396T3 ES 93110187 T ES93110187 T ES 93110187T ES 93110187 T ES93110187 T ES 93110187T ES 2100396 T3 ES2100396 T3 ES 2100396T3
Authority
ES
Spain
Prior art keywords
piridazinyl
furil
derivatives
processes
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93110187T
Other languages
English (en)
Inventor
Luisa Quadri
Luigi Bernardi
Giuseppe Bianci
Patrizia Ferrari
Piero Melloni
Loredana Valentino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2100396T3 publication Critical patent/ES2100396T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0021—Oxiranes at position 14(15)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

DERIVADOS DE 17-(3-FURIL) Y (4-PIRIDAZINIL)-5(BETA),14(BETA)-ANDROSTANOS DE LA FORMULA (I) EN DONDE EL SIMBOLO DE LINEA ONDULADA, EL SIMBOLO DE LINEA CONTINUA CON LINEA INTERRUMPIDA SUPERPUESTA, Y, R, R1, R2 Y R3 TIENEN EL SIGNIFICADO INDICADO EN LA ESPECIFICACION. TAMBIEN SE PRESENTAN LOS PROCESOS PARA LA PRODUCCION DE DICHOS COMPUESTOS Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES93110187T 1992-08-20 1993-06-25 Derivados de 17-(3-furil)- y 17-(4-piridazinil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2100396T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4227616A DE4227616C2 (de) 1992-08-20 1992-08-20 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen

Publications (1)

Publication Number Publication Date
ES2100396T3 true ES2100396T3 (es) 1997-06-16

Family

ID=6465993

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93110187T Expired - Lifetime ES2100396T3 (es) 1992-08-20 1993-06-25 Derivados de 17-(3-furil)- y 17-(4-piridazinil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (12)

Country Link
US (2) US5591734A (es)
EP (1) EP0583578B1 (es)
JP (2) JP3357427B2 (es)
KR (1) KR100276528B1 (es)
AT (1) ATE152118T1 (es)
CA (1) CA2103826C (es)
DE (2) DE4227616C2 (es)
DK (1) DK0583578T3 (es)
ES (1) ES2100396T3 (es)
GR (1) GR3023311T3 (es)
HK (1) HK1005876A1 (es)
ZA (1) ZA935865B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2327409A1 (en) 2001-07-13 2011-06-01 Paratek Pharmaceuticals, Inc. Tetracycline compound having target therapeutic activities
WO2007060206A2 (en) * 2005-11-25 2007-05-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Further crystalline forms of rostafuroxin
EP2431469A3 (en) 2006-05-15 2012-05-30 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
PT2160190E (pt) * 2007-06-07 2016-01-27 Sigma Tau Ind Farmaceuti Derivados de 5beta, 14 beta-androstano úteis para o tratamento de doenças causadas por fibroses de órgão
HUE027408T2 (en) * 2009-03-23 2016-10-28 Sigma Tau Ind Farmaceuti Proteinuria, 5ß, 14β-androstane derivatives for the treatment of glomerulosclerosis and renal failure
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
US20120238488A1 (en) 2009-09-08 2012-09-20 Konstantinos Alevizopoulos Compounds and methods for treating neoplasia
WO2011048033A2 (en) 2009-10-19 2011-04-28 Rostaquo S.P.A. Methods and systems for pharmacogenomic treatment of cardiovascular conditions
CN108152432B (zh) * 2017-12-29 2020-11-20 兆科药业（合肥）有限公司 一种罗他夫辛片高效液相检测方法
US11337988B2 (en) 2018-09-27 2022-05-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of ouabain antagonists to inhibit viral infection
KR102933801B1 (ko) 2023-11-14 2026-03-11 공간찬넬주식회사 창고용 캐비닛

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621803A5 (es) * 1974-08-08 1981-02-27 Siphar Sa
HU171166B (hu) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh ehpoksi-androstanov
DE2614046C2 (de) * 1976-04-01 1984-08-02 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Also Published As

Publication number Publication date
DE4227616C2 (de) 1995-04-13
ZA935865B (en) 1994-03-10
EP0583578B1 (en) 1997-04-23
CA2103826A1 (en) 1994-02-21
JPH06219951A (ja) 1994-08-09
EP0583578A2 (en) 1994-02-23
CA2103826C (en) 1998-12-22
ATE152118T1 (de) 1997-05-15
JPH06157586A (ja) 1994-06-03
GR3023311T3 (en) 1997-08-29
EP0583578A3 (en) 1994-07-06
US5591734A (en) 1997-01-07
KR940003964A (ko) 1994-03-14
KR100276528B1 (ko) 2001-02-01
DE69310052D1 (de) 1997-05-28
DE69310052T2 (de) 1997-09-18
HK1005876A1 (en) 1999-01-29
DK0583578T3 (da) 1997-07-21
DE4227616A1 (de) 1994-03-10
JP3357427B2 (ja) 2002-12-16
US5567697A (en) 1996-10-22

Similar Documents

Publication Publication Date Title
ES2095432T3 (es) Derivados de 2,4-tiazolidin-diona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DE3686483D1 (de) Arzneimittel.
DE3669315D1 (de) Phenoxyalkylaminopyrimidinderivate, deren herstellung und diese enthaltende insektizide und akarizide zusammensetzungen.
ES2094974T3 (es) Derivados de 17-aril- y 17-heterociclil-14beta-5alfa-androstano, androsteno y androstadieno, activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.
ES2052603T3 (es) Derivados de bencimidazol, procedimiento para su produccion y composicion farmaceutica que los contienen.
PT929565E (pt) Esteres de nitrato de compostos corticoides e suas aplicacoes farmaceuticas
GR1000118B (el) Συνθεσις 1,2-διοξετανων & ενδιαμεσαι ουσιαι δι αυτην.
ES2100396T3 (es) Derivados de 17-(3-furil)- y 17-(4-piridazinil)-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que los contienen.
ES2135429T3 (es) Derivados de ciclohexano sustituidos para el tratamiento de enfermedades.
NO304988B1 (no) 11-benzaldoksim-17<beta>-metoksy-17<alfa>-metoksymetyl-°stradienderivater samt farmas°ytisk preparat inneholdende slike
ES8307494A1 (es) "un procedimiento para preparar una composicion farmaceutica que proporciona un efecto anti-inflamatorio y analgesico junto con un dano gastrico minimizado".
FI925734A0 (fi) Polyaspartamidderivat som adsorptionsmedel foer gallsyra, polyaspartamidderivat innehaollande gallsyror och foerfarande foer framstaellning av dessa samt anvaendning av dessa som laekemedel
MX9303123A (es) Ciclopentano-y-penteno-beta-aminoacidos, procedimiento para su preparacion y medicamentos que los contienen.
SE8404065D0 (sv) Novel biologically active compounds
DE4493718T1 (de) Abbaubare Succinsäurederivatchelanten, Verwendungen und Zusammensetzungen davon
ES2116612T3 (es) Nuevas bis-naftalimidas para el tratamiento del cancer.
IT8021550A0 (it) Derivati adenosinici ad attivita'antinfiammatoria ed analgesica e composizioni terapeutiche che licontengono come principio attivo.
ES2133918T3 (es) Nuevos esteroides seco-d activos en el sistema cardiovascular y composiciones farmaceuticas que los contienen.
ES8403463A1 (es) "un procedimiento para la preparacion de un compuesto de imidazol".
ES2095531T3 (es) Derivados de 17-beta-aril- y 17-beta-heterociclil-5-beta,14-beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.
ES2095431T3 (es) N-(isoquinolein-5-il)-sulfonil-azacicloalcanos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DE59005233D1 (de) Neue Acylaminosäurederivate enthaltende Arzneimittel und Diätetika.
ES2093752T3 (es) Complejos de hierro que contienen conalbumina y sus derivados.
NO923266D0 (no) Heksahydrobenzo(f)quinolinoner
ES2162986T3 (es) Derivados de mercapto-alcanoil-dipeptidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 583578

Country of ref document: ES