ES2100558T3 - Antiepilepticos analogos del vpa. - Google Patents

Antiepilepticos analogos del vpa.

Info

Publication number
ES2100558T3
ES2100558T3 ES93918997T ES93918997T ES2100558T3 ES 2100558 T3 ES2100558 T3 ES 2100558T3 ES 93918997 T ES93918997 T ES 93918997T ES 93918997 T ES93918997 T ES 93918997T ES 2100558 T3 ES2100558 T3 ES 2100558T3
Authority
ES
Spain
Prior art keywords
compounds
image
formulae
hydrogen
antiepilepticos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93918997T
Other languages
English (en)
Inventor
Heinz Nau
Ursula Bojic
Ralf-Siegbert Hauck
Mohamed Mohey Eldin Elmazar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2100558T3 publication Critical patent/ES2100558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Peptides Or Proteins (AREA)
  • Socks And Pantyhose (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Electrotherapy Devices (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS, QUE SON ANTIEPILEPTICOS ACTIVOS DISPONIENDO SOLAMENTE DE ACCION SEDANTE BAJA O TERATOGENICA Y DISPONIENDO DE FORMULAS (I), (II), (III) O (IV) PUDIENDO TENER LOS COMPUESTOS DE LAS FORMULAS (I) Y (II) MULTIPLES ENLACES NO SATURADOS, DONDE R1, R2, R3 Y R4, INDEPENDIENTE UNO DE OTRO, PUEDEN SER UN GRUPO C1 - C6 - ALQUIL, R5 ES HIDROGENO O UN GRUPO C1 - C2 - ALQUIL Y DONDE EN LOS COMPUESTOS DE LAS FORMULAS (I) Y (II) AL MENOS UNO DE LOS RESTOS R1 HASTA R4 ES DIFERENTE DE HIDROGENO. EN LOS COMPUESTOS DE LA FORMULA (I) PARA EL CASO DE QUE UN ATOMO DE CARBONO ESTE PRESENTE EN LA POSICION 2 SE FORMA UN CENTRO DE ASIMETRIA, Y LOS COMPUESTOS DE LAS FORMULAS (II), (III) Y (IV) SE ENCUENTRAN PRESENTES EN FORMA DE SUS RACEMATOS, SUS ENANTIOMEROS PUROS O UNA DE LAS MEZCLAS DIFERENTES DE RACEMATO DE SUS ENANTIOMEROS, Y SUS SALES TOLERABLES FARMACEUTICAMENTE.
ES93918997T 1992-09-12 1993-09-10 Antiepilepticos analogos del vpa. Expired - Lifetime ES2100558T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4231085A DE4231085A1 (de) 1992-09-12 1992-09-12 VPA-analoge Antiepileptika

Publications (1)

Publication Number Publication Date
ES2100558T3 true ES2100558T3 (es) 1997-06-16

Family

ID=6468160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93918997T Expired - Lifetime ES2100558T3 (es) 1992-09-12 1993-09-10 Antiepilepticos analogos del vpa.

Country Status (13)

Country Link
US (1) US5786380A (es)
EP (1) EP0659172B1 (es)
JP (1) JP2887419B2 (es)
KR (1) KR100244883B1 (es)
AT (1) ATE151067T1 (es)
AU (1) AU683425B2 (es)
CA (1) CA2144419A1 (es)
DE (2) DE4231085A1 (es)
DK (1) DK0659172T3 (es)
ES (1) ES2100558T3 (es)
GR (1) GR3023558T3 (es)
NZ (2) NZ255317A (es)
WO (1) WO1994006743A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW248552B (es) 1993-06-01 1995-06-01 Onoda Yakuhin Kogyo Kk
US6300373B1 (en) * 1993-09-10 2001-10-09 American Biogenetic Sciences, Inc. Antiproliferative and neurotrophic molecules
US5672746A (en) * 1994-08-30 1997-09-30 American Biogenetic Sciences, Inc. Antiproliferative and neurotrophic molecules
US5717109A (en) * 1994-09-08 1998-02-10 Eli Lilly And Company Excitatory amino acid receptor antagonists
IL124118A (en) * 1998-04-16 2007-09-20 Yissum Res Dev Co Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, method for their synthesis and pharmaceutical compositions containing them
IL140415A0 (en) 1998-06-22 2002-02-10 American Biogenetic Sciences The use of valproic acid analog for the treatment and prevention of migraine and affective illness
CA2335603A1 (en) * 1998-06-22 1999-12-29 Heinz Nau Alpha-fluoro alkynoic acids with anticonvulsant activity
US6969732B2 (en) * 1999-04-12 2005-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them
DE10002945A1 (de) * 2000-01-13 2001-07-26 Heinz Nau Verfahren zur Herstellung von enantiomerenreinen Analoga der Valproinsäure
US6521790B2 (en) 2000-11-01 2003-02-18 Abbott Laboratories Alkynyl amides and their therapeutic applications
DE10393475B4 (de) * 2002-10-09 2014-09-25 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren und Vorrichtung zur Identifizierung von Verbindungen in einer Probe
US20060223888A1 (en) * 2002-12-16 2006-10-05 Abbott Frank S Valproic acid analogues and pharmaceutical composition thereof
US20110313037A1 (en) * 2008-12-20 2011-12-22 Saakian Susanna A [2.2.2] Bicyclic Derivatives and Methods of Use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2442M (fr) * 1962-10-17 1964-04-06 Henry Eugene L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central.
DE2854195A1 (de) * 1978-12-15 1980-06-26 Technochemie Gmbh Verfahren zur herstellung von dipropylessigsaeure
DE3718803A1 (de) * 1987-06-02 1988-12-15 Desitin Arzneimittel Gmbh Verfahren zur herstellung von e-2-propyl-2-pentensaeure und physiologisch vertraeglichen salzen derselben

Also Published As

Publication number Publication date
EP0659172A1 (de) 1995-06-28
DK0659172T3 (da) 1997-05-05
AU4944293A (en) 1994-04-12
NZ255317A (en) 1996-12-20
GR3023558T3 (en) 1997-08-29
KR100244883B1 (ko) 2000-02-15
DE59306054D1 (de) 1997-05-07
JPH08502045A (ja) 1996-03-05
ATE151067T1 (de) 1997-04-15
WO1994006743A1 (de) 1994-03-31
NZ299727A (en) 2000-11-24
US5786380A (en) 1998-07-28
CA2144419A1 (en) 1994-03-31
DE4231085A1 (de) 1994-03-17
EP0659172B1 (de) 1997-04-02
HK1008016A1 (en) 1999-04-30
AU683425B2 (en) 1997-11-13
JP2887419B2 (ja) 1999-04-26

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