ES2100891T3 - Neurotrofina-3, un nuevo factor neurotrofico relacionado con el factor de crecimiento nervioso y factor neurotrofico derivado del cerebro. - Google Patents

Neurotrofina-3, un nuevo factor neurotrofico relacionado con el factor de crecimiento nervioso y factor neurotrofico derivado del cerebro.

Info

Publication number
ES2100891T3
ES2100891T3 ES90913954T ES90913954T ES2100891T3 ES 2100891 T3 ES2100891 T3 ES 2100891T3 ES 90913954 T ES90913954 T ES 90913954T ES 90913954 T ES90913954 T ES 90913954T ES 2100891 T3 ES2100891 T3 ES 2100891T3
Authority
ES
Spain
Prior art keywords
neurotrophic factor
neurotrofina
brain
factor
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90913954T
Other languages
English (en)
Inventor
Andreas Hohn
Joachim Leibrock
Karen Bailey
Yves-Alain Barde
Hans F E Thoenen
Peter C Maisonpierre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Regeneron Pharmaceuticals Inc
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/400,591 external-priority patent/US5180820A/en
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV, Regeneron Pharmaceuticals Inc filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Application granted granted Critical
Publication of ES2100891T3 publication Critical patent/ES2100891T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B75/00—Other engines
    • F02B75/02—Engines characterised by their cycles, e.g. six-stroke
    • F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
    • F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LA NEUROTROFINA-3 (NT-3), MIEMBRO RECIENTEMENTE DESCUBIERTO DE LA FAMILIA DE GENES BDNF. ESTA BASADO, EN PARTE, EN LA IDENTIFICACION DE REGIONES DE LA SECUENCIA DE ACIDO NUCLEICO HOMOLOGAMENTE COMPARTIDA POR BDNF Y NGF (PATENTE DE LOS EEUU DE NUMERO DE SERIE 400.591, REGISTRADA EL 30 DE AGOSTO DE 1989, INCORPORADA POR REFERENCIA EN LA PRESENTE). DE ACUERDO CON LA PRESENTE INVENCION, ESTAS REGIONES DE HOMOLOGIA PUEDEN USARSE PARA IDENTIFICAR NUEVOS MIEMBROS DE LA FAMILIA DEL GEN BDNF/NGF; DICHA METODOLOGIA FUE USADA PARA IDENTIFICAR LA NT-3. LA PRESENTE INVENCION SUMINISTRA LOS GENES Y LOS PRODUCTOS DE GENE DEL NUEVO BDNF/NGF RELACIONADOS CON LOS FACTORES NEOTROFICOS IDENTIFICADOS POR ESTOS METODOS. DE ACUERDO CON LA INVENCION, LA NT-3 PUEDE USARSE EN EL DIAGNOSTICO Y/O TRATAMIENTO DE ENFERMEDADES NEUROLOGICAS, INCLUYENDO EL MAL DE ALZHEIMER Y LAS ENFERMEDADES DE PARKINSON. A CAUSA DE QUE SE HA OBSERVADO QUE LA NT-3 EXHIBE UN ESPECTRO DE ACTIVIDAD DIFERENTEDE LAS ESPECIFICACIONES DE BDNF O NGF, LA NT-3 SUMINISTRA NUEVAS Y VALORABLES OPCIONES PARA INDUCIR LA REGENERACION Y REPARACION EN EL SISTEMA NERVIOSO CENTRAL.
ES90913954T 1989-08-30 1990-08-29 Neurotrofina-3, un nuevo factor neurotrofico relacionado con el factor de crecimiento nervioso y factor neurotrofico derivado del cerebro. Expired - Lifetime ES2100891T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/400,591 US5180820A (en) 1989-08-30 1989-08-30 Brain-derived neurotrophic factor
US49000490A 1990-03-07 1990-03-07
US57018990A 1990-08-20 1990-08-20

Publications (1)

Publication Number Publication Date
ES2100891T3 true ES2100891T3 (es) 1997-07-01

Family

ID=27410411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90913954T Expired - Lifetime ES2100891T3 (es) 1989-08-30 1990-08-29 Neurotrofina-3, un nuevo factor neurotrofico relacionado con el factor de crecimiento nervioso y factor neurotrofico derivado del cerebro.

Country Status (21)

Country Link
EP (1) EP0441947B1 (es)
KR (1) KR100196203B1 (es)
CN (1) CN1124342C (es)
AT (1) ATE153074T1 (es)
AU (1) AU643705B2 (es)
CA (1) CA2040437C (es)
CZ (1) CZ286015B6 (es)
DE (1) DE69030719T2 (es)
ES (1) ES2100891T3 (es)
FI (1) FI105343B (es)
GR (1) GR1000980B (es)
HK (1) HK1006579A1 (es)
IE (1) IE903129A1 (es)
IL (1) IL95511A (es)
LV (1) LV10792B (es)
NO (1) NO303694B1 (es)
NZ (1) NZ235086A (es)
PT (1) PT95153B (es)
SG (1) SG70560A1 (es)
SK (1) SK279660B6 (es)
WO (1) WO1991003569A1 (es)

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US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
EP0499993B1 (en) * 1991-02-18 1997-06-11 Takeda Chemical Industries, Ltd. Method for producing human nerve growth factor-2
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
PT100501A (pt) * 1991-07-10 1993-09-30 Regeneron Pharma Composicoes farmaceuticas a base de um membro da familia de moleculas de bdnf/nt-3/ngf, processo para promover a sobrevivencia,crescimentoe/ou diferenciacao de neuronios motores in vitro e de diagnostico, e processo de ensaio de um agente de teste.
DE4237047A1 (en) * 1991-11-04 1993-05-06 I N R O Handels-Gmbh, 8750 Aschaffenburg, De Drug contg. polypeptide homologous to nerve growth factor and slow virus sequence - for treating amyotrophic lateral sclerosis, spinal muscle atrophy or Parkinson's disease
EP0573904B1 (en) * 1992-06-08 2001-09-26 Takeda Chemical Industries, Ltd. Therapeutic agent for neutropenia
WO1993025684A1 (en) * 1992-06-12 1993-12-23 Regeneron Pharmaceuticals, Inc. Therapeutic and diagnostic methods based on neurotrophin-4 expression
ZA936478B (en) * 1992-09-03 1994-09-30 Regeneron Pharma Dorsal tissue affecting factor and compositions
JP3560609B2 (ja) * 1992-11-13 2004-09-02 イミュネックス・コーポレーション Ｅｌｋリガンドと呼ばれる新規なサイトカイン
WO1994017831A1 (en) * 1993-02-11 1994-08-18 Erziehungsdirektion Of The Canton Zurich A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration
JPH07246040A (ja) * 1993-07-06 1995-09-26 Takeda Chem Ind Ltd ニューロトロフィン−３遺伝子が不活性化された胚幹細胞および該遺伝子発現不全動物
WO1995026363A1 (en) * 1994-03-29 1995-10-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Neurotrophin-6: a new member of the neurotrophin family
WO1995030434A1 (en) * 1994-05-06 1995-11-16 Regeneron Pharmaceuticals, Inc. Methods based on the role of neurotrophin 3 in female reproduction
US6303769B1 (en) 1994-07-08 2001-10-16 Immunex Corporation Lerk-5 dna
JP3738281B2 (ja) * 1994-07-22 2006-01-25 アベンティス ファーマ株式会社 新規な骨芽細胞増殖因子
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
AU693982B2 (en) * 1994-12-05 1998-07-09 Boehringer Mannheim Gmbh Genes and gene products for use in the diagnosis of degenerative nerve damage
US5859311A (en) * 1995-11-27 1999-01-12 University Of Kentucky Research Foundation Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
DE69738521T2 (de) 1996-04-05 2009-05-07 Novartis Vaccines and Diagnostics, Inc., Emeryville Alphaviren-vektors mit einer reduzierten inhibierung der synthese von zellmakromolekülen
AU6614398A (en) * 1997-01-17 1998-08-07 Institut National De La Sante Et De La Recherche Medicale Adenoviral-vector-mediated gene transfer into medullary motor neurons
WO1998032458A1 (en) 1997-01-23 1998-07-30 Sumitomo Pharmaceuticals Company, Limited Remedies for diabetes
EP1050758A1 (en) * 1999-05-03 2000-11-08 Evotec BioSystems AG Methods of diagnosing or treating neuropsychiatric diseases on basis of increased cerebrospinal fluid levels of neurotrophin 3
EP1173768B1 (en) * 1999-05-03 2006-10-25 Evotec AG Methods of diagnosing, prognosing, monitoring the progression or evaluating of a treatment of depression on basis of increased cerebrospinal fluid levels of neurotrophin 3
CN1112215C (zh) * 1999-12-28 2003-06-25 潘晓东 神经生长因子在治疗有机溶剂中毒性周围神经病中的用途
ATE446366T1 (de) * 2000-06-22 2009-11-15 Genentech Inc Agonistische monoklonale antikörper gegen trkc
WO2006108651A2 (en) * 2005-04-12 2006-10-19 Develogen Aktiengesellschaft Use of activin products for preventing and treating diabetes and/or metabolic syndrome
US20140314787A1 (en) 2011-11-08 2014-10-23 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute Treatment for neurodegenerative diseases
EP2776838A1 (en) 2011-11-08 2014-09-17 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Early diagnostic of neurodegenerative diseases
WO2014006114A1 (en) 2012-07-05 2014-01-09 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research New treatment for neurodegenerative diseases
CN110862447A (zh) * 2019-11-29 2020-03-06 武汉赛维尔生物科技有限公司 一种提高神经营养因子nt-3碱性蛋白产量的蛋白改造方法
CN113940308A (zh) * 2021-04-28 2022-01-18 重庆腾达牧业有限公司 大足黑山羊哺乳舍饲养管理方法

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* Cited by examiner, † Cited by third party
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US4699875A (en) * 1982-11-24 1987-10-13 Baylor College Of Medicine Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US6709837B1 (en) * 1989-03-10 2004-03-23 Takeda Chemical Industries, Inc. Polypeptide and production thereof
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US7020718B2 (en) 2000-05-15 2006-03-28 Hewlett-Packard Development Company, L.P. System and method of aggregating discontiguous address ranges into addresses and masks using a plurality of repeating address blocks

Also Published As

Publication number Publication date
GR900100647A (en) 1991-12-30
AU643705B2 (en) 1993-11-25
EP0441947A1 (en) 1991-08-21
FI105343B (fi) 2000-07-31
FI912105A0 (fi) 1991-04-30
CA2040437C (en) 2002-10-22
PT95153A (pt) 1991-05-22
CN1124342C (zh) 2003-10-15
LV10792B (en) 1995-12-20
IL95511A0 (en) 1991-06-30
CN1052141A (zh) 1991-06-12
DE69030719D1 (de) 1997-06-19
NZ235086A (en) 1993-10-26
SK423090A3 (en) 1999-02-11
ATE153074T1 (de) 1997-05-15
LV10792A (lv) 1995-08-20
EP0441947A4 (en) 1992-05-13
CA2040437A1 (en) 1991-03-01
CZ286015B6 (cs) 1999-12-15
IE903129A1 (en) 1991-03-13
GR1000980B (el) 1993-03-31
EP0441947B1 (en) 1997-05-14
NO911688L (no) 1991-05-31
CZ423090A3 (cs) 1999-09-15
KR920702865A (ko) 1992-10-28
SK279660B6 (sk) 1999-02-11
NO911688D0 (no) 1991-04-29
PT95153B (pt) 1993-12-31
WO1991003569A1 (en) 1991-03-21
SG70560A1 (en) 2000-02-22
IL95511A (en) 2000-10-31
KR100196203B1 (ko) 1999-06-15
DE69030719T2 (de) 1997-09-25
AU6404990A (en) 1991-04-08
NO303694B1 (no) 1998-08-17
HK1006579A1 (en) 1999-03-05

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