ES2101962T3 - La elucidacion y sintesis de las fenetilamidas de tetrapeptidos antineoplasticos del dolastatin 10. - Google Patents

La elucidacion y sintesis de las fenetilamidas de tetrapeptidos antineoplasticos del dolastatin 10.

Info

Publication number
ES2101962T3
ES2101962T3 ES93309708T ES93309708T ES2101962T3 ES 2101962 T3 ES2101962 T3 ES 2101962T3 ES 93309708 T ES93309708 T ES 93309708T ES 93309708 T ES93309708 T ES 93309708T ES 2101962 T3 ES2101962 T3 ES 2101962T3
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ES
Spain
Prior art keywords
dolastatin
synthesis
antineoplastic activity
fenetilamides
tetrapeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93309708T
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English (en)
Inventor
George R Petit
Jozsef Barkoczy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Arizona
Arizona's Public Universities
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University of Arizona
Arizona's Public Universities
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25531838&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2101962(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Arizona, Arizona's Public Universities filed Critical University of Arizona
Application granted granted Critical
Publication of ES2101962T3 publication Critical patent/ES2101962T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA DOLASTATINA 10, UN PENTAPEPTIDO LINEAL, HA DEMOSTRADO POSEER POTENTES PERFILES DE ACTIVIDAD ANTINEOPLASTICA CONTRA VARIOS SISTEMAS EXPERIMENTALES DEL CANCER. SE HA CONSEGUIDO EL DISEÑO Y SINTESIS DE LAS MODIFICACIONES ESTRUCTURALES DE LA DOLASTATINA 10 QUE TIENE UNA ACTIVIDAD ANTINEOPLASTICA SIGNIFICATIVA CONTRA LAS LINEAS DE CELULAS DEL CANCER HUMANO. MIEMBROS DE ESTE GRUPO HAN DEMOSTRADO UNA ACTIVIDAD ANTINEOPLASTICA SIGNIFICATIVA CONTRA LINEAS DE CELULAS DEL CANCER HUMANO. ESPECIALMENTE: OVARIOS OVCAR-3; SISTEMA NERVIOSO CENTRAL ("CNS") SF295; RENAL A498; PULMON NCI460; COLON KM20L2 Y MELANOMA SK - 3.
ES93309708T 1992-12-03 1993-12-03 La elucidacion y sintesis de las fenetilamidas de tetrapeptidos antineoplasticos del dolastatin 10. Expired - Lifetime ES2101962T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/985,831 US6034065A (en) 1992-12-03 1992-12-03 Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10

Publications (1)

Publication Number Publication Date
ES2101962T3 true ES2101962T3 (es) 1997-07-16

Family

ID=25531838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93309708T Expired - Lifetime ES2101962T3 (es) 1992-12-03 1993-12-03 La elucidacion y sintesis de las fenetilamidas de tetrapeptidos antineoplasticos del dolastatin 10.

Country Status (9)

Country Link
US (1) US6034065A (es)
EP (1) EP0600745B1 (es)
JP (1) JP3451493B2 (es)
AT (1) ATE150467T1 (es)
CA (1) CA2110556C (es)
DE (1) DE69308999T2 (es)
DK (1) DK0600745T3 (es)
ES (1) ES2101962T3 (es)
GR (1) GR3023384T3 (es)

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