ES2102366T3 - Superficies que presentan efectos deseables de adherencia celular. - Google Patents

Superficies que presentan efectos deseables de adherencia celular.

Info

Publication number
ES2102366T3
ES2102366T3 ES90914567T ES90914567T ES2102366T3 ES 2102366 T3 ES2102366 T3 ES 2102366T3 ES 90914567 T ES90914567 T ES 90914567T ES 90914567 T ES90914567 T ES 90914567T ES 2102366 T3 ES2102366 T3 ES 2102366T3
Authority
ES
Spain
Prior art keywords
treated
methods
hydroxyl units
amino acid
cell adhesion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90914567T
Other languages
English (en)
Inventor
Jeffrey A Hubbell
Stephen P Massia
Neil P Desai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/414,144 external-priority patent/US5278063A/en
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Application granted granted Critical
Publication of ES2102366T3 publication Critical patent/ES2102366T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • A61L17/145—Coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/044—Proteins; Polypeptides; Degradation products thereof
    • A61L29/048—Other specific proteins or polypeptides not covered by A61L29/045 - A61L29/047
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Primary Cells (AREA)
  • Sealing Battery Cases Or Jackets (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

SE DESCRIBE UNA SUPERFICIE DE ADHESION CELULAR DE ABSORCION DE PROTEINA INDEPENDIENTE. LA SUPERFICIE TRATADA COMPRENDE UN MATERIAL DE DERIVACION QUIMICA AL CUAL ESTAN COVALENTEMENTE LIGADOS PEQUEÑOS PEPTIDOS, TENIENDO MENOS DE 12 RESIDUOS AMINO ACIDOS E INCLUYENDO YIGSR, RGD O REDY SECUENCIAS AMINO ACIDAS. LOS PEPTIDOS DE ESTA INVENCION INCLUYEN UN AMINO ACIDO DE GLICINA TERMINAL. LA ACTIVACION DE CLORURO DE MESILO DE UNIDADES DE HIDROXILO SUPERFICIALES PROPORCIONA LOS LUGARES DE SUPERFICIE ACTIVA POR LOS CUALES UN BRAZO DE GLICINA TERMINAL DE UN PEPTIDO SELECCIONADO SE UNE PARA FORMAR UNIONES COVALENTES ENTRE EL SUSTRATO Y EL PEPTIDO. COMO POR EJEMPLO, SUPERFICIES QUE SE PUEDEN UTILIZAR EN CONJUNCION CON ESTA INVENCION INCLUYEN SUPERFICIES DE POLIMERO, METAL Y CERAMICA. ESTOS METODOS INCLUYEN TAMBIEN UN METODO DE PRETRATAMIENTO QUE PROPORCIONA UNIDADES HIDROXILAS A SUPERFICIES DESPROVISTAS DE UNIDADES HIDROXILAS FACILMENTE DISPONIBLES. SE INCLUYEN TAMBIEN EN ESTA INVENCION METODOS PARA PREPARAR LAS SUPERFICIES TRATADAS. TAMBIEN ESTAN INCLUIDAS DISPOSITIVOS DE IMPLANTE BIOMEDICO TRATADOS EN SUPERFICIE Y DISPOSITIVOS DE CULTIVO CELULAR . LA SUPERFICIE TRATADA PROMOCIONA UNA VELOCIDAD REALZADA Y UNA CANTIDAD REALZADA DE ADHESION CELULAR A LA SUPERFICIE INDEPENDIENTE DE LAS CONCENTRACIONES DE MEDIOS DE SUERO U OTRAS PROTEINAS ABSORBIDAS. LA INVENCION CONCIERNE TAMBIEN A SUSTRATOS POLIMERICOS CON UNA SUPERFICIE TENIENDO CADENAS DE POLIMERO SOLUBLES EN AGUA DE PENETRACION FISICA, Y METODOS PARA SU PRODUCCION.
ES90914567T 1989-09-28 1990-09-27 Superficies que presentan efectos deseables de adherencia celular. Expired - Lifetime ES2102366T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/414,144 US5278063A (en) 1989-09-28 1989-09-28 Chemical modification of promote animal cell adhesion on surfaces
US07/527,198 US5330911A (en) 1989-09-28 1990-05-21 Surfaces having desirable cell adhesive effects

Publications (1)

Publication Number Publication Date
ES2102366T3 true ES2102366T3 (es) 1997-08-01

Family

ID=27022433

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90914567T Expired - Lifetime ES2102366T3 (es) 1989-09-28 1990-09-27 Superficies que presentan efectos deseables de adherencia celular.

Country Status (10)

Country Link
US (1) US5330911A (es)
EP (1) EP0494216B1 (es)
JP (1) JPH05502998A (es)
AT (1) ATE153064T1 (es)
AU (1) AU646644B2 (es)
CA (1) CA2066213A1 (es)
DE (1) DE69030730T2 (es)
DK (1) DK0494216T3 (es)
ES (1) ES2102366T3 (es)
WO (1) WO1991005036A2 (es)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
DE69118826T2 (de) * 1990-11-27 1996-11-14 Fuji Photo Film Co Ltd Propenamidderivate, deren Polymere, Copolymere und deren Verwendung
US5197973A (en) * 1990-12-14 1993-03-30 Creative Biomolecules, Inc. Synthetic bioadhesive
JPH05252941A (ja) * 1991-08-12 1993-10-05 Sakai Enetsukusu Kk 動物細胞培養用担体
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
EP0567886A3 (en) * 1992-04-21 1994-11-02 Kurashiki Boseki Kk Composition for a layer for culturing animal adhesive cells and method for culturing cells in a serum-free medium.
USRE36844E (en) * 1993-04-05 2000-08-29 Desmos Incorporated Cellular attachment to trans-epithelial appliances
US5585267A (en) * 1993-04-05 1996-12-17 Desmos, Inc. Cellular attachment to trans-epithelial appliances
AU6486494A (en) * 1993-06-24 1995-01-05 Siemens Aktiengesellschaft Compound and method of applying anti-fouling coatings on medical devices
JP2500472B2 (ja) * 1993-10-06 1996-05-29 日本電気株式会社 細胞配列培養装置およびその方法
DE4339524C2 (de) * 1993-11-19 1999-02-18 Konrad Prof Dr Planz Vorrichtung und System zum temporären Schienen im Harnleiter- und Harnröhrentrakt
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
USRE38827E1 (en) 1994-07-27 2005-10-11 3M Innovative Properties Company Adhesive sealant composition
US5677276A (en) * 1994-12-23 1997-10-14 La Jolla Cancer Research Foundation Immobilization of peptides to hyaluronate
DE19505070C2 (de) * 1995-02-15 1997-03-27 Axel Prof Dr Med Haverich Künstliche Gefäßsysteme und Verfahren zu ihrer Herstellung
US5733538A (en) * 1995-06-07 1998-03-31 Thoratec Laboratories, Inc. Surface-modifying copolymers having cell adhesion properties
EP0877620A4 (en) * 1996-01-16 1999-04-14 Rensselaer Polytech Inst PEPTIDES USED FOR MODIFYING OSTEOBLASTIC ADHESION
EP0891421A4 (en) 1996-03-18 2001-07-25 Univ Pennsylvania BIOACTIVE SUBSTRATE MATERIAL FOR IMPROVED CELLULAR FIXATION AND FUNCTION
US5874165A (en) * 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
US5914182A (en) * 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
WO1998004680A1 (en) * 1996-07-26 1998-02-05 University Of Manitoba Serum-free medium for growth of anchorage-dependant mammalian cells
US6443942B2 (en) 1996-11-01 2002-09-03 Minimed, Inc. Medication device with protein stabilizing surface coating
WO1998019627A1 (en) * 1996-11-01 1998-05-14 Minimed Inc. Medication infusion pump with protein stabilized surface coating
DE19706667A1 (de) * 1997-02-20 1998-08-27 Merck Patent Gmbh Knochenersatzmaterial mit einer Oberflächenbelegung mit Peptiden mit RGD-Aminosäuresequenz
AU7121198A (en) * 1997-04-18 1998-11-13 California Institute Of Technology Multifunctional polymeric tissue coatings
US6548263B1 (en) * 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6368877B1 (en) * 1997-06-25 2002-04-09 Massachusetts Institute Of Technology Self-assembling peptide surfaces for cell patterning and interactions
DE19881727D2 (de) * 1997-11-24 2001-01-04 Herbert P Jennissen Verfahren zur Immobilisierung von Mediatormolekülen auf anorganischen und metallischen Implantatmaterialien
US6140127A (en) * 1998-02-18 2000-10-31 Cordis Corporation Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
US6267784B1 (en) 1998-05-01 2001-07-31 Benz Research And Development Corporation Intraocular lens and haptics made of a copolymer
US6096799A (en) 1998-05-07 2000-08-01 Benz Research & Development Corporation Contact lens of high water content and high water balance
US6428579B1 (en) 1998-07-01 2002-08-06 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
JP2003513682A (ja) * 1998-07-24 2003-04-15 ファーマカル、バイオテクノロジーズ、インコーポレーテッド 骨組織復元システムおよび方法
CA2359318C (en) 1999-02-01 2009-06-30 Universitat Zurich Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
US6958212B1 (en) * 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
JP2002537025A (ja) * 1999-02-17 2002-11-05 スーファルク アンパーツゼルスカブ 新規な機能を有する生体適合性材料
DE60041255D1 (de) * 1999-04-28 2009-02-12 Eidgenoess Tech Hochschule Polyionische beschichtungen für analytische und sensor-vorrichtungen
WO2001042786A2 (en) * 1999-12-09 2001-06-14 Cellomics, Inc. System for cell based screening : cell spreading
US6836559B2 (en) 2000-03-09 2004-12-28 The Regents Of The University Of California Automated video-microscopic imaging and data acquisition system for colloid deposition measurements
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
DE10037850A1 (de) * 2000-08-01 2002-02-21 Herbert P Jennissen Verfahren zur Herstellung bioaktiver Implantatoberflächen
EP1355965B1 (en) * 2000-10-19 2012-09-19 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method of synthesizing block copolymers for multifunctional self-assembled systems
US7326563B2 (en) 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
US7033821B2 (en) * 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US6844184B2 (en) * 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US6893851B2 (en) 2000-11-08 2005-05-17 Surface Logix, Inc. Method for arraying biomolecules and for monitoring cell motility in real-time
US6864065B2 (en) * 2000-11-08 2005-03-08 Surface Logix, Inc. Assays for monitoring cell motility in real-time
US7033819B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. System for monitoring cell motility in real-time
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US20030044468A1 (en) * 2001-03-20 2003-03-06 Francesco Cellesi Two-phase processing of thermosensitive polymers for use as biomaterials
US7524513B2 (en) 2001-06-15 2009-04-28 Mao Hai-Quan Biofunctional fibers
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169578B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7101693B2 (en) * 2001-09-07 2006-09-05 Brigham Young University Plasticized hydrophilic glasses for improved stabilization of biological agents
EP1444325A4 (en) * 2001-11-15 2006-02-15 Becton Dickinson Co METHODS AND DEVICES FOR INTEGRATED DISCOVERY OF CELL CULTURE ENVIRONMENTS
US7041506B2 (en) * 2001-11-19 2006-05-09 Becton Dickinson And Company Peptides promoting cell adherence, growth and secretion
US20030179692A1 (en) * 2002-03-19 2003-09-25 Yoshitaka Ohotomo Storage medium
US8282912B2 (en) * 2002-03-22 2012-10-09 Kuros Biosurgery, AG Compositions for tissue augmentation
US9492111B2 (en) * 2002-04-22 2016-11-15 Medtronic Minimed, Inc. Methods and materials for stabilizing analyte sensors
US7813780B2 (en) * 2005-12-13 2010-10-12 Medtronic Minimed, Inc. Biosensors and methods for making and using them
US20070227907A1 (en) * 2006-04-04 2007-10-04 Rajiv Shah Methods and materials for controlling the electrochemistry of analyte sensors
KR20050042819A (ko) 2002-09-13 2005-05-10 오큘라 사이언시즈, 인크. 시력 개선 장치 및 방법
US20040062882A1 (en) * 2002-09-30 2004-04-01 Andrea Liebmann-Vinson Cell adhesion resisting surfaces
US20050272989A1 (en) * 2004-06-04 2005-12-08 Medtronic Minimed, Inc. Analyte sensors and methods for making and using them
US20040074785A1 (en) * 2002-10-18 2004-04-22 Holker James D. Analyte sensors and methods for making them
US9237865B2 (en) * 2002-10-18 2016-01-19 Medtronic Minimed, Inc. Analyte sensors and methods for making and using them
EP1691854B1 (en) * 2003-11-03 2011-09-14 Medtronic, Inc. Hydrogel providing cell-specific ingrowth
WO2005072764A2 (en) * 2004-01-16 2005-08-11 Novocell, Inc. Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
KR101013999B1 (ko) 2004-03-19 2011-02-14 재단법인서울대학교산학협력재단 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
CN1972643A (zh) 2004-05-20 2007-05-30 库柏维景公司 用于提高视力的角膜覆盖物和波前像差矫正
WO2006026504A2 (en) * 2004-08-27 2006-03-09 Spherics, Inc. Mucoadhesive oral formulations of high permeability, high solubility drugs
AU2005286684B2 (en) 2004-09-23 2012-01-19 Tripath Imaging, Inc. Polycationic polymer coatings for immobilizing biological samples
CA2585215A1 (en) * 2004-10-28 2006-05-11 Surmodics, Inc. Pro-fibrotic coatings comprising collagen for medical implants
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US7387642B2 (en) * 2005-04-13 2008-06-17 Benz Research And Development Corporation Polymers for intraocular lenses
JP5329949B2 (ja) * 2005-05-31 2013-10-30 エコーレ ポリテクニーク フェデラーレ デ ローザンヌ 遺伝子に基づいた薬物の細胞質送達のためのトリブロックコポリマー
CN101405384B (zh) * 2006-03-17 2013-12-04 三洋化成工业株式会社 细胞培养用载体以及制造方法和应用
US7883520B2 (en) 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
EP2136850B1 (en) * 2007-04-13 2012-02-01 Kuros Biosurgery AG Polymeric tissue sealant
EP2193365A4 (en) * 2007-08-20 2015-05-13 Platypus Technologies Llc IMPROVED DEVICES FOR CELL TESTS
WO2009099539A2 (en) * 2008-01-30 2009-08-13 Corning Incorporated (meth)acrylate surfaces for cell culture, methods of making and using the surfaces
US8329469B2 (en) 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
KR20110007600A (ko) * 2008-01-30 2011-01-24 제론 코포레이션 세포배양 제품 및 스크리닝하는 방법
US8513009B2 (en) 2008-01-30 2013-08-20 Geron Corporation Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
CN105400735A (zh) * 2008-01-30 2016-03-16 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的心肌细胞的合成表面
WO2010068432A1 (en) 2008-11-25 2010-06-17 Ecole Polytechnique Federale De Lausanne (Epfl) Block copolymers and uses thereof
US8362144B2 (en) * 2009-05-21 2013-01-29 Corning Incorporated Monomers for making polymeric cell culture surface
US8660628B2 (en) * 2009-12-21 2014-02-25 Medtronic Minimed, Inc. Analyte sensors comprising blended membrane compositions and methods for making and using them
FR2980208B1 (fr) * 2011-09-19 2018-03-16 Institut Curie Dispositif de guidage de la migration cellulaire et methode de guidage mettant en oeuvre un tel dispositif
US10711106B2 (en) 2013-07-25 2020-07-14 The University Of Chicago High aspect ratio nanofibril materials
KR101595647B1 (ko) * 2014-03-05 2016-02-18 단국대학교 천안캠퍼스 산학협력단 미세담체를 사용한 혈관내피세포의 분리방법
EP2988130A1 (en) * 2014-08-20 2016-02-24 Eppendorf Ag Method for coating a solid support
CN104874031B (zh) * 2015-04-20 2017-10-10 苏州大学 模拟人体纤溶系统和血管内皮系统的聚氨酯衍生物及制备方法及相关产物制备方法
US11150251B2 (en) 2016-10-07 2021-10-19 Clemson University Research Foundation Bi-functional arginine-glycine-aspartic acid (RGD) peptides and methods to promote angiogenesis
CN110873795B (zh) * 2018-08-30 2023-04-07 华东理工大学 一种生物芯片及其制备和应用
JP7343924B2 (ja) * 2019-11-05 2023-09-13 国立大学法人東海国立大学機構 ポリペプチド
DE102021102377A1 (de) * 2021-02-02 2022-08-04 Phenox Gmbh Beschichtung für Medizinprodukte
CN114101012A (zh) * 2021-11-24 2022-03-01 泉州医学高等专科学校 一种Tresyl-氯修饰FN的种植体微沟槽钛片及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
WO1988001279A1 (en) * 1986-08-15 1988-02-25 Commonwealth Scientific And Industrial Research Or Promoting cell adhesion and growth on a substrate
IL85372A (en) * 1987-02-12 1992-12-01 Us Health Penta to nona-peptides with laminin - like activity having an amino acid sequence and anti- metastatic compositions containing them
US5092885A (en) * 1987-02-12 1992-03-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Peptides with laminin activity
US7221982B2 (en) * 2004-07-12 2007-05-22 Cardiac Pacemakers, Inc. Apparatus and method of coating implantable leads

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ATE153064T1 (de) 1997-05-15
EP0494216A1 (en) 1992-07-15
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AU6447290A (en) 1991-04-28
DE69030730T2 (de) 1998-01-02
AU646644B2 (en) 1994-03-03
WO1991005036A2 (en) 1991-04-18
WO1991005036A3 (en) 1991-05-16
JPH05502998A (ja) 1993-05-27
CA2066213A1 (en) 1991-03-29
EP0494216B1 (en) 1997-05-14
DE69030730D1 (de) 1997-06-19
US5330911A (en) 1994-07-19

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