ES2102423T3 - Composicion para el control del dolor y metodo de preparacion. - Google Patents

Composicion para el control del dolor y metodo de preparacion.

Info

Publication number
ES2102423T3
ES2102423T3 ES92107732T ES92107732T ES2102423T3 ES 2102423 T3 ES2102423 T3 ES 2102423T3 ES 92107732 T ES92107732 T ES 92107732T ES 92107732 T ES92107732 T ES 92107732T ES 2102423 T3 ES2102423 T3 ES 2102423T3
Authority
ES
Spain
Prior art keywords
butil
aminobenzoate
preparation
composition
range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92107732T
Other languages
English (en)
Inventor
Morton Shulman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2102423T3 publication Critical patent/ES2102423T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTA UN COMPUESTO, PARA PRODUCIR UN ALIVIO DEL DOLOR EN UNA ZONA DEL CUERPO, EL COMPUESTO COMPRENDE UNA SUSPENSION ESTABLE Y ESTERIL DE AMINOBENZOATO DE BUTIL EN UN MEDIO PORTADOR ACUOSO NO TOXICO EN EL CUAL EL AMINOBENZOATO DE BUTIL ES SUBSTANCIALMENTE INSOLUBLE. EL MEDIO PORTADOR ACUOSO CONSTA ESENCIALMENTE DE AGUA COMO CONSTITUYENTE PRINCIPAL Y DE UN AGENTE SUSPENSANTE COMPUESTO DE A) UN GLICOL DE POLIETILENO Y B) UN AGENTE HUMEDECEDOR PARA EL AMINOBENZOATO DE BUTIL, CON UNA RELACION DE A) RESPECTO A B) EN EL RANGO DE ENTRE 50 / 1 Y 125 / 1. EL AMINOBENZOATO DE BUTIL SE MUELE HASTA UN TAMAÑO DE PARTICULA EN EL RANGO DE ENTRE 5 Y 50 MICRONES EN LA PRESENCIA DEL AGENTE SUSPENSANTE.
ES92107732T 1991-05-09 1992-05-07 Composicion para el control del dolor y metodo de preparacion. Expired - Lifetime ES2102423T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69761891A 1991-05-09 1991-05-09
US07/870,767 US5206267A (en) 1991-05-09 1992-04-20 Pain controlling composition and method of preparation

Publications (1)

Publication Number Publication Date
ES2102423T3 true ES2102423T3 (es) 1997-08-01

Family

ID=27106049

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92107732T Expired - Lifetime ES2102423T3 (es) 1991-05-09 1992-05-07 Composicion para el control del dolor y metodo de preparacion.

Country Status (8)

Country Link
US (1) US5206267A (es)
EP (1) EP0512547B1 (es)
JP (1) JP2529055B2 (es)
CA (1) CA2068232C (es)
DE (1) DE69219197T2 (es)
DK (1) DK0512547T3 (es)
ES (1) ES2102423T3 (es)
NO (1) NO300113B1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
TW201023912A (en) 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
WO2010101989A1 (en) 2009-03-03 2010-09-10 Alcon Research, Ltd. PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
EP2627292B1 (en) 2010-10-15 2018-10-10 Clearside Biomedical, Inc. Device for ocular access
KR102467714B1 (ko) * 2012-11-08 2022-11-16 클리어사이드 바이오메디컬, 인코포레이드 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치
AU2014259694B2 (en) 2013-05-03 2018-11-08 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
WO2017192565A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
US10973681B2 (en) 2016-08-12 2021-04-13 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
US12090294B2 (en) 2017-05-02 2024-09-17 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB784659A (en) * 1954-11-26 1957-10-16 Upjohn Co Therapeutic compositions and aqueous suspensions thereof
US3337400A (en) * 1965-10-08 1967-08-22 Joel P Smith Aqueous post-surgical injection by infiltration with a local anesthetic, a substantially water-insoluble, local anti-inflammatory gluco corticoid, and an antibiotic
DE2714065A1 (de) * 1977-03-30 1978-10-12 Boehringer Mannheim Gmbh Instillationszubereitung
US4599354A (en) * 1985-03-11 1986-07-08 Morton Shulman Composition and method for producing prolonged pain relief
US4831023A (en) * 1986-06-27 1989-05-16 Thames Pharmacal Co., Inc. Water washable vehicles for topical use
JPH0794385B2 (ja) * 1987-11-28 1995-10-11 サンスター株式会社 口腔鎮痛用組成物
US5002974A (en) * 1988-04-04 1991-03-26 Warner-Lambert Co. Anesthetic/skin moisturizing composition and method of preparing same
NL9000634A (nl) * 1990-03-20 1991-10-16 Catharina Ziekenhuis Stichting Suspensie-injectiepreparaat op waterbasis, werkwijze voor de bereiding daarvan en toepassing van dit preparaat voor pijnbestrijding.

Also Published As

Publication number Publication date
EP0512547B1 (en) 1997-04-23
NO921834L (no) 1992-11-10
DK0512547T3 (da) 1997-08-25
JPH05155767A (ja) 1993-06-22
US5206267A (en) 1993-04-27
AU1614992A (en) 1992-11-12
CA2068232C (en) 1997-01-28
DE69219197T2 (de) 1997-08-07
NO921834D0 (no) 1992-05-08
CA2068232A1 (en) 1992-11-10
AU647999B2 (en) 1994-03-31
EP0512547A1 (en) 1992-11-11
DE69219197D1 (de) 1997-05-28
JP2529055B2 (ja) 1996-08-28
NO300113B1 (no) 1997-04-14

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