ES2102830T3 - Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco. - Google Patents

Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco.

Info

Publication number
ES2102830T3
ES2102830T3 ES94906446T ES94906446T ES2102830T3 ES 2102830 T3 ES2102830 T3 ES 2102830T3 ES 94906446 T ES94906446 T ES 94906446T ES 94906446 T ES94906446 T ES 94906446T ES 2102830 T3 ES2102830 T3 ES 2102830T3
Authority
ES
Spain
Prior art keywords
tumors
agents
drug resistance
alkyl piperidines
diaryl alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906446T
Other languages
English (en)
Inventor
Sai P Sunkara
Jules Freedman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2102830T3 publication Critical patent/ES2102830T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PIPERIDINAS DIARIALQUILO DE LA FORMULA (1) SE OPONEN A LA RESISTENCIA A LA DROGA EN TUMORES RESISTENTES A MULTIDROGAS. ESTOS COMPUESTOS APARENTEMENTE FUNCIONAN MEDIANTE LA INHIBICION DE UNA BOMBA DE UNA P-GLICOPROTEINA QUE SE ACTIVA EN EL ULTIMO ESTADO DE DESARROLLO DEL TUMOR Y QUE ESTA INHERENTEMENTE PRESENTE EN TUMORES DE CIERTOS ORIGENES.
ES94906446T 1993-01-21 1993-12-17 Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco. Expired - Lifetime ES2102830T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US656993A 1993-01-21 1993-01-21

Publications (1)

Publication Number Publication Date
ES2102830T3 true ES2102830T3 (es) 1997-08-01

Family

ID=21721516

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906446T Expired - Lifetime ES2102830T3 (es) 1993-01-21 1993-12-17 Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco.

Country Status (20)

Country Link
US (1) US5648365A (es)
EP (1) EP0680470B1 (es)
JP (1) JP3398748B2 (es)
KR (1) KR100377280B1 (es)
AT (1) ATE150748T1 (es)
AU (1) AU679723B2 (es)
CA (1) CA2152794C (es)
DE (1) DE69309310T2 (es)
DK (1) DK0680470T3 (es)
ES (1) ES2102830T3 (es)
FI (1) FI112474B (es)
GR (1) GR3023188T3 (es)
HU (1) HUT72078A (es)
IL (1) IL108369A (es)
MX (1) MX9400563A (es)
NO (1) NO305166B1 (es)
NZ (1) NZ261414A (es)
TW (1) TW243445B (es)
WO (1) WO1994017040A1 (es)
ZA (1) ZA94317B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0643693T3 (da) * 1992-02-06 1999-11-29 Merrell Pharma Inc Reversering af multi-lægemiddelresistens med triphenyl-piperidin-derivater
WO2001007034A1 (en) * 1999-07-23 2001-02-01 Colorado State University Research Foundation Multidrug resistance pump inhibitors and uses thereof
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2465886A1 (en) * 2001-11-07 2003-05-15 Kathleen S. Crowley Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
US8153184B2 (en) * 2001-11-26 2012-04-10 Samsung Mobile Display Co., Ltd. Organic EL display device and method of manufacturing the same
KR100656490B1 (ko) 2001-11-26 2006-12-12 삼성에스디아이 주식회사 풀칼라 유기전계 발광표시소자 및 그의 제조방법
CN108902893B (zh) 2013-02-08 2022-02-25 通用磨坊公司 低钠食品
CN110372571B (zh) * 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1049377B (de) * 1952-04-03 1959-01-29 Abbott Laboratories, North Chicago, 111. (V. St. A.) Verfahren zur Herstellung von substituierten Vinylpiperidinen
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US4035372A (en) * 1976-08-13 1977-07-12 G. D. Searle & Co. 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
US4851423A (en) * 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
US4990511A (en) * 1988-08-03 1991-02-05 Takeda Chemical Industries, Ltd. Amide compounds, their production and use
AU650421B2 (en) * 1989-06-19 1994-06-23 Wellcome Foundation Limited, The Medicaments useful in cancer therapy and having antihistaminic properties
GB9000305D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Anticholinergic agents
EP0467435A3 (en) * 1990-07-19 1992-04-01 Akzo N.V. Benzhydryl derivatives having calmodulin inhibitor properties
DE69128820T2 (de) * 1990-08-14 1998-06-10 Hoechst Marion Roussel Inc Neue 19-Nor Steroide, die eine Amid tragende Gruppe in der 11-Beta-Stelle haben, ihre Herstellung, ihre Verwendung als Medikamente und pharmazeutische Präparate davon
DK0643693T3 (da) * 1992-02-06 1999-11-29 Merrell Pharma Inc Reversering af multi-lægemiddelresistens med triphenyl-piperidin-derivater

Also Published As

Publication number Publication date
GR3023188T3 (en) 1997-07-30
NO952885D0 (no) 1995-07-20
JPH08505870A (ja) 1996-06-25
KR100377280B1 (ko) 2003-07-18
HU9502195D0 (en) 1995-09-28
NO952885L (no) 1995-09-20
NO305166B1 (no) 1999-04-12
NZ261414A (en) 1997-06-24
DE69309310D1 (de) 1997-04-30
EP0680470B1 (en) 1997-03-26
TW243445B (es) 1995-03-21
CA2152794C (en) 1999-04-06
ATE150748T1 (de) 1997-04-15
AU679723B2 (en) 1997-07-10
CA2152794A1 (en) 1994-08-04
HUT72078A (en) 1996-03-28
KR960700230A (ko) 1996-01-19
WO1994017040A1 (en) 1994-08-04
ZA94317B (en) 1994-08-18
FI112474B (fi) 2003-12-15
IL108369A0 (en) 1994-04-12
FI953506L (fi) 1995-07-20
DK0680470T3 (es) 1997-04-28
AU6014894A (en) 1994-08-15
US5648365A (en) 1997-07-15
MX9400563A (es) 1994-07-29
DE69309310T2 (de) 1997-11-06
EP0680470A1 (en) 1995-11-08
FI953506A0 (fi) 1995-07-20
IL108369A (en) 1999-08-17
JP3398748B2 (ja) 2003-04-21

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