DK0643693T3 - Reversering af multi-lægemiddelresistens med triphenyl-piperidin-derivater - Google Patents
Reversering af multi-lægemiddelresistens med triphenyl-piperidin-derivaterInfo
- Publication number
- DK0643693T3 DK0643693T3 DK93903678T DK93903678T DK0643693T3 DK 0643693 T3 DK0643693 T3 DK 0643693T3 DK 93903678 T DK93903678 T DK 93903678T DK 93903678 T DK93903678 T DK 93903678T DK 0643693 T3 DK0643693 T3 DK 0643693T3
- Authority
- DK
- Denmark
- Prior art keywords
- integer
- tumors
- triphenyl
- reversal
- drug resistance
- Prior art date
Links
- 230000036457 multidrug resistance Effects 0.000 title abstract 2
- OAAXCRABNCVUNG-UHFFFAOYSA-N 1,2,2-triphenylpiperidine Chemical class C1CCCC(C=2C=CC=CC=2)(C=2C=CC=CC=2)N1C1=CC=CC=C1 OAAXCRABNCVUNG-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- -1 bromo, hydroxy Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 abstract 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000005748 tumor development Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83254092A | 1992-02-06 | 1992-02-06 | |
| PCT/US1993/000669 WO1993016044A1 (en) | 1992-02-06 | 1993-01-11 | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0643693T3 true DK0643693T3 (da) | 1999-11-29 |
Family
ID=25261950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93903678T DK0643693T3 (da) | 1992-02-06 | 1993-01-11 | Reversering af multi-lægemiddelresistens med triphenyl-piperidin-derivater |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0643693B1 (da) |
| JP (1) | JPH07503957A (da) |
| KR (1) | KR950700248A (da) |
| AT (1) | ATE182582T1 (da) |
| AU (1) | AU662602B2 (da) |
| CA (1) | CA2129144C (da) |
| DE (1) | DE69325805T2 (da) |
| DK (1) | DK0643693T3 (da) |
| ES (1) | ES2135463T3 (da) |
| GR (1) | GR3031557T3 (da) |
| HU (1) | HUT70564A (da) |
| NO (1) | NO942920L (da) |
| NZ (1) | NZ249040A (da) |
| WO (1) | WO1993016044A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2102830T3 (es) * | 1993-01-21 | 1997-08-01 | Merrell Pharma Inc | Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco. |
| US5670521A (en) * | 1994-08-05 | 1997-09-23 | Merrell Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
| EP0777472A2 (en) | 1994-08-31 | 1997-06-11 | Eli Lilly And Company | Methods for identifying and treating resistant tumors |
| TW527186B (en) * | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
| GB0003685D0 (en) * | 2000-02-17 | 2000-04-05 | Univ Cardiff | Sensitisation of cellular material |
| CN110372571B (zh) * | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
| AU2021325024A1 (en) * | 2020-08-11 | 2023-04-13 | Board Of Trustees Of Michigan State University | Proteasome enhancers and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1049377B (de) * | 1952-04-03 | 1959-01-29 | Abbott Laboratories, North Chicago, 111. (V. St. A.) | Verfahren zur Herstellung von substituierten Vinylpiperidinen |
| EP0228893A3 (en) * | 1985-12-20 | 1990-01-03 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment |
| AU650421B2 (en) * | 1989-06-19 | 1994-06-23 | Wellcome Foundation Limited, The | Medicaments useful in cancer therapy and having antihistaminic properties |
| GB9000305D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Anticholinergic agents |
| EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
| ES2102830T3 (es) * | 1993-01-21 | 1997-08-01 | Merrell Pharma Inc | Diarilalquil piperidinas utiles como agentes para tumores con resistencia multifarmaco. |
-
1993
- 1993-01-11 DK DK93903678T patent/DK0643693T3/da active
- 1993-01-11 JP JP5514096A patent/JPH07503957A/ja active Pending
- 1993-01-11 WO PCT/US1993/000669 patent/WO1993016044A1/en not_active Ceased
- 1993-01-11 DE DE69325805T patent/DE69325805T2/de not_active Expired - Fee Related
- 1993-01-11 AU AU34842/93A patent/AU662602B2/en not_active Ceased
- 1993-01-11 CA CA002129144A patent/CA2129144C/en not_active Expired - Fee Related
- 1993-01-11 EP EP93903678A patent/EP0643693B1/en not_active Expired - Lifetime
- 1993-01-11 HU HU9402298A patent/HUT70564A/hu unknown
- 1993-01-11 ES ES93903678T patent/ES2135463T3/es not_active Expired - Lifetime
- 1993-01-11 AT AT93903678T patent/ATE182582T1/de not_active IP Right Cessation
- 1993-01-11 NZ NZ249040A patent/NZ249040A/en unknown
-
1994
- 1994-08-05 NO NO942920A patent/NO942920L/no unknown
- 1994-08-05 KR KR1019940702687A patent/KR950700248A/ko not_active Ceased
-
1999
- 1999-10-15 GR GR990402651T patent/GR3031557T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3031557T3 (en) | 2000-01-31 |
| WO1993016044A1 (en) | 1993-08-19 |
| CA2129144C (en) | 1999-07-13 |
| JPH07503957A (ja) | 1995-04-27 |
| HU9402298D0 (en) | 1994-10-28 |
| NZ249040A (en) | 1997-06-24 |
| ATE182582T1 (de) | 1999-08-15 |
| NO942920L (no) | 1994-08-05 |
| HUT70564A (en) | 1995-10-30 |
| CA2129144A1 (en) | 1993-08-19 |
| AU3484293A (en) | 1993-09-03 |
| EP0643693B1 (en) | 1999-07-28 |
| EP0643693A1 (en) | 1995-03-22 |
| NO942920D0 (da) | 1994-08-05 |
| DE69325805D1 (de) | 1999-09-02 |
| DE69325805T2 (de) | 2000-03-16 |
| AU662602B2 (en) | 1995-09-07 |
| KR950700248A (ko) | 1995-01-16 |
| ES2135463T3 (es) | 1999-11-01 |
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