ES2103832T3 - Derivados de 2-fenil y 2-tienil-(2)-piperidina que tienen propiedades neuroprotectoras. - Google Patents

Derivados de 2-fenil y 2-tienil-(2)-piperidina que tienen propiedades neuroprotectoras.

Info

Publication number
ES2103832T3
ES2103832T3 ES91920369T ES91920369T ES2103832T3 ES 2103832 T3 ES2103832 T3 ES 2103832T3 ES 91920369 T ES91920369 T ES 91920369T ES 91920369 T ES91920369 T ES 91920369T ES 2103832 T3 ES2103832 T3 ES 2103832T3
Authority
ES
Spain
Prior art keywords
tienyl
neuroprotecting
piperidine
phenyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91920369T
Other languages
English (en)
Inventor
Ronald Conrad Griffith
Richard John Schmiesing
Robert John Murray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2103832T3 publication Critical patent/ES2103832T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I) EN DONDE R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTE, REPRESENTAN HIDROGENO O C1-6 ALQUIL, R3 Y R4 DE FORMA INDEPENDIENTE REPRESENTAN UNO O MULTIPLES RADICALES SELECCIONADOS DE HIDROGENO, HALOGENO, NH2, NO2, HALOGENO, HIDROXIL, C1-6 ALCOXI O C1-6 ALQUIL, X REPRESENTA S O UN GRUPO CH = CH -, Y LOS DERIVADOS ADMISIBLES FARMACEUTICAMENTE A PARTIR DE ESTOS COMPUESTOS QUE SON UTILIZADOS COMO PRODUCTOS FARMACEUTICOS, EN PARTICULAR LOS QUE POSEEN N ARTATO (NMDA) DISPONIENDO DE PROPIEDADES DE BLOQUEO Y SIENDO UTILIZADOS EN EL TRATAMIENTO Y/O PREVENCION DE DESORDENES NEUROLOGICOS.
ES91920369T 1990-10-15 1991-10-11 Derivados de 2-fenil y 2-tienil-(2)-piperidina que tienen propiedades neuroprotectoras. Expired - Lifetime ES2103832T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59714790A 1990-10-15 1990-10-15

Publications (1)

Publication Number Publication Date
ES2103832T3 true ES2103832T3 (es) 1997-10-01

Family

ID=24390300

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91920369T Expired - Lifetime ES2103832T3 (es) 1990-10-15 1991-10-11 Derivados de 2-fenil y 2-tienil-(2)-piperidina que tienen propiedades neuroprotectoras.

Country Status (11)

Country Link
US (1) US5714500A (es)
EP (1) EP0553278B1 (es)
JP (1) JP3094450B2 (es)
AT (1) ATE154010T1 (es)
DE (1) DE69126438T2 (es)
DK (1) DK0553278T3 (es)
ES (1) ES2103832T3 (es)
GR (1) GR3024388T3 (es)
IE (1) IE913606A1 (es)
PT (1) PT99207B (es)
WO (1) WO1992006957A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW281670B (es) * 1993-09-02 1996-07-21 Hoffmann La Roche
US5563157B1 (en) 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
EP1436258A4 (en) * 2001-03-08 2005-03-23 Univ Emory PH VALVE DEPENDENT NMDA RECEPTOR ANTAGONISTS
KR20100045983A (ko) 2007-06-29 2010-05-04 에모리 유니버시티 신경보호를 위한 ｎｍｄａ 수용체 길항물질

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2524643A (en) * 1947-12-04 1950-10-03 Maltbie Lab Inc 3-phenyl-2-piperidones
US2636881A (en) * 1951-01-06 1953-04-28 Sharp & Dohme Inc 3-substituted, 3-aryl, 2-pipecolines and salts thereof
EP0317953A3 (en) * 1987-11-24 1990-12-05 G.D. Searle & Co. N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury
DE68914336T2 (de) * 1988-06-14 1994-09-08 Searle & Co 1,2-Diarylethylamine zur Behandlung neurotoxischer Verletzungen.
US4924008A (en) * 1989-05-04 1990-05-08 American Home Products Corporation Benzobicycloalkane derivatives as anticonvulsant neuroprotective agents
US5109017A (en) * 1990-09-26 1992-04-28 Fisons Corporation (2-thienyl)alkylamine derivatives having neuroprotective properties

Also Published As

Publication number Publication date
IE913606A1 (en) 1992-04-22
GR3024388T3 (en) 1997-11-28
DE69126438T2 (de) 1997-10-02
EP0553278A1 (en) 1993-08-04
EP0553278B1 (en) 1997-06-04
US5714500A (en) 1998-02-03
DE69126438D1 (de) 1997-07-10
ATE154010T1 (de) 1997-06-15
WO1992006957A1 (en) 1992-04-30
JP3094450B2 (ja) 2000-10-03
JPH06501701A (ja) 1994-02-24
PT99207B (pt) 1999-04-30
DK0553278T3 (da) 1997-08-25
PT99207A (pt) 1992-09-30

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