ATE168681T1 - 3-phenylureido-1,5-benzodiazepin-dione verwendbar als gastrin- oder cck antagonisten - Google Patents

3-phenylureido-1,5-benzodiazepin-dione verwendbar als gastrin- oder cck antagonisten

Info

Publication number: ATE168681T1
Authority: AT; Austria
Prior art keywords: phenylureido; gastrin; benzodiazepine; antagonists; pct
Prior art date: 1993-04-23

Application number

AT94915089T

Other languages

English (en)

Inventor

Harry Finch

David Gordon Trist

Aldo Feriani

Giorgio Tarzia

Pritom Shah

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-23

Filing date

1994-04-22

Publication date

1998-08-15

1994-04-22 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

1998-08-15 Application granted granted Critical

1998-08-15 Publication of ATE168681T1 publication Critical patent/ATE168681T1/de

Links

102100021022 Gastrin Human genes 0.000 title abstract 2
108010052343 Gastrins Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 title abstract 2
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT94915089T 1993-04-23 1994-04-22 3-phenylureido-1,5-benzodiazepin-dione verwendbar als gastrin- oder cck antagonisten ATE168681T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939308431A GB9308431D0 (en)	1993-04-23	1993-04-23	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE168681T1 true ATE168681T1 (de)	1998-08-15

Family

ID=10734357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94915089T ATE168681T1 (de)	1993-04-23	1994-04-22	3-phenylureido-1,5-benzodiazepin-dione verwendbar als gastrin- oder cck antagonisten

Country Status (8)

Country	Link
US (1)	US5641775A (de)
EP (1)	EP0698014B1 (de)
JP (1)	JPH08509236A (de)
AT (1)	ATE168681T1 (de)
AU (1)	AU6646894A (de)
DE (1)	DE69411909D1 (de)
GB (1)	GB9308431D0 (de)
WO (1)	WO1994025444A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9308431D0 (en) *	1993-04-23	1993-06-09	Glaxo Spa	Chemical compounds
US5739129A (en) *	1994-04-14	1998-04-14	Glaxo Wellcome Inc.	CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PE27497A1 (es) *	1994-04-15	1997-08-07	Glaxo Inc	Derivados de 1,5 benzodiazepina
CA2274669C (en) *	1996-12-10	2006-11-14	Zeria Pharmaceutical Co., Ltd.	1,5-benzodiazepine derivatives
JP2000026434A (ja)	1998-06-05	2000-01-25	Zeria Pharmaceut Co Ltd	新規１，５−ベンゾジアゼピン誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
IL101514A (en) *	1991-04-10	1996-01-31	Merck & Co Inc	Benzodiazepinone derivatives and cholecystokinin antagonist pharmaceutical compositions containing them
EP0538945A1 (de) *	1991-10-24	1993-04-28	Glaxo Group Limited	Benzodiazepinderivate, und ihre Verwendung als Gastrin und/oder Cholecystokinin-Antagonisten
GB9201180D0 (en) *	1992-01-21	1992-03-11	Glaxo Group Ltd	Chemical compounds
GB9308431D0 (en) *	1993-04-23	1993-06-09	Glaxo Spa	Chemical compounds

1993
- 1993-04-23 GB GB939308431A patent/GB9308431D0/en active Pending
1994
- 1994-04-22 AU AU66468/94A patent/AU6646894A/en not_active Abandoned
- 1994-04-22 EP EP94915089A patent/EP0698014B1/de not_active Expired - Lifetime
- 1994-04-22 WO PCT/EP1994/001252 patent/WO1994025444A1/en not_active Ceased
- 1994-04-22 US US08/532,811 patent/US5641775A/en not_active Expired - Fee Related
- 1994-04-22 DE DE69411909T patent/DE69411909D1/de not_active Expired - Lifetime
- 1994-04-22 AT AT94915089T patent/ATE168681T1/de active
- 1994-04-22 JP JP6523841A patent/JPH08509236A/ja active Pending

Also Published As

Publication number	Publication date
DE69411909D1 (de)	1998-08-27
WO1994025444A1 (en)	1994-11-10
JPH08509236A (ja)	1996-10-01
EP0698014B1 (de)	1998-07-22
US5641775A (en)	1997-06-24
AU6646894A (en)	1994-11-21
EP0698014A1 (de)	1996-02-28
GB9308431D0 (en)	1993-06-09

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IL104816A0 (en)	1993-06-10	Indoles
ATE168681T1 (de)	1998-08-15	3-phenylureido-1,5-benzodiazepin-dione verwendbar als gastrin- oder cck antagonisten
DK0689575T3 (da)	1997-08-18	Anthraquinoner som mærknigsmidler for mineralolier
FI970434A0 (fi)	1997-01-31	Uudet 3-substituoidut 3H-2,3-bentsodiatsepiinijohdannaiset, niiden valmistus ja käyttö lääkkeenä
GR3027609T3 (en)	1998-11-30	Carbamate derivatives and their use in medicine.
EP0641346A1 (de)	1995-03-08	Antibiotische 7-aminonaphthazarinderivate.
DE69332019D1 (de)	2002-07-18	4-oxo-und 4h-imidazo(5,1-c)(1,4)benzoxazine nützlich als benzodiazepinrezeptor-bindemittel.
FI971528A0 (fi)	1997-04-11	Pyrrolyylitetrahydrobentsokinoksaliinidionit, niiden valmistus ja käyttö glutamaattireseptoriantagonisteina
ES2175424T3 (es)	2002-11-16	Sal de metansulfonato de una arilpiperazina derivada de triptamina y sus solvatos para uso farmaceutico.
ATE154601T1 (de)	1997-07-15	4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten