|
US6132763A
(en)
*
|
1988-10-20 |
2000-10-17 |
Polymasc Pharmaceuticals Plc |
Liposomes
|
|
US6645463B1
(en)
|
1994-05-16 |
2003-11-11 |
The Board Of Regents Of The University Of Michigan |
Blood-pool selective carrier for lipophilic imaging agents
|
|
US20020055786A1
(en)
*
|
1994-08-16 |
2002-05-09 |
Anthony Atala |
Reconstruction of urological structures with polymeric matrices
|
|
US5688781A
(en)
*
|
1994-08-19 |
1997-11-18 |
Bristol-Myers Squibb Company |
Method for treating vascular leak syndrome
|
|
US5885613A
(en)
*
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5820873A
(en)
*
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
US6383814B1
(en)
*
|
1994-12-09 |
2002-05-07 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
US5948767A
(en)
*
|
1994-12-09 |
1999-09-07 |
Genzyme Corporation |
Cationic amphiphile/DNA complexes
|
|
GB9503486D0
(en)
*
|
1995-02-22 |
1995-04-12 |
Secr Defence |
Pharmaceuticals and assays using enzyme subunits
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
GB9509016D0
(en)
*
|
1995-05-03 |
1995-06-21 |
Royal Free Hosp School Med |
Tissue entrapment
|
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
|
US6673364B1
(en)
|
1995-06-07 |
2004-01-06 |
The University Of British Columbia |
Liposome having an exchangeable component
|
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US6331289B1
(en)
*
|
1996-10-28 |
2001-12-18 |
Nycomed Imaging As |
Targeted diagnostic/therapeutic agents having more than one different vectors
|
|
DE69735354T2
(de)
*
|
1996-10-28 |
2006-11-30 |
Amersham Health As |
Verbesserungen an oder in verbindung mit diagnostischen/therapeutischen verbindungen
|
|
US20070036722A1
(en)
*
|
1996-10-28 |
2007-02-15 |
Pal Rongved |
Separation processes
|
|
US6261537B1
(en)
*
|
1996-10-28 |
2001-07-17 |
Nycomed Imaging As |
Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
|
|
US5827533A
(en)
*
|
1997-02-06 |
1998-10-27 |
Duke University |
Liposomes containing active agents aggregated with lipid surfactants
|
|
WO1998046275A2
(en)
*
|
1997-04-11 |
1998-10-22 |
The Board Of Regents Of The University Of Michigan |
Blood-pool carrier for lipophilic imaging agents
|
|
US5948925A
(en)
*
|
1997-05-06 |
1999-09-07 |
Genzyme Corporation |
Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
|
|
US5952516A
(en)
*
|
1997-05-08 |
1999-09-14 |
Genzyme Corporation |
Cationic amphiphiles containing multiplesteroid lipophilic groups
|
|
US5942634A
(en)
*
|
1997-05-09 |
1999-08-24 |
Genzyme Corporation |
Cationic amphiphiles for cell transfections
|
|
DE69841002D1
(de)
*
|
1997-05-14 |
2009-09-03 |
Univ British Columbia |
Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
|
|
US6436365B2
(en)
*
|
1997-09-23 |
2002-08-20 |
Schering Aktiengesellschaft |
Process for therapeutic treatment of proliferative diseases
|
|
US20030220234A1
(en)
|
1998-11-02 |
2003-11-27 |
Selvaraj Naicker |
Deuterated cyclosporine analogs and their use as immunodulating agents
|
|
US6734171B1
(en)
|
1997-10-10 |
2004-05-11 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating nucleic acids in lipid bilayers
|
|
US6083923A
(en)
*
|
1997-10-31 |
2000-07-04 |
Isis Pharmaceuticals Inc. |
Liposomal oligonucleotide compositions for modulating RAS gene expression
|
|
ATE322255T1
(de)
*
|
1997-12-23 |
2006-04-15 |
Inex Pharmaceuticals Corp |
Polyamid-oligomere
|
|
US6320017B1
(en)
|
1997-12-23 |
2001-11-20 |
Inex Pharmaceuticals Corp. |
Polyamide oligomers
|
|
IL140892A0
(en)
*
|
1998-08-12 |
2002-02-10 |
Yissum Res Dev Co |
Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
|
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
|
US6613352B2
(en)
|
1999-04-13 |
2003-09-02 |
Universite De Montreal |
Low-rigidity liposomal formulation
|
|
EP1190705A4
(en)
*
|
1999-06-24 |
2009-03-18 |
Kyowa Hakko Kogyo Kk |
METHOD FOR REGULATING THE LEAKAGE OF ENCAPSULATED MEDICINES IN LIPOSOMES
|
|
ATE280571T1
(de)
*
|
1999-08-06 |
2004-11-15 |
Max Delbrueck Centrum |
Implantierbares wirkstoffdepot
|
|
US20030147944A1
(en)
*
|
1999-12-10 |
2003-08-07 |
Mayer Lawrence D |
Lipid carrier compositions with protected surface reactive functions
|
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20060122082A1
(en)
*
|
2000-02-17 |
2006-06-08 |
Leonard Paul |
Foam/spray producing compositions and dispensing system therefor
|
|
WO2002045688A2
(en)
*
|
2000-12-07 |
2002-06-13 |
Universiteit Utrecht Holding B.V. |
Composition for treatment of inflammatory disorders
|
|
DE10116197A1
(de)
*
|
2001-03-30 |
2002-10-17 |
Bernina Biosystems Gmbh |
Neue Methylprednisolonderivate mit therapeutischer Wirkung
|
|
US20030077829A1
(en)
*
|
2001-04-30 |
2003-04-24 |
Protiva Biotherapeutics Inc.. |
Lipid-based formulations
|
|
AU2002312410A1
(en)
*
|
2001-06-08 |
2002-12-23 |
Target Protein Technologies, Inc. |
Tissue-specific endothelial membrane proteins
|
|
US7803915B2
(en)
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
|
ES2372321T3
(es)
|
2001-06-20 |
2012-01-18 |
Genentech, Inc. |
Composiciones y métodos para el diagnóstico y tratamiento de un tumor de pulmón.
|
|
EP2270024B1
(en)
|
2001-06-21 |
2018-10-24 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
ATE486092T1
(de)
|
2001-09-18 |
2010-11-15 |
Genentech Inc |
Zusammensetzungen und verfahren für die diagnose von tumoren
|
|
DE10148065A1
(de)
*
|
2001-09-28 |
2003-04-17 |
Max Planck Gesellschaft |
(Ester)-Lysolecithine in Liposomen
|
|
NZ585001A
(en)
|
2001-10-09 |
2011-08-26 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
US20030087813A1
(en)
*
|
2001-10-12 |
2003-05-08 |
Or Yat Sun |
Cyclosporin analogs for the treatment of lung diseases
|
|
BRPI0213658A8
(pt)
|
2001-10-19 |
2016-12-06 |
F Hoffmann La Roche Ltd |
Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
|
|
JP2005506990A
(ja)
|
2001-10-19 |
2005-03-10 |
アイソテクニカ インコーポレーテッド |
新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
|
|
US20030228319A1
(en)
|
2002-04-16 |
2003-12-11 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
CA2465860A1
(en)
|
2001-11-02 |
2004-04-22 |
Insert Therapeutics, Inc. |
Methods and compositions for therapeutic use of rna interference
|
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
|
AU2002367318B2
(en)
|
2002-01-02 |
2007-07-12 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US6806095B2
(en)
*
|
2002-03-06 |
2004-10-19 |
Padmapani C. Nallan |
Method of plasma etching of high-K dielectric materials with high selectivity to underlying layers
|
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
|
US20050152962A1
(en)
*
|
2002-06-12 |
2005-07-14 |
Metselaar Josbert M. |
Composition for treatment of inflammatory disorders
|
|
EP1371362A1
(en)
*
|
2002-06-12 |
2003-12-17 |
Universiteit Utrecht Holding B.V. |
Composition for treatment of inflammatory disorders
|
|
AU2003268087A1
(en)
*
|
2002-08-23 |
2004-03-11 |
Ian Ma |
Liposomal gemcitabine compositions for better drug delivery
|
|
EP1393720A1
(en)
*
|
2002-08-27 |
2004-03-03 |
Universiteit Utrecht |
Vesicle-encapsulated corticosteroids for treatment of cancer
|
|
AR036316A1
(es)
*
|
2002-08-29 |
2004-08-25 |
Monte Verde S A |
Una composicion farmaceutica de liposomas de tamano pequeno y metodo de preparacion
|
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
|
EP2330194A3
(en)
*
|
2002-09-13 |
2011-10-12 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
|
EP2272958A1
(en)
|
2002-09-26 |
2011-01-12 |
ISIS Pharmaceuticals, Inc. |
Modulation of forkhead box O1A expression
|
|
AU2003287505A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
AU2003291755A1
(en)
|
2002-11-05 |
2004-06-07 |
Isis Pharmaceuticals, Inc. |
Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
|
|
EP2336318B1
(en)
|
2002-11-13 |
2013-04-24 |
Genzyme Corporation |
Antisense modulation of apolipoprotein b expression
|
|
PT2336318E
(pt)
|
2002-11-13 |
2013-06-12 |
Genzyme Corp |
Modulação anti-sentido da expressão de apolipoproteína b
|
|
US20040224010A1
(en)
*
|
2002-11-15 |
2004-11-11 |
Optime Therapeutics, Inc. |
Ophthalmic liposome compositions and uses thereof
|
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
|
CA2515484C
(en)
|
2003-02-11 |
2011-09-20 |
Antisense Therapeutics Ltd |
Modulation of insulin like growth factor i receptor expression
|
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
|
EP1610763A2
(en)
*
|
2003-03-31 |
2006-01-04 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
CA2522184A1
(en)
*
|
2003-04-17 |
2004-11-04 |
The Trustees Of Columbia University In The City Of New York |
Desmoglein 4 is a novel gene involved in hair growth
|
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
|
JP4579911B2
(ja)
|
2003-06-03 |
2010-11-10 |
アイシス・ファーマシューティカルズ・インコーポレイテッド |
スルビビン発現の調節
|
|
CN1852702A
(zh)
*
|
2003-07-31 |
2006-10-25 |
得克萨斯大学体系董事会 |
磷脂与抗炎药物的无菌制剂及其制备和使用方法
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
US20080051373A1
(en)
*
|
2003-07-31 |
2008-02-28 |
The Board Of Regents Of The University Of Texas System |
Parenteral preparations of GI-safer phospholipid-associated anti-inflammatories and methods of preparation and use
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
US20060115523A1
(en)
*
|
2004-12-01 |
2006-06-01 |
Konduri Kameswari S |
Sterically stabilized liposome and triamcinolone composition for treating the respiratory tract of a mammal
|
|
US11324698B2
(en)
|
2003-08-28 |
2022-05-10 |
Vgsk Technologies, Inc. |
Sterically stabilized carrier for aerosol therapeutics, compositions and methods for treating the respiratory tract of a mammal
|
|
US7425544B2
(en)
|
2003-09-18 |
2008-09-16 |
Eli Lilly And Company |
Modulation of eIF4E expression
|
|
CN1882602B
(zh)
|
2003-10-10 |
2011-02-09 |
阿尔卡米亚肿瘤股份有限公司 |
在疾病治疗中乙酰透明质酸合成的调节和降解
|
|
US7960350B2
(en)
|
2003-10-24 |
2011-06-14 |
Ader Enterprises, Inc. |
Composition and method for the treatment of eye disease
|
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
|
AU2004291141B2
(en)
|
2003-11-17 |
2009-06-11 |
Genentech, Inc. |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
|
TWI262798B
(en)
*
|
2003-12-31 |
2006-10-01 |
Ind Tech Res Inst |
Liposome and drug deliver system
|
|
JP2007520222A
(ja)
|
2004-01-20 |
2007-07-26 |
アイシス ファーマシューティカルズ インコーポレイテッド |
グルココルチコイドレセプター発現の調節
|
|
US7468431B2
(en)
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
|
AU2005219413A1
(en)
*
|
2004-03-02 |
2005-09-15 |
Massachusetts Institute Of Technology |
Nanocell drug delivery system
|
|
US20070053845A1
(en)
*
|
2004-03-02 |
2007-03-08 |
Shiladitya Sengupta |
Nanocell drug delivery system
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
EP2899278A1
(en)
*
|
2004-03-12 |
2015-07-29 |
Alnylam Pharmaceuticals Inc. |
iRNA agents targeting VEGF
|
|
EP1730309B1
(en)
|
2004-03-15 |
2016-05-04 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of rna by rnase h
|
|
ES2707393T3
(es)
*
|
2004-03-26 |
2019-04-03 |
Curis Inc |
Moduladores de interferencia de ARN de señalización de hedgehog y usos de los mismos
|
|
PT1737428T
(pt)
*
|
2004-03-31 |
2017-10-02 |
Univ Utah Res Found |
Sistemas de libertação macromoleculares para imagiologia não invasiva, avaliação e tratamento de artrite e outras doenças inflamatórias
|
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
US7744920B2
(en)
*
|
2004-09-09 |
2010-06-29 |
Hadasit Medical Research Services & Development Limited |
Use of liposomal glucocorticoids for treating inflammatory states
|
|
ATE514776T1
(de)
|
2004-10-05 |
2011-07-15 |
California Inst Of Techn |
Aptamer-regulierte nukleinsäuren und verwendungen davon
|
|
US20060078580A1
(en)
*
|
2004-10-08 |
2006-04-13 |
Mediquest Therapeutics, Inc. |
Organo-gel formulations for therapeutic applications
|
|
US7740875B2
(en)
*
|
2004-10-08 |
2010-06-22 |
Mediquest Therapeutics, Inc. |
Organo-gel formulations for therapeutic applications
|
|
WO2006068759A2
(en)
*
|
2004-11-22 |
2006-06-29 |
Magellan Companies, Inc. |
Liposomes containing phytochemical agents and methods for making and using same
|
|
WO2006071659A1
(en)
*
|
2004-12-29 |
2006-07-06 |
Trustees Of Boston University |
Delivery of h2 antagonists
|
|
ES2852549T3
(es)
|
2005-02-09 |
2021-09-13 |
Sarepta Therapeutics Inc |
Composición antisentido para tratamiento de la atrofia muscular
|
|
EP1869076A2
(en)
|
2005-03-10 |
2007-12-26 |
Genentech, Inc. |
Methods and compositions for modulating vascular integrity
|
|
WO2006099445A2
(en)
*
|
2005-03-14 |
2006-09-21 |
Massachusetts Institute Of Technology |
Nanocells for diagnosis and treatment of diseases and disorders
|
|
JP5038128B2
(ja)
*
|
2005-03-16 |
2012-10-03 |
日本ケミカルリサーチ株式会社 |
薬物運搬体
|
|
US8647613B2
(en)
*
|
2005-03-16 |
2014-02-11 |
Jcr Pharmaceuticals Co., Ltd. |
Drug carrier
|
|
WO2006100692A2
(en)
|
2005-03-21 |
2006-09-28 |
Lifecare Innovations Pvt. Ltd. |
A novel inter and intra multilamellar vesicular composition.
|
|
WO2006105361A2
(en)
|
2005-03-31 |
2006-10-05 |
Calando Pharmaceuticals, Inc. |
Inhibitors of ribonucleotide reductase subunit 2 and uses thereof
|
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
|
US20070197460A1
(en)
|
2005-11-01 |
2007-08-23 |
Alnylam Pharmaceuticals, Inc. |
Rnai inhibition of influenza virus replication
|
|
BRPI0618643A2
(pt)
|
2005-11-09 |
2011-09-06 |
Combinatorx Inc |
composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso
|
|
EP1966377A2
(en)
|
2005-11-21 |
2008-09-10 |
Isis Pharmaceuticals, Inc. |
Modulation of eif4e-bp2 expression
|
|
PL2161038T3
(pl)
|
2006-01-26 |
2014-06-30 |
Ionis Pharmaceuticals Inc |
Kompozycje i ich zastosowanie ukierunkowane na huntingtynę
|
|
WO2007115168A2
(en)
|
2006-03-31 |
2007-10-11 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of eg5 gene
|
|
CA2647277A1
(en)
|
2006-04-05 |
2007-11-08 |
Genentech, Inc. |
Method for using boc/cdo to modulate hedgehog signaling
|
|
US7691824B2
(en)
*
|
2006-04-28 |
2010-04-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a gene from the JC virus
|
|
EP2013344B1
(en)
|
2006-05-03 |
2012-08-29 |
Baltic Technology Development, Ltd. |
Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
|
|
US7812150B2
(en)
|
2006-05-19 |
2010-10-12 |
Alnylam Pharmaceuticals, Inc. |
RNAi modulation of Aha and therapeutic uses thereof
|
|
WO2007137220A2
(en)
|
2006-05-22 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
|
US8598333B2
(en)
*
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
|
WO2008011473A2
(en)
|
2006-07-19 |
2008-01-24 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to hbxip
|
|
CA2600220C
(en)
*
|
2006-09-07 |
2014-12-09 |
Canadian Blood Services |
Surface cross-linked lipidic particles, methods of production and uses therefor
|
|
US20090004294A1
(en)
*
|
2006-11-07 |
2009-01-01 |
Pharmwest, Inc. |
Personal lubricant formulations comprising colloidal metals and methods of use
|
|
WO2008058291A2
(en)
*
|
2006-11-09 |
2008-05-15 |
California Institute Of Technology |
Modular aptamer-regulated ribozymes
|
|
CN101209243B
(zh)
|
2006-12-29 |
2010-12-08 |
石药集团中奇制药技术(石家庄)有限公司 |
一种脂质体药物及其制备方法
|
|
US8048998B2
(en)
*
|
2007-01-19 |
2011-11-01 |
Exiqon A/S |
Mediated cellular delivery of LNA oligonucleotides
|
|
WO2008091655A2
(en)
*
|
2007-01-23 |
2008-07-31 |
The Regents Of The University Of California |
Methods, compositions and device for directed and controlled heating and release of agents
|
|
EP2114981B1
(en)
|
2007-01-29 |
2013-05-08 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
|
DK2436781T3
(en)
|
2007-02-22 |
2016-01-11 |
Genentech Inc |
Methods for the detection of inflammatory bowel disease
|
|
AP3018A
(en)
|
2007-03-29 |
2014-10-31 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expressionof a gene from the ebola
|
|
JP2010527618A
(ja)
|
2007-05-24 |
2010-08-19 |
アメリカ合衆国 |
ヌクレオシドサルベージ経路を通しての核内タンパク質伝達
|
|
AR066984A1
(es)
|
2007-06-15 |
2009-09-23 |
Novartis Ag |
Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
|
|
US20080317768A1
(en)
|
2007-06-21 |
2008-12-25 |
Boeing Company |
Bioconjugated nanoparticles
|
|
US20090082217A1
(en)
*
|
2007-07-16 |
2009-03-26 |
California Institute Of Technology |
Selection of nucleic acid-based sensor domains within nucleic acid switch platform
|
|
US20120165387A1
(en)
|
2007-08-28 |
2012-06-28 |
Smolke Christina D |
General composition framework for ligand-controlled RNA regulatory systems
|
|
US8367815B2
(en)
*
|
2007-08-28 |
2013-02-05 |
California Institute Of Technology |
Modular polynucleotides for ligand-controlled regulatory systems
|
|
US8865667B2
(en)
*
|
2007-09-12 |
2014-10-21 |
California Institute Of Technology |
Higher-order cellular information processing devices
|
|
EP2205741A2
(en)
|
2007-10-02 |
2010-07-14 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
|
US9029524B2
(en)
*
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
|
AU2008335202A1
(en)
|
2007-12-10 |
2009-06-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Factor VII gene
|
|
SG188121A1
(en)
|
2008-03-05 |
2013-03-28 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of eg5 and vegf genes
|
|
NZ587955A
(en)
|
2008-03-06 |
2012-10-26 |
Anacor Pharmaceuticals Inc |
Boron-containing small molecules as anti-inflammatory agents
|
|
EP2105145A1
(en)
*
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Method for muscle-specific delivery lipid-conjugated oligonucleotides
|
|
AU2009232355A1
(en)
|
2008-04-04 |
2009-10-08 |
Calando Pharmaceuticals, Inc. |
Compositions and use of EPAS1 inhibitors
|
|
US8324366B2
(en)
|
2008-04-29 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for delivering RNAI using lipoproteins
|
|
US20100003315A1
(en)
|
2008-07-02 |
2010-01-07 |
Willeford Kenneth L |
Method and Composition for the Treatment of Skin Conditions
|
|
WO2010008582A2
(en)
|
2008-07-18 |
2010-01-21 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell drug delivery system
|
|
EP3081648A1
(en)
|
2008-08-25 |
2016-10-19 |
Excaliard Pharmaceuticals, Inc. |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
|
EP3208337A1
(en)
|
2008-09-02 |
2017-08-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions for combined inhibition of mutant egfr and il-6 expression
|
|
WO2010033248A2
(en)
|
2008-09-22 |
2010-03-25 |
Rxi Pharmaceuticals Corporation |
Neutral nanotransporters
|
|
EP3584320A1
(en)
|
2008-09-25 |
2019-12-25 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
|
|
DK2344639T3
(en)
|
2008-10-20 |
2015-07-27 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TRANSTHYRETINE
|
|
WO2010068414A2
(en)
*
|
2008-11-25 |
2010-06-17 |
Bowen Richard L |
Methods for treating obesity related disease
|
|
ES2760912T3
(es)
|
2008-12-04 |
2020-05-18 |
Curna Inc |
Tratamiento de enfermedades relacionadas con la Sirtuina 1 (SIRT1) por inhibición del transcrito antisentido natural de la Sirtuina 1
|
|
KR20110091796A
(ko)
|
2008-12-04 |
2011-08-12 |
오피케이오 큐알엔에이, 엘엘씨 |
종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
|
|
JP6091752B2
(ja)
|
2008-12-04 |
2017-03-08 |
クルナ・インコーポレーテッド |
Epoに対する天然アンチセンス転写物の抑制によるエリスロポエチン(epo)関連疾患の治療
|
|
CA2746514C
(en)
|
2008-12-10 |
2018-11-27 |
Alnylam Pharmaceuticals, Inc. |
Gnaq targeted dsrna compositions and methods for inhibiting expression
|
|
WO2010078536A1
(en)
|
2009-01-05 |
2010-07-08 |
Rxi Pharmaceuticals Corporation |
Inhibition of pcsk9 through rnai
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
CN102439149B
(zh)
|
2009-02-12 |
2018-01-02 |
库尔纳公司 |
通过抑制针对胶质细胞衍生神经营养因子(gdnf)的天然反义转录物来治疗gdnf相关的疾病
|
|
ES2560107T3
(es)
|
2009-02-12 |
2016-02-17 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF
|
|
US8329882B2
(en)
|
2009-02-18 |
2012-12-11 |
California Institute Of Technology |
Genetic control of mammalian cells with synthetic RNA regulatory systems
|
|
WO2010099341A1
(en)
|
2009-02-26 |
2010-09-02 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of mig-12 gene
|
|
JP6250263B2
(ja)
|
2009-03-04 |
2017-12-20 |
クルナ・インコーポレーテッド |
サーチュイン1(sirt1)に対する天然アンチセンス転写物の抑制によるsirt1関連疾患の治療
|
|
EP2406376A1
(en)
|
2009-03-12 |
2012-01-18 |
Alnylam Pharmaceuticals, Inc. |
LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
|
|
EP2408919B1
(en)
|
2009-03-16 |
2017-10-18 |
CuRNA, Inc. |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
|
|
MX2011009752A
(es)
|
2009-03-17 |
2011-09-29 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas a homologo tipo delta 1(dlk1) por inhibicion de transcrito antisentido natural a homologo tipo delta (dlk1).
|
|
WO2010114768A1
(en)
*
|
2009-03-30 |
2010-10-07 |
Cerulean Pharma Inc. |
Polymer-epothilone conjugates, particles, compositions, and related methods of use
|
|
BRPI1014854A2
(pt)
*
|
2009-03-30 |
2016-05-03 |
Cerulean Pharma Inc |
"conjugados polímero-agente, partículas, composições, e métodos de uso relacionados"
|
|
WO2010114770A1
(en)
*
|
2009-03-30 |
2010-10-07 |
Cerulean Pharma Inc. |
Polymer-agent conjugates, particles, compositions, and related methods of use
|
|
US9145555B2
(en)
|
2009-04-02 |
2015-09-29 |
California Institute Of Technology |
Integrated—ligand-responsive microRNAs
|
|
EP3524275A1
(en)
|
2009-04-22 |
2019-08-14 |
Massachusetts Institute Of Technology |
Innate immune supression enables repeated delivery of long rna molecules
|
|
EP2424987B1
(en)
|
2009-05-01 |
2017-11-15 |
CuRNA, Inc. |
Treatment of hemoglobin (hbf/hbg) related diseases by inhibition of natural antisense transcript to hbf/hbg
|
|
JP6250930B2
(ja)
|
2009-05-06 |
2017-12-20 |
クルナ・インコーポレーテッド |
トリステトラプロリン(ttp)に対する天然アンチセンス転写物の抑制によるttp関連疾患の治療
|
|
WO2010129799A2
(en)
|
2009-05-06 |
2010-11-11 |
Curna, Inc. |
Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
|
|
US8957037B2
(en)
|
2009-05-18 |
2015-02-17 |
Curna, Inc. |
Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
|
|
KR101703695B1
(ko)
|
2009-05-22 |
2017-02-08 |
큐알엔에이, 인크. |
전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의해 tfe3 및 인슐린 수용체 기질 2(irs2)의 치료
|
|
CN103221541B
(zh)
|
2009-05-28 |
2017-03-01 |
库尔纳公司 |
通过抑制抗病毒基因的天然反义转录物来治疗抗病毒基因相关疾病
|
|
US8951981B2
(en)
|
2009-06-16 |
2015-02-10 |
Curna, Inc. |
Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
|
|
JP5944311B2
(ja)
|
2009-06-16 |
2016-07-05 |
クルナ・インコーポレーテッド |
コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療
|
|
ES2618894T3
(es)
|
2009-06-24 |
2017-06-22 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2
|
|
JP5907866B2
(ja)
|
2009-06-26 |
2016-04-26 |
クルナ・インコーポレーテッド |
ダウン症候群遺伝子に対する天然アンチセンス転写物の抑制によるダウン症候群遺伝子関連疾患の治療
|
|
CN102725401A
(zh)
|
2009-07-10 |
2012-10-10 |
哈佛大学校长及研究员协会 |
作为抗炎药的永久带电荷的钠和钙通道阻断剂
|
|
WO2011017516A2
(en)
|
2009-08-05 |
2011-02-10 |
Curna, Inc. |
Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
|
|
AP3574A
(en)
|
2009-08-14 |
2016-02-08 |
Alnylam Pharmaceuticals Inc |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
|
JP5964232B2
(ja)
|
2009-08-25 |
2016-08-03 |
カッパーアールエヌエー,インコーポレイテッド |
‘iqモチーフ含有gtpアーゼ活性化タンパク質’(iqgap)に対する天然アンチセンス転写産物の阻害によるiqgap関連疾患の治療
|
|
US9321823B2
(en)
|
2009-09-02 |
2016-04-26 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
|
US20130079382A1
(en)
|
2009-10-12 |
2013-03-28 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
|
BR112012009409A2
(pt)
|
2009-10-22 |
2017-02-21 |
Genentech Inc |
método de identificação de uma substância inibidora, molécula antagonista, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar a molécula, composição, artigo de fabricação, método de inibição de uma atividade biológica, método de tratamento de uma condição patológica, método para detectar msp em uma amostra e método para detectar hepsina em uma amostra
|
|
US20120244169A1
(en)
|
2009-11-06 |
2012-09-27 |
Fibrogen, Inc. |
Treatment for Radiation-Induced Disorders
|
|
SG10201408598XA
(en)
|
2009-11-30 |
2015-02-27 |
Genentech Inc |
Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid2 )
|
|
BR112012014022A2
(pt)
|
2009-12-11 |
2017-04-04 |
Genecode As |
composto, composição, dispositivo médico e método ex vivo para modulação do crescimento de um neurônico
|
|
DK2513310T3
(en)
|
2009-12-16 |
2018-02-05 |
Curna Inc |
TREATMENT OF DISEASES CONNECTED WITH MEMBRANE-BONDED TRANSCRIPTION FACTOR Peptidase, site 1 (MBTPS1), BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTION TO MBTPS1
|
|
CA2784824A1
(en)
|
2009-12-18 |
2011-06-23 |
Achelios Therapeutics Llc |
Methods and compositions for treating and preventing trigeminal autonomic cephalgias, migraine, and vascular conditions
|
|
CA2782375C
(en)
|
2009-12-23 |
2023-10-31 |
Opko Curna, Llc |
Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
|
|
ES2661387T3
(es)
|
2009-12-23 |
2018-03-28 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor de crecimiento de hepatocitos (hgf) mediante inhibición del transcrito antisentido natural a hgf
|
|
JP5993744B2
(ja)
|
2009-12-29 |
2016-09-14 |
カッパーアールエヌエー,インコーポレイテッド |
核呼吸因子1(nrf1)に対する天然アンチセンス転写物の阻害による核呼吸因子1関連疾患の治療
|
|
EP2519634B1
(en)
|
2009-12-29 |
2016-06-01 |
CuRNA, Inc. |
TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
|
|
DK2521784T3
(en)
|
2010-01-04 |
2018-03-12 |
Curna Inc |
TREATMENT OF INTERFERON REGULATORY FACTOR 8- (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IRF8
|
|
KR101853509B1
(ko)
|
2010-01-06 |
2018-04-30 |
큐알엔에이, 인크. |
췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료
|
|
KR101854926B1
(ko)
|
2010-01-11 |
2018-05-04 |
큐알엔에이, 인크. |
성 호르몬 결합 글로불린 (shbg)에 대한 자연 안티센스 전사체의 저해에 의한 성 호르몬 결합 글로불린 (shbg) 관련된 질환의 치료
|
|
WO2011090971A2
(en)
|
2010-01-19 |
2011-07-28 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for male reproductive disorders
|
|
ES2671877T3
(es)
|
2010-01-25 |
2018-06-11 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la RNASA (H1) mediante inhibición del transcrito antisentido natural a RNASA H1
|
|
US8716478B2
(en)
|
2010-01-27 |
2014-05-06 |
Anacor Pharmaceuticals, Inc. |
Boron-containing small molecules
|
|
US8198337B2
(en)
*
|
2010-01-27 |
2012-06-12 |
Momentive Performance Materials Inc. |
Demulsifier compositions and methods for separating emulsions using the same
|
|
US8198361B2
(en)
*
|
2010-01-27 |
2012-06-12 |
Momentive Performance Materials Inc. |
Silicon polyethers and a method of producing the same
|
|
ES2600356T3
(es)
|
2010-02-22 |
2017-02-08 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con pirrolin-5-carboxilato reductasa 1 (PYCR1) por inhibición de transcrito antisentido natural para PYCR1
|
|
NZ601293A
(en)
|
2010-02-23 |
2014-10-31 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US9080171B2
(en)
|
2010-03-24 |
2015-07-14 |
RXi Parmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
|
ES2893199T3
(es)
|
2010-03-29 |
2022-02-08 |
Alnylam Pharmaceuticals Inc |
Terapia de ARNbc para amiloidosis ocular relacionada con transtiretina (TTR)
|
|
JP2013523162A
(ja)
|
2010-04-06 |
2013-06-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Cd274/pd−l1遺伝子の発現を阻害するための組成物および方法
|
|
JP5978203B2
(ja)
|
2010-04-09 |
2016-08-24 |
カッパーアールエヌエー,インコーポレイテッド |
Fgf21に対する天然アンチセンス転写物の阻害による線維芽細胞増殖因子(fgf21)線維芽細胞増殖因子fgf21)関連疾患の治療
|
|
US20110294868A1
(en)
|
2010-04-29 |
2011-12-01 |
Monia Brett P |
Modulation of transthyretin expression
|
|
EP2957636B1
(en)
|
2010-05-03 |
2020-04-01 |
CuRNA, Inc. |
Treatment of sirtuin 3 (sirt3) related diseases by inhibition of natural antisense transcript to sirt3
|
|
RU2636461C2
(ru)
|
2010-05-03 |
2017-11-23 |
Дженентек, Инк. |
Композиции и способы для диагностики и лечения опухоли
|
|
US9457079B2
(en)
|
2010-05-12 |
2016-10-04 |
The Trustees Of Columbia University In The City Of New York |
Methods for producing enteroendocrine cells that make and secrete insulin
|
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
|
US8895528B2
(en)
|
2010-05-26 |
2014-11-25 |
Curna, Inc. |
Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
|
|
AU2011261434B2
(en)
|
2010-06-02 |
2015-11-26 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
|
JP5998131B2
(ja)
|
2010-07-14 |
2016-09-28 |
カッパーアールエヌエー,インコーポレイテッド |
Discslargehomolog(dlg)dlg1への天然アンチセンス転写物の阻害によるdlg関連疾患の治療
|
|
JP5974012B2
(ja)
|
2010-10-05 |
2016-08-23 |
ジェネンテック, インコーポレイテッド |
突然変異体スムースンド及びその使用方法
|
|
US8993533B2
(en)
|
2010-10-06 |
2015-03-31 |
Curna, Inc. |
Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
|
|
US9222088B2
(en)
|
2010-10-22 |
2015-12-29 |
Curna, Inc. |
Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
|
|
RU2611195C2
(ru)
|
2010-10-27 |
2017-02-21 |
Курна, Инк. |
Лечение заболеваний, связанных с интерферон- связанным регулятором развития 1 (ifrd1), путем ингибирования природного антисмыслового транскрипта к ifrd1
|
|
US20140134181A1
(en)
|
2010-11-05 |
2014-05-15 |
Kenneth E. Lipson |
Treatment Method For Lung Remodeling Diseases
|
|
WO2012064824A1
(en)
|
2010-11-09 |
2012-05-18 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
|
|
JP6071893B2
(ja)
|
2010-11-23 |
2017-02-01 |
カッパーアールエヌエー,インコーポレイテッド |
Nanogへの天然アンチセンス転写物の阻害によるnanog関連疾患の治療
|
|
WO2012078967A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (epo) production
|
|
US9127275B2
(en)
|
2010-12-10 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
|
|
SI2670411T1
(sl)
|
2011-02-02 |
2019-06-28 |
Excaliard Pharmaceuticals, Inc. |
Protismiselne spojine, ki so usmerjene na rastni faktor veznega tkiva (CTGF), za uporabo v postopku zdravljenja keloidov ali hipertrofnih brazgotin
|
|
WO2012109495A1
(en)
|
2011-02-09 |
2012-08-16 |
Metabolic Solutions Development Company, Llc |
Cellular targets of thiazolidinediones
|
|
KR102365961B1
(ko)
|
2011-03-29 |
2022-02-23 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
|
|
US8658783B2
(en)
|
2011-04-13 |
2014-02-25 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
KR101970634B1
(ko)
|
2011-06-02 |
2019-04-19 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
생체외 조직 배양 시스템을 위한 방법 및 용도
|
|
ES2653247T3
(es)
|
2011-06-09 |
2018-02-06 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la frataxina (FXN) mediante inhibición del transcrito antisentido natural al gen FXN
|
|
CA2839437A1
(en)
|
2011-06-16 |
2012-12-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
|
KR20230084331A
(ko)
|
2011-06-21 |
2023-06-12 |
알닐람 파마슈티칼스 인코포레이티드 |
아포리포단백질 c-iii(apoc3) 유전자의 발현 억제를 위한 조성물 및 방법
|
|
EP3388068A1
(en)
|
2011-06-21 |
2018-10-17 |
Alnylam Pharmaceuticals, Inc. |
Composition and methods for inhibition of expression of protein c (proc) genes
|
|
WO2012177906A1
(en)
|
2011-06-21 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Assays and methods for determining activity of a therapeutic agent in a subject
|
|
EP2723390B1
(en)
|
2011-06-23 |
2017-12-27 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
|
WO2013003112A1
(en)
|
2011-06-27 |
2013-01-03 |
The Jackson Laboratory |
Methods and compositions for treatment of cancer and autoimmune disease
|
|
WO2013019857A2
(en)
|
2011-08-01 |
2013-02-07 |
Alnylam Pharmaceuticals, Inc. |
Method for improving the success rate of hematopoietic stem cell transplants
|
|
EP3401401B1
(en)
|
2011-09-20 |
2020-04-15 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of gcgr expression
|
|
CN103796668B
(zh)
*
|
2011-09-28 |
2016-12-28 |
泰尔茂株式会社 |
含有血红蛋白的脂质体及其制造方法
|
|
US20130085139A1
(en)
|
2011-10-04 |
2013-04-04 |
Royal Holloway And Bedford New College |
Oligomers
|
|
AU2012328680A1
(en)
|
2011-10-25 |
2014-05-01 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of GCCR expression
|
|
HUE040179T2
(hu)
|
2012-03-15 |
2019-02-28 |
Curna Inc |
Agyi eredetû neutrotróf faktorral (Brain-derived neurotrophic factor, BDNF) összefüggõ betegségek kezelése a BDNF-fel kapcsolatos természetes antiszensz transzkriptumok gátlása révén
|
|
GB201204632D0
(en)
*
|
2012-03-16 |
2012-05-02 |
Univ Belfast |
Delivery system
|
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
EP2849728A1
(en)
|
2012-05-04 |
2015-03-25 |
The Johns Hopkins University |
Lipid-based drug carriers for rapid penetration through mucus linings
|
|
WO2013173693A1
(en)
|
2012-05-18 |
2013-11-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Nanoparticles with enhanced entry into cancer cells
|
|
EP2943194A1
(en)
|
2012-09-17 |
2015-11-18 |
Chemedest Ltd. |
Treatment of peripheral neuropathy using gfr(alpha)3 type receptor agonists
|
|
CA2897398A1
(en)
|
2013-01-07 |
2014-07-10 |
Mucosal Vaccine Technologies Llc |
Use of vaccines for the treatment of herpes simplex virus type 2 infections
|
|
WO2014152497A2
(en)
|
2013-03-15 |
2014-09-25 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for cognitive disorders
|
|
US20140275261A1
(en)
|
2013-03-15 |
2014-09-18 |
Dr. Reddy's Laboratories, Inc. |
Diclofenac parenteral compositions
|
|
US9937231B2
(en)
|
2013-03-27 |
2018-04-10 |
The General Hospital Corporation |
Methods and agents for treating Alzheimer's disease
|
|
US10246708B2
(en)
|
2013-05-06 |
2019-04-02 |
Alnylam Pharmaceuticals, Inc. |
Dosages and methods for delivering lipid formulated nucleic acid molecules
|
|
DK3007704T3
(da)
|
2013-06-13 |
2021-03-29 |
Antisense Therapeutics Ltd |
Kombinationsterapi til akromegali
|
|
AU2014317961B2
(en)
|
2013-09-05 |
2020-07-30 |
Murdoch University |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
|
WO2015042466A2
(en)
|
2013-09-19 |
2015-03-26 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Compositions and methods for inhibiting jc virus (jcv)
|
|
EP3052626A1
(en)
|
2013-10-02 |
2016-08-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
US10119143B2
(en)
|
2013-10-04 |
2018-11-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
US20150132369A1
(en)
*
|
2013-11-09 |
2015-05-14 |
Exir Nano Sina Company |
Nanoliposomal cyclosorin formulations for immunosuppresion and methods for the production thereof
|
|
WO2015116902A1
(en)
|
2014-01-31 |
2015-08-06 |
Genentech, Inc. |
G-protein coupled receptors in hedgehog signaling
|
|
JP6736467B2
(ja)
|
2014-02-04 |
2020-08-05 |
ジェネンテック, インコーポレイテッド |
平滑化変異体及びその使用方法
|
|
TWI565480B
(zh)
*
|
2014-03-14 |
2017-01-11 |
國立陽明大學 |
羽扇豆醇醋酸酯微脂體及其用於製備抑制蝕骨細胞生成藥物的應用
|
|
WO2015171918A2
(en)
|
2014-05-07 |
2015-11-12 |
Louisiana State University And Agricultural And Mechanical College |
Compositions and uses for treatment thereof
|
|
CA2985344A1
(en)
|
2014-06-26 |
2015-12-30 |
The Trustees Of Columbia University In The City Of New York |
Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
|
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
|
JP7175608B2
(ja)
|
2014-11-19 |
2022-11-21 |
ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク |
加齢に伴うフレイルのための治療としてのオステオカルシン
|
|
JP2017536421A
(ja)
|
2014-12-01 |
2017-12-07 |
アケリオス セラピューティクス,インコーポレーテッド |
片頭痛及び疼痛に関連する状態を処置するための方法及び組成物
|
|
TW201702218A
(zh)
|
2014-12-12 |
2017-01-16 |
美國杰克森實驗室 |
關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
|
|
EP3234141A4
(en)
|
2014-12-18 |
2018-06-20 |
Alnylam Pharmaceuticals, Inc. |
Reversir tm compounds
|
|
EP3247386A4
(en)
|
2015-01-20 |
2018-10-03 |
The Children's Medical Center Corporation |
Anti-net compounds for treating and preventing fibrosis and for facilitating wound healing
|
|
MA41795A
(fr)
|
2015-03-18 |
2018-01-23 |
Sarepta Therapeutics Inc |
Exclusion d'un exon induite par des composés antisens dans la myostatine
|
|
US10849917B2
(en)
|
2015-06-01 |
2020-12-01 |
Sarepta Therapeutics, Inc. |
Antisense-induced exon exclusion in type VII collagen
|
|
EP3316685A4
(en)
|
2015-07-02 |
2019-03-13 |
Otsuka Pharmaceutical Co., Ltd. |
Lyophilized Pharmaceutical Compositions
|
|
AU2016295168B2
(en)
|
2015-07-17 |
2021-08-19 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
CN108348774A
(zh)
|
2015-08-03 |
2018-07-31 |
哈佛大学校长及研究员协会 |
带电离子通道阻断剂及其应用
|
|
EP3349729A4
(en)
|
2015-09-14 |
2019-06-26 |
VGSK Technologies, Inc. |
STERILE-STABILIZED CARRIER FOR SUBCUTANEOUS, SUB-LINGUAL AND ORAL THERAPEUTICS, COMPOSITIONS AND METHOD FOR TREATING ANIMALS
|
|
WO2017048843A1
(en)
|
2015-09-14 |
2017-03-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the alas1 gene
|
|
WO2017053464A1
(en)
*
|
2015-09-21 |
2017-03-30 |
Mallinckrodt Llc |
Improved stability of liposome formulations and uses thereof
|
|
US10954300B2
(en)
|
2015-09-28 |
2021-03-23 |
The Trustees Of Columbia University In The City Of New York |
Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
|
|
WO2017062835A2
(en)
|
2015-10-09 |
2017-04-13 |
Sarepta Therapeutics, Inc. |
Compositions and methods for treating duchenne muscular dystrophy and related disorders
|
|
CA3007424A1
(en)
|
2015-11-05 |
2017-05-11 |
Children's Hospital Los Angeles |
"mobilizing leukemia cells"
|
|
CN108697728A
(zh)
|
2015-12-23 |
2018-10-23 |
昆士兰科技大学 |
核酸寡聚体及其用途
|
|
US20190201372A1
(en)
*
|
2016-04-12 |
2019-07-04 |
Habi Pharma Pty Ltd |
Liposomal preparation and methods of treatment
|
|
BR112018071477A2
(pt)
|
2016-04-18 |
2019-02-19 |
Sarepta Therapeutics, Inc. |
oligômeros antisenso e métodos de utilização dos mesmos para tratamento de doenças associadas com o gene da alfa-glicosidase ácida
|
|
AU2017312116A1
(en)
|
2016-08-17 |
2019-03-07 |
Solstice Biologics, Ltd. |
Polynucleotide constructs
|
|
WO2018195355A1
(en)
|
2017-04-19 |
2018-10-25 |
Rxi Pharmaceuticals Corporation |
Topical delivery of nucleic acid compounds
|
|
WO2018209288A1
(en)
|
2017-05-12 |
2018-11-15 |
Massachusetts Institute Of Technology |
Argonaute protein-double stranded rna complexes and uses related thereto
|
|
US11597744B2
(en)
|
2017-06-30 |
2023-03-07 |
Sirius Therapeutics, Inc. |
Chiral phosphoramidite auxiliaries and methods of their use
|
|
US10590416B2
(en)
|
2017-07-06 |
2020-03-17 |
Arrowhead Pharmaceuticals, Inc. |
RNAi agents for inhibiting expression of alpha-ENaC and methods of use
|
|
CN111182908A
(zh)
|
2017-08-03 |
2020-05-19 |
大塚制药株式会社 |
药物化合物及其纯化方法
|
|
US11999953B2
(en)
|
2017-09-13 |
2024-06-04 |
The Children's Medical Center Corporation |
Compositions and methods for treating transposon associated diseases
|
|
JP7394753B2
(ja)
|
2017-10-18 |
2023-12-08 |
サレプタ セラピューティクス, インコーポレイテッド |
アンチセンスオリゴマー化合物
|
|
WO2019195738A1
(en)
|
2018-04-06 |
2019-10-10 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
|
EP3837367A1
(en)
|
2018-08-16 |
2021-06-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
US20220024999A1
(en)
|
2018-11-29 |
2022-01-27 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating rna
|
|
CN119874561A
(zh)
|
2019-03-11 |
2025-04-25 |
诺西恩医疗公司 |
带电的离子通道阻滞剂及其使用方法
|
|
CN113811305A
(zh)
|
2019-03-11 |
2021-12-17 |
诺西恩医疗公司 |
带电的离子通道阻滞剂及其使用方法
|
|
SG11202109713PA
(en)
|
2019-03-11 |
2021-10-28 |
Nocion Therapeutics Inc |
Ester substituted ion channel blockers and methods for use
|
|
US10786485B1
(en)
|
2019-03-11 |
2020-09-29 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|
|
US10780083B1
(en)
|
2019-03-11 |
2020-09-22 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|
|
US12496279B2
(en)
|
2019-04-11 |
2025-12-16 |
The Johns Hopkins University |
Nanoparticles for drug delivery to brain
|
|
US20220401391A1
(en)
|
2019-05-09 |
2022-12-22 |
Apkarian Tech Llc |
Methods and compositions for treating pain
|
|
EP4021934A4
(en)
|
2019-08-30 |
2024-02-14 |
The Regents of the University of California |
Gene fragment overexpression screening methodologies, and uses thereof
|
|
CN114616331B
(zh)
|
2019-09-03 |
2024-10-22 |
阿尔尼拉姆医药品有限公司 |
抑制lect2基因表达的组合物和方法
|
|
WO2021067747A1
(en)
|
2019-10-04 |
2021-04-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
|
US20230040920A1
(en)
|
2019-11-01 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
|
AU2020380118A1
(en)
|
2019-11-06 |
2022-05-19 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|
|
JP7513713B2
(ja)
|
2019-11-06 |
2024-07-09 |
ノシオン セラピューティクス,インコーポレイテッド |
荷電したイオンチャンネル遮断薬および使用方法
|
|
MX2022009763A
(es)
|
2020-02-10 |
2022-09-09 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para silenciar la expresion del factor de crecimiento endotelial vascular a (vegf-a).
|
|
US12162851B2
(en)
|
2020-03-11 |
2024-12-10 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|
|
US11332446B2
(en)
|
2020-03-11 |
2022-05-17 |
Nocion Therapeutics, Inc. |
Charged ion channel blockers and methods for use
|
|
US20230190785A1
(en)
|
2020-03-30 |
2023-06-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
|
MX2022012493A
(es)
|
2020-04-06 |
2022-10-27 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para el silenciamiento de la expresion de miocilina (myoc).
|
|
AU2021251754A1
(en)
|
2020-04-07 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing SCN9A expression
|
|
WO2021237097A1
(en)
|
2020-05-21 |
2021-11-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
|
WO2021252649A2
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Sirna compositions and methods for silencing gpam (glycerol-3-phosphate acyltransferase 1, mitochondrial) expression
|
|
JP2024516168A
(ja)
|
2021-04-22 |
2024-04-12 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
がんを治療するための組成物および方法
|
|
EP4333809A4
(en)
|
2021-05-05 |
2025-03-12 |
VGSK Technologies, Inc. |
Liposomal-encapsulated corticosteroids to inhibit SARS-CoV-2 replication and reduce pneumonia
|
|
US12410209B2
(en)
|
2021-06-29 |
2025-09-09 |
Board Of Regents, The University Of Texas System |
Modified glucocorticoids
|
|
EP4367237A2
(en)
|
2021-07-09 |
2024-05-15 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
|
AU2022339821A1
(en)
|
2021-08-31 |
2024-03-07 |
Alnylam Pharmaceuticals, Inc. |
Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof
|
|
EP4569113A1
(en)
|
2022-09-15 |
2025-06-18 |
Regeneron Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|
|
TW202449152A
(zh)
|
2023-02-09 |
2024-12-16 |
美商艾拉倫製藥股份有限公司 |
Reversir分子及其使用方法
|