ES2104663T3 - Sulfonamidas aromaticas sustituidas como agentes antiglaucoma. - Google Patents

Sulfonamidas aromaticas sustituidas como agentes antiglaucoma.

Info

Publication number
ES2104663T3
ES2104663T3 ES91303269T ES91303269T ES2104663T3 ES 2104663 T3 ES2104663 T3 ES 2104663T3 ES 91303269 T ES91303269 T ES 91303269T ES 91303269 T ES91303269 T ES 91303269T ES 2104663 T3 ES2104663 T3 ES 2104663T3
Authority
ES
Spain
Prior art keywords
aromatic sulfonamides
antiglaucoma agents
sulfonamides substituted
substituted
antiglaucoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91303269T
Other languages
English (en)
Inventor
John J Baldwin
Gerald S Ponticello
Charles N Habecker
Harold G Selnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2104663T3 publication Critical patent/ES2104663T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Photosensitive Polymer And Photoresist Processing (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SULFONAMIDAS-2-TIENO[2,3-B]TIOPIRAN Y ANILLOS HOMOLOGOS CON UN GRUPO DE ALQUILO SUSTITUIDO HIDROFILICO ADYACENTE AL SULFURO TIOPIRANO SON INHIBIDORES DE ANHIDRASA CARBONICA TOPICAMENTE EFECTIVOS EN BAJAR LA PRESION INTRAOCULAR.
ES91303269T 1990-04-12 1991-04-12 Sulfonamidas aromaticas sustituidas como agentes antiglaucoma. Expired - Lifetime ES2104663T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50780590A 1990-04-12 1990-04-12

Publications (1)

Publication Number Publication Date
ES2104663T3 true ES2104663T3 (es) 1997-10-16

Family

ID=24020208

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91303269T Expired - Lifetime ES2104663T3 (es) 1990-04-12 1991-04-12 Sulfonamidas aromaticas sustituidas como agentes antiglaucoma.

Country Status (16)

Country Link
EP (1) EP0452151B1 (es)
KR (1) KR0182610B1 (es)
AT (1) ATE155468T1 (es)
AU (1) AU645075B2 (es)
CA (1) CA2040312C (es)
DE (1) DE69126814T2 (es)
DK (1) DK0452151T3 (es)
ES (1) ES2104663T3 (es)
FI (1) FI98371C (es)
GR (1) GR3024818T3 (es)
IE (1) IE911192A1 (es)
IL (1) IL97828A (es)
NO (1) NO180680C (es)
NZ (1) NZ237783A (es)
PT (1) PT97359B (es)
ZA (1) ZA912703B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3031498B2 (ja) * 1990-04-12 2000-04-10 メルク エンド カムパニー インコーポレーテッド 抗緑内障剤としての置換芳香族スルホンアミド類
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
WO1993016701A2 (en) * 1992-02-21 1993-09-02 Alcon Laboratories, Inc. Topical antiglaucoma compositions comprising carbonic anhydrase inhibitors and beta-blockers
US5276025A (en) * 1992-09-09 1994-01-04 Merck & Co., Inc. Heterobicyclic sulfonamides
AU3722793A (en) * 1992-09-17 1994-04-12 Alcon Laboratories, Inc. Topical carbonic anhydrase inhibitor composition
US5646142A (en) * 1994-07-08 1997-07-08 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5464831A (en) * 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) * 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
FR2754712B1 (fr) 1996-10-17 1999-09-03 Merck Sharp Dohme Chibret Lab Compositions ophtalmiques
ES2177415B1 (es) 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
EP1918293A1 (en) * 2006-10-02 2008-05-07 Sandoz AG Process for the preparation of 6-substituted-4-oxo-thieno [2,3b]thiopyran-2-sulfonic acid
CA2924562A1 (en) 2013-10-17 2015-04-23 Sentiss Pharma Private Limited Preservative-free ophthalmic pharmaceutical formulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4677115A (en) * 1984-12-12 1987-06-30 Merck & Co., Inc. Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
ATE62683T1 (de) * 1985-03-01 1991-05-15 Hoechst Roussel Pharma Labdanderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel.
US4816474A (en) * 1987-02-27 1989-03-28 Ciba-Geigy Corporation Amino substituted thienothiopyran derivatives, composition containing them, and method of using them to stimulate presynaptic dopamine receptors
US5120757A (en) * 1989-07-31 1992-06-09 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU7434391A (en) 1991-10-17
NO911420D0 (no) 1991-04-11
GR3024818T3 (en) 1998-01-30
DE69126814D1 (de) 1997-08-21
NO911420L (no) 1991-10-14
IL97828A0 (en) 1992-06-21
PT97359A (pt) 1991-12-31
FI911747L (fi) 1991-10-13
FI98371C (fi) 1997-06-10
KR910018386A (ko) 1991-11-30
KR0182610B1 (ko) 1999-05-01
CA2040312C (en) 2001-06-12
EP0452151B1 (en) 1997-07-16
FI98371B (fi) 1997-02-28
ATE155468T1 (de) 1997-08-15
DE69126814T2 (de) 1998-02-12
AU645075B2 (en) 1994-01-06
EP0452151A1 (en) 1991-10-16
ZA912703B (en) 1991-12-24
IL97828A (en) 2000-06-01
NO180680C (no) 1997-05-28
DK0452151T3 (da) 1997-09-08
FI911747A0 (fi) 1991-04-11
PT97359B (pt) 1998-08-31
IE911192A1 (en) 1991-10-23
NO180680B (no) 1997-02-17
CA2040312A1 (en) 1991-10-13
NZ237783A (en) 1994-05-26

Similar Documents

Publication Publication Date Title
ES2104663T3 (es) Sulfonamidas aromaticas sustituidas como agentes antiglaucoma.
ES2180530T3 (es) Sulfonamidas de tiofeno utiles como inhibidores de anhidrasa carbonica.
ES2066991T3 (es) Agentes hipoglucemiantes de oxazolidinadiona.
ES2159330T3 (es) Metodo para producir un ester opticamente activo de acido gamma-sustituido-beta-hidroxibutirico.
ES2052574T3 (es) Antibioticos glicopeptidos.
NO924225D0 (no) Modulering av genekspressjon ved inngrep med rna sekundaerstruktur
ES8705114A1 (es) Perfeccionamientos en un revolver o pistola
ATE42815T1 (de) Dichtungsherstellung.
JPS6456672A (en) Thiophene sulfonamide antiglaucoma
MX9303742A (es) Derivados de 4-hidroxi-bencentio, procedimientp para su preparacion y su empleo para la preparacion de derivados de amonoalcoxibencensulfonilos.
DE68924657D1 (de) Geschwindigkeitsschaltanordnung eines laufenden hydraulischen motors.
FI900078L (fi) Alkyyliaromaattinen voiteluaineena käyttökelpoinen hiilivetyseos
FR2378802A1 (fr) Nouveaux polystyrenes modifies et leur application a la catalyse de la transformation d'isocyanates en carbodiimides
ES2112244T3 (es) Compuestos de disulfuro del complejo ll-33288.
PT97116A (pt) Processo para modular a producao de metabolitos secundarios nomeadamente derivados de beta-lactama
IT1133026B (it) Medicamento a base di d,l-piroglutamato i l-arginina con attivita' to nica a livello neuro-endocrino
BE864011A (fr) Composition a base d'un derive imidazolique, destine a influencer la croissance des plantes
IT8920213A0 (it) Punteria idraulica a compensazione migliorata del gioco dopo un periodo di inattivita' del motore.
ES2062435T3 (es) Nuevas 2-amino-5-ariloximetil-oxazolinas y sus sales.
KR890000087A (ko) 녹내장치료제인 치환된 방향족 설폰 아미드
IT8434837V0 (it) Catena di trasporto a piastre, riportate,e dotata di elevate caratteristiche di indeformabilita'alla trazione
ES531379A0 (es) Un metodo para mejorar la procesabilidad de diversas fibras por tratamiento de las mismas con una sal de un polimero
MX9605426A (es) Derivados de acidos aminosulfonicos, utilizacion de los mismos en la sintesis de pseudopeptidos y procedimiento para su preparacion.
ATE198591T1 (de) Verfahren zur racemisierungsfreien dehalogenierung von halogensubstituierten aryl- alkylaminen
ES506775A0 (es) Un procedimiento para preparar un pirrol-2-acetato de alquilo inferior sustituido en las posiciones 1 y 4.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 452151

Country of ref document: ES