IL97828A - Substituted 4-amino-thieno¬2,3-b¾thiopyran-(and thiepin)-2-sulfonamides and pharmaceutical compositions containing them - Google Patents

Substituted 4-amino-thieno¬2,3-b¾thiopyran-(and thiepin)-2-sulfonamides and pharmaceutical compositions containing them

Info

Publication number: IL97828A
Authority: IL; Israel
Prior art keywords: thieno; sulfonamides; substituted; thiepin; amino
Prior art date: 1990-04-12

Application number

IL9782891A

Other languages

English (en)

Other versions

IL97828A0 (en

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-12

Filing date

1991-04-11

Publication date

2000-06-01

1991-04-11 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1992-06-21 Publication of IL97828A0 publication Critical patent/IL97828A0/xx

2000-06-01 Publication of IL97828A publication Critical patent/IL97828A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
DKMGRCMCQGPAHN-UHFFFAOYSA-N 7ah-thieno[2,3-b]thiopyran-2-sulfonamide Chemical class C1=CSC2SC(S(=O)(=O)N)=CC2=C1 DKMGRCMCQGPAHN-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 abstract 1
239000003489 carbonate dehydratase inhibitor Substances 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
IBBLKSWSCDAPIF-UHFFFAOYSA-N thiopyran Chemical compound S1C=CC=C=C1 IBBLKSWSCDAPIF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Lubricants (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Photosensitive Polymer And Photoresist Processing (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL9782891A 1990-04-12 1991-04-11 Substituted 4-amino-thieno¬2,3-b¾thiopyran-(and thiepin)-2-sulfonamides and pharmaceutical compositions containing them IL97828A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US50780590A	1990-04-12	1990-04-12

Publications (2)

Publication Number	Publication Date
IL97828A0 IL97828A0 (en)	1992-06-21
IL97828A true IL97828A (en)	2000-06-01

Family

ID=24020208

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9782891A IL97828A (en)	1990-04-12	1991-04-11	Substituted 4-amino-thieno¬2,3-b¾thiopyran-(and thiepin)-2-sulfonamides and pharmaceutical compositions containing them

Country Status (16)

Country	Link
EP (1)	EP0452151B1 (es)
KR (1)	KR0182610B1 (es)
AT (1)	ATE155468T1 (es)
AU (1)	AU645075B2 (es)
CA (1)	CA2040312C (es)
DE (1)	DE69126814T2 (es)
DK (1)	DK0452151T3 (es)
ES (1)	ES2104663T3 (es)
FI (1)	FI98371C (es)
GR (1)	GR3024818T3 (es)
IE (1)	IE911192A1 (es)
IL (1)	IL97828A (es)
NO (1)	NO180680C (es)
NZ (1)	NZ237783A (es)
PT (1)	PT97359B (es)
ZA (1)	ZA912703B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3031498B2 (ja) *	1990-04-12	2000-04-10	メルクエンドカムパニーインコーポレーテッド	抗緑内障剤としての置換芳香族スルホンアミド類
US5932572A (en) *	1992-02-21	1999-08-03	Alcon Laboratories, Inc.	Topical anti-glaucoma compositions
WO1993016701A2 (en) *	1992-02-21	1993-09-02	Alcon Laboratories, Inc.	Topical antiglaucoma compositions comprising carbonic anhydrase inhibitors and beta-blockers
US5276025A (en) *	1992-09-09	1994-01-04	Merck & Co., Inc.	Heterobicyclic sulfonamides
AU3722793A (en) *	1992-09-17	1994-04-12	Alcon Laboratories, Inc.	Topical carbonic anhydrase inhibitor composition
US5646142A (en) *	1994-07-08	1997-07-08	Alcon Laboratories, Inc.	Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5464831A (en) *	1994-09-09	1995-11-07	Alcon Laboratories, Inc.	Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) *	1994-09-09	1996-04-23	Alcon Laboratories, Inc.	Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
FR2754712B1 (fr)	1996-10-17	1999-09-03	Merck Sharp Dohme Chibret Lab	Compositions ophtalmiques
ES2177415B1 (es)	2000-09-04	2004-10-16	Ragactives, S.L.	Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
EP1918293A1 (en) *	2006-10-02	2008-05-07	Sandoz AG	Process for the preparation of 6-substituted-4-oxo-thieno [2,3b]thiopyran-2-sulfonic acid
CA2924562A1 (en)	2013-10-17	2015-04-23	Sentiss Pharma Private Limited	Preservative-free ophthalmic pharmaceutical formulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4863922A (en) *	1984-12-12	1989-09-05	Merck & Co., Inc.	Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4677115A (en) *	1984-12-12	1987-06-30	Merck & Co., Inc.	Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof
US4797413A (en) *	1986-05-14	1989-01-10	Merck & Co., Inc.	Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
ATE62683T1 (de) *	1985-03-01	1991-05-15	Hoechst Roussel Pharma	Labdanderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel.
US4816474A (en) *	1987-02-27	1989-03-28	Ciba-Geigy Corporation	Amino substituted thienothiopyran derivatives, composition containing them, and method of using them to stimulate presynaptic dopamine receptors
US5120757A (en) *	1989-07-31	1992-06-09	Merck & Co., Inc.	Substituted aromatic sulfonamides as antiglaucoma agents
IL96507A0 (en) *	1989-12-08	1991-08-16	Merck & Co Inc	Nitrogen-containing spirocycles and pharmaceutical compositions containing them

1991
- 1991-04-09 IE IE119291A patent/IE911192A1/en unknown
- 1991-04-10 NZ NZ237783A patent/NZ237783A/en unknown
- 1991-04-11 AU AU74343/91A patent/AU645075B2/en not_active Ceased
- 1991-04-11 FI FI911747A patent/FI98371C/fi not_active IP Right Cessation
- 1991-04-11 NO NO911420A patent/NO180680C/no not_active IP Right Cessation
- 1991-04-11 IL IL9782891A patent/IL97828A/xx not_active IP Right Cessation
- 1991-04-11 ZA ZA912703A patent/ZA912703B/xx unknown
- 1991-04-12 PT PT97359A patent/PT97359B/pt not_active IP Right Cessation
- 1991-04-12 EP EP91303269A patent/EP0452151B1/en not_active Expired - Lifetime
- 1991-04-12 DE DE69126814T patent/DE69126814T2/de not_active Expired - Fee Related
- 1991-04-12 KR KR1019910005824A patent/KR0182610B1/ko not_active Expired - Fee Related
- 1991-04-12 CA CA002040312A patent/CA2040312C/en not_active Expired - Fee Related
- 1991-04-12 DK DK91303269.4T patent/DK0452151T3/da active
- 1991-04-12 AT AT91303269T patent/ATE155468T1/de not_active IP Right Cessation
- 1991-04-12 ES ES91303269T patent/ES2104663T3/es not_active Expired - Lifetime
1997
- 1997-09-24 GR GR970402452T patent/GR3024818T3/el unknown

Also Published As

Publication number	Publication date
AU7434391A (en)	1991-10-17
NO911420D0 (no)	1991-04-11
GR3024818T3 (en)	1998-01-30
DE69126814D1 (de)	1997-08-21
NO911420L (no)	1991-10-14
IL97828A0 (en)	1992-06-21
PT97359A (pt)	1991-12-31
FI911747L (fi)	1991-10-13
FI98371C (fi)	1997-06-10
ES2104663T3 (es)	1997-10-16
KR910018386A (ko)	1991-11-30
KR0182610B1 (ko)	1999-05-01
CA2040312C (en)	2001-06-12
EP0452151B1 (en)	1997-07-16
FI98371B (fi)	1997-02-28
ATE155468T1 (de)	1997-08-15
DE69126814T2 (de)	1998-02-12
AU645075B2 (en)	1994-01-06
EP0452151A1 (en)	1991-10-16
ZA912703B (en)	1991-12-24
NO180680C (no)	1997-05-28
DK0452151T3 (da)	1997-09-08
FI911747A0 (fi)	1991-04-11
PT97359B (pt)	1998-08-31
IE911192A1 (en)	1991-10-23
NO180680B (no)	1997-02-17
CA2040312A1 (en)	1991-10-13
NZ237783A (en)	1994-05-26

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Legal Events

Date	Code	Title
2000-11-21	FF	Patent granted
2001-04-30	KB	Patent renewed
2001-07-24	KB	Patent renewed
2006-02-05	MM9K	Patent not in force due to non-payment of renewal fees