ES2104908T3 - Nuevos derivados del acido tiofeno-2-carboxilico y procedimiento para su preparacion. - Google Patents

Nuevos derivados del acido tiofeno-2-carboxilico y procedimiento para su preparacion.

Info

Publication number
ES2104908T3
ES2104908T3 ES92908327T ES92908327T ES2104908T3 ES 2104908 T3 ES2104908 T3 ES 2104908T3 ES 92908327 T ES92908327 T ES 92908327T ES 92908327 T ES92908327 T ES 92908327T ES 2104908 T3 ES2104908 T3 ES 2104908T3
Authority
ES
Spain
Prior art keywords
procedure
thiopheno
preparation
carboxylic acid
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92908327T
Other languages
English (en)
Inventor
Dieter Binder
Gerhard Greier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laevosan GmbH and Co KG
Original Assignee
Laevosan GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laevosan GmbH and Co KG filed Critical Laevosan GmbH and Co KG
Application granted granted Critical
Publication of ES2104908T3 publication Critical patent/ES2104908T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Indicating Or Recording The Presence, Absence, Or Direction Of Movement (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVOS COMPUESTOS DE FORMULA (I), DONDE R EN POSICION 3 O 4, HIDROGENO, METILO, CLORO O BROMO Y R(2) ALQUILO DE C1 A 10 CICLOALQUILO DE C3 A 7 O BENCILO Y SUS SALES DE ADICION TOLERABLES FARMACEUTICAMENTE CON ACIDOS ORGANICOS DEBILES ASI COMO UN PROCEDIMIENTO PARA SU OBTENCION. LOS COMPUESTOS DE FORMULA (I) SON INHIBIDORES DE TROMBOXANOSINTETASA.
ES92908327T 1991-04-04 1992-04-01 Nuevos derivados del acido tiofeno-2-carboxilico y procedimiento para su preparacion. Expired - Lifetime ES2104908T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0071691A AT395425B (de) 1991-04-04 1991-04-04 Neue thiophen-2-carbonsaeurederivate und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES2104908T3 true ES2104908T3 (es) 1997-10-16

Family

ID=3497929

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92908327T Expired - Lifetime ES2104908T3 (es) 1991-04-04 1992-04-01 Nuevos derivados del acido tiofeno-2-carboxilico y procedimiento para su preparacion.

Country Status (15)

Country Link
US (1) US5352692A (es)
EP (2) EP0581797B1 (es)
JP (1) JPH06506208A (es)
AT (2) AT395425B (es)
AU (1) AU656772B2 (es)
CA (1) CA2107662A1 (es)
CZ (1) CZ280202B6 (es)
DE (1) DE59208727D1 (es)
DK (1) DK0581797T3 (es)
ES (1) ES2104908T3 (es)
FI (1) FI934184L (es)
GR (1) GR3024594T3 (es)
HU (1) HUT68476A (es)
SK (1) SK106093A3 (es)
WO (1) WO1992017472A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000507593A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
US8189397B2 (en) * 2008-01-08 2012-05-29 Spansion Israel Ltd Retention in NVM with top or bottom injection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2126597A1 (de) * 1971-05-28 1972-12-14 Farbwerke Hoechst AG, vormals, Meister Lucius & Brüning, 6000 Frankfurt Aminothiophencarbonsäureester und Verfahren zu ihrer Herstellung
GB2065121A (en) * 1979-12-13 1981-06-24 Pfizer Ltd Isoquinoline Derivatives
AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon

Also Published As

Publication number Publication date
EP0581797B1 (de) 1997-07-23
US5352692A (en) 1994-10-04
HUT68476A (en) 1995-06-28
CZ9302002A3 (en) 1994-07-13
CZ280202B6 (cs) 1995-11-15
DK0581797T3 (da) 1998-02-02
HU9302786D0 (en) 1993-12-28
ATA71691A (de) 1992-05-15
JPH06506208A (ja) 1994-07-14
FI934184A0 (fi) 1993-09-24
CA2107662A1 (en) 1992-10-05
ATE155783T1 (de) 1997-08-15
AU1640292A (en) 1992-11-02
FI934184A7 (fi) 1993-09-24
DE59208727D1 (de) 1997-09-04
SK106093A3 (en) 1994-08-10
GR3024594T3 (en) 1997-12-31
FI934184L (fi) 1993-09-24
EP0507763A1 (de) 1992-10-07
WO1992017472A1 (de) 1992-10-15
AT395425B (de) 1992-12-28
AU656772B2 (en) 1995-02-16
EP0581797A1 (de) 1994-02-09

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