ES8405778A1 - Procedimiento para la preparacion de nuevos benzo-heterociclos. - Google Patents
Procedimiento para la preparacion de nuevos benzo-heterociclos.Info
- Publication number
- ES8405778A1 ES8405778A1 ES521871A ES521871A ES8405778A1 ES 8405778 A1 ES8405778 A1 ES 8405778A1 ES 521871 A ES521871 A ES 521871A ES 521871 A ES521871 A ES 521871A ES 8405778 A1 ES8405778 A1 ES 8405778A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- preparation
- heterociclos
- procedure
- broncolitics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 238000005984 hydrogenation reaction Methods 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE BENZO-HETEROCICLOS, DE FORMULA GENERAL (I), EN LA QUE A SIGNIFICA UN ENLACE SIMPLE O EL GRUPO -CH2-CH2-; R1 SIGNIFICA OH, O-ACILO, CLORO O HIDROGENO; R2 SIGNIFICA HIDROGENO, METILO O ETILO; Y R3 SIGNIFICA UN RADICAL, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HIDROGENAR UN COMPUESTO DE FORMULA (II), EN LA QUE A Y R2 TIENEN LOS SIGNIFICADOS YA INDICADOS; R1 SIGNIFICA UN GRUPO BENCILOXI; R3 REPRESENTA R3; Y R REPRESENTA HIDROGENO O BENCILO EVENTUALMENTE SUSTITUIDO. LA REACCION DE HIDROGENACION SE EFECTUA EN UN DISOLVENTEA TEMPERATURA AMBIENTE Y EN PRESENCIA DE UN CATALIZADOR DE HIDROGENACION, HASTA LA ABSORCION DE LA CANTIDAD CALCULADA DE HIDROGENO.DE APLICACION EN LA PREPARACION DE MEDICAMENTOS POR SUS EFECTOS BRONCOLITICOS, ESPASMOLITICOS Y ANTIALERGICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813134590 DE3134590A1 (de) | 1981-09-01 | 1981-09-01 | Neue benzo-heterocyclen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8405778A1 true ES8405778A1 (es) | 1984-06-16 |
| ES521871A0 ES521871A0 (es) | 1984-06-16 |
Family
ID=6140603
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515380A Granted ES515380A0 (es) | 1981-09-01 | 1982-08-31 | "procedimiento para la preparacion de nuevos benzo-heterociclos". |
| ES521870A Granted ES521870A0 (es) | 1981-09-01 | 1983-04-27 | Procedimiento para la preparacion de nuevos benzo-heterociclos. |
| ES521871A Granted ES521871A0 (es) | 1981-09-01 | 1983-04-27 | Procedimiento para la preparacion de nuevos benzo-heterociclos. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515380A Granted ES515380A0 (es) | 1981-09-01 | 1982-08-31 | "procedimiento para la preparacion de nuevos benzo-heterociclos". |
| ES521870A Granted ES521870A0 (es) | 1981-09-01 | 1983-04-27 | Procedimiento para la preparacion de nuevos benzo-heterociclos. |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0073505B1 (es) |
| JP (1) | JPS5852278A (es) |
| KR (1) | KR890000380B1 (es) |
| AR (2) | AR231976A1 (es) |
| AT (1) | ATE16703T1 (es) |
| AU (1) | AU553589B2 (es) |
| CA (1) | CA1180012A (es) |
| CS (1) | CS236679B2 (es) |
| DD (1) | DD204477A5 (es) |
| DE (2) | DE3134590A1 (es) |
| DK (1) | DK158664C (es) |
| ES (3) | ES515380A0 (es) |
| FI (1) | FI78475C (es) |
| GB (1) | GB2106105B (es) |
| GR (1) | GR77275B (es) |
| HU (1) | HU186112B (es) |
| IE (1) | IE53615B1 (es) |
| IL (1) | IL66683A0 (es) |
| NO (1) | NO157738C (es) |
| NZ (1) | NZ201777A (es) |
| PL (1) | PL139375B1 (es) |
| PT (1) | PT75478A (es) |
| SU (1) | SU1149876A3 (es) |
| YU (1) | YU42794B (es) |
| ZA (1) | ZA826349B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554284A (en) * | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones |
| DE3743265A1 (de) * | 1987-12-19 | 1989-06-29 | Boehringer Ingelheim Kg | Neue ammoniumverbindungen, ihre herstellung und verwendung |
| TW372967B (en) * | 1994-12-27 | 1999-11-01 | Kanebo Ltd | 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof |
| USD474664S1 (en) | 2002-04-30 | 2003-05-20 | Trudeau Corporation 1889 Inc. | Corkscrew |
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| DE10253282A1 (de) * | 2002-11-15 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| AU2004226824B2 (en) * | 2003-04-04 | 2008-05-01 | Novartis Ag | Quinoline-2-one-derivatives for the treatment of airways diseases |
| GB0307856D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
| US7307076B2 (en) | 2004-05-13 | 2007-12-11 | Boehringer Ingelheim International Gmbh | Beta agonists for the treatment of respiratory diseases |
| EP1789394A1 (de) * | 2004-05-13 | 2007-05-30 | Boehringer Ingelheim International Gmbh | Hydroxy-substituierte benzkondensierte heterozyklen als betaagonisten zur behandlung von atemwegserkrankungen |
| DE102004024451A1 (de) * | 2004-05-14 | 2005-12-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten |
| DE102004024454A1 (de) * | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US7745621B2 (en) | 2004-05-14 | 2010-06-29 | Boehringer Ingelheim International Gmbh | Long acting bronchodilators for the treatment of respiratory diseases |
| DE102004024452A1 (de) * | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation von Betaagonisten |
| DE102004024453A1 (de) * | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen |
| US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| KR101360803B1 (ko) * | 2005-08-15 | 2014-02-11 | 베링거 인겔하임 인터내셔날 게엠베하 | 베타모방제의 제조방법 |
| US20070088030A1 (en) * | 2005-10-10 | 2007-04-19 | Barbara Niklaus-Humke | Aerosol formulations for the inhalation of beta-agonists |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| EP2057152A1 (de) * | 2006-08-07 | 2009-05-13 | Boehringer Ingelheim International GmbH | Enantiomerenreine betaagonisten, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| UY30543A1 (es) * | 2006-08-18 | 2008-03-31 | Boehringer Ingelheim Int | Formulacion de aerosol para la inhalacion de beta- agonistas |
| NZ579007A (en) * | 2007-01-25 | 2012-02-24 | Boehringer Ingelheim Int | Method for producing betamimetics |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2035749A1 (es) * | 1969-02-06 | 1970-12-24 | Bellon Labor Sa Roger | |
| DE2429253A1 (de) * | 1974-06-19 | 1976-01-15 | Boehringer Sohn Ingelheim | Phenylalkanolamine |
-
1981
- 1981-09-01 DE DE19813134590 patent/DE3134590A1/de not_active Withdrawn
-
1982
- 1982-08-27 SU SU823483451A patent/SU1149876A3/ru active
- 1982-08-28 AT AT82107919T patent/ATE16703T1/de not_active IP Right Cessation
- 1982-08-28 EP EP82107919A patent/EP0073505B1/de not_active Expired
- 1982-08-28 DE DE8282107919T patent/DE3267702D1/de not_active Expired
- 1982-08-30 PL PL1982238077A patent/PL139375B1/pl unknown
- 1982-08-30 DD DD82242881A patent/DD204477A5/de unknown
- 1982-08-30 PT PT75478A patent/PT75478A/pt not_active IP Right Cessation
- 1982-08-30 FI FI822985A patent/FI78475C/fi not_active IP Right Cessation
- 1982-08-30 AR AR290473A patent/AR231976A1/es active
- 1982-08-30 YU YU1949/82A patent/YU42794B/xx unknown
- 1982-08-31 AU AU87874/82A patent/AU553589B2/en not_active Ceased
- 1982-08-31 IL IL66683A patent/IL66683A0/xx not_active IP Right Cessation
- 1982-08-31 HU HU822793A patent/HU186112B/hu not_active IP Right Cessation
- 1982-08-31 ZA ZA826349A patent/ZA826349B/xx unknown
- 1982-08-31 CS CS826329A patent/CS236679B2/cs unknown
- 1982-08-31 NZ NZ201777A patent/NZ201777A/en unknown
- 1982-08-31 NO NO822932A patent/NO157738C/no unknown
- 1982-08-31 JP JP57151626A patent/JPS5852278A/ja active Granted
- 1982-08-31 DK DK389082A patent/DK158664C/da not_active IP Right Cessation
- 1982-08-31 GB GB08224810A patent/GB2106105B/en not_active Expired
- 1982-08-31 GR GR69166A patent/GR77275B/el unknown
- 1982-08-31 CA CA000410462A patent/CA1180012A/en not_active Expired
- 1982-08-31 ES ES515380A patent/ES515380A0/es active Granted
- 1982-08-31 IE IE2105/82A patent/IE53615B1/en not_active IP Right Cessation
- 1982-09-01 KR KR8203945A patent/KR890000380B1/ko not_active Expired
-
1983
- 1983-04-27 ES ES521870A patent/ES521870A0/es active Granted
- 1983-04-27 ES ES521871A patent/ES521871A0/es active Granted
- 1983-11-17 AR AR294856A patent/AR231977A1/es active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8404355A1 (es) | "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables". | |
| ES8604226A1 (es) | Procedimiento para preparar (2-oxo-1, 2, 3, 5-tetrahidroimidazo (2, 1-b) quinazolinil) oxialquilamidas | |
| MX9203239A (es) | Derivados de 1-(dihidroxifenil)-2-amino-etanol y composiciones farmaceuticas que los contienen. | |
| ES8604545A1 (es) | Procedimiento para preparar nuevos derivados de acidos feni-laceticos | |
| ES8500727A1 (es) | Procedimiento para la obtencion de derivados de feniletilamina | |
| ES8308318A1 (es) | "procedimiento para la preparacion de nuevos benzo-heterociclos". | |
| ES8306375A1 (es) | "un procedimiento para la preparacion de imidazoquinazolinas". | |
| ES2069281T3 (es) | Derivado de fenantreno. | |
| ES8607299A1 (es) | Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas | |
| ES8605513A1 (es) | Un procedimiento para preparar derivados de piridina | |
| ES8608502A1 (es) | Procedimiento para la obtencion de benzofuranonas | |
| ES8301200A1 (es) | Procedimiento para la preparacion de derivados de ciclohexe-no | |
| ES8101048A1 (es) | Procedimiento para la preparacion de nuevos derivados indo- licos | |
| ES8307718A1 (es) | "procedimiento de preparar amidoaminoacidos y similares". | |
| ES8603810A1 (es) | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dietilaminoalcoxi sustituido y sus sales deadicion acidas y amonicas cuaternarias | |
| ES8405758A1 (es) | Procedimiento oxidativo del cabello. | |
| ES463971A1 (es) | Perfeccionamientos en o relacionados con compuestos organi- cos. | |
| ES8302626A1 (es) | "procedimiento de preparacion de derivados carboxilato". | |
| ES469353A1 (es) | Un procedimiento para la preparacion de compuestos derivadosde bencimidazol | |
| ES8504189A1 (es) | Un compuesto de pirazol (3,4-b) piridina. | |
| ES8402280A1 (es) | Procedimiento para la obtencion de benzofuranonas. | |
| ES8603834A1 (es) | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias | |
| ES8405013A1 (es) | Procedimiento para preparar derivados de tieno-tiazol | |
| ES8707496A1 (es) | Un procedimiento para preparar derivados de azetidinona | |
| ES8304978A1 (es) | "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos". |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970203 |