ES2105122T3 - Receptores de fijacion de kainato de la familia aae5 del snc humano. - Google Patents
Receptores de fijacion de kainato de la familia aae5 del snc humano.Info
- Publication number
- ES2105122T3 ES2105122T3 ES93307325T ES93307325T ES2105122T3 ES 2105122 T3 ES2105122 T3 ES 2105122T3 ES 93307325 T ES93307325 T ES 93307325T ES 93307325 T ES93307325 T ES 93307325T ES 2105122 T3 ES2105122 T3 ES 2105122T3
- Authority
- ES
- Spain
- Prior art keywords
- family
- kainato
- aae5
- receptors
- eaa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101100161367 Arabidopsis thaliana AAE5 gene Proteins 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 6
- 108020003175 receptors Proteins 0.000 abstract 6
- 239000003257 excitatory amino acid Substances 0.000 abstract 2
- 230000002461 excitatory amino acid Effects 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- VLSMHEGGTFMBBZ-OOZYFLPDSA-M Kainate Chemical compound CC(=C)[C@H]1C[NH2+][C@H](C([O-])=O)[C@H]1CC([O-])=O VLSMHEGGTFMBBZ-OOZYFLPDSA-M 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000005062 synaptic transmission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B75/00—Other engines
- F02B75/02—Engines characterised by their cycles, e.g. six-stroke
- F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
- F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
LA NEUROTRANSMISION MEDIANTE AMINOACIDOS EXCITATORIOS (EAAS) TALES COMO EL GLUTAMATO ES INTERMEDIADA POR MEDIO DE RECEPTORES SUPERFICIALES QUE SE UNEN A LA MEMBRANA. SE HA AISLADO LA DECODIFICACION DEL DNA PARA UNA FAMILIA DE ESTOS RECEPTORES DEL TIPO DE LOS QUE SE UNEN AL CAINATO DE LOS RECEPTORES DEL EAA Y SE HA CARACTERIZADO LA PROTEINA RECEPTORA. SE DESCRIBEN LINEAS DE CELULAS RECOMBINANTES QUE PRODUCEN EL RECEPTOR DEL EAA COMO UN PRODUCTO HETEROLOGO QUE SE UNE A LA MEMBRANA. TAMBIEN SE DESCRIBEN LOS ASPECTOS RELACIONADOS DE LA INVENCION, QUE TIENEN SIGNIFICANCIA COMERCIAL. SE INCLUYE EL USO DE LAS LINEAS CELULARES COMO UNA HERRAMIENTA PARA DESCUBRIR LOS COMPUESTOS QUE MODULAN LA ESTIMULACION EL RECEPTOR DEL EAA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94521092A | 1992-09-17 | 1992-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2105122T3 true ES2105122T3 (es) | 1997-10-16 |
Family
ID=25482790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93307325T Expired - Lifetime ES2105122T3 (es) | 1992-09-17 | 1993-09-16 | Receptores de fijacion de kainato de la familia aae5 del snc humano. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6333161B1 (es) |
| EP (1) | EP0588642B1 (es) |
| JP (1) | JPH06205680A (es) |
| AT (1) | ATE156188T1 (es) |
| CA (1) | CA2105804C (es) |
| DE (1) | DE69312608T2 (es) |
| DK (1) | DK0588642T3 (es) |
| ES (1) | ES2105122T3 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2316616A (en) * | 1996-09-02 | 1998-03-04 | Lilly Industries Ltd | Modulation of GluR5 receptors in the hippocampus to treat psychiatric disorders |
| ES2172359B1 (es) * | 1999-02-04 | 2003-11-01 | Univ Pais Vasco | Peptido capaz de inducir anticuerpos contra la subunidad ka1 de los receptores de kainato de mamiferos, anticuerpo policlonal contra dicha subunidad ka1 y un procedimiento para su obtencion. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991006648A1 (en) * | 1989-10-27 | 1991-05-16 | The Salk Institute For Biological Studies | Glutamate receptor compositions and methods |
| NZ240921A (en) | 1990-12-12 | 1994-06-27 | Zymogenetics Inc | G protein coupled glutamate receptor (neurotransmitters), recombinant production |
| PT529994E (pt) * | 1991-08-26 | 2000-10-31 | Nps Allelix Corp | Receptor de ka-1 humano um receptor de cainato de elevada afinidade da familia eaa1 (aminoacido excitatorio) |
| DE69230872T2 (de) * | 1991-08-27 | 2000-10-26 | Allelix Biopharmaceuticals Inc., Mississauga | Menschlicher KA-2-Rezeptor, Rezeptor aus der EAA2-Familie (Excitatory Amino Acid) mit hoher Affinität für Kainat |
-
1993
- 1993-09-09 CA CA002105804A patent/CA2105804C/en not_active Expired - Fee Related
- 1993-09-16 ES ES93307325T patent/ES2105122T3/es not_active Expired - Lifetime
- 1993-09-16 DE DE69312608T patent/DE69312608T2/de not_active Expired - Fee Related
- 1993-09-16 EP EP93307325A patent/EP0588642B1/en not_active Expired - Lifetime
- 1993-09-16 DK DK93307325.6T patent/DK0588642T3/da active
- 1993-09-16 AT AT93307325T patent/ATE156188T1/de active
- 1993-09-17 JP JP5255037A patent/JPH06205680A/ja active Pending
-
1994
- 1994-01-06 US US08/178,019 patent/US6333161B1/en not_active Expired - Fee Related
-
1995
- 1995-01-24 US US08/377,503 patent/US6322999B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2105804A1 (en) | 1994-03-18 |
| US6333161B1 (en) | 2001-12-25 |
| US6322999B1 (en) | 2001-11-27 |
| EP0588642B1 (en) | 1997-07-30 |
| JPH06205680A (ja) | 1994-07-26 |
| ATE156188T1 (de) | 1997-08-15 |
| DE69312608T2 (de) | 1997-12-04 |
| DE69312608D1 (de) | 1997-09-04 |
| DK0588642T3 (da) | 1997-09-22 |
| EP0588642A1 (en) | 1994-03-23 |
| CA2105804C (en) | 2003-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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