ES2105382T3 - Procedimiento para la sintesis de glucosaminoglucanos semisinteticos que contienen acido alfa-l-galacturonico sustituido con radicales nucleofilos en posicion 3. - Google Patents

Procedimiento para la sintesis de glucosaminoglucanos semisinteticos que contienen acido alfa-l-galacturonico sustituido con radicales nucleofilos en posicion 3.

Info

Publication number
ES2105382T3
ES2105382T3 ES94104309T ES94104309T ES2105382T3 ES 2105382 T3 ES2105382 T3 ES 2105382T3 ES 94104309 T ES94104309 T ES 94104309T ES 94104309 T ES94104309 T ES 94104309T ES 2105382 T3 ES2105382 T3 ES 2105382T3
Authority
ES
Spain
Prior art keywords
synthesis
glucosaminoglucanes
semisynthetic
procedure
galacturonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94104309T
Other languages
English (en)
Inventor
Fabrizio Ungarelli
Silvano Piani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Application granted granted Critical
Publication of ES2105382T3 publication Critical patent/ES2105382T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA SINTESIS DE GLICOSAMINOGLICANOS SEMISINTETICOS DE LA FORMULA GENERAL III EN QUE UNA DE LAS UNIDADES SACARIDAS CARACTERISTICA DE LOS GLICOSAMINOGLICANOS CON UNA ESTRUCTURA DE HEPARINA O HEPARAN, Y DE FORMA MAS ESPECIFICA LA DEL ACIDO DEL (ALFA)-L-IDURONIC-2-O-SULFATO, HA SUFRIDO UNA MODIFICACION ESTRUCTURAL, TOTAL O PARCIAL, CON UNA TRANSFORMACION EN ACIDO (ALFA)-LGALACTURONICO SUSTITUIDO EN LA POSICION 3 POR RADICALES NUCLEOFILICOS DE LA FORMULA GENERAL II. DICHO PROCESO SE LLEVA A CABO TRATANDO LOS GLICOSAMINOGLICANOS CON UNA ESTRUCTURA DE HEPARINA O DE HEPARAN MEDIANTE UN REACTIVO NUCLEOFILICO EN UN MEDIO ALCALINO.
ES94104309T 1993-03-29 1994-03-18 Procedimiento para la sintesis de glucosaminoglucanos semisinteticos que contienen acido alfa-l-galacturonico sustituido con radicales nucleofilos en posicion 3. Expired - Lifetime ES2105382T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000126A IT1264102B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali

Publications (1)

Publication Number Publication Date
ES2105382T3 true ES2105382T3 (es) 1997-10-16

Family

ID=11338860

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94104309T Expired - Lifetime ES2105382T3 (es) 1993-03-29 1994-03-18 Procedimiento para la sintesis de glucosaminoglucanos semisinteticos que contienen acido alfa-l-galacturonico sustituido con radicales nucleofilos en posicion 3.

Country Status (18)

Country Link
US (1) US5410039A (es)
EP (1) EP0618235B1 (es)
JP (1) JP2726620B2 (es)
KR (1) KR100191885B1 (es)
AT (1) ATE155798T1 (es)
AU (1) AU664938B2 (es)
CA (1) CA2114863C (es)
DE (1) DE69404353T2 (es)
DK (1) DK0618235T3 (es)
ES (1) ES2105382T3 (es)
FI (1) FI105100B (es)
GR (1) GR3024710T3 (es)
IL (1) IL108690A (es)
IT (1) IT1264102B1 (es)
NO (1) NO305993B1 (es)
NZ (1) NZ250816A (es)
TW (1) TW266216B (es)
ZA (1) ZA94892B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
EP1353556A4 (en) 2001-01-23 2009-09-09 Massachusetts Inst Technology SYNTHESIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS IN SOLID PHASE AND SOLUTION PHASE
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
US10913763B2 (en) 2016-03-09 2021-02-09 Glytech, Inc. Method for producing sugar having sulfate group and/or phosphate group

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
AU5504594A (en) * 1993-02-08 1994-08-11 Applied Sorting Technologies Pty Ltd Metal detection in highly mineralised ground

Also Published As

Publication number Publication date
ITBO930126A1 (it) 1994-09-29
ATE155798T1 (de) 1997-08-15
DE69404353T2 (de) 1997-11-13
EP0618235B1 (en) 1997-07-23
AU664938B2 (en) 1995-12-07
FI941432L (fi) 1994-09-30
CA2114863C (en) 1999-07-20
DE69404353D1 (de) 1997-09-04
US5410039A (en) 1995-04-25
FI941432A0 (fi) 1994-03-28
IL108690A (en) 1998-02-22
TW266216B (es) 1995-12-21
NO941129D0 (no) 1994-03-28
KR100191885B1 (ko) 1999-06-15
GR3024710T3 (en) 1997-12-31
NZ250816A (en) 1996-02-27
NO305993B1 (no) 1999-08-30
FI105100B (fi) 2000-06-15
NO941129L (no) 1994-09-30
DK0618235T3 (da) 1998-01-26
KR940021583A (ko) 1994-10-19
IL108690A0 (en) 1994-05-30
JPH06322002A (ja) 1994-11-22
CA2114863A1 (en) 1994-09-30
JP2726620B2 (ja) 1998-03-11
ITBO930126A0 (it) 1993-03-29
AU5508494A (en) 1994-10-06
IT1264102B1 (it) 1996-09-10
ZA94892B (en) 1994-08-23
EP0618235A1 (en) 1994-10-05

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