NO941129L - Fremgangsmåte for syntetisering av semisyntetiske glykosaminoglykaner inneholdende d nukleofile radikaler i posisjon 3 - Google Patents

Fremgangsmåte for syntetisering av semisyntetiske glykosaminoglykaner inneholdende d nukleofile radikaler i posisjon 3

Info

Publication number: NO941129L
Authority: NO; Norway
Prior art keywords: synthesis; heading; glycosaminoglycans; containing nucleophilic; radicals
Prior art date: 1993-03-29

Application number

NO941129A

Other languages

English (en)

Other versions

NO941129D0 (no

NO305993B1 (no

Inventor

Fabrizio Ungarelli

Silvano Piani

Original Assignee

Alfa Wassermann Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-29

Filing date

1994-03-28

Publication date

1994-09-30

1994-03-28 Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa

1994-03-28 Publication of NO941129D0 publication Critical patent/NO941129D0/no

1994-09-30 Publication of NO941129L publication Critical patent/NO941129L/no

1999-08-30 Publication of NO305993B1 publication Critical patent/NO305993B1/no

Links

229920002683 Glycosaminoglycan Polymers 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title abstract 2
230000000269 nucleophilic effect Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
229920002971 Heparan sulfate Chemical group 0.000 abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
229920000669 heparin Polymers 0.000 abstract 2
229960002897 heparin Drugs 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000000837 carbohydrate group Chemical group 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
239000012434 nucleophilic reagent Substances 0.000 abstract 1
230000009466 transformation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

NO941129A 1993-03-29 1994-03-28 Fremgangsmåte for syntese av semisyntetiske glykosaminoglykaner inneholdende <alfa>-L-galakturonsyre substituert med nukleofile radikaler i 3-stilling NO305993B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT93BO000126A IT1264102B1 (it)	1993-03-29	1993-03-29	Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali

Publications (3)

Publication Number	Publication Date
NO941129D0 NO941129D0 (no)	1994-03-28
NO941129L true NO941129L (no)	1994-09-30
NO305993B1 NO305993B1 (no)	1999-08-30

Family

ID=11338860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO941129A NO305993B1 (no)	1993-03-29	1994-03-28	Fremgangsmåte for syntese av semisyntetiske glykosaminoglykaner inneholdende <alfa>-L-galakturonsyre substituert med nukleofile radikaler i 3-stilling

Country Status (18)

Country	Link
US (1)	US5410039A (no)
EP (1)	EP0618235B1 (no)
JP (1)	JP2726620B2 (no)
KR (1)	KR100191885B1 (no)
AT (1)	ATE155798T1 (no)
AU (1)	AU664938B2 (no)
CA (1)	CA2114863C (no)
DE (1)	DE69404353T2 (no)
DK (1)	DK0618235T3 (no)
ES (1)	ES2105382T3 (no)
FI (1)	FI105100B (no)
GR (1)	GR3024710T3 (no)
IL (1)	IL108690A (no)
IT (1)	IT1264102B1 (no)
NO (1)	NO305993B1 (no)
NZ (1)	NZ250816A (no)
TW (1)	TW266216B (no)
ZA (1)	ZA94892B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6255295B1 (en)	1996-12-23	2001-07-03	Nutramax Laboratories, Inc.	Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en)	2000-06-07	2007-08-21	Alfa Wasserman, Inc.	Methods and compositions using sulodexide for the treatment of diabetic nephropathy
AU2002243630A1 (en)	2001-01-23	2002-08-06	Massachusetts Institute Of Technology	Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
US7575886B2 (en)	2002-03-11	2009-08-18	Momenta Pharmaceuticals, Inc.	Analysis of sulfated polysaccharides
US9139876B1 (en)	2007-05-03	2015-09-22	Momenta Pharmacueticals, Inc.	Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) *	2010-01-19	2013-05-07	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
US9068957B2 (en)	2011-02-21	2015-06-30	Momenta Pharmaceuticals, Inc.	Evaluating heparin preparations
EP3428175B1 (en) *	2016-03-09	2024-09-25	Glytech, Inc.	Method for producing oligosaccharides and polysaccharides having non-protected sulfate groups

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4987223A (en) *	1981-12-23	1991-01-22	Choay S.A.	Derivatives of the uronic acid
IT1234508B (it) *	1988-06-10	1992-05-19	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) *	1989-01-30	1992-05-29	Alfa Wassermann Spa	Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) *	1990-11-13	1994-05-16	Alfa Wassermann Spa	Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) *	1992-04-17	1996-03-28	Alfa Wassermann Spa	Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) *	1992-04-17	1996-03-28	Alfa Wassermann Spa	Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
AU5504594A (en) *	1993-02-08	1994-08-11	Applied Sorting Technologies Pty Ltd	Metal detection in highly mineralised ground

1993
- 1993-03-29 IT IT93BO000126A patent/IT1264102B1/it active IP Right Grant
1994
- 1994-02-03 CA CA002114863A patent/CA2114863C/en not_active Expired - Fee Related
- 1994-02-03 NZ NZ250816A patent/NZ250816A/en unknown
- 1994-02-09 ZA ZA94892A patent/ZA94892B/xx unknown
- 1994-02-10 AU AU55084/94A patent/AU664938B2/en not_active Ceased
- 1994-02-17 IL IL108690A patent/IL108690A/en not_active IP Right Cessation
- 1994-02-18 TW TW083101329A patent/TW266216B/zh active
- 1994-03-07 US US08/207,140 patent/US5410039A/en not_active Expired - Lifetime
- 1994-03-18 DE DE69404353T patent/DE69404353T2/de not_active Expired - Fee Related
- 1994-03-18 EP EP94104309A patent/EP0618235B1/en not_active Expired - Lifetime
- 1994-03-18 AT AT94104309T patent/ATE155798T1/de not_active IP Right Cessation
- 1994-03-18 DK DK94104309.3T patent/DK0618235T3/da active
- 1994-03-18 ES ES94104309T patent/ES2105382T3/es not_active Expired - Lifetime
- 1994-03-25 KR KR1019940006019A patent/KR100191885B1/ko not_active Expired - Fee Related
- 1994-03-28 NO NO941129A patent/NO305993B1/no not_active IP Right Cessation
- 1994-03-28 FI FI941432A patent/FI105100B/fi not_active IP Right Cessation
- 1994-03-29 JP JP6059448A patent/JP2726620B2/ja not_active Expired - Fee Related
1997
- 1997-09-11 GR GR970402354T patent/GR3024710T3/el unknown

Also Published As

Publication number	Publication date
CA2114863C (en)	1999-07-20
AU664938B2 (en)	1995-12-07
IL108690A0 (en)	1994-05-30
US5410039A (en)	1995-04-25
FI941432L (fi)	1994-09-30
ITBO930126A0 (it)	1993-03-29
JPH06322002A (ja)	1994-11-22
FI941432A0 (fi)	1994-03-28
DE69404353T2 (de)	1997-11-13
EP0618235B1 (en)	1997-07-23
DK0618235T3 (da)	1998-01-26
IL108690A (en)	1998-02-22
NZ250816A (en)	1996-02-27
IT1264102B1 (it)	1996-09-10
DE69404353D1 (de)	1997-09-04
KR940021583A (ko)	1994-10-19
ES2105382T3 (es)	1997-10-16
GR3024710T3 (en)	1997-12-31
NO941129D0 (no)	1994-03-28
NO305993B1 (no)	1999-08-30
AU5508494A (en)	1994-10-06
ZA94892B (en)	1994-08-23
KR100191885B1 (ko)	1999-06-15
CA2114863A1 (en)	1994-09-30
ATE155798T1 (de)	1997-08-15
ITBO930126A1 (it)	1994-09-29
EP0618235A1 (en)	1994-10-05
TW266216B (no)	1995-12-21
FI105100B (fi)	2000-06-15
JP2726620B2 (ja)	1998-03-11

Legal Events

Date	Code	Title	Description
2004-12-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
HUT57043A (en)	1991-11-28	Process for producing pharmaceutical solutions comprising macrolide
NO305992B1 (no)	1999-08-30	Halvsyntetiske glykosaminglykosaner med heparin- eller heparanstruktur og fremgangsmåte til fremstilling derav
NO306305B1 (no)	1999-10-18	Halvsyntetiske glykosaminoglykaner som inneholder <alfa>-L-galakturonsyre med et nukleofilt radikal i 3-stillingen, samt fremgangsmÕte til fremstilling av samme
ES2077071T3 (es)	1995-11-16	Derivados de quinolin-3-carboxamida.
NO941129D0 (no)	1994-03-28	Fremgangsmåte for syntetisering av semisyntetiske glykosaminoglykaner inneholdende d nukleofile radikaler i posisjon 3
GR3024416T3 (en)	1997-11-28	Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid.
TW216794B (no)	1993-12-01
DK0379239T3 (da)	1995-06-19	Fremgangsmåde til fraspaltning af delta4-umættet uronsyre fra glycosaminoglycaner
ZA92431B (en)	1993-03-08	Process for producing hemiketals and hemithioketals.