ES2105663T3 - Procedimiento para la preparacion, por extrusion seguida de liofilizacion, de particulas aisladas. - Google Patents

Procedimiento para la preparacion, por extrusion seguida de liofilizacion, de particulas aisladas.

Info

Publication number
ES2105663T3
ES2105663T3 ES94909968T ES94909968T ES2105663T3 ES 2105663 T3 ES2105663 T3 ES 2105663T3 ES 94909968 T ES94909968 T ES 94909968T ES 94909968 T ES94909968 T ES 94909968T ES 2105663 T3 ES2105663 T3 ES 2105663T3
Authority
ES
Spain
Prior art keywords
particles
lyophilization
procedure
preparation
freeze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909968T
Other languages
English (en)
Inventor
Thanh-Tam Nguyen
Joelle Jacquot-Leyder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Application granted granted Critical
Publication of ES2105663T3 publication Critical patent/ES2105663T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25C—PRODUCING, WORKING OR HANDLING ICE
    • F25C1/00—Producing ice

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Thermal Sciences (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Drying Of Solid Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Seeds, Soups, And Other Foods (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Noodles (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE PARTICULAS QUE COMPRENDEN CADA UNA UN EXCIPIENTE QUE FORMA UNA MATRIZ Y AL MENOS UN INGREDIENTE REGULARMENTE REPARTIDO EN LA MASA DE DICHA MATRIZ, DICHO PROCESO, QUE COMPRENDE LAS OPERACIONES DE EXTRUSION Y A CONTINUACION DE LIOFILIZACION, CARACTERIZANDOSE EN QUE COMPRENDE LAS ETAPAS QUE CONSISTEN EN: 1) LA PREPARACION DE UNA MEZCLA HOMOGENEA A PARTIR (A) DE AL MENOS UN INGREDIENTE ACTIVO, (B) DE UN EXCIPIENTE HIDROFILICO FISIOLOGICAMENTE ACEPTABLE, Y (C) DE AGUA, DE MANERA A OBTENER UNA MEZCLA PASTOSA QUE TIENE UNA VISCOSIDAD, MEDIDA A TEMPERATURA AMBIENTE (15-20 (GRADOS) C) INFERIOR A 1 PA.S; 2) LA EXTRUSION DE LA MEZCLA HOMOGENEA, ASI OBTENIDO, Y EL CORTE DEL EXTRUIDO, PARA OBTENER CORPUSCULOS HUMEDOS; 3) LA CONGELACION DE DICHOS CORPUSCULOS, ASI OBTENIDOS MIENTRAS CAEN POR GRAVEDAD EN UNA CORRIENTE GASEOSA INERTE QUE TIENE UNA TEMPERATURA INFERIOR A O (GRADOS) C; Y 4) LA CRIODISECACION DE DICHOS CORPUSCULOS.
ES94909968T 1993-03-23 1994-03-15 Procedimiento para la preparacion, por extrusion seguida de liofilizacion, de particulas aisladas. Expired - Lifetime ES2105663T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9303316A FR2702968B1 (fr) 1993-03-23 1993-03-23 Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .

Publications (1)

Publication Number Publication Date
ES2105663T3 true ES2105663T3 (es) 1997-10-16

Family

ID=9445245

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909968T Expired - Lifetime ES2105663T3 (es) 1993-03-23 1994-03-15 Procedimiento para la preparacion, por extrusion seguida de liofilizacion, de particulas aisladas.

Country Status (10)

Country Link
EP (1) EP0690747B1 (es)
JP (1) JP3601825B2 (es)
AT (1) ATE153562T1 (es)
CA (1) CA2156915C (es)
DE (1) DE69403463T2 (es)
DK (1) DK0690747T3 (es)
ES (1) ES2105663T3 (es)
FR (1) FR2702968B1 (es)
GR (1) GR3024243T3 (es)
WO (1) WO1994021371A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU729586B2 (en) * 1994-10-06 2001-02-08 Cephalon, Inc. Modafinil having defined particle size
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
DE19750679B4 (de) * 1997-11-15 2004-10-21 Institut für Lebensmittelwissenschaft, Lehrstuhl für Lebensmittelverfahrenstechnik Verfahren zum Erzeugen von kaltgesprühten, verfestigten, lagerstabilen und rieselfähigen Mikrokapselsystemen sowie deren Verwendung
DE19848849A1 (de) * 1998-10-22 2000-04-27 Knoll Ag Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz
GB9908014D0 (en) 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
SE9903236D0 (sv) * 1999-09-10 1999-09-10 Astra Ab Method to obtain microparticles
WO2002024168A1 (fr) * 2000-09-25 2002-03-28 Nippon Shinyaku Co., Ltd. Procede de production d'une dispersion solide medicinale
BR0114814A (pt) * 2000-10-11 2005-01-25 Cephalon Inc Composições compreendendo composto de modafinila e seu uso
IL155322A0 (en) * 2000-10-11 2003-11-23 Cephalon Inc Compositions comprising modafinil compounds
ES2250502T3 (es) * 2000-12-13 2006-04-16 Merckle Gmbh Microparticulas con un perfil de liberacion mejorado y procedimient0 para su preparacion.
US7704975B2 (en) 2000-12-19 2010-04-27 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7141555B2 (en) * 2000-12-19 2006-11-28 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
AUPR272901A0 (en) * 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
US7297346B2 (en) * 2001-05-25 2007-11-20 Cephalon Inc. Pharmaceutical formulations of modafinil
PT1275377E (pt) 2001-07-11 2003-11-28 Fidia Farmaceutici Granulados contendo substancias lipossoluveis e sua preparacao
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US20080044468A1 (en) * 2002-07-25 2008-02-21 Romi Barat Singh Processes For The Preparation Of Oral Dosage Formulations Of Modafinil
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
WO2004075841A2 (en) 2003-02-24 2004-09-10 Mallinckrodt Inc. Process for preparing benzhydrylthioacetamide
EP1582221A1 (en) 2004-03-31 2005-10-05 Chiesi S.A. Pharmaceutical oral compositions with a taste masking effect
FR2889910B1 (fr) * 2005-08-25 2012-02-10 Virbac Sa Produit pour la preparation d'aliments supplementes pour animaux
ES2963291T3 (es) * 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
EP2238973A1 (en) 2009-04-07 2010-10-13 Cephalon France Lyophilized preparations of proteasome inhibitors
CA3212595A1 (en) * 2021-04-13 2022-10-20 Sebastien RICOULT Compositions, systems, and methods of making and using encapsulated lyophilised microspheres
CN116222158B (zh) * 2023-03-06 2026-01-02 青岛海尔生物医疗股份有限公司 用于控制冻干机的方法及装置、冻干机、存储介质

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403078A1 (fr) * 1977-09-19 1979-04-13 Lafon Labor Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic
US4230687A (en) * 1978-05-30 1980-10-28 Griffith Laboratories U.S.A., Inc. Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices
FR2539626B2 (fr) * 1983-01-25 1985-06-21 Lafon Labor Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede
FR2581541B1 (fr) * 1985-05-09 1988-05-20 Rhone Poulenc Sante Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.

Also Published As

Publication number Publication date
CA2156915A1 (fr) 1994-09-29
EP0690747A1 (fr) 1996-01-10
CA2156915C (fr) 2005-01-11
DE69403463D1 (de) 1997-07-03
GR3024243T3 (en) 1997-10-31
DK0690747T3 (da) 1997-12-22
FR2702968A1 (fr) 1994-09-30
WO1994021371A1 (fr) 1994-09-29
FR2702968B1 (fr) 1995-06-23
JPH08507940A (ja) 1996-08-27
DE69403463T2 (de) 1998-01-15
EP0690747B1 (fr) 1997-05-28
ATE153562T1 (de) 1997-06-15
JP3601825B2 (ja) 2004-12-15

Similar Documents

Publication Publication Date Title
CA2156915A1 (fr) Procede de preparation de particules renfermant un ingredient actif par extrusion et lyophilisation
CA1142082A (en) Process for the production of pancreatin pellets
FI59322C (fi) Foerfarande foer framstaellning av foedoaemnen i kornform
US5660857A (en) Biopolymer composites
KR100193003B1 (ko) 압출에 의한 활성성분 과립 제조 방법 및 이로써 얻어진 과립
ATE79305T1 (de) In wasser dispergierbare granulate.
DE69322809T2 (de) Biopolymerverbundmaterial
EP0761213A3 (en) Method of production of sustained-release preparation
PL326358A1 (en) Preparation for and method of stabilising biological materials by drying them without freezing
DK0642301T3 (da) Farmaceutisk acceptable fikserede, tørrede humane blodplader
JP2002511777A (ja) 調放性粒子の埋包およびカプセル化
SK11192001A3 (sk) Prostriedok sušený mrazením obsahujúci paramylon, jeho výroba a použitie
CA2290017A1 (en) Method for producing orally administered, solid pharmaceutical products with controlled release of the active substance
CA2335686A1 (en) Particulate acellular tissue matrix
BR9006598A (pt) Conjunto de matrizes de extrusao auto-suportado,processo para a producao de um produto alimentar extrudado e sistema para a producao de um produto extrudado
EP1485140B1 (en) Polymer composite loaded with cells
ATE393622T1 (de) System mit kontrollierter freisetzung bioaktiver wirkstoffe
US4315002A (en) Solid pharmaceutical or diagnostic agent containing dextran and its preparation
WO1999039692A3 (en) Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization
IT1229930B (it) Procedimento per la preparazione di miscele per uso alimentare e mangimistico comprendenti sostanze attive distribuite in modo uniforme
AU2673688A (en) Method of producing free flowing beads of biological materials and method for their application to the leaf surface of plants
HU206180B (en) Process for producing pharmaceutical compositions with long effect and comprising macrolide
FR2720645B1 (fr) Procédé d'obtention d'une matière première sous forme de granulés, matière première sous forme de granulés et son utilisation dans le domaine cosmétique, capillaire, vétérinaire ou pharmaceutique.
Jochelson et al. Acute and chronic pulmonary complications following autologous bone marrow transplantation in non-Hodgkin's lymphoma
ES2056254T3 (es) Procedimiento para la fabricacion de un producto instantaneo granulado conteniendo almidon.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 690747

Country of ref document: ES