ES2106015T3 - Derivados de indol. - Google Patents
Derivados de indol.Info
- Publication number
- ES2106015T3 ES2106015T3 ES90121950T ES90121950T ES2106015T3 ES 2106015 T3 ES2106015 T3 ES 2106015T3 ES 90121950 T ES90121950 T ES 90121950T ES 90121950 T ES90121950 T ES 90121950T ES 2106015 T3 ES2106015 T3 ES 2106015T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- atom
- compounds
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 102000035037 5-HT3 receptors Human genes 0.000 abstract 1
- 108091005477 5-HT3 receptors Proteins 0.000 abstract 1
- 125000005330 8 membered heterocyclic group Chemical group 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010021518 Impaired gastric emptying Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000001288 gastroparesis Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 indolyl carbonyl group Chemical group 0.000 abstract 1
- 208000015238 neurotic disease Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
SE EXPONEN LOS COMPUESTOS DE LA FORMULA I DONDE R SUB 1 ES UN ATOMO DE HIDROGENO,UN GRUPO ALCALINO C SUB 1GRUPO DE BENCILO O DE CARBONILO INDOLYL, R SUB 2 ES UN GRUPO HETEROCILICO DE 5 OMO HETEROCICLICO DE UNO O MAS ATOMOS DE NITROGENO, EL GRUPO HETEROCICLICO SE SUSTITUYE OPCIONALMENTE EN UN ATOMO N O C POR OTRO GRUPO ALCALINO C SUB 1 -C SUB 6 O ARALCALINO, N IS UN ENTERO DE 1 A 5 Y UNO O MAS ATOMOS DE HIDROGENO, ES UNA CADENA ALCALINA -(CH SUB 2)SUB N SE SUSTITUYEN OPCIONALMENTE POR UN GRUPO ALCALINO C SUB 1 -C SUB 6, FENILO Y/O HIDROXILO SALES FISIOLOGICAMENTE ACEPTABLES Y SALES DE AMONIO CUATERNARIO DE DICHO GRUPO. LOS COMPUESTOS SON SELECTIVAMENTE ANTAGONISTAS DE LOS RECEPTORES 5-HT SUB 3 Y SON UTILES PARA EL TRATAMIENTO DE DESORDENES SICOTICOS, DE ENFERMEDADES NEUROTICAS, DE SINTOMAS DE ESTASIS GASTRICAS, DE DESORDENES INTESTINALES, DE NAUSEA Y VOMITOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29749789 | 1989-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2106015T3 true ES2106015T3 (es) | 1997-11-01 |
Family
ID=17847274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90121950T Expired - Lifetime ES2106015T3 (es) | 1989-11-17 | 1990-11-16 | Derivados de indol. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5124324A (es) |
| EP (1) | EP0429984B1 (es) |
| KR (1) | KR0178023B1 (es) |
| AT (1) | ATE155778T1 (es) |
| BR (1) | BR9005848A (es) |
| CA (1) | CA2030051C (es) |
| DE (1) | DE69031111T2 (es) |
| ES (1) | ES2106015T3 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
| GB9103862D0 (en) * | 1991-02-25 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| WO1993003725A1 (en) * | 1991-08-20 | 1993-03-04 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
| US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| WO1993018036A1 (en) * | 1992-03-12 | 1993-09-16 | Smithkline Beecham Plc | Condensed indole derivatives as 5ht4-receptor antagonists |
| MX9305947A (es) * | 1992-09-29 | 1994-06-30 | Smithkline Beecham Plc | Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
| GR1001378B (el) * | 1992-10-08 | 1993-10-29 | Smithkline Beecham Plc | Ανταγωνιστές 5-ΗΤ4 πιπεριδυλαλκυλίου. |
| ES2056728B1 (es) * | 1992-10-28 | 1995-05-01 | Smithkline Beecham Plc | Nuevos derivados de piperidilo y aminoalquilo con actividad antagonista del receptor 5-ht4 |
| US5874593A (en) | 1994-05-16 | 1999-02-23 | Sumitomo Chemical Company, Limited | Production process and intermediate of tetrazole compound |
| AU2003292508A1 (en) * | 2002-11-28 | 2004-06-18 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| CN108148059A (zh) * | 2018-02-08 | 2018-06-12 | 山东齐都药业有限公司 | 托烷司琼双吲哚杂质的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1220141A (en) * | 1981-06-13 | 1987-04-07 | John R. Fozard | Treatment of migraine with tropyl benzoate derivatives |
| FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
| JPS5936675A (ja) * | 1982-07-13 | 1984-02-28 | サンド・アクチエンゲゼルシヤフト | 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド |
| US4486441A (en) * | 1982-12-03 | 1984-12-04 | Merrell Toraude Et Compagnie | Pseudotropyl halogeno-benzoates and their use in migraine treatment |
| JPS60123485A (ja) * | 1983-12-08 | 1985-07-02 | Yoshitomi Pharmaceut Ind Ltd | インド−ル−３−カルボキサミド誘導体 |
| FR2557110B1 (fr) * | 1983-12-23 | 1989-11-24 | Sandoz Sa | Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments |
| US4910193A (en) * | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
| HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
| DE3885357T2 (de) * | 1987-06-29 | 1994-03-24 | Duphar Int Res | Anellierte Indolderivate. |
| GB8720693D0 (en) * | 1987-09-03 | 1987-10-07 | Glaxo Group Ltd | Chemical compounds |
| IT1231413B (it) * | 1987-09-23 | 1991-12-04 | Angeli Inst Spa | Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht |
| GB8814277D0 (en) * | 1988-06-16 | 1988-07-20 | Glaxo Group Ltd | Chemical compounds |
-
1990
- 1990-11-15 CA CA002030051A patent/CA2030051C/en not_active Expired - Fee Related
- 1990-11-16 ES ES90121950T patent/ES2106015T3/es not_active Expired - Lifetime
- 1990-11-16 DE DE69031111T patent/DE69031111T2/de not_active Expired - Fee Related
- 1990-11-16 US US07/614,219 patent/US5124324A/en not_active Expired - Lifetime
- 1990-11-16 AT AT90121950T patent/ATE155778T1/de active
- 1990-11-16 EP EP90121950A patent/EP0429984B1/en not_active Expired - Lifetime
- 1990-11-17 KR KR1019900018638A patent/KR0178023B1/ko not_active Expired - Fee Related
- 1990-11-19 BR BR909005848A patent/BR9005848A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR0178023B1 (ko) | 1999-03-20 |
| CA2030051A1 (en) | 1991-05-18 |
| CA2030051C (en) | 2001-08-07 |
| DE69031111T2 (de) | 1997-11-13 |
| EP0429984A3 (en) | 1992-01-02 |
| BR9005848A (pt) | 1991-09-24 |
| EP0429984B1 (en) | 1997-07-23 |
| KR910009693A (ko) | 1991-06-28 |
| DE69031111D1 (de) | 1997-09-04 |
| EP0429984A2 (en) | 1991-06-05 |
| ATE155778T1 (de) | 1997-08-15 |
| US5124324A (en) | 1992-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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