DK0712406T3 - Kondenserende indolderivater som 5-HT4-receptorantagonister - Google Patents

Kondenserende indolderivater som 5-HT4-receptorantagonister

Info

Publication number: DK0712406T3
Authority: DK; Denmark
Prior art keywords: alkyl; hydrogen; receptor antagonists; indole derivatives; formula
Prior art date: 1993-08-05

Application number

DK94926128T

Other languages

English (en)

Inventor

Paul Adrian Wyman

Laramie Mary Gaster

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-05

Filing date

1994-07-28

Publication date

1999-07-05

1994-07-28 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1999-07-05 Application granted granted Critical

1999-07-05 Publication of DK0712406T3 publication Critical patent/DK0712406T3/da

Links

108091005482 5-HT4 receptors Proteins 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
-1 polymethylene chain Polymers 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
239000003523 serotonin 4 antagonist Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK94926128T 1993-08-05 1994-07-28 Kondenserende indolderivater som 5-HT4-receptorantagonister DK0712406T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939316195A GB9316195D0 (en)	1993-08-05	1993-08-05	Pharmaceuticals
PCT/EP1994/002514 WO1995004737A1 (en)	1993-08-05	1994-07-28	Condensed indole derivatives as 5-ht4-receptor antagonists

Publications (1)

Publication Number	Publication Date
DK0712406T3 true DK0712406T3 (da)	1999-07-05

Family

ID=10739981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94926128T DK0712406T3 (da)	1993-08-05	1994-07-28	Kondenserende indolderivater som 5-HT4-receptorantagonister

Country Status (13)

Country	Link
EP (1)	EP0712406B1 (da)
JP (1)	JPH09502168A (da)
CN (1)	CN1131949A (da)
AT (1)	ATE172732T1 (da)
AU (1)	AU695034B2 (da)
CA (1)	CA2168750A1 (da)
DE (1)	DE69414255T2 (da)
DK (1)	DK0712406T3 (da)
ES (1)	ES2125481T3 (da)
GB (1)	GB9316195D0 (da)
NZ (1)	NZ271972A (da)
WO (1)	WO1995004737A1 (da)
ZA (1)	ZA945773B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5852014A (en) *	1992-03-12	1998-12-22	Smithkline Beecham P.L.C.	Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) *	1992-03-12	1999-12-07	Smithkline Beecham Plc	Condensed indole derivatives as 5HT4 -receptor antagonists
WO1994008965A1 (en) *	1992-10-16	1994-04-28	Smithkline Beecham Plc	N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
ES2208870T3 (es) *	1996-02-15	2004-06-16	Janssen Pharmaceutica N.V.	Uso de antagonistas del receptor 5ht4 para resolver los efectos gastrointestinales de los inhibidores de la reabsorcion de serotonina.
GB9820294D0 (en) *	1998-09-17	1998-11-11	Smithkline Beecham Plc	Pharmaceuticals
MX2007005199A (es)	2004-11-01	2007-05-11	Wyeth Corp	Indolizinas sustituidas y derivados como agentes del sistema nervioso central.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60142981A (ja) *	1983-12-28	1985-07-29	Yoshitomi Pharmaceut Ind Ltd	３−インド−ルカルボキサミド誘導体
WO1993018036A1 (en) *	1992-03-12	1993-09-16	Smithkline Beecham Plc	Condensed indole derivatives as 5ht4-receptor antagonists

1993
- 1993-08-05 GB GB939316195A patent/GB9316195D0/en active Pending
1994
- 1994-07-28 NZ NZ271972A patent/NZ271972A/en unknown
- 1994-07-28 DE DE69414255T patent/DE69414255T2/de not_active Expired - Fee Related
- 1994-07-28 AU AU76098/94A patent/AU695034B2/en not_active Ceased
- 1994-07-28 WO PCT/EP1994/002514 patent/WO1995004737A1/en not_active Ceased
- 1994-07-28 EP EP94926128A patent/EP0712406B1/en not_active Expired - Lifetime
- 1994-07-28 DK DK94926128T patent/DK0712406T3/da active
- 1994-07-28 CN CN94193556A patent/CN1131949A/zh active Pending
- 1994-07-28 JP JP7506201A patent/JPH09502168A/ja active Pending
- 1994-07-28 AT AT94926128T patent/ATE172732T1/de not_active IP Right Cessation
- 1994-07-28 CA CA002168750A patent/CA2168750A1/en not_active Abandoned
- 1994-07-28 ES ES94926128T patent/ES2125481T3/es not_active Expired - Lifetime
- 1994-08-03 ZA ZA945773A patent/ZA945773B/xx unknown

Also Published As

Publication number	Publication date
JPH09502168A (ja)	1997-03-04
DE69414255T2 (de)	1999-05-12
EP0712406B1 (en)	1998-10-28
DE69414255D1 (de)	1998-12-03
AU7609894A (en)	1995-02-28
HK1012347A1 (en)	1999-07-30
NZ271972A (en)	1997-07-27
WO1995004737A1 (en)	1995-02-16
ES2125481T3 (es)	1999-03-01
ATE172732T1 (de)	1998-11-15
ZA945773B (en)	1996-02-05
AU695034B2 (en)	1998-08-06
CA2168750A1 (en)	1995-02-16
EP0712406A1 (en)	1996-05-22
CN1131949A (zh)	1996-09-25
GB9316195D0 (en)	1993-09-22

Publication	Publication Date	Title
NO965125L (no)	1997-06-02	Heterosykliske forbindelser med tachykininreseptor-antagonistaktivitet, deres fremstilling og anvendelse
NO20020823D0 (no)	2002-02-19	Heterosykliske forbindelser og deres anvendelse som metabotrofisk glutamatreseptor-antagonister
PE46899A1 (es)	1999-06-24	Derivados de n-fenil-sulfonamida
DK0625977T3 (da)	1998-05-04	Piperazinderivater som 5-1A-antagonister
ES2095855T3 (es)	1997-03-01	Derivados de tetrahidrobencimidazol.
NO952208L (no)	1995-08-02	Amin-derivater
DE69507293D1 (de)	1999-02-25	Benzamid-derivate als vasopressin-antagonisten
EA200400748A1 (ru)	2004-12-30	Агонисты рецепторов, активируемых пероксисомным пролифератором
CA2179306A1 (en)	1995-06-29	Dopamine receptor ligands
DK0712406T3 (da)	1999-07-05	Kondenserende indolderivater som 5-HT4-receptorantagonister
EP1430898A4 (en)	2005-11-02	Receptor antagonist
ES2106015T3 (es)	1997-11-01	Derivados de indol.
AU3327399A (en)	1999-08-23	Benzisoxazole derivatives having d4-antagonistic activity
TW334428B (en)	1998-06-21	Novel benzodiazepine derivatives
ATE168686T1 (de)	1998-08-15	N,n'-disubstituierte amidderivate
TW340844B (en)	1998-09-21	Amide derivatives
NO20002833D0 (no)	2000-06-02	Asykliske, acylerte heterosykliske derivater
MX9202178A (es)	1992-11-01	Nuevos derivados de 2-piperacinil bencimidazol.
DE69402703D1 (de)	1997-05-22	3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
FI953618A0 (fi)	1995-07-28	Kondensoituneita heterosyklisiä glutamiinijohdannaisia antiproliferatiivisina aineina
FI902775A0 (fi)	1990-06-04	Aryloxi-, aryltio-, heteroaryloxi-, heteroaryltio-alkylenderivat av aminer.
EA200101176A1 (ru)	2002-04-25	Циклокарбаматные производные в качестве модуляторов рецептора прогестерона