ES2107048T3 - Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos. - Google Patents

Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos.

Info

Publication number
ES2107048T3
ES2107048T3 ES93916889T ES93916889T ES2107048T3 ES 2107048 T3 ES2107048 T3 ES 2107048T3 ES 93916889 T ES93916889 T ES 93916889T ES 93916889 T ES93916889 T ES 93916889T ES 2107048 T3 ES2107048 T3 ES 2107048T3
Authority
ES
Spain
Prior art keywords
antioxidants
pulmonary surfactants
surfactants
synthetic peptidic
covalently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93916889T
Other languages
English (en)
Inventor
Larry R Mclean
J Vincent Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2107048T3 publication Critical patent/ES2107048T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE HAN PREPARADO SURFACTANTES PULMONARES SINTETICOS QUE TIENE PROPIEDADES ANTIOXIDANTES Y CONSISTEN EN UN COMPLEJO DE UN POLIPEPTIDO DE RESIDUOS 3-4 AMINOACIDOS, CON UNA UNIDAD ANTIOXIDANTE Y UN LIPIDO QUE CONSISTE EN UNO O MAS DE LOS LIPIDOS ASOCIADOS AL SURFACTANTE PULMONAR NATURAL. ESTOS SURFACTANTES SON UTILES PARA EL TRATAMIENTO DEL SINDROME DE AGOTAMIENTO RESPIRATORIO.
ES93916889T 1992-07-31 1993-06-30 Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos. Expired - Lifetime ES2107048T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92309292A 1992-07-31 1992-07-31
US7780293A 1993-06-21 1993-06-21

Publications (1)

Publication Number Publication Date
ES2107048T3 true ES2107048T3 (es) 1997-11-16

Family

ID=26759685

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93916889T Expired - Lifetime ES2107048T3 (es) 1992-07-31 1993-06-30 Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos.

Country Status (13)

Country Link
US (2) US5623052A (es)
EP (1) EP0652894B1 (es)
JP (1) JPH07509713A (es)
KR (1) KR100279059B1 (es)
AT (1) ATE157671T1 (es)
AU (1) AU664112B2 (es)
CA (1) CA2137348C (es)
DE (1) DE69313647T2 (es)
ES (1) ES2107048T3 (es)
IL (1) IL106503A0 (es)
MX (1) MX9304621A (es)
NZ (1) NZ254496A (es)
WO (1) WO1994003484A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU664112B2 (en) * 1992-07-31 1995-11-02 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants
ES2527760T3 (es) * 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
IL141021A0 (en) 1998-07-23 2002-02-10 Yeda Res & Dev Treatment of autoimmune conditions with copolymer 1 and related copolymers
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US7022663B2 (en) 2000-02-18 2006-04-04 Yeda Research And Development Co., Ltd. Oral, nasal and pulmonary dosage formulations of copolymer 1
US20020077278A1 (en) 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
EP1307212B1 (en) 2000-07-31 2007-03-28 World Resources Corporation Plant derived antioxidants
US6465432B1 (en) 2000-08-28 2002-10-15 Kraft Food Holdings, Inc. Isolated antioxidant peptides form casein and methods for preparing, isolating, and identifying antioxidant peptides
US7429374B2 (en) 2001-12-04 2008-09-30 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
AU2003223718B2 (en) * 2002-04-25 2007-08-16 The Scripps Research Institute Treatment and prevention of pulmonary conditions
EP1809272A4 (en) * 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
AU664112B2 (en) * 1992-07-31 1995-11-02 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants

Also Published As

Publication number Publication date
JPH07509713A (ja) 1995-10-26
EP0652894A1 (en) 1995-05-17
US5623052A (en) 1997-04-22
NZ254496A (en) 1996-08-27
KR950702573A (ko) 1995-07-29
AU4659693A (en) 1994-03-03
DE69313647D1 (de) 1997-10-09
MX9304621A (es) 1994-02-28
CA2137348C (en) 2000-11-28
US5886156A (en) 1999-03-23
AU664112B2 (en) 1995-11-02
ATE157671T1 (de) 1997-09-15
DE69313647T2 (de) 1998-03-12
IL106503A0 (en) 1993-11-15
CA2137348A1 (en) 1994-02-17
WO1994003484A1 (en) 1994-02-17
EP0652894B1 (en) 1997-09-03
KR100279059B1 (ko) 2001-01-15

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