MX9304621A - Tensioactivos pulmonares de peptidos sinteticos que tienen antioxidantes unidos covalentemente. - Google Patents

Tensioactivos pulmonares de peptidos sinteticos que tienen antioxidantes unidos covalentemente.

Info

Publication number
MX9304621A
MX9304621A MX9304621A MX9304621A MX9304621A MX 9304621 A MX9304621 A MX 9304621A MX 9304621 A MX9304621 A MX 9304621A MX 9304621 A MX9304621 A MX 9304621A MX 9304621 A MX9304621 A MX 9304621A
Authority
MX
Mexico
Prior art keywords
antioxidants
synthetic peptides
lung surfaces
covalently
united
Prior art date
Application number
MX9304621A
Other languages
English (en)
Inventor
Larry R Mclean
J Vincent Edwards
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of MX9304621A publication Critical patent/MX9304621A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención describe la preparación de tensioactivos pulmonares sintéticos que tienen propiedades antioxidantes que consisten de un complejo de un polipéptido de 3-4 residuos aminoácidos, con una porción antioxidante, y un lípido que consiste de uno o más de los lípidos asociados con el tensioactivo pulmonar natural. Estos tensioactivos son útiles en el tratamiento del síndrome malestar respiratorio.
MX9304621A 1992-07-31 1993-07-30 Tensioactivos pulmonares de peptidos sinteticos que tienen antioxidantes unidos covalentemente. MX9304621A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92309292A 1992-07-31 1992-07-31
US7780293A 1993-06-21 1993-06-21

Publications (1)

Publication Number Publication Date
MX9304621A true MX9304621A (es) 1994-02-28

Family

ID=26759685

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304621A MX9304621A (es) 1992-07-31 1993-07-30 Tensioactivos pulmonares de peptidos sinteticos que tienen antioxidantes unidos covalentemente.

Country Status (13)

Country Link
US (2) US5623052A (es)
EP (1) EP0652894B1 (es)
JP (1) JPH07509713A (es)
KR (1) KR100279059B1 (es)
AT (1) ATE157671T1 (es)
AU (1) AU664112B2 (es)
CA (1) CA2137348C (es)
DE (1) DE69313647T2 (es)
ES (1) ES2107048T3 (es)
IL (1) IL106503A0 (es)
MX (1) MX9304621A (es)
NZ (1) NZ254496A (es)
WO (1) WO1994003484A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU664112B2 (en) * 1992-07-31 1995-11-02 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants
ES2527760T3 (es) 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
EP1098902A4 (en) 1998-07-23 2002-07-24 Yeda Res & Dev TREATMENT OF AUTOIMMUNE DISEASES WITH COPOLYMER 1 AND RELATED COPOLYMERS AND PEPTIDES
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US7022663B2 (en) 2000-02-18 2006-04-04 Yeda Research And Development Co., Ltd. Oral, nasal and pulmonary dosage formulations of copolymer 1
US20020077278A1 (en) 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
EP1307212B1 (en) 2000-07-31 2007-03-28 World Resources Corporation Plant derived antioxidants
US6465432B1 (en) 2000-08-28 2002-10-15 Kraft Food Holdings, Inc. Isolated antioxidant peptides form casein and methods for preparing, isolating, and identifying antioxidant peptides
EP1459065B1 (en) 2001-12-04 2010-07-28 Teva Pharmaceutical Industries, Ltd. Processes for the measurement of the potency of glatiramer acetate
NZ536796A (en) * 2002-04-25 2007-03-30 Scripps Research Inst Treatment and prevention of pulmonary conditions comprising at least one lung surfactant polypeptide and at least one protease inhibitor, lipase inhibitor or an anti-oxidant
US20060121016A1 (en) * 2004-10-18 2006-06-08 Lee Raphael C Methods and compositions for treatment of free radical injury

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
AU664112B2 (en) * 1992-07-31 1995-11-02 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants

Also Published As

Publication number Publication date
DE69313647T2 (de) 1998-03-12
IL106503A0 (en) 1993-11-15
DE69313647D1 (de) 1997-10-09
CA2137348A1 (en) 1994-02-17
EP0652894A1 (en) 1995-05-17
WO1994003484A1 (en) 1994-02-17
ES2107048T3 (es) 1997-11-16
ATE157671T1 (de) 1997-09-15
AU4659693A (en) 1994-03-03
US5623052A (en) 1997-04-22
CA2137348C (en) 2000-11-28
KR100279059B1 (ko) 2001-01-15
US5886156A (en) 1999-03-23
JPH07509713A (ja) 1995-10-26
AU664112B2 (en) 1995-11-02
NZ254496A (en) 1996-08-27
EP0652894B1 (en) 1997-09-03
KR950702573A (ko) 1995-07-29

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