ES2107430T3 - Procedimiento para preparar complejos de piroxicam/ciclodextrina, los productos obtenidos y sus composiciones farmaceuticas. - Google Patents

Procedimiento para preparar complejos de piroxicam/ciclodextrina, los productos obtenidos y sus composiciones farmaceuticas.

Info

Publication number
ES2107430T3
ES2107430T3 ES91104649T ES91104649T ES2107430T3 ES 2107430 T3 ES2107430 T3 ES 2107430T3 ES 91104649 T ES91104649 T ES 91104649T ES 91104649 T ES91104649 T ES 91104649T ES 2107430 T3 ES2107430 T3 ES 2107430T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
procedure
preparing
products obtained
cyclodextrin complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91104649T
Other languages
English (en)
Inventor
Fabio Carli
Paolo Chiesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Application granted granted Critical
Publication of ES2107430T3 publication Critical patent/ES2107430T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PROCESO PARA PREPARAR COMPLEJOS DE PIROXICAM CON CICLODEXTRINAS EN EL QUE LOS DOS COMPONENTES EN EL ESTADO EN POLVO SON PRE-MEZCLADOS Y DESPUES CO-MOLIDOS EN UN MOLINO DE GRAN ENERGIA EN LA PRESENCIA DE VAPOR. EL PRODUCTO OBTENIDO TIENE CARACTERISTICAS TECNOLOGICAS, FISICAS Y BIOFARMACEUTICAS QUE SON DE GRANDES VENTAJAS COMPARADAS CON LAS DE LOS COMPLEJOS EN ESTADO LIQUIDO OBTENIDOS POR METODOS TRADICIONALES, Y SON APROPIADOS PARA PREPARAR COMPOSICIONES FARMACEUTICAS PARA USO ORAL, RECTAL Y TOPICO.
ES91104649T 1990-03-27 1991-03-25 Procedimiento para preparar complejos de piroxicam/ciclodextrina, los productos obtenidos y sus composiciones farmaceuticas. Expired - Lifetime ES2107430T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19829A IT1241088B (it) 1990-03-27 1990-03-27 Procedimento per la preparazione di complessi piroxicam/ciclodestrina,prodotti ottenuti e loro composizioni farmaceutiche

Publications (1)

Publication Number Publication Date
ES2107430T3 true ES2107430T3 (es) 1997-12-01

Family

ID=11161628

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91104649T Expired - Lifetime ES2107430T3 (es) 1990-03-27 1991-03-25 Procedimiento para preparar complejos de piroxicam/ciclodextrina, los productos obtenidos y sus composiciones farmaceuticas.

Country Status (24)

Country Link
US (1) US5164380A (es)
EP (1) EP0449167B1 (es)
JP (1) JPH04221314A (es)
KR (1) KR0175934B1 (es)
AT (1) ATE157883T1 (es)
AU (1) AU644417B2 (es)
CA (1) CA2039052C (es)
CZ (1) CZ280164B6 (es)
DE (1) DE69127566T2 (es)
DK (1) DK0449167T3 (es)
ES (1) ES2107430T3 (es)
FI (1) FI102461B (es)
GR (1) GR3025305T3 (es)
HU (1) HU217834B (es)
IE (1) IE910969A1 (es)
IL (1) IL97693A (es)
IT (1) IT1241088B (es)
MA (1) MA22089A1 (es)
NO (1) NO178456C (es)
NZ (1) NZ237583A (es)
PT (1) PT97176B (es)
RU (1) RU2034544C1 (es)
SK (1) SK279171B6 (es)
ZA (1) ZA912282B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254541A (en) * 1991-11-15 1993-10-19 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indole/cyclodextrin complex
IL111184A (en) * 1993-10-08 2000-08-13 Farmarc Nederland B V Of Cito Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin
ZA959469B (en) * 1994-11-15 1996-05-15 South African Druggists Ltd Pharmaceutical composition
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
IT1295289B1 (it) * 1997-10-07 1999-05-04 Telos S R L Co-macinati per uso cosmetico e dermatologico
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
AU764001B2 (en) 1998-05-29 2003-08-07 Skyepharma Canada Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
SK288117B6 (sk) * 1998-11-20 2013-09-03 Skyepharma Canada Inc. Rapidly dispersing solid dry therapeutic dosage form
US20060073188A1 (en) * 1999-03-31 2006-04-06 Pierre Fabre Medicament Fast-dissolving isotropic expanded microporous composition or structure for pharmaceutical, veterinary, dietetic, food or cosmetic use and method for obtaining same
ITMI20012749A1 (it) * 2001-12-21 2003-06-21 Chiesi Farma Spa Procedimento per la preparazione mediante trattamento con microonde di composti di inclusione tra farmaco e ciclodestrine e prodotti ottenut
EP2260871B1 (fr) 2004-04-01 2013-05-15 Pierre Fabre Medicament Complexes d'inclusions comprenant du piroxicam, une cyclodextrine et l'arginine
FR2868315B1 (fr) * 2004-04-01 2006-07-14 Pierre Fabre Medicament Sa Procede de preparation d'un compose d'inclusion soluble de substances actives dans une molecule hote avec l'aide d'un agent d'interaction par fluide supercritique
US8715731B2 (en) * 2006-03-22 2014-05-06 Isp Investments Inc. Process of reducing the bitter taste of water soluble actives by co-grinding the active with β cyclodextrin
JP5552400B2 (ja) * 2010-09-07 2014-07-16 東亜薬品株式会社 生薬類の苦味・不快味をマスキングした顆粒剤、及び口腔内速崩壊錠
CN102008450B (zh) * 2010-12-10 2013-01-30 杭州艾瑞莎生物医药科技有限公司 一种药物-环糊精纳米颗粒及其制备方法
ITMI20120092A1 (it) 2012-01-26 2013-07-27 Micro Macinazione S A Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia
ITUB20161027A1 (it) * 2016-02-24 2017-08-24 Altergon Sa Preparazioni farmaceutiche oromucosali ad elevata biodisponibilita’ a base di ciclodestrina e sucralosio
US10532102B2 (en) 2016-08-19 2020-01-14 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical composition and methods of uses
GB202105833D0 (en) * 2021-04-23 2021-06-09 Nacamed As Silicon particles for drug delivery
KR102337124B1 (ko) * 2021-05-13 2021-12-10 (주)바이오제닉스 탈모 개선용 복합 파우더 및 이를 포함하는 모발용 화장료 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
IT1196033B (it) * 1984-02-22 1988-11-10 Chiesi Farma Spa Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche
JPS6165805A (ja) * 1984-09-10 1986-04-04 Nippon Ekishiyou Kk 防殺虫フイルムの製造方法
US4564614A (en) * 1984-10-11 1986-01-14 Pfizer Inc. Antiinflammatory methods
US4672061A (en) * 1985-01-28 1987-06-09 Pfizer Inc. Antiinflammatory compositions and methods
IT1196307B (it) * 1984-10-22 1988-11-16 Chiesi Farma Spa Formulazioni farmaceutiche acquose di piroxicam monoidrato
US4888343A (en) * 1986-09-15 1989-12-19 Bristol-Myers Company Pharmaceutical compositions for relief of dysmenorrhea and/or premenstrual syndrome and process
US5081118A (en) * 1987-10-26 1992-01-14 Pfizer Inc. Benzothiazine dioxide derivatives
US5068226A (en) * 1987-12-07 1991-11-26 Cyclex, Inc. Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies
IT1216686B (it) * 1988-04-01 1990-03-08 Chiesi Farma Spa Formulazioni farmaceutiche acquose di piroxicam e procedimento per laloro preparazione.
CA1321192C (en) * 1988-04-20 1993-08-10 Abdul Majid Inclusion complexes of cyclodextrins by agglomeration
IT1227626B (it) * 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione

Also Published As

Publication number Publication date
KR0175934B1 (ko) 1999-03-20
NO178456B (no) 1995-12-27
HU217834B (hu) 2000-04-28
ZA912282B (en) 1991-12-24
FI102461B1 (fi) 1998-12-15
DE69127566D1 (de) 1997-10-16
NO911216D0 (no) 1991-03-25
DE69127566T2 (de) 1998-02-12
FI102461B (fi) 1998-12-15
IT1241088B (it) 1993-12-29
CS9100833A2 (en) 1991-10-15
EP0449167B1 (en) 1997-09-10
CZ280164B6 (cs) 1995-11-15
CA2039052C (en) 2002-07-30
IL97693A (en) 1995-03-30
PT97176B (pt) 1998-07-31
ATE157883T1 (de) 1997-09-15
NO911216L (no) 1991-09-30
NZ237583A (en) 1992-08-26
MA22089A1 (fr) 1991-10-01
RU2034544C1 (ru) 1995-05-10
SK279171B6 (sk) 1998-07-08
US5164380A (en) 1992-11-17
FI911448A0 (fi) 1991-03-26
HUT60738A (en) 1992-10-28
AU7383891A (en) 1991-10-03
DK0449167T3 (da) 1998-03-09
IE910969A1 (en) 1991-10-09
CA2039052A1 (en) 1991-09-28
EP0449167A1 (en) 1991-10-02
HU911016D0 (en) 1991-10-28
GR3025305T3 (en) 1998-02-27
JPH04221314A (ja) 1992-08-11
FI911448A7 (fi) 1991-09-28
IT9019829A0 (it) 1990-03-27
IT9019829A1 (it) 1991-09-27
IL97693A0 (en) 1992-06-21
NO178456C (no) 1996-04-03
AU644417B2 (en) 1993-12-09
KR910016333A (ko) 1991-11-05
PT97176A (pt) 1991-11-29

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