ES2107659T3 - Complejos ligandos mezclados de aditivos nucleofilos de oxido nitrico empleados como agentes cardiovasculares. - Google Patents

Complejos ligandos mezclados de aditivos nucleofilos de oxido nitrico empleados como agentes cardiovasculares.

Info

Publication number
ES2107659T3
ES2107659T3 ES93908556T ES93908556T ES2107659T3 ES 2107659 T3 ES2107659 T3 ES 2107659T3 ES 93908556 T ES93908556 T ES 93908556T ES 93908556 T ES93908556 T ES 93908556T ES 2107659 T3 ES2107659 T3 ES 2107659T3
Authority
ES
Spain
Prior art keywords
cardiovascular agents
nitle
nucleophil
oxide
additives used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93908556T
Other languages
English (en)
Inventor
Danae D Christodoulou
David A Wink Jr
Larry K Keefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Health and Human Services
Original Assignee
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Health and Human Services filed Critical United States Department of Health and Human Services
Application granted granted Critical
Publication of ES2107659T3 publication Critical patent/ES2107659T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/30—Copper compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/005—Compounds of elements of Group 5 of the Periodic Table without metal-carbon linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPLEJOS METALICOS DE LIGADO MEZCLADO DE ADUCTOS DE NUCLEOFILOS Y OXIDO NITRICO, UTILES COMO AGENTES CARDIOVASCULARES DE LA FORMULA KA EN LA QUE A ES [(M)X''X(L)Y(R1R2N-N2O2)Z] Y M ES UN METAL FARMACEUTICAMENTE ACEPTABLE, O CUANDO X ES AL MENOS DOS, M PUEDE SER UNA MEZCLA DE DOS METALES DIFERENTES FARMACEUTICAMENTE ACEPTABLES; L ES UN LIGANDO, DISTINTO DE (R1R2N-N2O2) Y ESTA ENLAZADO A AL MENOS UN METAL; R1 Y R2 SON CADA UNO UNIDADES ORGANICAS Y PUEDEN SER IGUALES O DIFERENTES; X ES UN ENTERO DE 1 A 10 INCLUSIVE; X'' ES EL ESTADO DE OXIDACION FORMAL DEL METAL M Y ES UN ENTERO DE 1 A 6 INCLUSIVE; Y ES UN ENTERO DE 1 A 18 INCLUSIVE Y CUANDO Y ES AL MENOS DOS, L PUEDE SER EL MISMO LIGANDO O UNA MEZCLA DE LIGANDOS DIFERENTES; Z ES UN ENTERO DE 1 A 20 INCLUSIVE; SIEMPRE Y CUANDO SI M ES COBRE, X SEA UNO, L SEA METANOL E Y SEA UNO, Y AL MENOS UNO DE ENTRE R1 O R2 NO SEA ETILO; Y K ES UN CONTRAION FARMACEUTICAMENTE ACEPTABLE PRESENTE EN LA COMPOSICION CUANDO LA CARGA TOTAL DE A NO ES CERO, EN DONDEEL CONTRAION K SOLO SE ENCUENTRA PRESENTE EN UNA CANTIDAD QUE NEUTRALICE A. SE PRESENTAN LOS METODOS DE TRATAMIENTO DE MAMIFEROS CON TALES COMPUESTOS. TAMBIEN SE PRESENTAN LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS.
ES93908556T 1992-03-27 1993-03-24 Complejos ligandos mezclados de aditivos nucleofilos de oxido nitrico empleados como agentes cardiovasculares. Expired - Lifetime ES2107659T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/858,885 US5389675A (en) 1992-03-27 1992-03-27 Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents

Publications (1)

Publication Number Publication Date
ES2107659T3 true ES2107659T3 (es) 1997-12-01

Family

ID=25329430

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93908556T Expired - Lifetime ES2107659T3 (es) 1992-03-27 1993-03-24 Complejos ligandos mezclados de aditivos nucleofilos de oxido nitrico empleados como agentes cardiovasculares.

Country Status (9)

Country Link
US (1) US5389675A (es)
EP (1) EP0632812B1 (es)
JP (1) JP3637418B2 (es)
AT (1) ATE155475T1 (es)
AU (1) AU661903B2 (es)
CA (1) CA2132847C (es)
DE (1) DE69312276T2 (es)
ES (1) ES2107659T3 (es)
WO (1) WO1993020088A1 (es)

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US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5721365A (en) * 1989-09-15 1998-02-24 Us Health N-substituted piperazine NONOates
US5814666A (en) * 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5691423A (en) * 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5910316A (en) * 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US6255277B1 (en) 1993-09-17 2001-07-03 Brigham And Women's Hospital Localized use of nitric oxide-adducts to prevent internal tissue damage
US5631284A (en) * 1993-10-06 1997-05-20 University Of British Columbia Compositions and methods for relaxing smooth muscles
AU685178B2 (en) * 1993-10-08 1998-01-15 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
US5840759A (en) * 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
HU218280B (en) * 1994-04-26 2000-07-28 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes
US5714511A (en) * 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
WO1998008496A1 (en) * 1996-08-27 1998-03-05 The University Of Akron Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use
CA2266908C (en) * 1996-09-27 2010-07-20 Joseph E. Saavedra O2-arylated or o2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and o2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
US5958427A (en) * 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
US6436996B1 (en) 1997-09-30 2002-08-20 Duke University Modulation of nitric oxide production
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
ITMI20010426A1 (it) * 2001-03-01 2002-09-01 Consiglio Nazionale Ricerche Donatori di ossido di azoto basati su centri metallici
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1436018A1 (en) * 2001-09-26 2004-07-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Nitric oxide-releasing coated medical devices and method of preparing same
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
CA2480033C (en) * 2002-03-21 2011-05-10 The University Of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors
JP2005534485A (ja) * 2002-08-02 2005-11-17 アメリカ合衆国 架橋した一酸化窒素−放出ポリアミン被覆基質、それを含む組成物及びその製造方法
WO2005004884A2 (en) * 2003-07-09 2005-01-20 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US7829553B2 (en) * 2004-02-09 2010-11-09 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
US20060039950A1 (en) * 2004-08-23 2006-02-23 Zhengrong Zhou Multi-functional biocompatible coatings for intravascular devices
EP1794195B1 (en) 2004-09-27 2014-12-17 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
US8557300B2 (en) * 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
JP2009500083A (ja) * 2005-06-30 2009-01-08 エムシー３， インコーポレイテッド 検体センサーおよびその中で使用するための組成物
WO2007005758A2 (en) * 2005-06-30 2007-01-11 Mc3, Inc. Methods , compositions and devices for promoting angiogenesis
US20090118819A1 (en) * 2005-06-30 2009-05-07 Mc3, Inc. Nitric Oxide Coatings for Medical Devices
WO2007053292A2 (en) * 2005-10-31 2007-05-10 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
CN101378792A (zh) * 2005-12-02 2009-03-04 密执安大学评议会 聚合物组合物、涂层和装置及其制备和使用方法
WO2007067477A1 (en) * 2005-12-06 2007-06-14 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
US20090196930A1 (en) * 2007-12-27 2009-08-06 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof
WO2009114368A2 (en) 2008-03-07 2009-09-17 University Of Utah Research Foundation Activated nitric oxide donors and methods of making and using thereof
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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US3153094A (en) * 1959-06-10 1964-10-13 Du Pont Nitrosamine manufacture
NL145762B (nl) * 1970-05-27 1975-05-15 Sandoz Ag Werkwijze ter bereiding van een farmaceutisch preparaat met hypotensieve/antihypertensieve werking, alsmede gevormd preparaat.
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5155137A (en) * 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines

Also Published As

Publication number Publication date
EP0632812B1 (en) 1997-07-16
WO1993020088A1 (en) 1993-10-14
US5389675A (en) 1995-02-14
CA2132847C (en) 2005-05-24
CA2132847A1 (en) 1993-10-14
EP0632812A1 (en) 1995-01-11
JP3637418B2 (ja) 2005-04-13
DE69312276D1 (de) 1997-08-21
AU661903B2 (en) 1995-08-10
DE69312276T2 (de) 1998-01-02
ATE155475T1 (de) 1997-08-15
JPH08501276A (ja) 1996-02-13
AU3933893A (en) 1993-11-08

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