ES2107790T3 - Inhibidor de trombina procedente de la saliva de protostomias. - Google Patents

Inhibidor de trombina procedente de la saliva de protostomias.

Info

Publication number
ES2107790T3
ES2107790T3 ES94900764T ES94900764T ES2107790T3 ES 2107790 T3 ES2107790 T3 ES 2107790T3 ES 94900764 T ES94900764 T ES 94900764T ES 94900764 T ES94900764 T ES 94900764T ES 2107790 T3 ES2107790 T3 ES 2107790T3
Authority
ES
Spain
Prior art keywords
saliva
protostomies
thrombin inhibitor
protein
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94900764T
Other languages
English (en)
Inventor
Christiane Noeske-Jungblut
Wolf-Dieter Schleuning
Alejandro Alagon
Lourival Possani
Delia Cuevas-Aguierre
Peter Donner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19924241659 external-priority patent/DE4241659C1/de
Priority claimed from DE19934304731 external-priority patent/DE4304731A1/de
Priority claimed from DE19934328336 external-priority patent/DE4328336A1/de
Priority claimed from DE19934340798 external-priority patent/DE4340798A1/de
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2107790T3 publication Critical patent/ES2107790T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A PROTEINA NATURAL O ELABORABLE SINTETICAMENTE QUE ACTUA COMO INHIBIDOR DE COAGULACION Y PUEDE SER AISLADA A PARTIR DE LA SALIVA DE INSECTOS QUE CHUPAN SANGRE DE MAMIFEROS. EL INSECTO PREFERIDO ES TRIATOMA PALLIDIPENNIS. LA PROTEINA SE UTILIZA EN EL TRATAMIENTO DE TROMBOSIS O ANGINA INESTABLE O ARTERIOSCLEROSIS O PARA PREVENIR EL CIERRE DE LOS VASOS DESPUES DE PTCA/PTA O PARA PREVENIR LA COAGULACION DE LA SANGRE EN HEMODIALISIS.
ES94900764T 1992-12-04 1993-12-03 Inhibidor de trombina procedente de la saliva de protostomias. Expired - Lifetime ES2107790T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19924241659 DE4241659C1 (de) 1992-12-04 1992-12-04 Thrombininhibitor aus Speichel von Protostomiern
DE19934304731 DE4304731A1 (de) 1993-02-12 1993-02-12 Thrombininhibitor aus Speichel von Protostomiern
DE19934328336 DE4328336A1 (de) 1993-08-17 1993-08-17 Thrombininhibitor aus Speichel von Protostomiern
DE19934340798 DE4340798A1 (de) 1993-11-25 1993-11-25 Thrombininhibitor aus Speichel von Protostomiern

Publications (1)

Publication Number Publication Date
ES2107790T3 true ES2107790T3 (es) 1997-12-01

Family

ID=27435649

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94900764T Expired - Lifetime ES2107790T3 (es) 1992-12-04 1993-12-03 Inhibidor de trombina procedente de la saliva de protostomias.

Country Status (16)

Country Link
US (1) US5876971A (es)
EP (1) EP0677107B1 (es)
JP (1) JP3490444B2 (es)
KR (1) KR100311883B1 (es)
AT (1) ATE156519T1 (es)
AU (1) AU680643B2 (es)
CA (1) CA2150909A1 (es)
DE (1) DE59307091D1 (es)
DK (1) DK0677107T3 (es)
ES (1) ES2107790T3 (es)
FI (1) FI110669B (es)
GR (1) GR3025015T3 (es)
HU (1) HU220301B (es)
NO (1) NO952215L (es)
RU (1) RU2183214C2 (es)
WO (1) WO1994013807A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011271A1 (en) * 1994-10-07 1996-04-18 Heska Corporation Novel ectoparasite saliva proteins and apparatus to collect such proteins
US20020169104A1 (en) 1997-05-01 2002-11-14 Glenn Frank Novel ectoparasite saliva proteins and apparatus to collect such proteins
GB2304048A (en) * 1995-08-12 1997-03-12 John William Carson Medicament containing saliva extract
DE19724791B4 (de) * 1997-06-06 2006-09-28 Schering Ag Thrombin hemmende Peptide, deren Verwendung und diese enthaltende pharmazeutische Zusammensetzungen
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
EP1482882B1 (en) * 2002-02-11 2011-09-14 Gold-T Tech, Inc. Implantable device for preventing thrombus formation
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
JP6813510B2 (ja) * 2015-06-18 2021-01-13 ナショナル ユニヴァーシティー オブ シンガポール 新規トロンビン阻害物質

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341417C (fr) * 1984-03-27 2003-01-21 Paul Tolstoshev Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
DE3931839A1 (de) * 1989-09-23 1991-04-04 Basf Ag Neue proteine und ihre herstellung
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
ATE156519T1 (de) 1997-08-15
DE59307091D1 (de) 1997-09-11
RU2183214C2 (ru) 2002-06-10
FI952712L (fi) 1995-06-02
NO952215D0 (no) 1995-06-02
US5876971A (en) 1999-03-02
NO952215L (no) 1995-06-02
FI110669B (fi) 2003-03-14
JP3490444B2 (ja) 2004-01-26
WO1994013807A1 (de) 1994-06-23
CA2150909A1 (en) 1994-06-23
AU5560394A (en) 1994-07-04
JPH08507200A (ja) 1996-08-06
DK0677107T3 (da) 1998-03-16
HUT71210A (en) 1995-11-28
HU9501626D0 (en) 1995-08-28
FI952712A0 (fi) 1995-06-02
GR3025015T3 (en) 1998-01-30
KR950704488A (ko) 1995-11-20
EP0677107A1 (de) 1995-10-18
KR100311883B1 (ko) 2002-06-24
EP0677107B1 (de) 1997-08-06
AU680643B2 (en) 1997-08-07
HU220301B (hu) 2001-11-28

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