ATE153665T1 - Tricyclische inhibitoren von gp ii b iii a rezeptoren - Google Patents

Tricyclische inhibitoren von gp ii b iii a rezeptoren

Info

Publication number
ATE153665T1
ATE153665T1 AT94923512T AT94923512T ATE153665T1 AT E153665 T1 ATE153665 T1 AT E153665T1 AT 94923512 T AT94923512 T AT 94923512T AT 94923512 T AT94923512 T AT 94923512T AT E153665 T1 ATE153665 T1 AT E153665T1
Authority
AT
Austria
Prior art keywords
receptors
iii
platelet aggregation
nonpeptidyl
inhibitors
Prior art date
Application number
AT94923512T
Other languages
English (en)
Inventor
Brent K Blackburn
Kirk Robarge
Todd C Somers
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE153665T1 publication Critical patent/ATE153665T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT94923512T 1993-07-29 1994-07-15 Tricyclische inhibitoren von gp ii b iii a rezeptoren ATE153665T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/099,019 US5493020A (en) 1993-07-29 1993-07-29 Tricyclic inhibitors of the GPIIb IIIa receptor

Publications (1)

Publication Number Publication Date
ATE153665T1 true ATE153665T1 (de) 1997-06-15

Family

ID=22272077

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923512T ATE153665T1 (de) 1993-07-29 1994-07-15 Tricyclische inhibitoren von gp ii b iii a rezeptoren

Country Status (7)

Country Link
US (3) US5493020A (de)
EP (1) EP0708775B1 (de)
JP (1) JP3929483B2 (de)
AT (1) ATE153665T1 (de)
CA (1) CA2166811C (de)
DE (1) DE69403479T2 (de)
WO (1) WO1995004057A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5493020A (en) * 1993-07-29 1996-02-20 Genentech, Inc. Tricyclic inhibitors of the GPIIb IIIa receptor
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US20030125317A1 (en) 1996-10-02 2003-07-03 Smithkline Beecham Corporation Vitronectin receptor antagonists
US7109326B2 (en) 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
EP1027337A4 (de) * 1997-09-04 2002-04-03 Smithkline Beecham Corp Integrin-rezeptor-antagonisten
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
WO1999050249A2 (en) 1998-04-01 1999-10-07 Du Pont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
US6204282B1 (en) 1998-11-30 2001-03-20 Schering Corporation Benzimidazole compounds that are vitronectin receptor antagonists
WO2001004103A1 (en) 1999-07-13 2001-01-18 F. Hoffmann-La Roche Ag Benzazepinones and quinazolines
US6514964B1 (en) * 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
HUP0303074A3 (en) 2000-09-27 2007-08-28 Ajinomoto Kk Benzodiazepine derivatives and pharmaceutical compositions them
CA2577060A1 (en) * 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
US9806270B2 (en) * 2011-03-25 2017-10-31 Udc Ireland Limited 4H-imidazo[1,2-a]imidazoles for electronic applications

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177071A (en) * 1991-06-17 1993-01-05 Merck & Co., Inc. 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5493020A (en) * 1993-07-29 1996-02-20 Genentech, Inc. Tricyclic inhibitors of the GPIIb IIIa receptor

Also Published As

Publication number Publication date
JP3929483B2 (ja) 2007-06-13
DE69403479T2 (de) 1998-01-22
DE69403479D1 (de) 1997-07-03
CA2166811A1 (en) 1995-02-09
EP0708775A1 (de) 1996-05-01
EP0708775B1 (de) 1997-05-28
CA2166811C (en) 2007-04-24
US5716951A (en) 1998-02-10
US5493020A (en) 1996-02-20
WO1995004057A1 (en) 1995-02-09
JPH09501158A (ja) 1997-02-04
US5705890A (en) 1998-01-06

Similar Documents

Publication Publication Date Title
FI941222A0 (fi) Ei-peptidyyli-tyyppisiä integriini-inhibiittoreita, jotka ovat spesifisiä GPIIbIIIa-reseptorin suhteen
DE69403479D1 (de) TRICYCLISCHE INHIBITOREN VON GP II b III a REZEPTOREN
ES2126661T3 (es) Pirazoles que tienen actividad antagonista de crf.
NO933999L (no) Fibrinogenreseptorantagonister
ES2156934T3 (es) Compuestos que presentan una potente actividad de antagonistas del calcio y de antioxidantes y su utilizacion como agentes citoprotectores.
ECSP941135A (es) Antagonistas triciclicos de vasopresina de benzacepina
ES2154262T3 (es) Uso de compuestos macrolidos para enfermedades oculares.
BG101841A (bg) Инхибитори на клетъчна адхезия
PE20020521A1 (es) Compuestos heterociclicos sustituidos para tratar la resistencia a multiples drogas
ES2114882T3 (es) Acidos hidroxialquilquinolinos insaturados como antagonistas de leucotrienos.
ES2133807T3 (es) Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteasas.
UY23835A1 (es) Procedimiento para la preparacion de compuesto de acilo
MX9700557A (es) Dihidrobenzofuranos.
CO5011115A1 (es) Compuestos y metodos quimioquina
ES2163407T3 (es) Derivados piperidinilos tiaciclicos.
ES2154741T3 (es) Uso de agentes de union a cd23 en el tratamiento de enfermedades autoinmunes.
ES2164088T3 (es) Antagonistas de la sustancia p para el tratamiento de la emesis.
IT1285770B1 (it) Composti corticoidei
ES2079068T3 (es) 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas.
ATE198202T1 (de) Fibrinogen receptor antagonisten
MX9302951A (es) Composicion farmaceutica para tratar la hiperproliferacion celular.
ES2044100T3 (es) Ciertas combinaciones de antagonistas del "paf" y antihistaminicos y metodos.
DK1294732T3 (da) Ruthenium (II)-forbindelser til anvendelse i cancerterapi
DE69125175D1 (de) Verwendung von angiotensin-ii-rezeptorantagonisten bei der behandlung von atheromen
DE69409961D1 (de) Triarylethylenderivate zur therapeutischen verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee