ATE153665T1 - Tricyclische inhibitoren von gp ii b iii a rezeptoren - Google Patents

Tricyclische inhibitoren von gp ii b iii a rezeptoren

Info

Publication number
ATE153665T1
ATE153665T1 AT94923512T AT94923512T ATE153665T1 AT E153665 T1 ATE153665 T1 AT E153665T1 AT 94923512 T AT94923512 T AT 94923512T AT 94923512 T AT94923512 T AT 94923512T AT E153665 T1 ATE153665 T1 AT E153665T1
Authority
AT
Austria
Prior art keywords
receptors
iii
platelet aggregation
nonpeptidyl
inhibitors
Prior art date
Application number
AT94923512T
Other languages
English (en)
Inventor
Brent K Blackburn
Kirk Robarge
Todd C Somers
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE153665T1 publication Critical patent/ATE153665T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT94923512T 1993-07-29 1994-07-15 Tricyclische inhibitoren von gp ii b iii a rezeptoren ATE153665T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/099,019 US5493020A (en) 1993-07-29 1993-07-29 Tricyclic inhibitors of the GPIIb IIIa receptor

Publications (1)

Publication Number Publication Date
ATE153665T1 true ATE153665T1 (de) 1997-06-15

Family

ID=22272077

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923512T ATE153665T1 (de) 1993-07-29 1994-07-15 Tricyclische inhibitoren von gp ii b iii a rezeptoren

Country Status (7)

Country Link
US (3) US5493020A (de)
EP (1) EP0708775B1 (de)
JP (1) JP3929483B2 (de)
AT (1) ATE153665T1 (de)
CA (1) CA2166811C (de)
DE (1) DE69403479T2 (de)
WO (1) WO1995004057A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5693636A (en) * 1991-06-28 1997-12-02 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5493020A (en) * 1993-07-29 1996-02-20 Genentech, Inc. Tricyclic inhibitors of the GPIIb IIIa receptor
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US20030125317A1 (en) 1996-10-02 2003-07-03 Smithkline Beecham Corporation Vitronectin receptor antagonists
US7109326B2 (en) 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
JP2001514253A (ja) * 1997-09-04 2001-09-11 スミスクライン・ビーチャム・コーポレイション インテグリンレセプターアンタゴニスト
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
JP2003504301A (ja) 1998-04-01 2003-02-04 ブリストル−マイヤーズ スクイブ ファーマ カンパニー インテグリンアンタゴニスト
US6204282B1 (en) 1998-11-30 2001-03-20 Schering Corporation Benzimidazole compounds that are vitronectin receptor antagonists
AU5826100A (en) * 1999-07-13 2001-01-30 F. Hoffmann-La Roche Ag Benzazepinones and quinazolines
US6514964B1 (en) * 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
IL155035A0 (en) 2000-09-27 2003-10-31 Ajinomoto Kk Benzodiazepine derivatives
EP1784390A2 (de) * 2004-08-13 2007-05-16 Amgen Inc. Substituierte benzokondensierte heterozyklen
US9806270B2 (en) * 2011-03-25 2017-10-31 Udc Ireland Limited 4H-imidazo[1,2-a]imidazoles for electronic applications

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177071A (en) * 1991-06-17 1993-01-05 Merck & Co., Inc. 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5493020A (en) * 1993-07-29 1996-02-20 Genentech, Inc. Tricyclic inhibitors of the GPIIb IIIa receptor

Also Published As

Publication number Publication date
WO1995004057A1 (en) 1995-02-09
DE69403479T2 (de) 1998-01-22
JPH09501158A (ja) 1997-02-04
JP3929483B2 (ja) 2007-06-13
CA2166811C (en) 2007-04-24
DE69403479D1 (de) 1997-07-03
EP0708775A1 (de) 1996-05-01
US5716951A (en) 1998-02-10
EP0708775B1 (de) 1997-05-28
CA2166811A1 (en) 1995-02-09
US5705890A (en) 1998-01-06
US5493020A (en) 1996-02-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee