ES2108258T3 - Granulos que contienen sustancias medicamentosas peptidicas y su preparacion asi como su empleo. - Google Patents

Granulos que contienen sustancias medicamentosas peptidicas y su preparacion asi como su empleo.

Info

Publication number
ES2108258T3
ES2108258T3 ES93902032T ES93902032T ES2108258T3 ES 2108258 T3 ES2108258 T3 ES 2108258T3 ES 93902032 T ES93902032 T ES 93902032T ES 93902032 T ES93902032 T ES 93902032T ES 2108258 T3 ES2108258 T3 ES 2108258T3
Authority
ES
Spain
Prior art keywords
preparation
well
drug substances
granules containing
peptidic drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902032T
Other languages
English (en)
Inventor
Jens-Christian Wunderlich
Ursula Schick
Jurgen Werry
Jurgen Freidenreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Alfatec Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4201179A external-priority patent/DE4201179A1/de
Application filed by Alfatec Pharma GmbH filed Critical Alfatec Pharma GmbH
Application granted granted Critical
Publication of ES2108258T3 publication Critical patent/ES2108258T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN PELLETS QUE CONTIENEN MEDICAMENTO PEPTIDO INCORPORADO EN UNA MATRIZ CONSISTENTE EN GELATINA O GELATINA FRACCIONADA Y PLASTIFICANTES, DISPONIENDO EL PELLETS DE UNA CONSISTENCIA SEMISOLIDA O SIMILAR AL GEL. TALES FORMAS DE MEDICAMENTO EXHIBEN, DESPUES DE LA APLICACION, PROPIEDADES BIOADHESIVAS Y, EN VIRTUD DE LA MATRIZ DE MATERIALES ESPECIFICADOS, PERMITE O REFUERZA LA REABSORCION DEL MEDICAMENTO PEPTIDO POR EL CUERPO.
ES93902032T 1992-01-17 1993-01-18 Granulos que contienen sustancias medicamentosas peptidicas y su preparacion asi como su empleo. Expired - Lifetime ES2108258T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4201179A DE4201179A1 (de) 1992-01-17 1992-01-17 Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
US87686592A 1992-04-30 1992-04-30

Publications (1)

Publication Number Publication Date
ES2108258T3 true ES2108258T3 (es) 1997-12-16

Family

ID=25911046

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902032T Expired - Lifetime ES2108258T3 (es) 1992-01-17 1993-01-18 Granulos que contienen sustancias medicamentosas peptidicas y su preparacion asi como su empleo.

Country Status (8)

Country Link
EP (1) EP0621775B1 (es)
AT (1) ATE156350T1 (es)
AU (1) AU3343093A (es)
DE (1) DE59307073D1 (es)
DK (1) DK0621775T3 (es)
ES (1) ES2108258T3 (es)
GR (1) GR3024529T3 (es)
WO (1) WO1993013753A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59303759C5 (de) 1992-01-17 2009-04-09 Alfatec-Pharma Gmbh Wirkstoff-enthaltende festkörper mit einem gerüst aus hydrophilen makromolekülen und verfahren zu ihrer herstellung
AU1677095A (en) * 1994-01-11 1995-08-01 Alkermes Controlled Therapeutics, Inc. Oral dosage form of desmopressin (ddavp)
CA2164262A1 (en) * 1995-12-01 1997-06-02 Charles J. Doillon Biostable porous material comprising composite biopolymers
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
WO1997039762A1 (en) * 1996-04-22 1997-10-30 Rothschild, Peter, R. Stabilized antihepatitis-b vaccine tablets
IT1293087B1 (it) * 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital Microparticelle a base di materiali polimerici ibridi per il rilascio controllato di molecole biologicamente attive, procedimento per la
CN1244794A (zh) * 1997-11-06 2000-02-16 奥尔班公司 用于药物释放的稳定的干燥药物组合物及其制备方法
DE19821951A1 (de) * 1998-05-15 1999-11-18 Basf Ag Cyclosporin-Zubereitungen
DE10332160A1 (de) * 2003-07-15 2005-02-03 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102005054937A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Angiogenese förderndes Substrat
DE102005054938A1 (de) * 2005-11-17 2007-05-24 Gelita Ag Formkörper auf Basis eines vernetzten, Gelatine enthaltenden Materials, Verfahren zu deren Herstellung sowie deren Verwendung
EP2061440A2 (en) 2007-04-04 2009-05-27 Sigmoid Pharma Limited A pharmaceutical composition of tacrolimus
ES2963291T3 (es) 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
ES2530049T3 (es) 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
BR112012002963A2 (pt) 2009-08-12 2017-10-24 Sigmoid Pharma Ltd composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa
ES2561652T3 (es) * 2010-02-25 2016-02-29 Evonik Röhm Gmbh Formulación farmacéutica o nutracéutica
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
GB201319792D0 (en) * 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EA036036B1 (ru) 2014-11-07 2020-09-16 Сигмойд Фарма Лимитед Композиции, содержащие циклоспорин

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB887901A (es) * 1960-04-13 1900-01-01
US3312594A (en) * 1963-06-21 1967-04-04 Squibb & Sons Inc Longlasting troche
GB8514090D0 (en) * 1985-06-04 1985-07-10 Sandoz Ltd Organic compounds
EP0138216B1 (en) * 1983-10-14 1993-01-07 Sumitomo Pharmaceuticals Company, Limited Sustained-release ifn preparation for parenteral administration
WO1985005029A1 (en) * 1984-05-09 1985-11-21 Medaphore Inc. Oral insulin and a method of making the same
ATE87469T1 (de) * 1985-12-27 1993-04-15 Sumitomo Pharma Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung.
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5215756A (en) * 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution

Also Published As

Publication number Publication date
AU3343093A (en) 1993-08-03
WO1993013753A1 (de) 1993-07-22
DE59307073D1 (de) 1997-09-11
DK0621775T3 (da) 1997-10-06
ATE156350T1 (de) 1997-08-15
EP0621775A1 (de) 1994-11-02
EP0621775B1 (de) 1997-08-06
GR3024529T3 (en) 1997-12-31

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