ES2133633T3 - Procedimiento para la produccion de polvos, granulados o peletes que contienen una sustancia activa, con una estructura a base de macromoleculas hidrofilas, y su utilizacion. - Google Patents

Procedimiento para la produccion de polvos, granulados o peletes que contienen una sustancia activa, con una estructura a base de macromoleculas hidrofilas, y su utilizacion.

Info

Publication number
ES2133633T3
ES2133633T3 ES95113398T ES95113398T ES2133633T3 ES 2133633 T3 ES2133633 T3 ES 2133633T3 ES 95113398 T ES95113398 T ES 95113398T ES 95113398 T ES95113398 T ES 95113398T ES 2133633 T3 ES2133633 T3 ES 2133633T3
Authority
ES
Spain
Prior art keywords
pelets
granulates
powders
procedure
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95113398T
Other languages
English (en)
Inventor
Jens-Christian Wunderlich
Ursula Schick
Jurgen Werry
Jurgen Freidenreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Alfatec Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27435369&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2133633(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4201173A external-priority patent/DE4201173C2/de
Priority claimed from DE4201179A external-priority patent/DE4201179A1/de
Application filed by Alfatec Pharma GmbH filed Critical Alfatec Pharma GmbH
Application granted granted Critical
Publication of ES2133633T3 publication Critical patent/ES2133633T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Glanulating (AREA)

Abstract

LA INVENCION SE REFIERE UN PROCEDIMIENTO PARA LA ELABORACION DE AL MENOS UN POLVO CONTENIENDO SUSTANCIA ACTIVA, GRANULADO O PELETS, CON MACROMOLECULAS HIDROFILAS, SUSTANCIA ACTIVA Y EVENTUALMENTE OTRAS SUSTANCIAS AUXILIARES Y DE ARMADURA ACEPTABLE FARMACEUTICAMENTE, DONDE LA SUSTANCIA ACTIVA SE ENCUENTRA ACTIVA EN UNA MATRIZ, SUSPENDIDA O PRESENTE DE FORMA EMULSIONADA, DONDE EL PROCESO ES ESPECIALMENTE ECONOMICO E INOFENSIVO DESDE EL PUNTO DE VISTA ECONOMICO. PUEDE SER ELABORADO CON EL PROCEDIMIENTO DE ACUERDO CON LA INVENCION POLVOS, GRANULADOS O PELETS PRODUCTOS INTERMEDIOS O TERMINALES PARA APLICACIONES FARMACEUTICAS, COSMETICAS, DE DIAGNOSTICO, ANALITICA O DIETETICAS (CUIDADO DE LA SALUD DE FORMA ESPECIALMENTE VENTAJOSA. TALES MEDICAMENTOS MUESTRAN POR EJEMPLO UNA BIODISPONIBILIDAD AUMENTADA, ASI COMO UNA BUENA CONSERVACION Y TOLERABILIDAD.
ES95113398T 1992-01-17 1993-01-18 Procedimiento para la produccion de polvos, granulados o peletes que contienen una sustancia activa, con una estructura a base de macromoleculas hidrofilas, y su utilizacion. Expired - Lifetime ES2133633T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4201173A DE4201173C2 (de) 1992-01-17 1992-01-17 Akutarzneimittel in Form von Dihydropyridinderivaten enthaltenden Pellets und ihre Herstellung
DE4201179A DE4201179A1 (de) 1992-01-17 1992-01-17 Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
US07/876,864 US5405616A (en) 1992-01-17 1992-04-30 Means for containing active substances, having a shell of hydrophilic macromolecules, active substances and process for preparation thereof
US07/876,877 US5384129A (en) 1992-01-17 1992-04-30 Pellets containing dihydropyridine derivatives process for the production thereof and use as rapid action dosage in heart and circulatory diseases

Publications (1)

Publication Number Publication Date
ES2133633T3 true ES2133633T3 (es) 1999-09-16

Family

ID=27435369

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95113398T Expired - Lifetime ES2133633T3 (es) 1992-01-17 1993-01-18 Procedimiento para la produccion de polvos, granulados o peletes que contienen una sustancia activa, con una estructura a base de macromoleculas hidrofilas, y su utilizacion.
ES93902034T Expired - Lifetime ES2092808T3 (es) 1992-01-17 1993-01-18 Cuerpos solidos con contenido en principio activo con una estructura a base de macromoleculas hidrofilas y procedimiento para su produccion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES93902034T Expired - Lifetime ES2092808T3 (es) 1992-01-17 1993-01-18 Cuerpos solidos con contenido en principio activo con una estructura a base de macromoleculas hidrofilas y procedimiento para su produccion.

Country Status (10)

Country Link
EP (2) EP0701815B1 (es)
JP (1) JPH07502736A (es)
AT (2) ATE142484T1 (es)
AU (1) AU679906B2 (es)
CA (1) CA2128244C (es)
DE (2) DE59303759C5 (es)
DK (2) DK0701815T3 (es)
ES (2) ES2133633T3 (es)
GR (2) GR3021223T3 (es)
WO (1) WO1993013757A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714575B1 (fr) * 1994-01-03 1996-02-02 Rhone Poulenc Nutrition Animal Nouveaux granulés contenant des organismes vivant pour l'alimentation animale.
SE9704401D0 (sv) 1997-11-28 1997-11-28 Astra Ab Matrix pellets for greasy, oily or sticky drug substances
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
ES2238353T3 (es) * 2001-03-22 2005-09-01 Cognis Ip Management Gmbh Microcapsulas.
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
WO2003105768A2 (en) 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
FR2843301B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
FR2843302B1 (fr) 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
WO2004035023A1 (de) * 2002-10-16 2004-04-29 Dr. Suwelack Skin & Health Care Ag Verwendung von formkörpern zur äusseren anwendung
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物，制剂及其用途
FR2887455B1 (fr) * 2005-06-28 2007-08-10 Sanofi Aventis Sa Formulation a liberation prolongee de principes actifs de medicaments
WO2008033023A2 (en) * 2006-09-15 2008-03-20 Echo Pharmaceuticals B.V. Granulate containing a pharmaceutically active substance and anemulsifier and method for its manufacture
CA2664315C (en) 2006-09-15 2016-01-19 Echo Pharmaceuticals B.V. Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
US20100272762A1 (en) 2009-04-22 2010-10-28 Dr. Suwelack Skin & Health Care Ag Freeze-Dried Coated Molded Article
WO2014022195A1 (en) * 2012-08-01 2014-02-06 Tavakoli Zahra Free flowing, frozen compositions comprising a therapeutic agent
ITMI20122145A1 (it) * 2012-12-14 2014-06-15 Velleja Res Srl Composizioni per uso orale contenenti idrolizzati di collagene, di elastina e vitamina c favorenti la deposizione di matrice extra-cellulare
LU102656B1 (de) 2021-03-11 2022-09-12 Prosecur Gmbh Flüssiges Nahrungsergänzungsmittel zur Immunstimulation, Verfahren zu dessen Herstellung sowie Verwendung

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IE53696B1 (en) * 1981-12-02 1989-01-18 Wyeth John & Brother Ltd Solid shaped articles
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ATE151631T1 (de) 1992-01-17 1997-05-15 Alfatec Pharma Gmbh Pflanzenwirkstoffextrakt enthaltende kryopelletierte formkörper und ihre pharmazeutische oder kosmetische verwendung
WO1993013753A1 (de) 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh Peptidarzneistoffe enthaltende pellets und ihre herstellung sowie deren verwendung
AU670771B2 (en) 1992-01-17 1996-08-01 Alfatec-Pharma Gmbh Process for the manufacture of soft gelatin capsules by a drip-feed method
DE4221880A1 (de) * 1992-07-03 1994-01-05 Alfatec Pharma Gmbh Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen

Also Published As

Publication number Publication date
DE59309678D1 (de) 1999-08-05
DE59303759C5 (de) 2009-04-09
EP0701815A1 (de) 1996-03-20
WO1993013757A1 (de) 1993-07-22
CA2128244C (en) 1998-09-22
AU3343293A (en) 1993-08-03
DK0621777T3 (da) 1996-10-21
ATE181666T1 (de) 1999-07-15
ES2092808T3 (es) 1996-12-01
EP0701815B1 (de) 1999-06-30
DK0701815T3 (da) 2000-02-07
GR3021223T3 (en) 1997-01-31
EP0621777B1 (de) 1996-09-11
AU679906B2 (en) 1997-07-17
JPH07502736A (ja) 1995-03-23
GR3030675T3 (en) 1999-11-30
CA2128244A1 (en) 1993-07-22
ATE142484T1 (de) 1996-09-15
EP0621777A1 (de) 1994-11-02
DE59303759D1 (de) 1996-10-17

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